Find Research Projects

Search results

• A Phase I Dose Escalation and Dose Expansion and Phase II Monotherapy Open-label, First-in-Human, Multicenter Study of OP-1250 in Adult Subjects with Advanced and/or Metastatic Hormone Receptor (HR)-positive, HER2-negative Breast Cancer

  Niravath, P. A. & Chang, J. C.

  Project: Clinical Trial

• A Phase II/III Trial of Neoadjuvant FOLFOX w/ Selective Use of Combined Modality Chemoradiation versus Preoperative Combined Modality Chemoradiation for Locally Advanced Rectal Cancer Patients Undergoing Low Anterior Resection w/ Total Mesorectal Excisio

  Bernicker, E. H., Darcourt, J. & Singh, M.

  University of Michigan

  6/11/13 → 6/10/38

  Project: Non Profit

• A Phase IIa, randomised, double-blind, placebo-controlled trial to evaluate the safety, efficacy, pharmacokinetics and pharmacodynamics of BI 706321 orally administered for 12 weeks in patients with Crohn`s Disease (CD) receiving ustekinumab induction treatment

  Abraham, B. P. & Glassner, K.

  Project: Clinical Trial

• A Phase II and Biomarker Study of Dual VEGF/PD-L1 Blockade in Neoadjuvant Setting in Resectable Hepatocellular Carcinoma Patients

  Ghobrial, R. M., Abdelrahim, M. & Kodali, S.

  4/1/21 → 3/31/26

  Project: Federal Funding Agencies

• A Phase IIa randomized, double-blind, placebo-controlled study of the effects of L-serine on Mild Cognitive Impairment (MCI)

  Roman, G. C., Masdeu, J. C. & Pascual, M. B.

  8/11/22 → …

  Project: Clinical Trial

• A Phase IIb/III, Randomized, Double-blind, Placebo-controlled Trial of Troriluzole in Adult Subjects With Spinocerebellar Ataxia

  Ashizawa, T., Ondo, W. G. & Waln, O.

  1/25/17 → …

  Project: Clinical Trial

• A Phase II Clinical tRial of neoADjuVant sAsanlimab and stereotaCtiC body radIatioN thErapy as an in situ vaccine for cisplatin-ineligible Muscle Invasive Bladder Cancer (RAD VACCINE MIBC)

  Satkunasivam, R., Chen, S., Esnaola, N. F., Farach, A. M., Teh, B. S. & Zhang, J.

  1/20/22 → …

  Project: Clinical Trial

• A Phase III, Long-Term, Randomized, Double-blind, Placebo-controlled Trial of Troriluzole in Adult Subjects With Spinocerebellar Ataxia.

  Ashizawa, T. & Ondo, W. G.

  5/10/19 → …

  Project: Clinical Trial

• A Phase III, Multicenter, Open-Label, Extension Clinical Trial to Demonstrate the Effectiveness and Safety of Liposomal Cyclosporine A (L-CsA) Inhalation Solution Delivered via the PARI Investigational eFlow® Device plus Standard of Care in the Treatment of Bronchiolitis Obliterans Syndrome in Patients post Single or Double Lung Transplantation (BT-L-CsA-303-FU (BOSTON-3))

  Goodarzi, A., Yau, S. W. & Youssef, J. G.

  5/27/20 → …

  Project: Clinical Trial

• A phase III, multicenter, randomized, study of atezolizumab/placebo administered in combination with paclitaxel, carboplatin, and bevacizumab to patients with newly-diagnosed stage III or stage IV ovarian, fallopian tube, or primary peritoneal cancer

  Kamat, A. A., Alaniz, A., Bernicker, E. H., Darcourt, J., Heyne, K., Singh, M., Suri, A. & Zaid, T.

  3/13/18 → 3/12/43

  Project: Non Profit

• A Phase III, Open-Label, Randomized Study to Investigate the Efficacy and Safety of Atezolizumab (Anti-PD-L1 Antibody) Compared With Best Supportive Care Following Adjuvant Cisplatin-Based Chemotherapy in Patients With Completely Resected Stage IB-IIIA

  Bernicker, E. H., Heyne, K., Singh, M. & Zhang, J.

  Project: Clinical Trial

• A Phase III, Randomized, Open-Label, Multicenter Study Evaluating the Efficacy and Safety of Adjuvant Giredestrant Compared with Physician's Choice of Adjuvant Endocrine Monotherapy in Patients with Estrogen Receptor-Positive, Her2-Negative Early Breast Cancer

  Chang, J. C. & Niravath, P. A.

  Project: Clinical Trial

• A Phase III Double-Blind Trial for Surgically Resected Early Stage Non-small Cell Lung Cancer: Crizotinib Versus Placebo for Patients With Tumors Harboring the Anaplastic Lymphoma Kinase (ALK) Fusion Protein

  Bernicker, E. H., Heyne, K., Singh, M. & Zhang, J.

  Project: Clinical Trial

• A Phase III Randomized, Placebo-Controlled Study of Pembrolizumab (MK-3475, NSC #776864)) in addition to Paclitaxel and Carboplatin for Measurable Stage III or IVA, Stage IVB or Recurrent Endometrial Cancer

  Kamat, A. A., Darcourt, J., Singh, M., Suri, A. & Zaid, T.

  3/1/19 → 2/28/25

  Project: Non Profit

• A Phase III Randomized Placebo-Controlled Study to Examine the Efficacy and Safety of DAS181 for the Treatment of Lower Respiratory Tract Parainfluenza Infection in Immunocompromised Subjects

  Goodarzi, A., Yau, S. W. & Youssef, J. G.

  Project: Clinical Trial

• A phase III Randomized Trial to Evaluate the Influence of BCG Strain Differences and T Cell Priming with Intradermal BCG Before Intravesical Therapy for BCG-Naive, High Grade Non-Muscle Invasive Bladder Cancer.

  Satkunasivam, R.

  Project: Clinical Trial

• A PHASE III TRIAL EVALUATING THE ADDITION OF TRASTUZUMAB TO TRIMODALITY TREATMENT OF HER2-OVEREXPRESSING ESOPHAGEAL ADENOCARCINOMA

  Butler, E. B., Kim, M. P. & Teh, B. S.

  University of Michigan

  7/24/13 → 7/23/38

  Project: Non Profit

• A phase II multi-center trial evaluating dual targeting of the PI3K/AKT and NOS pathways for treating metaplastic breast cancer (MpBC)

  Chang, J. C.

  6/10/22 → 5/31/27

  Project: Federal Funding Agencies

• A Phase II Neo-Adjuvant Study of Cisplatin Paclitaxel with or without RAD001 in patients with Triple-Negative Locally Advanced Breast Cancer

  Chang, J. C.

  Vanderbilt University

  3/8/11 → 6/17/15

  Project: Non Profit

• A Phase II Randomized, Open-label, Multi-center Study of the Safety and Efficacy of IMCgp100 Compared With Investigator Choice in HLA-A*0201 Positive Patients With Previously Untreated Advanced Uveal Melanoma

  Bernicker, E. H., Abdelrahim, M., Chang, J. C., Heyne, K., Niravath, P. A. & Singh, M.

  Project: Clinical Trial

• A Phase II Trial of Ribociclib (LEE011) Plus Letrozole in Women With Recurrent Low-Grade Serous Carcinoma of the Ovary, Fallopian Tube or Peritoneum (GOG-3026)

  Kamat, A. A., Alaniz, A., Singh, M., Suri, A. & Zaid, T.

  12/19/19 → …

  Project: Clinical Trial

• A Phase I Trial to Evaluate Safety and Tolerability of Abatacept followed by Subcutaneous Interleukin-2 Administration in Patients with Amyotrophic Lateral Sclerosis

  Thonhoff, J. R. & Shroff, S.

  11/18/21 → …

  Project: Clinical Trial

• A pilot, phase IIb, randomized, multi-center trial of Argatroban in combination with recombinant tissue plasminogen activator for acute stroke (ARTSS-2).

  Volpi, J. J., Chiu, D. & Gadhia, R. R.

  U T Health Science Center at Houston

  11/26/14 → 11/25/39

  Project: Non Profit

• A Pilot Randomized Controlled Trial of De Novo Belatacept-Based Immunosuppression in Lung Transplantation

  3/26/20 → 3/25/45

  Project: Non Profit

• A Pilot Randomized Controlled Trial of De Novo Belatacept-Based Immunosuppression in Lung Transplantation

  Goodarzi, A.

  7/10/18 → 12/31/22

  Project: Federal Funding Agencies

• A PILOT RANDOMIZED CONTROLLED TRIAL OF DE NOVO BELATACEPT-BASED IMMUNOSUPPRESSION IN LUNG TRANSPLANTATION

  Goodarzi, A. & Yau, S. W.

  4/23/20 → …

  Project: Clinical Trial

• A Pilot Study of Hydroxytyrosol, a Component of Olive Oil for Breast Cancer Prevention In Women At High Risk Of Breast Cancer

  Chang, J. C., Arentz, C., Dubrovsky, E., Niravath, P. A., Singh, M. & Templeton, S.

  Project: Clinical Trial

• A Pilot Study to Determine the Risk of Graft Contamination Following Transvaginal extraction of the Kidney during Laparoscopic Living Donor Nephrectomy

  Soc of Amer Gastro Endoscopic Surgeons

  3/15/10 → 12/31/12

  Project: Non Profit

• A PILOT TRIAL OF THE SAFETY, TOLERABILITY AND PHARMACOKINETICS OF EXPANED AND INFUSED T-REGULATORY CELLS WITH IL-2 DELIVERED BY INTRAVENOUS INFUSION IN SUBJECTS WITH ALS

  Appel, S. H. & Greene, E. P.

  ALS Association

  6/1/15 → 6/1/17

  Project: Non Profit

• A Placebo-Controlled Study of Oral Ozanimod as Maintenance Therapy for Moderately to Severely Active Crohn's Disease

  Abraham, B. P. & Glassner, K.

  2/13/19 → …

  Project: Clinical Trial

• APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO)

  Ibrahim, H. N.

  6/1/19 → 5/31/20

  Project: Federal Funding Agencies

• A prospective, multi-center, observational study of the safety, tolerability and effectiveness of SPINRAZA in adult patients with Spinal Muscular Atr

  Thonhoff, J. R., Greene, E. P. & Shroff, S.

  Project: Clinical Trial

• A prospective, multi-center, observational study of the safety, tolerability and effectiveness of SPINRAZA in adult patients with Spinal Muscular Atrophy

  Thonhoff, J. R., Greene, E. P. & Shroff, S.

  4/26/19 → 4/25/44

  Project: Non Profit

• A Prospective, Multicenter Study to Evaluate the ConforMIS iTotal® (CR) Knee Replacement System

  Project: Clinical Trial

• A PROSPECTIVE, RANDOMIZED, MULTICENTER, TWO-PARALLEL ARM STUDY EVALUATING THE OVERALL EFFICACY AND SAFETY OF DESENSITIZATION THERAPY ON SELECTED PATIENTS AWAITING HEART TRANSPLANTATION

  Bhimaraj, A. & Torre-Amione, G.

  Mount Sinai School of Medicine

  9/1/13 → 8/31/14

  Project: Federal Funding Agencies

• A Prospective Registry Study to Evaluate the Effect of the DCISionRT Test on Treatment Decisions in Patients With DCIS Following Breast Conserving Therapy

  Templeton, S., Arentz, C., Chang, J. C., Darcourt, J., Dubrovsky, E., Haque, W. M., Heyne, K., Morgan, P. B., Niravath, P. A. & Singh, M.

  Project: Clinical Trial

• A Randomized, Double-blind, Phase 3 Comparison of Platinum-based Therapy With TSR-042 and Niraparib Versus Standard of Care Platinum-based Therapy as First-line Treatment of Stage III or IV Nonmucinous Epithelial Ovarian Cancer (ENGOT-0V44 The FIRST)

  Suri, A., Alaniz, A., Singh, M. & Zaid, T.

  Project: Clinical Trial

• A Randomized, Double-Blind, Phase III Clinical Trial of Neoadjuvant Chemotherapy With Atezolizumab or Placebo in Patients With Triple-Negative Breast Cancer Followed by Adjuvant Continuation of Atezolizumab or Placebo

  Niravath, P. A., Abdelrahim, M., Arentz, C., Chang, J. C., Heyne, K. & Singh, M.

  Project: Clinical Trial

• A randomized, double-blind, phase III study comparing NIS793 in combination with gemcitabine and nab-paclitaxel versus placebo combined with gemcitabine and nabpaclitaxel for first line treatment of metastatic pancreatic ductal adenocarcinoma (mPDAC)

  Abdelrahim, M., Heyne, K. & Singh, M.

  Project: Clinical Trial

• A Randomized, Double-Blind, Phase III Trial of Paclitaxel/Trastuzumab/Pertuzumab With Atezolizumab or Placebo in First-Line HER2-Positive Metastatic Breast Cancer

  Chang, J. C., Darcourt, J., Geyer, C. E. & Niravath, P. A.

  Project: Clinical Trial

• A randomized, double-blind, placebo-controlled, multicenter, Phase 3 study evaluating long-term efficacy and safety of lanifibranor in adult patients with non-cirrhotic non-alcoholic steatohepatitis (NASH) and fibrosis 2/fibrosis 3 stage of liver fibrosis

  Victor, III, D. W., Kodali, S. & Shetty, A.

  5/16/22 → …

  Project: Clinical Trial

• A Randomized, Double-blind, Placebo-controlled, Parallel-group, Multiple-dose Phase 2 Study to Evaluate the Efficacy and Safety of BMS-986263 in Adults with Compensated Cirrhosis from Nonalcoholic Steatohepatitis (NASH)

  Victor, III, D. W., Kodali, S. & Shetty, A.

  Project: Clinical Trial

• A Randomized, Double-blind, Placebo-controlled, Phase 2b study to Evaluate Safety and Efficacy of DUR-928 in Subjects with Alcoholic Hepatitis

  Victor, III, D. W., Kodali, S., Mobley, C. M. & Shetty, A.

  10/5/21 → …

  Project: Clinical Trial

• A Randomized, Double-Blind, Placebo-Controlled, Two-Part Study in Parkinson's Disease Patients With Dyskinesia to Assess the Efficacy and Safety/Tolerability of Fixed Dose Combinations of JM-010 and Its Individual Components

  Waln, O. & Ondo, W. G.

  7/30/21 → …

  Project: Clinical Trial

• A Randomized, Double-Blind, Placebo Controlled Dose-Ranging Study of Auxora in Patients with Acute Pancreatitis and Accompanying Systemic Inflammatory Response Syndrome (CARPO)

  Sanchez Leon, R.

  Project: Clinical Trial

• A Randomized, Open-label, Phase II Study of Canakinumab or Pembrolizumab as Monotherapy or in Combination as Neoadjuvant Therapy in Subjects With Resectable Non-small Cell Lung Cancer (CANOPY-N)

  Bernicker, E. H., Barrios, R., Chan, E. Y., Chang, J. C., Heyne, K., Kim, M. P., Niravath, P. A., Singh, M. & Zhang, J.

  Project: Clinical Trial

• A Randomized, Phase II/III Study of Pegylated Liposomal Doxorubicin and CTEP-Supplied Atezolizumab (IND #134427) Versus Pegylated Liposomal Doxorubicin/Bevacizumab and CTEP-Supplied Atezolizumab Versus Pegylated Liposomal Doxorubicin/Bevacizumab in P

  Kamat, A. A., Darcourt, J., Singh, M., Suri, A. & Zaid, T.

  3/1/14 → 2/28/39

  Project: Non Profit

• A Randomized, Phase III Trial to Evaluate the Efficacy and Safety of MK-3475 (Pembrolizumab) as Adjuvant Therapy for Triple Receptor-Negative Breast Cancer With ? 1 CM Residual Invasive Cancer or Positive Lymph Nodes (ypN+) After Neoadjuvant Chemotherapy

  Niravath, P. A., Bernicker, E. H., Chang, J. C., Heyne, K., Morgan, P. B. & Singh, M.

  Project: Clinical Trial

• A Randomized Controlled Open-label Study to Assess the Safety and Tolerability of Nebulized PC945 for Prophylaxis or Pre-emptive Therapy Against Pulmonary Aspergillosis in Lung Transplant Recipients

  Goodarzi, A., Long, S. W., Yau, S. W. & Youssef, J. G.

  2/15/22 → …

  Project: Clinical Trial

• A Randomized Controlled Trial of cryoSPHERE (CRYOS/CRYOS-L) Ablation of Intercostal Nerves for Postoperative Pain Management in Opioid-Tolerant Patients Undergoing Robotic-Assisted Thoracoscopic Surgery

  Kim, M. P., Chan, E. Y., Chihara, R., Graviss, E. A. & Moore, L. W.

  11/4/21 → …

  Project: Clinical Trial