3D-image-guided high-dose-rate intracavitary brachytherapy for salvage treatment of locally persistent nasopharyngeal carcinoma

Yu Feng Ren, Xin Ping Cao, Jia Xu, Wei Jun Ye, Yuan Hong Gao, Bin S. Teh, Bi Xiu Wen

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Background: To evaluate the therapeutic benefit of 3D-image-guided high-dose-rate intracavitary brachytherapy (3D-image-guided HDR-BT) used as a salvage treatment of intensity modulated radiation therapy (IMRT) in patients with locally persistent nasopharyngeal carcinoma (NPC).Methods: Thirty-two patients with locally persistent NPC after full dose of IMRT were evaluated retrospectively. 3D-image-guided HDR-BT treatment plan was performed on a 3D treatment planning system (PLATO BPS 14.2). The median dose of 16 Gy was delivered to the 100% isodose line of the Gross Tumor Volume.Results: The whole procedure was well tolerated under local anesthesia. The actuarial 5-y local control rate for 3D-image-guided HDR-BT was 93.8%, patients with early-T stage at initial diagnosis had 100% local control rate. The 5-y actuarial progression-free survival and distant metastasis-free survival rate were 78.1%, 87.5%. One patient developed and died of lung metastases. The 5-y actuarial overall survival rate was 96.9%.Conclusions: Our results showed that 3D-image-guided HDR-BT would provide excellent local control as a salvage therapeutic modality to IMRT for patients with locally persistent disease at initial diagnosis of early-T stage NPC.

Original languageEnglish (US)
Article number165
JournalRadiation Oncology
Volume8
Issue number1
DOIs
StatePublished - Jul 5 2013

Keywords

  • 3D-image-guided HDR Brachytherapy
  • Intensity-modulated radiotherapy
  • Local tumor control
  • Nasopharyngeal carcinoma
  • Persistent disease

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging

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