Abstract
A bi-directional channel of communication, the gut-brain axis, has been recognized for decades; now another dimension is added, the gut microbiome. Evidence now indicates a critical role for gut microbes in brain development and function; findings that have spurred a plethora of studies into relationships between gut microbiota profiles and neurodegenerative disorders. While findings in animal models suggest that a disturbed gut microbiome might contribute to the pathophysiology of neurological disorders, a causative relationship has yet to be defined and effective therapeutic strategies based on microbiota modulation have not, as yet, emerged.
| Original language | English (US) |
|---|---|
| Title of host publication | Comprehensive Gut Microbiota |
| Publisher | Elsevier |
| Pages | 412-422 |
| Number of pages | 11 |
| Volume | 2 |
| ISBN (Electronic) | 9780128192658 |
| ISBN (Print) | 9780128220368 |
| DOIs | |
| State | Published - Jan 1 2022 |
Keywords
- Alzheimer's disease
- Amyotrophic lateral sclerosis
- Antibiotic
- Central nervous system
- Diet
- Fecal microbiota transplantation
- Gut-brain axis
- Huntington's disease
- Microbiome
- Microbiota
- Multiple sclerosis
- Neurodegeneration
- Parkinson's disease
- Prebiotic
- Probiotic
ASJC Scopus subject areas
- General Immunology and Microbiology
Divisions
- Gastroenterology and Hepatology
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