76-space analysis of grey matter diffusivity: Methods and applications

Tianming Liu, Geoffrey Young, Ling Huang, Nan Kuei Chen, Stephen T.C. Wong

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Scopus citations

Abstract

Diffusion Weighted Imaging (DWI) and Diffusion Tensor Imaging (DTI) are widely used in the study and diagnosis of neurological diseases involving the White Matter (WM). However, many neurological and neurodegenerative diseases (e.g., Alzheimer's disease and Creutzfeldt-Jakob disease) are generally considered to involve the Grey Matter (GM). Investigation of GM diffusivity of normal aging and pathological brains has both scientific significance and clinical applications. Most of previous research reports on quantification of GM diffusivity were based on the manually labeled Region of Interests (ROI) analysis of specific neuroanatomic regions. The well-known drawbacks of ROI analysis include inter-rater variations, irreproducible results, tediousness, and requirement of a priori definition of interested regions. In this paper, we present a new framework of automated 76-space analysis of GM diffusivity using DWI/DTI. The framework will be evaluated using clinical data, and applied for study of normal brain, Creutzfeldt-Jakob disease and Schizophrenia.

Original languageEnglish (US)
Title of host publicationMedical Image Computing and Computer-Assisted Intervention - MICCAI 2005 - 8th International Conference, Proceedings
PublisherSpringer-Verlag
Pages148-155
Number of pages8
ISBN (Print)3540293272, 9783540293279
DOIs
StatePublished - 2005
Event8th International Conference on Medical Image Computing and Computer-Assisted Intervention - MICCAI 2005 - Palm Springs, CA, United States
Duration: Oct 26 2005Oct 29 2005

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume3749 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Other

Other8th International Conference on Medical Image Computing and Computer-Assisted Intervention - MICCAI 2005
CountryUnited States
CityPalm Springs, CA
Period10/26/0510/29/05

ASJC Scopus subject areas

  • Theoretical Computer Science
  • Computer Science(all)

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