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  Gossamer_GB002-2102_Phase 2 OLE_Pulmonary Arterial Hypertension An Open-label Extension Study Evaluating the Long-term Safety and Efficacy of Oral Inhalation of GB002 for the Treatment of WHO Group 1 Pulmonary Arterial Hypertension (PAH)

  Sahay, S. & Safdar, Z.

  9/15/21 → …

  Project: Clinical Trial

• AOCT - Phase3_MK4482-013_COVID-19

  Moran, D., Gotur, D. B. & Zahiruddin, F.

  9/15/21 → …

  Project: Clinical Trial

• Targeting Inflammation and Alloimmunity in Lung Transplant Recipients with Clazakizumab

  9/14/21 → 6/30/22

  Project: Federal Funding Agencies

• Tregs in AD clinical trial A Phase II Clinical Trial of Interleukin-2 (IL-2) in Patients with Mild to Moderate Alzheimer?s Disease Progress

  Faridar, A., Appel, S. H., Masdeu, J. C. & Pascual, M. B.

  9/9/21 → …

  Project: Clinical Trial

• ER stress response and chronic lymphocytic leukemia

  Hu, A., Pingali, S. R. & Tang, C. A.

  9/3/21 → …

  Project: Clinical Trial

• Safe Babies Evaluation Project: Mobile mental health support

  9/1/21 → 8/31/22

  Project: Federal Funding Agencies

• Sexual Assault Nurse Examiner (SANE) expansion Sugarland Hospital

  9/1/21 → 2/28/23

  Project: State

• Sexual Assault Nurse Examiner (SANE) expansion - Clearlake Hospital

  9/1/21 → 2/28/23

  Project: State

• Sexual Assault Nurse Examiner (SANE) expansion Woodlands Hospital

  9/1/21 → 2/28/23

  Project: State

• SARS-CoV-2 and Precursors of Alzheimer Disease and Related Dementias: An Ultrahigh Field (7T) MRI Study in a Diverse Multinational Cohort

  Roman, G. C., Vahidy, F. S. & Masdeu, J. C.

  9/1/21 → 8/31/22

  Project: Federal Funding Agencies

• Chemoprevention of lung cancer by targeting lonidamine to mitochondria

  You, M., Wang, Y., Xiong, D. & Zhang, Q.

  9/1/21 → 8/31/24

  Project: Federal Funding Agencies

• Leveraging glioma stem cell electrophysiology for therapy

  Rostomily, R. C.

  8/31/21 → 8/30/23

  Project: State

• CPRIT Scholar Application - Rising Star - Yong Lu

  Lu, Y.

  8/31/21 → 8/30/26

  Project: State

• Role of ATRA in Overcoming Myeloma Resistance to Proteasome Inhibitors

  Yi, Q. & Wang, Q.

  8/31/21 → 8/30/23

  Project: State

• Dendritic Cell Immunotherapy Plus Standard Treatment of Advanced Renal Cell Carcinoma-CoImmune CMN-001-1

  Satkunasivam, R., Singh, M. & Zhang, J.

  8/26/21 → …

  Project: Clinical Trial

• Phase III_Parsaclisib and Ruxolitinib_Myelofibrosis_INCB 50465-313 A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of the Combination of PI3K Inhibitor Parsaclisib and Ruxolitinib in Participants With Myelofibrosis

  Shah, S., Ganguly, S., Petkova, J., Pingali, S. R. & Rice, L.

  8/23/21 → …

  Project: Clinical Trial

• Contemporary Classification of Myocardial Injury Events in MESA: Defining Distinct Risk Factor Associations with Myocardial Infarction Type 1-5 and Acute Non-Ischemic Myocardial Injury.

  Nasir, K.

  8/20/21 → 7/31/26

  Project: Federal Funding Agencies

• LIVERFASt Clinical performance evaluation of the LIVERFASt Tests to determine fibrosis staging, inflammatory activity and steatosis grading compared with Liver Biopsy in patients with metabolic factors and presumed Non-Alcoholic Fatty Liver Disease (NAFLD)

  Kodali, S. & Victor, III, D. W.

  8/18/21 → …

  Project: Clinical Trial

• ROSE - Recovery and Outcome from StrokE (ROSE)

  Vahidy, F. S. & Misra, V.

  8/10/21 → …

  Project: Clinical Trial

• Phase 3_Sotatercept_ Pulmonary Arterial Hypertension _Acceleron A011-12 SOTERIA A Long-term Follow-up Study of Sotatercept for PAH Treatment

  Safdar, Z. & Sahay, S.

  8/5/21 → …

  Project: Clinical Trial

• A novel tool in high- dimensional single-cell space to predict neurotoxicity of CAR T cell therapies

  Lu, Y.

  8/1/21 → 7/31/26

  Project: Federal Funding Agencies

• Regulatory T cells as a novel therapeutic target in Alzheimer's Disease

  Appel, S. H., Faridar, A. & Masdeu, J. C.

  8/1/21 → 7/31/23

  Project: Non Profit

• Prevascularized encapsulation platform with local immunosuppression for Islet transplantation

  Gaber, A. O. & Grattoni, A.

  8/1/21 → 7/31/23

  Project: Non Profit

• Transfer Application - R01 CA223804 - Chemoimmunoprevention of EGFR-Driven Non-Small Cell Lung Cancer

  You, M.

  8/1/21 → 7/31/23

  Project: Federal Funding Agencies

• Non-invasive spinal neuromodulation and robotic exoskeleton to recover upper limb function after SCI

  Sayenko, D., Horner, P. J. & Kaldis, T.

  7/31/21 → 7/30/23

  Project: Non Profit

• Neuromodulation and the Neuroimmune Axis of Repair

  Horner, P. J. & Weng, Y.

  7/31/21 → 7/30/24

  Project: Non Profit

• A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Compare the Efficacy and Safety of Sotatercept Versus Placebo When Added to Background Pulmonary Arterial Hypertension (PAH) Therapy for the Treatment of PAH_A011-11 (STELLAR)

  Safdar, Z. & Sahay, S.

  7/30/21 → …

  Project: Clinical Trial

• A Randomized, Double-Blind, Placebo-Controlled, Two-Part Study in Parkinson's Disease Patients With Dyskinesia to Assess the Efficacy and Safety/Tolerability of Fixed Dose Combinations of JM-010 and Its Individual Components

  Waln, O. & Ondo, W. G.

  7/30/21 → …

  Project: Clinical Trial

• A PHASE 3, MULTICENTER, RANDOMIZED, OPEN-LABEL, ACTIVE-CONTROLLED STUDY OF TRASTUZUMAB DERUXTECAN (T-DXd) VERSUS TRASTUZUMAB EMTANSINE (T-DM1) IN SUBJECTS WITH HIGH-RISK HER2 POSITIVE PRIMARY BREAST CANCER WHO HAVE RESIDUAL INVASIVE DISEASE IN BREAST OR AXILLARY LYMPH NODES FOLLOWING NEOADJUVANT THERAPY

  Chang, J. C. & Niravath, P. A.

  7/30/21 → …

  Project: Clinical Trial

• VAS-WRAPSODY Endovascular Stent Graft for Hemodialysis Patients Merit Medical

  Peden, E. K., Le, L., Rahimi, M. & Roy, T.

  7/30/21 → …

  Project: Clinical Trial

• A Double-Blind, Placebo-Controlled, Randomized, 18-Month Phase 2a Study to Evaluate the Efficacy, Safety, Tolerability, and Pharmacokinetics of Oral UCB0599 in Study Participants With Early Parkinson's Disease

  Waln, O. & Ondo, W. G.

  7/23/21 → …

  Project: Clinical Trial

• Fulvestrant Plus Abemaciclib With or Without Run-In of Fulvestrant in Er-Positive, Her2-Negative Metastatic Breast Cancer

  Chang, J. C., Darcourt, J., Geyer, C. E. & Niravath, P. A.

  7/15/21 → …

  Project: Clinical Trial

• A Randomized Placebo-controlled Trial of Zoledronic Acid for Prevention of Fractures in Patients with Parkinson¿s Disease

  Waln, O. & Ondo, W. G.

  7/14/21 → 7/13/23

  Project: Non Profit

• Sepsis Prediction with Deep Learning and Wearable Monitoring Patch'd

  Pingali, S. R., Ganguly, S., Gotur, D. B., Jones, S. L., Masud, F. N. & Shah, S.

  7/14/21 → …

  Project: Clinical Trial

• A Randomized Double-Blind Placebo-Controlled Study to Evaluate the Efficacy and Safety of Volixibat in the Treatment of Cholestatic Pruritus in Patients with Primary Sclerosing Cholangitis (VISTAS)

  Victor, III, D. W., Kodali, S. & Shetty, A.

  7/9/21 → …

  Project: Clinical Trial

• NeoSoma Neuro-oncology AI Platform

  Fung, S. H. & Baskin, D. S.

  7/7/21 → …

  Project: Clinical Trial

• Targeting the HIV-1 Reservoir in Myeloid Cells

  Wang, J.

  7/6/21 → 5/31/26

  Project: Federal Funding Agencies

• A PHASE 3, MULTICENTER, RANDOMIZED, OPEN-LABEL, ACTIVE-CONTROLLED STUDY OF TRASTUZUMAB DERUXTECAN (T-DXd) VERSUS TRASTUZUMAB EMTANSINE (T-DM1) IN SUBJECTS WITH HIGH-RISK HER2-POSITIVE PRIMARY BREAST CANCER WHO HAVE RESIDUAL INVASIVE DISEASE IN BREAST OR

  7/6/21 → 7/5/31

  Project: Non Profit

• Understanding the mechanisms that regulate cytoplasmic capping and defining its contributions to post-transcriptional gene regulation (Same as parent grant)

  Kiss, D. L.

  7/1/21 → 6/30/23

  Project: Federal Funding Agencies

• A versatile reporter for visualization of myelin plasticity in the genetically modified rat

  Horner, P. J.

  7/1/21 → 12/31/22

  Project: Federal Funding Agencies

• Engineered Enteric Nervous System-Peri Neural Invasion platform to improve predictive preclinical screens in early-stage colorectal adenocarcinomas

  Esnaola, N. F.

  7/1/21 → 6/30/23

  Project: Federal Funding Agencies

• Understanding the mechanisms that regulate cytoplasmic capping and defining itscontributions to post-transcriptional gene regulation (Same as parent grant)

  Kiss, D. L.

  7/1/21 → 6/30/25

  Project: Federal Funding Agencies

• HEALEY ALS Platform Trial - Regimen-Specific Appendix D - For pridopidine 45 mg oral capsule administered twice daily (BID) or its matching placebo.

  Appel, S. H., Greene, E. P., Liao, B., Shroff, S. & Thonhoff, J. R.

  6/29/21 → 7/23/25

  Project: Non Profit

• SH:HighLife Transseptal Transcatheter Mitral Valve Replacement HighLife Medical

  Goel, S., Faza, N., Kleiman, N., Little, S. H. & Reardon, M. J.

  6/29/21 → …

  Project: Clinical Trial

• Long-Term, Observational, Registry of Patients With Generalized Myasthenia Gravis Who Have Received Treatment With Complement C5 Inhibition Therapies

  Greene, E. P., Liao, B., Shroff, S. & Thonhoff, J. R.

  6/28/21 → …

  Project: Clinical Trial

• AOCT - Intuitive da Vinci SP in Colorectal Surgical Procedures

  6/28/21 → …

  Project: Clinical Trial

• MERCK MK-5475 in PAH, Phase 23 A Phase 2/3, Multicenter, Randomized, Double-blind, Placebo-Controlled, Adaptive Design Study to Evaluate the Efficacy and Safety of MK-5475 in Adults With Pulmonary Arterial Hypertension

  Sahay, S. & Safdar, Z.

  6/28/21 → …

  Project: Clinical Trial

• SH-REPAIR MR - Mitraclip Device vs. Surgical Repair for Mitral Regurgitation Abbott Percutaneous MitraClipTM Device or Surgical Mitral Valve REpair in PAtients with PrImaRy Mitral Regurgitation who are Candidates for Surgery (REPAIR MR)

  Goel, S., Bhimaraj, A., Faza, N., Guha, A., Kassi, M., Kleiman, N., Lawrie, G. M., Little, S. H., Reardon, M. J. & Yousefzai, R.

  6/28/21 → …

  Project: Clinical Trial

• High-speed biophysical and biochemical monitoring to discover early markers of unconventional brain injury

  Villapol, S.

  6/16/21 → 9/15/22

  Project: Federal Funding Agencies

• Mitochondrial function in symptomatic chronic COVID-19 patients COVID-19 Associated Mitochondria Functional Changes in Subjects with Post-Acute Sequelae of SARS-CoV-2 Infections (PASC)

  Hamilton, D. J., Kansara, A. & Youssef, J. G.

  6/16/21 → …

  Project: Clinical Trial