4425: Quantum-inspired computing analysis of spatial omics uncovers immune pathways relevant to T-DXd resistance in metastatic breast cancer

Stephen T. Wong; Glori Das; Wenjuan Dong; Matthew Vasquez; Hong Zhao; Jenny C. Chang

doi:10.1158/1538-7445.AM2025-4425

4425: Quantum-inspired computing analysis of spatial omics uncovers immune pathways relevant to T-DXd resistance in metastatic breast cancer

Stephen T. Wong, Glori Das, Wenjuan Dong, Matthew Vasquez, Hong Zhao, Jenny C. Chang

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Trastuzumab deruxtecan (T-DXd) is a key therapy for HER2+/HER2-low metastatic breast cancer (mBC), but up to 50% of patients develop resistance. Resistance mechanisms have implicated dysfunctions in DNA repair, lysosomal activity, and immune responses. This study combines spatial omics and quantum-inspired regulatory network analysis to investigate tumor-immune-extracellular matrix interactions contributing to T-DXd resistance.

Original language	English (US)
Title of host publication	Quantum-inspired computing analysis of spatial omics uncovers immune pathways relevant to T-DXd resistance in metastatic breast cancer
Publisher	Cancer Research
Volume	85
Edition	8_Supplement_1: 4425
ISBN (Electronic)	1538-7445
ISBN (Print)	0008-5472
DOIs	https://doi.org/10.1158/1538-7445.AM2025-4425
State	Published - Mar 19 2025
Event	American Association for Cancer Research - Duration: Apr 25 2025 → Apr 30 2025

Conference

Conference	American Association for Cancer Research
Period	4/25/25 → 4/30/25

Divisions

Medical Oncology

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10.1158/1538-7445.AM2025-4425License: Unspecified

Cite this

Wong, S. T., Das, G., Dong, W., Vasquez, M., Zhao, H., & Chang, J. C. (2025). 4425: Quantum-inspired computing analysis of spatial omics uncovers immune pathways relevant to T-DXd resistance in metastatic breast cancer. In Quantum-inspired computing analysis of spatial omics uncovers immune pathways relevant to T-DXd resistance in metastatic breast cancer (8_Supplement_1: 4425 ed., Vol. 85). Cancer Research. https://doi.org/10.1158/1538-7445.AM2025-4425

4425: Quantum-inspired computing analysis of spatial omics uncovers immune pathways relevant to T-DXd resistance in metastatic breast cancer. / Wong, Stephen T.; Das, Glori; Dong, Wenjuan et al.
Quantum-inspired computing analysis of spatial omics uncovers immune pathways relevant to T-DXd resistance in metastatic breast cancer. Vol. 85 8_Supplement_1: 4425. ed. Cancer Research, 2025.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Wong, ST, Das, G, Dong, W, Vasquez, M, Zhao, H & Chang, JC 2025, 4425: Quantum-inspired computing analysis of spatial omics uncovers immune pathways relevant to T-DXd resistance in metastatic breast cancer. in Quantum-inspired computing analysis of spatial omics uncovers immune pathways relevant to T-DXd resistance in metastatic breast cancer. 8_Supplement_1: 4425 edn, vol. 85, Cancer Research, American Association for Cancer Research, 4/25/25. https://doi.org/10.1158/1538-7445.AM2025-4425

Wong ST, Das G, Dong W, Vasquez M, Zhao H, Chang JC. 4425: Quantum-inspired computing analysis of spatial omics uncovers immune pathways relevant to T-DXd resistance in metastatic breast cancer. In Quantum-inspired computing analysis of spatial omics uncovers immune pathways relevant to T-DXd resistance in metastatic breast cancer. 8_Supplement_1: 4425 ed. Vol. 85. Cancer Research. 2025 doi: 10.1158/1538-7445.AM2025-4425

Wong, Stephen T. ; Das, Glori ; Dong, Wenjuan et al. / 4425: Quantum-inspired computing analysis of spatial omics uncovers immune pathways relevant to T-DXd resistance in metastatic breast cancer. Quantum-inspired computing analysis of spatial omics uncovers immune pathways relevant to T-DXd resistance in metastatic breast cancer. Vol. 85 8_Supplement_1: 4425. ed. Cancer Research, 2025.

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title = "4425: Quantum-inspired computing analysis of spatial omics uncovers immune pathways relevant to T-DXd resistance in metastatic breast cancer",

abstract = "Trastuzumab deruxtecan (T-DXd) is a key therapy for HER2+/HER2-low metastatic breast cancer (mBC), but up to 50\% of patients develop resistance. Resistance mechanisms have implicated dysfunctions in DNA repair, lysosomal activity, and immune responses. This study combines spatial omics and quantum-inspired regulatory network analysis to investigate tumor-immune-extracellular matrix interactions contributing to T-DXd resistance.",

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AU - Wong, Stephen T.

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AU - Vasquez, Matthew

AU - Zhao, Hong

AU - Chang, Jenny C.

PY - 2025/3/19

Y1 - 2025/3/19

N2 - Trastuzumab deruxtecan (T-DXd) is a key therapy for HER2+/HER2-low metastatic breast cancer (mBC), but up to 50% of patients develop resistance. Resistance mechanisms have implicated dysfunctions in DNA repair, lysosomal activity, and immune responses. This study combines spatial omics and quantum-inspired regulatory network analysis to investigate tumor-immune-extracellular matrix interactions contributing to T-DXd resistance.

AB - Trastuzumab deruxtecan (T-DXd) is a key therapy for HER2+/HER2-low metastatic breast cancer (mBC), but up to 50% of patients develop resistance. Resistance mechanisms have implicated dysfunctions in DNA repair, lysosomal activity, and immune responses. This study combines spatial omics and quantum-inspired regulatory network analysis to investigate tumor-immune-extracellular matrix interactions contributing to T-DXd resistance.

U2 - 10.1158/1538-7445.AM2025-4425

DO - 10.1158/1538-7445.AM2025-4425

M3 - Conference contribution

SN - 0008-5472

VL - 85

BT - Quantum-inspired computing analysis of spatial omics uncovers immune pathways relevant to T-DXd resistance in metastatic breast cancer

PB - Cancer Research

T2 - American Association for Cancer Research

Y2 - 25 April 2025 through 30 April 2025

ER -

4425: Quantum-inspired computing analysis of spatial omics uncovers immune pathways relevant to T-DXd resistance in metastatic breast cancer

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