3750: Spatial crosstalk modeling of the tumor microenvironment uncovers CCR5-mediated glia-to-glia signaling as a key regulator of brain metastases

Stephen T. Wong; Wenjuan Dong; Matthew Vasquez; Jianting Sheng; Ju Young Ahn

doi:10.1158/1538-7445.AM2025-3750

3750: Spatial crosstalk modeling of the tumor microenvironment uncovers CCR5-mediated glia-to-glia signaling as a key regulator of brain metastases

Stephen T. Wong, Wenjuan Dong, Matthew Vasquez, Jianting Sheng, Ju Young Ahn

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Therapies targeting tumor cells and their microenvironment have demonstrated efficacy across various cancers, yet limited impact on brain metastases due to challenges with blood-brain barrier (BBB) penetration, the brain's immune privilege, and its glia composition. Here, we performed a detailed spatiotemporal analysis of glial cells in the brain metastasis microenvironment to characterize tumor-glial versus glia-to-glia communication.

Original language	English (US)
Title of host publication	Spatial crosstalk modeling of the tumor microenvironment uncovers CCR5-mediated glia-to-glia signaling as a key regulator of brain metastases
Publisher	Cancer Research
Volume	85
Edition	8_Supplement_1: 3750
ISBN (Electronic)	1538-7445
ISBN (Print)	0008-5472
DOIs	https://doi.org/10.1158/1538-7445.AM2025-3750
State	Published - Apr 21 2025
Event	American Association for Cancer Research - Duration: Apr 25 2025 → Apr 30 2025

Conference

Conference	American Association for Cancer Research
Period	4/25/25 → 4/30/25

Divisions

Medical Oncology

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Cite this

Wong, S. T., Dong, W., Vasquez, M., Sheng, J., & Ahn, J. Y. (2025). 3750: Spatial crosstalk modeling of the tumor microenvironment uncovers CCR5-mediated glia-to-glia signaling as a key regulator of brain metastases. In Spatial crosstalk modeling of the tumor microenvironment uncovers CCR5-mediated glia-to-glia signaling as a key regulator of brain metastases (8_Supplement_1: 3750 ed., Vol. 85). Cancer Research. https://doi.org/10.1158/1538-7445.AM2025-3750

3750: Spatial crosstalk modeling of the tumor microenvironment uncovers CCR5-mediated glia-to-glia signaling as a key regulator of brain metastases. / Wong, Stephen T.; Dong, Wenjuan; Vasquez, Matthew et al.
Spatial crosstalk modeling of the tumor microenvironment uncovers CCR5-mediated glia-to-glia signaling as a key regulator of brain metastases. Vol. 85 8_Supplement_1: 3750. ed. Cancer Research, 2025.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Wong, ST , Dong, W, Vasquez, M, Sheng, J & Ahn, JY 2025, 3750: Spatial crosstalk modeling of the tumor microenvironment uncovers CCR5-mediated glia-to-glia signaling as a key regulator of brain metastases. in Spatial crosstalk modeling of the tumor microenvironment uncovers CCR5-mediated glia-to-glia signaling as a key regulator of brain metastases. 8_Supplement_1: 3750 edn, vol. 85, Cancer Research, American Association for Cancer Research, 4/25/25. https://doi.org/10.1158/1538-7445.AM2025-3750

Wong ST , Dong W, Vasquez M, Sheng J, Ahn JY. 3750: Spatial crosstalk modeling of the tumor microenvironment uncovers CCR5-mediated glia-to-glia signaling as a key regulator of brain metastases. In Spatial crosstalk modeling of the tumor microenvironment uncovers CCR5-mediated glia-to-glia signaling as a key regulator of brain metastases. 8_Supplement_1: 3750 ed. Vol. 85. Cancer Research. 2025 doi: 10.1158/1538-7445.AM2025-3750

Wong, Stephen T. ; Dong, Wenjuan ; Vasquez, Matthew et al. / 3750: Spatial crosstalk modeling of the tumor microenvironment uncovers CCR5-mediated glia-to-glia signaling as a key regulator of brain metastases. Spatial crosstalk modeling of the tumor microenvironment uncovers CCR5-mediated glia-to-glia signaling as a key regulator of brain metastases. Vol. 85 8_Supplement_1: 3750. ed. Cancer Research, 2025.

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abstract = "Therapies targeting tumor cells and their microenvironment have demonstrated efficacy across various cancers, yet limited impact on brain metastases due to challenges with blood-brain barrier (BBB) penetration, the brain's immune privilege, and its glia composition. Here, we performed a detailed spatiotemporal analysis of glial cells in the brain metastasis microenvironment to characterize tumor-glial versus glia-to-glia communication.",

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AU - Ahn, Ju Young

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N2 - Therapies targeting tumor cells and their microenvironment have demonstrated efficacy across various cancers, yet limited impact on brain metastases due to challenges with blood-brain barrier (BBB) penetration, the brain's immune privilege, and its glia composition. Here, we performed a detailed spatiotemporal analysis of glial cells in the brain metastasis microenvironment to characterize tumor-glial versus glia-to-glia communication.

AB - Therapies targeting tumor cells and their microenvironment have demonstrated efficacy across various cancers, yet limited impact on brain metastases due to challenges with blood-brain barrier (BBB) penetration, the brain's immune privilege, and its glia composition. Here, we performed a detailed spatiotemporal analysis of glial cells in the brain metastasis microenvironment to characterize tumor-glial versus glia-to-glia communication.

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M3 - Conference contribution

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BT - Spatial crosstalk modeling of the tumor microenvironment uncovers CCR5-mediated glia-to-glia signaling as a key regulator of brain metastases

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ER -

3750: Spatial crosstalk modeling of the tumor microenvironment uncovers CCR5-mediated glia-to-glia signaling as a key regulator of brain metastases

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