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  CPRIT RNA Therapeutics Core

  Cooke, J. P., Godin, B. & Kiss, D. L.

  8/31/20 → 8/30/25

  Project: State

• HF - preCardia System EFS for Treatment of ADHF preCardia, Inc.

  Yousefzai, R., Bhimaraj, A., Goel, S., Guha, A., Hussain, I., Kassi, M., Kim, J. H. & Suarez, E. E.

  8/28/20 → …

  Project: Clinical Trial

• HF - PROACTIVE-HF Trial

  Guha, A., Bhimaraj, A., Hussain, I., Kassi, M., Kim, J. H., Lin, C. H. & Yousefzai, R.

  8/20/20 → …

  Project: Clinical Trial

• IMG-Cytokinetics

  Nagueh, S., Buergler, J. & Kurrelmeyer, K. M.

  8/19/20 → …

  Project: Clinical Trial

• Elucidating spinal sensorimotor network components that underlie recovery of motor functions via lumbosacral epidural electrical stimulation in humans with spinal cord injury

  Sayenko, D.

  8/15/20 → 7/31/25

  Project: Federal Funding Agencies

• Understanding the mechanisms that regulate cytoplasmic capping and defining its contributions to post-transcriptional gene regulation

  Kiss, D. L.

  8/15/20 → 6/30/25

  Project: Federal Funding Agencies

• A Study of Biological Markers for the Nervous and Immune Systems and Free Radical Mediated Processes in Amyotrophic Lateral Sclerosis (ALS)

  Appel, S. H., Beers, D., Greene, E. P., Lai, E. C., Liao, B., Shroff, S., Thonhoff, J. R. & Zhao, W.

  8/13/20 → …

  Project: Clinical Trial

• PSLOT_Radiocephalic Fistulas.

  Peden, E. K., Le, L., Lumsden, A. B. & Rahimi, M.

  8/12/20 → …

  Project: Clinical Trial

• ECP - BOS - CAG-00324R2

  Huang, H. J., Goodarzi, A. & Yau, S. W.

  8/6/20 → …

  Project: Clinical Trial

• A Phase 3, Double-Blind, Randomized, Placebo-Controlled, Parallel-Group, 27-Week Trial to Evaluate the Efficacy, Safety, and Tolerability of Two Fixed Doses of Tavapadon in Early Parkinson's Disease (TEMPO-1 TRIAL)

  Ondo, W. G. & Waln, O.

  8/6/20 → …

  Project: Clinical Trial

• Study of Sasanlimab (PF-06801591) in Combination With Bacillus Calmette-Guerin (BCG) in Participants With High-Risk Non-Muscle Invasive Bladder Cancer (CREST)

  Satkunasivam, R., Singh, M. & Zhang, J.

  8/6/20 → …

  Project: Clinical Trial

• Neuro-Afib Study

  Gadhia, R. R. & Garg, T.

  8/6/20 → …

  Project: Clinical Trial

• Transforming triple negative breast cancer treatment through intratumoral immunotherapy via nanofluidic drug eluting seed

  Grattoni, A.

  8/1/20 → 7/31/23

  Project: Federal Funding Agencies

• Outcome-Driven Approach to Minimize the Risks of Facial Distortion Following CMF Surgery

  Gateno, J.

  8/1/20 → 7/31/25

  Project: Federal Funding Agencies

• Yap1 function in sex-biased medulloblastoma tumorigenesis, progression, and pro-tumor immunity

  Yun, K.

  8/1/20 → 7/31/23

  Project: Federal Funding Agencies

• Transforming triple negative breast cancer treatment through intratumoral immunotherapy via nanofluidic drug eluting seed

  Chen, S. & Chang, J. C.

  8/1/20 → 7/31/23

  Project: Federal Funding Agencies

• Systematic identification of astrocyte-tumor crosstalk regulating brain metastatic tumors

  Wong, S. T., Zhao, H. & Sheng, J.

  8/1/20 → 1/31/25

  Project: Federal Funding Agencies

• HEALEY ALS Platform Trial - Regimen-Specific Appendix B - For verdiperstat (also known as BHV-3241)

  Appel, S. H., Greene, E. P., Liao, B., Shroff, S. & Thonhoff, J. R.

  7/24/20 → 7/23/25

  Project: Non Profit

• HEALEY ALS Platform Trial - Regimen-Specific Appendix A - For 0.3mh/kg SC zilucoplan administered once daily and placebo

  Appel, S. H., Greene, E. P., Liao, B., Shroff, S. & Thonhoff, J. R.

  7/24/20 → 7/23/25

  Project: Non Profit

• HEALEY ALS Platform Trial - Regimen-Specific Appendix C - For CNM-Au8

  Appel, S. H., Greene, E. P., Liao, B., Shroff, S. & Thonhoff, J. R.

  7/24/20 → 7/23/25

  Project: Non Profit

• Reversal of Heart Failure: Role of Vascular Recovery

  Cooke, J. P. & Youker, K. A.

  7/15/20 → 3/31/24

  Project: Federal Funding Agencies

• Neuro-Afib Study - Retrospective Phase (Phase I)

  Gadhia, R. R. & Garg, T.

  7/13/20 → 7/12/45

  Project: Non Profit

• SH-PORTICO NG

  Kleiman, N., Faza, N., Gadhia, R. R., Garg, T., Goel, S., Little, S. H., Reardon, M. J. & Volpi, J. J.

  7/8/20 → …

  Project: Clinical Trial

• Clazakizumab - COVID-19

  Huang, H. J., Gaber, A. O., Goodarzi, A., Graviss, E. A., Moore, L. W., Yau, S. W. & Youssef, J. G.

  7/8/20 → …

  Project: Clinical Trial

• Evaluation of the Portico¿ NG Transcatheter Aortic Valve in High and Extreme Risk Patients with Symptomatic Severe Aortic Stenosis (ABT-CIP-10297)

  Kleiman, N., Gadhia, R. R., Garg, T., Goel, S., Reardon, M. J. & Volpi, J. J.

  7/6/20 → 7/5/45

  Project: Non Profit

• SH-XyloCor XC001

  Reardon, M. J., Al-Mallah, M., Kleiman, N. & Shah, A. R.

  7/2/20 → …

  Project: Clinical Trial

• Targeting novel checkpoint regulator to control viral myocarditis

  Xing, J., Cooke, J. P., Li, X. C. & Zhang, Z.

  7/1/20 → 6/30/23

  Project: Non Profit

• Elucidating the role(s) of cytoplasmic capping in the response to oxidative stress in vascular endothelial cells

  Kiss, D. L.

  7/1/20 → 6/30/23

  Project: Non Profit

• A Novel Non-Invasive Approach for Regaining Self-Assisted Standing after Spinal Cord Injury: Combining Transcutaneous Spinal Stimulation and Functional Electrical Stimulation

  Sayenko, D.

  7/1/20 → 7/31/23

  Project: Non Profit

• Remote controlled nanochannel implant for tunable drug delivery

  Grattoni, A.

  7/1/20 → 6/30/23

  Project: Federal Funding Agencies

• CMR for COVID Patients

  Shah, D. J., Graviss, E. A., Malahfji, M. & Nasir, K.

  6/16/20 → …

  Project: Clinical Trial

• Systems-wide analysis of oxidative stress-responsive m6A epitranscriptome

  Weng, Y. & Krencik, R. C.

  6/15/20 → 3/31/25

  Project: Federal Funding Agencies

• LONGITUDINAL EARLY ONSET ALZHEIMER¿S DISEASE (LEADS) supplement

  Masdeu, J. C.

  6/1/20 → 5/31/23

  Project: Federal Funding Agencies

• Convergent AI for Precise Breast Cancer Risk Assessment

  Wong, S. T., Chang, J. C. & Ensor, Jr., J. E.

  6/1/20 → 5/31/25

  Project: Federal Funding Agencies

• Influence of pre-analytical factors in glioblastoma MGMT promoter methylation biomarker assay

  Rostomily, R. C., Mitra, S. & Powell, S. Z.

  6/1/20 → 5/31/25

  Project: Federal Funding Agencies

• Phase III Trial of Docetaxel vs. Docetaxel and Radium-223 for Metastatic Castration-Resistant Prostate Cancer (mCRPC)

  Heyne, K., Singh, M. & Zhang, J.

  5/27/20 → …

  Project: Clinical Trial

• A Phase III, Multicenter, Open-Label, Extension Clinical Trial to Demonstrate the Effectiveness and Safety of Liposomal Cyclosporine A (L-CsA) Inhalation Solution Delivered via the PARI Investigational eFlow® Device plus Standard of Care in the Treatment of Bronchiolitis Obliterans Syndrome in Patients post Single or Double Lung Transplantation (BT-L-CsA-303-FU (BOSTON-3))

  Huang, H. J., Goodarzi, A., Yau, S. W. & Youssef, J. G.

  5/27/20 → …

  Project: Clinical Trial

• Prospective Sudden Cardiac Death Risk Stratification Using Cardiac MRI and Echocardiography Machine Learning in Mitral Valve Prolapse.

  Shah, D. J.

  5/26/20 → 4/30/25

  Project: Federal Funding Agencies

• SH-AltaValve

  Reardon, M. J., Chang, S., Faza, N., Goel, S., Kleiman, N., Lawrie, G. M. & Little, S. H.

  5/19/20 → …

  Project: Clinical Trial

• A Phase 1a/b Dose-Escalation Study Followed by Expansion Cohorts of NGM120, a GFRAL Antagonist Monoclonal Antibody Blocking GDF15 Signaling, in Subjects With Advanced Solid Tumors and Pancreatic Cancer Using Combination Therapy

  Singh, M., Abdelrahim, M., Beinart, G. & Heyne, K.

  5/18/20 → …

  Project: Clinical Trial

• Registry for Neurological Endpoint Assessments among patients with Ischemic and Hemorrhagic Stroke (REINAH)

  Vahidy, F. S., Britz, G. W., Horner, P. J. & Misra, V.

  4/28/20 → …

  Project: Clinical Trial

• A PILOT RANDOMIZED CONTROLLED TRIAL OF DE NOVO BELATACEPT-BASED IMMUNOSUPPRESSION IN LUNG TRANSPLANTATION

  Huang, H. J., Goodarzi, A. & Yau, S. W.

  4/23/20 → …

  Project: Clinical Trial

• Voice Rest Adherence After Phonomicrosurgery

  Yiu, Y.

  4/20/20 → 3/31/23

  Project: Federal Funding Agencies

• DOD - Dehisced-Wound

  Oviedo, R. J.

  4/16/20 → …

  Project: Clinical Trial

• A new conditional TDP¿NLS knock-in mouse model generated using CRISPR/Cas9 technology to study the linkage of TDP-43 pathology to motor and cognitive defects in ALS, FTD and ADRD

  Hegde, M., Mitra, J. & Wang, H.

  4/15/20 → 2/28/23

  Project: Federal Funding Agencies

• Defining the altered FUS-PARP-1-DNA Ligase III axis and its implications to nuclear and mitochondrial genome damage response in Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD)

  Hegde, M., Hamilton, D. J., Horner, P. J., Mitra, J. & Wang, H.

  4/15/20 → 3/31/25

  Project: Federal Funding Agencies

• Sample and Data Collection for Houston Methodist Cancer Center Research

  Chang, J. C., Bernicker, E. H., Darcourt, J., Heyne, K., Niravath, P. A. & Singh, M.

  4/9/20 → …

  Project: Clinical Trial

• Novel carbon nanozyme mechanisms for traumatic brain injury therapy

  Hegde, M.

  4/1/20 → 3/31/25

  Project: Federal Funding Agencies

• U.S. Study to Protect Brain Health through Lifestyle Intervention to Reduce Risk:Neuroimaging Ancillary Study

  Masdeu, J. C.

  4/1/20 → 6/30/23

  Project: Federal Funding Agencies

• Myotonic Dystrophy Compilation of Clinical Findings

  Greene, E. P., Appel, S. H., Ashizawa, T., Mathuria, N., Shroff, S. & Thonhoff, J. R.

  4/1/20 → …

  Project: Clinical Trial