Find Research Projects

Search results

• Active

  A PHASE 3, MULTICENTER, RANDOMIZED, OPEN-LABEL, ACTIVE-CONTROLLED STUDY OF TRASTUZUMAB DERUXTECAN (T-DXd) VERSUS TRASTUZUMAB EMTANSINE (T-DM1) IN SUBJECTS WITH HIGH-RISK HER2-POSITIVE PRIMARY BREAST CANCER WHO HAVE RESIDUAL INVASIVE DISEASE IN BREAST OR

  7/6/21 → 7/5/31

  Project: Non Profit

• Engineered Enteric Nervous System-Peri Neural Invasion platform to improve predictive preclinical screens in early-stage colorectal adenocarcinomas

  Esnaola, N. F.

  7/1/21 → 6/30/23

  Project: Federal Funding Agencies

• A versatile reporter for visualization of myelin plasticity in the genetically modified rat

  Horner, P. J.

  7/1/21 → 12/31/23

  Project: Federal Funding Agencies

• Understanding the mechanisms that regulate cytoplasmic capping and defining its contributions to post-transcriptional gene regulation (Same as parent grant)

  Kiss, D. L.

  7/1/21 → 6/30/23

  Project: Federal Funding Agencies

• Understanding the mechanisms that regulate cytoplasmic capping and defining itscontributions to post-transcriptional gene regulation (Same as parent grant)

  Kiss, D. L.

  7/1/21 → 6/30/25

  Project: Federal Funding Agencies

• SH:HighLife Transseptal Transcatheter Mitral Valve Replacement HighLife Medical

  Goel, S., Faza, N., Kleiman, N., Little, S. H. & Reardon, M. J.

  6/29/21 → …

  Project: Clinical Trial

• HEALEY ALS Platform Trial - Regimen-Specific Appendix D - For pridopidine 45 mg oral capsule administered twice daily (BID) or its matching placebo.

  Appel, S. H., Greene, E. P., Liao, B., Shroff, S. & Thonhoff, J. R.

  6/29/21 → 7/23/25

  Project: Non Profit

• Long-Term, Observational, Registry of Patients With Generalized Myasthenia Gravis Who Have Received Treatment With Complement C5 Inhibition Therapies

  Greene, E. P., Liao, B., Shroff, S. & Thonhoff, J. R.

  6/28/21 → …

  Project: Clinical Trial

• AOCT - Intuitive da Vinci SP in Colorectal Surgical Procedures

  6/28/21 → …

  Project: Clinical Trial

• MERCK MK-5475 in PAH, Phase 23 A Phase 2/3, Multicenter, Randomized, Double-blind, Placebo-Controlled, Adaptive Design Study to Evaluate the Efficacy and Safety of MK-5475 in Adults With Pulmonary Arterial Hypertension

  Sahay, S. & Safdar, Z.

  6/28/21 → …

  Project: Clinical Trial

• SH-REPAIR MR - Mitraclip Device vs. Surgical Repair for Mitral Regurgitation Abbott Percutaneous MitraClipTM Device or Surgical Mitral Valve REpair in PAtients with PrImaRy Mitral Regurgitation who are Candidates for Surgery (REPAIR MR)

  Goel, S., Bhimaraj, A., Faza, N., Guha, A., Kassi, M., Kleiman, N., Lawrie, G. M., Little, S. H., Reardon, M. J. & Yousefzai, R.

  6/28/21 → …

  Project: Clinical Trial

• Mitochondrial function in symptomatic chronic COVID-19 patients COVID-19 Associated Mitochondria Functional Changes in Subjects with Post-Acute Sequelae of SARS-CoV-2 Infections (PASC)

  Hamilton, D. J., Kansara, A. & Youssef, J. G.

  6/16/21 → …

  Project: Clinical Trial

• Studies of a new checkpoint regulator in the control of intestinal inflammation

  Zhang, Z. & Li, X. C.

  6/7/21 → 5/31/26

  Project: Federal Funding Agencies

• A Randomized, Open-Label, Phase 3 Study Evaluating Efficacy and Safety of Navitoclax in Combination With Ruxolitinib Versus Best Available Therapy in Subjects With Relapsed/Refractory Myelofibrosis (TRANSFORM-2)

  Shah, S., Ganguly, S., Pingali, S. R. & Rice, L.

  6/7/21 → …

  Project: Clinical Trial

• Molecular Mechanism of Virulence Regulation in Streptococcus Pyogenes

  Kumaraswami, M. & Olsen, R. J.

  6/7/21 → 5/31/26

  Project: Federal Funding Agencies

• Assessing Energy Needs, Nutritional Status, and Physical Functioning in Patients with Hepatocellular Carcinoma (HCC)

  Kodali, S.

  6/7/21 → …

  Project: Clinical Trial

• Novel Stem Cell Immunotherapy for MDR-Tuberculosis

  Jagannath, C.

  6/4/21 → 5/31/26

  Project: Federal Funding Agencies

• A Novel M2 Lipogenic Macrophage Associated with Fracture Callus are Altered in Type 2 Diabetes

  Davis, B.

  6/1/21 → 5/31/23

  Project: Federal Funding Agencies

• Recovery and Outcomes from StrokE

  Vahidy, F. S.

  6/1/21 → 4/30/23

  Project: Federal Funding Agencies

• The immunosuppressive function of secretory IgM in tumor-bearing mice

  Tang, C. A. & Yin, Z.

  6/1/21 → 5/31/24

  Project: Federal Funding Agencies

• Converting HR Breast Cancer Into an Individualized Vaccine

  Chang, J. C. & Niravath, P. A.

  5/26/21 → …

  Project: Clinical Trial

• Potentiation of Multi-peptide Lung Cancer Vaccines with Immune Checkpoint Antagonist CA-170

  You, M. & Yi, Q.

  5/24/21 → 11/23/23

  Project: Federal Funding Agencies

• Houston Alzheimer Disease Study

  Masdeu, J. C., Faridar, A., Fujita, M., Karmonik, C., Nakawah, M. O., Pascual, B., Roman, G. C., Toledo, J. B. & Wong, S. T.

  5/17/21 → …

  Project: Clinical Trial

• Systematic modeling and prediction of cell-type-specific and spatiotemporal crosstalk pathways in Alzheimer¿s Disease

  Wong, S. T., Sheng, J. & Yin, Z.

  5/15/21 → 4/30/26

  Project: Federal Funding Agencies

• CVL-751-PD-004 (TEMPO-1 TRIAL)

  Ondo, W. G. & Waln, O.

  5/11/21 → …

  Project: Clinical Trial

• EGFR and KRAS Vaccine to Prevent Lung Cancer

  Wang, Y. & You, M.

  5/10/21 → 8/31/23

  Project: Federal Funding Agencies

• African trypanosome parasites: a new tool to unveil potential immunological strategies totarget CLL

  Hu, C. A.

  5/3/21 → 4/30/23

  Project: Federal Funding Agencies

• Determinants of COVID19-induced venous thrombosis and targeted therapy assessed with bioengineered Vein-Chip.

  Cooke, J. P.

  5/1/21 → 4/30/25

  Project: Federal Funding Agencies

• BO41843: Phase III_GDC-9545 RO7197597_Breast Cancer_Roche BO41843: A Phase III Randomized, Double-Blind, Placebo-Controlled, Multicenter Study Evaluating the Efficacy and Safety of GDC-9545 Combined With Palbociclib Compared With Letrozole Combined With Palbociclib in Patients With Estrogen Receptor-Positive, HER2-Negative Locally Advanced or Metastatic Breast Cancer

  Niravath, P. A. & Chang, J. C.

  4/28/21 → …

  Project: Clinical Trial

• EP-CATALYST - Amulet Device Compared to NOACs for A-Fib Treatment Abbott

  Valderrábano, M., Dave, A., Goel, S., Lador, A., Mathuria, N. & Schurmann, P. A.

  4/19/21 → …

  Project: Clinical Trial

• GOG-3044 LAE002INT2001

  Kamat, A. A., Alaniz, A., Singh, M., Suri, A. & Zaid, T.

  4/16/21 → …

  Project: Clinical Trial

• Nanozyme Therapy for Chronic Venous Stasis Dermatitis: New Approach for a Major Unmet Clinical Need

  Cooke, J. P.

  4/1/21 → 3/31/23

  Project: Federal Funding Agencies

• S100A4 mediated immune suppression in GBM

  Yun, K. & Xu, S.

  4/1/21 → 1/31/26

  Project: Federal Funding Agencies

• Targeting ER stress response in B-cell chronic lymphocytic leukemia

  Hu, C. A., Pingali, S. R. & Tang, C. A.

  4/1/21 → 3/31/24

  Project: Federal Funding Agencies

• TB/MDR-TB research Capacity Building in LMIC in Southeast Asia

  Graviss, E. A.

  4/1/21 → 2/28/23

  Project: Federal Funding Agencies

• Automated Assessment for Robotic Suturing utilizing Deep Learning Algorithms

  Miles, B. J.

  4/1/21 → 3/31/23

  Project: Federal Funding Agencies

• A Phase II and Biomarker Study of Dual VEGF/PD-L1 Blockade in Neoadjuvant Setting in Resectable Hepatocellular Carcinoma Patients

  Ghobrial, R. M., Abdelrahim, M. & Kodali, S.

  4/1/21 → 3/31/26

  Project: Federal Funding Agencies

• RE-ENERGIZE FONTAN - RandomizEd Exercise INtERvention desiGned to MaximIZE Fitness in Pediatric FONTAN patients

  Cooke, J. P.

  3/26/21 → 2/28/25

  Project: Federal Funding Agencies

• IL2 Plus Abatacept in AD

  Faridar, A., Appel, S. H. & Masdeu, J. C.

  3/24/21 → …

  Project: Clinical Trial

• An Open-Label Randomized Active-Controlled Phase II Clinical Study to Assess the Efficacy and Safety of Afuresertib Plus Paclitaxel Versus Paclitaxel in Patients with Platinum-ResistantOvarian Cancer

  Kamat, A. A., Alaniz, A., Darcourt, J., Singh, M., Suri, A. & Zaid, T.

  3/15/21 → 3/14/46

  Project: Non Profit

• A Study of Donanemab (LY3002813) in Participants With Early Alzheimer's Disease (TRAILBLAZER-ALZ 2)

  Masdeu, J. C., Faridar, A., Nakawah, M. O., Pascual, B. & Toledo, J. B.

  3/12/21 → …

  Project: Clinical Trial

• CHEST CYTOSTORM study

  Gotur, D. B.

  3/8/21 → …

  Project: Clinical Trial

• Nanoparticle delivery of miRNA-based therapeutics to overcome clinical challenges in triple negative breast cancer

  Wang, Z. & Cristini, V.

  3/4/21 → 2/28/26

  Project: Federal Funding Agencies

• SCS for motor recovery after SCI A Single-Center Randomized Prospective Study to Evaluate the Effect of Spinal Cord Stimulation on Motor Recovery and Peripheral Immunity after Spinal Cord Injury

  Barber, S., Horner, P. J., Kaldis, T. & Sayenko, D.

  3/2/21 → …

  Project: Clinical Trial

• Minimal Residual Disease Assessment in Colorectal Cancer (MiRDA-C)

  Abdelrahim, M.

  3/1/21 → 2/28/23

  Project: State

• Role of Metabolic Me-Macrophages in the Pathogenesis of Tuberculosis during Diabetes

  Jagannath, C.

  3/1/21 → 2/28/23

  Project: Federal Funding Agencies

• Nanotechnology-based targeting of breast cancer liver metastases

  Godin, B., Chen, S., Niravath, P. A., Rosato, R. R. & Xu, S.

  3/1/21 → 2/29/24

  Project: Federal Funding Agencies

• Multicenter Phase I/Ib Trial of Olaparib in Combination With Vorinostat in Patients With Relapsed/Refractory and/or Metastatic Breast Cancer

  Chang, J. C. & Niravath, P. A.

  2/9/21 → …

  Project: Clinical Trial

• Using a Human Lung Microphysiologic System to Model SARS-CoV-2 Infection and Test Candidate Countermeasures

  Nichols, J.

  2/4/21 → 2/28/23

  Project: Federal Funding Agencies

• Building A Regional Adult Congenital Heart Research Collaborative: A Multi-Stakeholder Patient-Driven Approach in the South Central U.S.

  Lin, C. H.

  2/1/21 → 2/28/23

  Project: Non Profit