2,3,7,8-tetrachlorodibenzo-p-dioxin as an antiestrogen: Effect on rat uterine peroxidase activity

Barry Astroff, Stephen Safe

Research output: Contribution to journalArticle

78 Scopus citations

Abstract

Treatment of 25-day-old female Sprague-Dawley rats with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) significantly lowered constitutive uterine peroxidase activity and decreased uterine wet weights in a dose-response fashion. In cotreatment studies with 17β-estradiol, 2,3,7,8-TCDD antagonized the increase in uterine peroxidase activity and uterine wet weights, and these effects persisted for up to 156 hr. In the rat uterus, the antiestrogenic affects of two potent Ah receptor agonists, 2,3,7.8-TCDD and 2,3,4,7,8-pentachlorodibenzofuran, were comparable at a dose of 80μ/kg, whereas the weaker Ah receptor agonist, 2,3,7,8-tetrachlorodibenzo-p-dioxin, was relatively inactive at this dose. These results show that 2,3,7,8-TCDD antagonizes a well-characterized estrogen-induced response (uterine peroxidase activity), and the structure-activity data suggest that the Ah receptor is involved in mediating the antiestrogenic responses in target cells/organs.

Original languageEnglish (US)
Pages (from-to)485-488
Number of pages4
JournalBiochemical pharmacology
Volume39
Issue number3
DOIs
StatePublished - Feb 1 1990

ASJC Scopus subject areas

  • Biochemistry
  • Pharmacology

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