6-substituted-1,3,8-trichlorodibenzofurans as 2,3,7,8-tetrachlorodibenzo-p-dioxin antagonists in the rat: structure activity relationships

Keyphrases

• 2,3,7,8-tetrachlorodibenzo-p-dioxin 100%
• Structure-activity Relationship 100%
• Propyl 45%
• Methyl 27%
• Ethyl 27%
• Ethoxyresorufin-O-deethylase 27%
• Aryl Hydrocarbon Hydroxylases 27%
• Nitro 27%
• Ah Receptor 27%
• Tert-butyl 27%
• Cyclohexyl 27%
• Enzyme Activity 18%
• Binding Studies 9%
• Mechanism of Action 9%
• Inducer 9%
• Competitive Binding 9%
• Scatchard Plot 9%
• In Vivo Activity 9%
• Radioligand 9%
• In Vitro Binding 9%
• Isopropyl 9%
• Structure-dependent 9%
• Monooxygenase 9%
• Receptor Binding Affinity 9%
• Binding Avidity 9%
• Administration Study 9%
• Dixon Plot 9%

Pharmacology, Toxicology and Pharmaceutical Science

• 2,3,7,8-Tetrachlorodibenzodioxin 100%
• Structure Activity Relationship 100%
• Unspecific Monooxygenase 36%
• Aromatic Hydrocarbon Receptor 27%
• Ethoxyresorufin 27%
• Radioligand 9%