2.32 - Microbiota-Brain-Gut Axis and Neurodegenerative Disorders

Shaadi J. Abughazaleh, Lindsay A. Euers, Eamonn M.M. Quigley

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


A bi-directional channel of communication, the gut-brain axis, has been recognized for decades; now another dimension is added, the gut microbiome. Evidence now indicates a critical role for gut microbes in brain development and function; findings that have spurred a plethora of studies into relationships between gut microbiota profiles and neurodegenerative disorders. While findings in animal models suggest that a disturbed gut microbiome might contribute to the pathophysiology of neurological disorders, a causative relationship has yet to be defined and effective therapeutic strategies based on microbiota modulation have not, as yet, emerged.

Original languageEnglish (US)
Title of host publicationComprehensive Gut Microbiota
Number of pages11
ISBN (Electronic)9780128192658
ISBN (Print)9780128220368
StatePublished - Jan 1 2022


  • Alzheimer's disease
  • Amyotrophic lateral sclerosis
  • Antibiotic
  • Central nervous system
  • Diet
  • Fecal microbiota transplantation
  • Gut-brain axis
  • Huntington's disease
  • Microbiome
  • Microbiota
  • Multiple sclerosis
  • Neurodegeneration
  • Parkinson's disease
  • Prebiotic
  • Probiotic

ASJC Scopus subject areas

  • Immunology and Microbiology(all)


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