3D-CT implanted interstitial brachytherapy for T2b nasopharyngeal carcinoma

Yu Feng Ren, Yuan Hong Gao, Xin Ping Cao, Wei Jun Ye, Bin S. Teh

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Background: To compare the results of external beam radiotherapy in combination with 3D- computed tomography (CT)-implanted interstitial high dose rate brachytherapy (ERT/3D-HDR-BT) versus conventional external beam radiotherapy (ERT) for the treatment of stage T2b nasopharyngeal carcinoma (NPC).Methods: Forty NPC patients diagnosed with stage T2b NPC were treated with ERT/3D-HDR-BT under local anesthesia. These patients received a mean dose of 60 Gy, followed by 12-20 Gy administered by 3D-HDR-BT. Another 101 patients diagnosed with non-metastatic T2b NPC received a mean dose of 68 Gy by ERT alone during the same period.Results: Patients treated with ERT/3D-HDR-BT versus ERT alone exhibited an improvement in their 5-y local failure-free survival rate (97.5% vs. 80.2%, P = 0.012) and disease-free survival rate (92.5% vs. 73.3%, P = 0.014). Using multivariate analysis, administration of 3D-HDR-BT was found to be favorable for local control (P = 0.046) and was statistically significant for disease-free survival (P = 0.021). The incidence rate of acute and chronic complications between the two groups was also compared.Conclusions: It is possible that the treatment modality enhances local control due to improved conformal dose distributions and the escalated radiation dose applied.

Original languageEnglish (US)
Article number113
JournalRadiation Oncology
Volume5
Issue number1
DOIs
StatePublished - Nov 23 2010

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging

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