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  Transforming triple negative breast cancer treatment through intratumoral immunotherapy via nanofluidic drug eluting seed

  Chen, S. & Chang, J. C.

  8/1/20 → 7/31/23

  Project: Federal Funding Agencies

• Transforming triple negative breast cancer treatment through intratumoral immunotherapy via nanofluidic drug eluting seed

  Grattoni, A.

  8/1/20 → 7/31/23

  Project: Federal Funding Agencies

• Yap1 function in sex-biased medulloblastoma tumorigenesis, progression, and pro-tumor immunity

  Yun, K.

  8/1/20 → 7/31/22

  Project: Federal Funding Agencies

• Outcome-Driven Approach to Minimize the Risks of Facial Distortion Following CMF Surgery

  Xia, J. J. & Gateno, J.

  8/1/20 → 7/31/25

  Project: Federal Funding Agencies

• Supraspinal mechanisms involved in neurogenic voiding dysfunction

  Khavari, R., Boone, T. B., Helekar, S. & Karmonik, C.

  8/1/20 → 7/31/22

  Project: Federal Funding Agencies

• Systematic identification of astrocyte-tumor crosstalk regulating brain metastatic tumors

  Wong, S. T., Zhao, H. & Sheng, J.

  8/1/20 → 1/31/25

  Project: Federal Funding Agencies

• Massachusetts General Hospital Healey Center for ALS - Healey ALS Platform Trial

  Appel, S. H., Greene, E. P., Shroff, S. & Thonhoff, J. R.

  7/24/20 → 12/31/22

  Project: Non Profit

• HEALEY ALS Platform Trial - Regimen-Specific Appendix A - For 0.3mh/kg SC zilucoplan administered once daily and placebo

  Appel, S. H., Greene, E. P., Liao, B., Shroff, S. & Thonhoff, J. R.

  7/24/20 → 7/23/25

  Project: Non Profit

• HEALEY ALS Platform Trial - Regimen-Specific Appendix B - For verdiperstat (also known as BHV-3241)

  Appel, S. H., Greene, E. P., Liao, B., Shroff, S. & Thonhoff, J. R.

  7/24/20 → 7/23/25

  Project: Non Profit

• TSS and Upper Limb Robotics

  Sayenko, D. & Horner, P. J.

  7/24/20 → …

  Project: Clinical Trial

• HEALEY ALS Platform Trial - Regimen-Specific Appendix C - For CNM-Au8

  Appel, S. H., Greene, E. P., Liao, B., Shroff, S. & Thonhoff, J. R.

  7/24/20 → 7/23/25

  Project: Non Profit

• To study the EMT contributions in tumor metastasis and chemoresisitance by using lineage tracing models

  Wong, S. T. & Sheng, J.

  7/17/20 → 6/30/22

  Project: Federal Funding Agencies

• Medpace - MAU868-201

  Gaber, A. O., Knight, R. J., Saharia, A. & Yi, S.

  7/16/20 → …

  Project: Clinical Trial

• EPIGENETIC REPROGRAMMING TO GENERATE NOVEL CHONDRO-OSSEOUS STEM CELLS FOR BONE TISSUE ENGINEERING

  Davis, B.

  7/15/20 → 6/30/22

  Project: Federal Funding Agencies

• Reversal of Heart Failure: Role of Vascular Recovery

  Cooke, J. P. & Youker, K. A.

  7/15/20 → 3/31/24

  Project: Federal Funding Agencies

• Neuro-Afib Study - Retrospective Phase (Phase I)

  Gadhia, R. R. & Garg, T.

  7/13/20 → 7/12/45

  Project: Non Profit

• Clazakizumab - COVID-19

  Gaber, A. O., Goodarzi, A., Graviss, E. A., Moore, L. W., Yau, S. W., Youssef, J. G. & Zahiruddin, F.

  7/8/20 → …

  Project: Clinical Trial

• SH-PORTICO NG

  Kleiman, N., Faza, N., Gadhia, R. R., Garg, T., Goel, S., Little, S. H., Reardon, M. J. & Volpi, J. J.

  7/8/20 → …

  Project: Clinical Trial

• Evaluation of the Portico¿ NG Transcatheter Aortic Valve in High and Extreme Risk Patients with Symptomatic Severe Aortic Stenosis (ABT-CIP-10297)

  Kleiman, N., Gadhia, R. R., Garg, T., Goel, S., Reardon, M. J. & Volpi, J. J.

  7/6/20 → 7/5/45

  Project: Non Profit

• SH-XyloCor XC001

  Al-Mallah, M., Kleiman, N. & Shah, A. R.

  7/2/20 → …

  Project: Clinical Trial

• Targeting novel checkpoint regulator to control viral myocarditis

  Xing, J., Cooke, J. P., Li, X. C. & Zhang, Z.

  7/1/20 → 6/30/23

  Project: Non Profit

• Elucidating the role(s) of cytoplasmic capping in the response to oxidative stress in vascular endothelial cells

  Kiss, D. L.

  7/1/20 → 6/30/23

  Project: Non Profit

• A Novel Non-Invasive Approach for Regaining Self-Assisted Standing after Spinal Cord Injury: Combining Transcutaneous Spinal Stimulation and Functional Electrical Stimulation

  Sayenko, D.

  7/1/20 → 6/30/22

  Project: Non Profit

• Integrating imaging mass cytometry with spatial transcriptomics and single-cell RNA-seq for understanding of drug resistance in ovarian cancer

  Wong, S. T.

  7/1/20 → 6/30/22

  Project: State

• Phase 3 Multicenter, Double-Blind, randomized, placebo-controlled trail of Infigratinib for the Adjuvant Treatment of Subjects with Invasive Urothelial Carcinoma with Susceptible FGFR3 Genetic Alterations (PROOF 302)

  Satkunasivam, R., Singh, M. & Zhang, J.

  6/24/20 → …

  Project: Clinical Trial

• SH-PROTECTED TAVR

  Kleiman, N., Garg, T., Goel, S., Reardon, M. J. & Volpi, J. J.

  6/24/20 → …

  Project: Clinical Trial

• CMR for COVID Patients

  Shah, D. J., Graviss, E. A., Malahfji, M. & Nasir, K.

  6/16/20 → …

  Project: Clinical Trial

• Systems-wide analysis of oxidative stress-responsive m6A epitranscriptome

  Weng, Y. & Krencik, R. C.

  6/15/20 → 3/31/25

  Project: Federal Funding Agencies

• Novel Therapeutic Strategies to Co-Target Undifferentiated Prostate Cancer (PCa) Stem Cells and Bulk PCa Cells

  6/1/20 → 5/31/22

  Project: Federal Funding Agencies

• Convergent AI for Precise Breast Cancer Risk Assessment

  Wong, S. T., Chang, J. C. & Ensor, Jr., J. E.

  6/1/20 → 5/31/25

  Project: Federal Funding Agencies

• Influence of pre-analytical factors in glioblastoma MGMT promoter methylation biomarker assay

  Rostomily, R. C., Mitra, S. & Powell, S. Z.

  6/1/20 → 5/31/25

  Project: Federal Funding Agencies

• Phase III Trial of Docetaxel vs. Docetaxel and Radium-223 for Metastatic Castration-Resistant Prostate Cancer (mCRPC)

  Heyne, K., Singh, M. & Zhang, J.

  5/27/20 → …

  Project: Clinical Trial

• A Phase III, Multicenter, Open-Label, Extension Clinical Trial to Demonstrate the Effectiveness and Safety of Liposomal Cyclosporine A (L-CsA) Inhalation Solution Delivered via the PARI Investigational eFlow® Device plus Standard of Care in the Treatment of Bronchiolitis Obliterans Syndrome in Patients post Single or Double Lung Transplantation (BT-L-CsA-303-FU (BOSTON-3))

  Goodarzi, A., Yau, S. W. & Youssef, J. G.

  5/27/20 → …

  Project: Clinical Trial

• Prospective Sudden Cardiac Death Risk Stratification Using Cardiac MRI and Echocardiography Machine Learning in Mitral Valve Prolapse.

  Shah, D. J.

  5/26/20 → 4/30/25

  Project: Federal Funding Agencies

• SH-AltaValve

  Chang, S., Faza, N., Goel, S., Kleiman, N., Lawrie, G. M., Little, S. H. & Reardon, M. J.

  5/19/20 → …

  Project: Clinical Trial

• A Phase 1a/b Dose-Escalation Study Followed by Expansion Cohorts of NGM120, a GFRAL Antagonist Monoclonal Antibody Blocking GDF15 Signaling, in Subjects With Advanced Solid Tumors and Pancreatic Cancer Using Combination Therapy

  Singh, M., Abdelrahim, M., Beinart, G. & Heyne, K.

  5/18/20 → …

  Project: Clinical Trial

• Evaluation of immune responses to CD44-targeted nanovectors for designing a novel anti-tuberculosis host-directed therapy

  Godin, B., Jagannath, C. & Leonard, F.

  5/1/20 → 10/31/22

  Project: Federal Funding Agencies

• A PILOT RANDOMIZED CONTROLLED TRIAL OF DE NOVO BELATACEPT-BASED IMMUNOSUPPRESSION IN LUNG TRANSPLANTATION

  Goodarzi, A. & Yau, S. W.

  4/23/20 → …

  Project: Clinical Trial

• Voice Rest Adherence After Phonomicrosurgery

  Yiu, Y.

  4/20/20 → 3/31/23

  Project: Federal Funding Agencies

• DOD - Dehisced-Wound

  Oviedo, R. J. & Rupert, P.

  4/16/20 → …

  Project: Clinical Trial

• A new conditional TDP¿NLS knock-in mouse model generated using CRISPR/Cas9 technology to study the linkage of TDP-43 pathology to motor and cognitive defects in ALS, FTD and ADRD

  Hegde, M., Mitra, J. & Wang, H.

  4/15/20 → 2/28/23

  Project: Federal Funding Agencies

• Defining the altered FUS-PARP-1-DNA Ligase III axis and its implications to nuclear and mitochondrial genome damage response in Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD)

  Hegde, M., Hamilton, D. J., Horner, P. J., Mitra, J. & Wang, H.

  4/15/20 → 3/31/25

  Project: Federal Funding Agencies

• Sample and Data Collection for Houston Methodist Cancer Center Research

  Chang, J. C., Bernicker, E. H., Darcourt, J., Heyne, K., Niravath, P. A. & Singh, M.

  4/9/20 → …

  Project: Clinical Trial

• U.S. Study to Protect Brain Health through Lifestyle Intervention to Reduce Risk:Neuroimaging Ancillary Study

  Masdeu, J. C.

  4/1/20 → 6/30/22

  Project: Federal Funding Agencies

• Myotonic Dystrophy Compilation of Clinical Findings

  Greene, E. P., Appel, S. H., Ashizawa, T., Mathuria, N., Shroff, S. & Thonhoff, J. R.

  4/1/20 → …

  Project: Clinical Trial

• Novel carbon nanozyme mechanisms for traumatic brain injury therapy

  Hegde, M.

  4/1/20 → 3/31/25

  Project: Federal Funding Agencies

• A Study of TAK-018 in Preventing the Recurrence of Crohn's Disease After Surgery

  Abraham, B. P. & Glassner, K.

  3/27/20 → …

  Project: Clinical Trial

• LEAP-012 - MERCK (7902-012, Site No. 0784) Safety and Efficacy of Lenvatinib (E7080 / MK-7902) With Pembrolizumab (MK-3475) in Combination With Transarterial Chemoembolization (TACE) in Participants With Incurable / Non-metastatic Hepatocellular Carcinoma (MK-7902-012 / E7080-G000-318 / LEAP-012)

  Kodali, S., Abdelrahim, M., Ghobrial, R. M., Gibbs, J. M., Heyne, K., Saharia, A., Shetty, A. & Victor, III, D. W.

  3/27/20 → …

  Project: Clinical Trial

• AOCT - COVID-19 Plasma Donation

  Castillo, B., Chen, J. & Leveque, C.

  3/26/20 → …

  Project: Clinical Trial

• A Pilot Randomized Controlled Trial of De Novo Belatacept-Based Immunosuppression in Lung Transplantation

  3/26/20 → 3/25/45

  Project: Non Profit