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  AOCT - I-MAB Phase 1b2 study of TJ003234 in Subjects with Severe COVID 19

  Gotur, D. B., Hsu, S. H. & Moran, D.

  6/26/20 → …

  Project: Clinical Trial

• SH-PROTECTED TAVR

  Kleiman, N., Goel, S., Reardon, M. J. & Volpi, J. J.

  6/24/20 → …

  Project: Clinical Trial

• Gingival Bacteria in AD - GAIN Trial

  Masdeu, J. C., Faridar, A. & Nakawah, M. O.

  6/17/20 → …

  Project: Clinical Trial

• CMR for COVID Patients

  Shah, D. J., Graviss, E. A., Malahfji, M. & Nasir, K.

  6/16/20 → …

  Project: Clinical Trial

• A Randomized, Double-Blind, Phase III Clinical Trial of Neoadjuvant Chemotherapy With Atezolizumab or Placebo in Patients With Triple-Negative Breast Cancer Followed by Adjuvant Continuation of Atezolizumab or Placebo

  Niravath, P. A., Abdelrahim, M., Arentz, C., Chang, J. C., Darcourt, J., Geyer, C. E., Heyne, K. & Singh, M.

  6/16/20 → …

  Project: Clinical Trial

• Systems-wide analysis of oxidative stress-responsive m6A epitranscriptome

  Weng, Y. & Krencik, R. C.

  6/15/20 → 3/31/25

  Project: Federal Funding Agencies

• HOPE Part 2 - Heron

  Swan, J. T., Caplan, R. E., Gaber, A. O., Moore, L. W. & Reader, M. M.

  6/5/20 → …

  Project: Clinical Trial

• Influence of pre-analytical factors in glioblastoma MGMT promoter methylation biomarker assay

  Rostomily, R. C., Mitra, S. & Powell, S. Z.

  6/1/20 → 5/31/25

  Project: Federal Funding Agencies

• Convergent AI for Precise Breast Cancer Risk Assessment

  Wong, S. T., Chang, J. C. & Ensor, Jr., J. E.

  6/1/20 → 5/31/25

  Project: Federal Funding Agencies

• A Phase III, Multicenter, Open-Label, Extension Clinical Trial to Demonstrate the Effectiveness and Safety of Liposomal Cyclosporine A (L-CsA) Inhalation Solution Delivered via the PARI Investigational eFlow® Device plus Standard of Care in the Treatment of Bronchiolitis Obliterans Syndrome in Patients post Single or Double Lung Transplantation (BT-L-CsA-303-FU (BOSTON-3))

  Goodarzi, A., Yau, S. W. & Youssef, J. G.

  5/27/20 → …

  Project: Clinical Trial

• AOCT-ALXN-Efficacy and Safety Study of IV Ravulizumab in Patients with COVID-19 Severe Pneumonia

  Khoshnevis, M. R.

  5/27/20 → …

  Project: Clinical Trial

• Phase III Trial of Docetaxel vs. Docetaxel and Radium-223 for Metastatic Castration-Resistant Prostate Cancer (mCRPC)

  Darcourt, J., Heyne, K., Singh, M. & Zhang, J.

  5/27/20 → …

  Project: Clinical Trial

• Prospective Sudden Cardiac Death Risk Stratification Using Cardiac MRI and Echocardiography Machine Learning in Mitral Valve Prolapse.

  Shah, D. J.

  5/26/20 → 4/30/25

  Project: Federal Funding Agencies

• A Randomized, Double-Blind, Phase III Trial of Paclitaxel/Trastuzumab/Pertuzumab With Atezolizumab or Placebo in First-Line HER2-Positive Metastatic Breast Cancer

  Chang, J. C., Darcourt, J., Geyer, C. E. & Niravath, P. A.

  5/19/20 → …

  Project: Clinical Trial

• SH-AltaValve

  Chang, S., Faza, N., Goel, S., Kleiman, N., Lawrie, G. M., Little, S. H. & Reardon, M. J.

  5/19/20 → …

  Project: Clinical Trial

• A Phase 1a/b Dose-Escalation Study Followed by Expansion Cohorts of NGM120, a GFRAL Antagonist Monoclonal Antibody Blocking GDF15 Signaling, in Subjects With Advanced Solid Tumors and Pancreatic Cancer Using Combination Therapy

  Singh, M., Abdelrahim, M., Beinart, G. & Heyne, K.

  5/18/20 → …

  Project: Clinical Trial

• Evaluation of immune responses to CD44-targeted nanovectors for designing a novel anti-tuberculosis host-directed therapy

  Godin, B., Jagannath, C. & Leonard, F.

  5/1/20 → 4/30/22

  Project: Federal Funding Agencies

• A Phase 2, Multicenter, Open-label, Safety and Efficacy Study of XERMELO® (Telotristat Ethyl) Plus First-line Chemotherapy in Patients With Locally Advanced, Unresectable, Recurrent or Metastatic Biliary Tract Cancer (BTC)

  Abdelrahim, M., Bernicker, E. H., Chang, J. C., Darcourt, J., Heyne, K., Niravath, P. A., Singh, M. & Zhang, J.

  4/27/20 → …

  Project: Clinical Trial

• A PILOT RANDOMIZED CONTROLLED TRIAL OF DE NOVO BELATACEPT-BASED IMMUNOSUPPRESSION IN LUNG TRANSPLANTATION

  Goodarzi, A. & Yau, S. W.

  4/23/20 → …

  Project: Clinical Trial

• Voice Rest Adherence After Phonomicrosurgery

  Yiu, Y.

  4/20/20 → 3/31/23

  Project: Federal Funding Agencies

• DOD - Dehisced-Wound

  Oviedo, R. J. & Rupert, P.

  4/16/20 → …

  Project: Clinical Trial

• Defining the altered FUS-PARP-1-DNA Ligase III axis and its implications to nuclear and mitochondrial genome damage response in Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD)

  Hegde, M., Hamilton, D. J., Horner, P. J., Mitra, J. & Wang, H.

  4/15/20 → 3/31/25

  Project: Federal Funding Agencies

• A new conditional TDP¿NLS knock-in mouse model generated using CRISPR/Cas9 technology to study the linkage of TDP-43 pathology to motor and cognitive defects in ALS, FTD and ADRD

  Hegde, M., Mitra, J. & Wang, H.

  4/15/20 → 2/28/22

  Project: Federal Funding Agencies

• SANOFI - TED16414

  Gaber, A. O., Knight, R. J. & Yi, S.

  4/15/20 → …

  Project: Clinical Trial

• Biodegradability and Biocompatiblity of a Shape Memory Polymer Wrap to Improve Saphenous Vein Graft Patency in Peripheral and Coronary Artery Bypass Grafting Surgeries

  Peden, E. K., Cooke, J. P. & Karmonik, C.

  4/15/20 → 10/31/21

  Project: Federal Funding Agencies

• Sample and Data Collection for Houston Methodist Cancer Center Research

  Chang, J. C., Bernicker, E. H., Darcourt, J., Heyne, K., Niravath, P. A. & Singh, M.

  4/9/20 → …

  Project: Clinical Trial

• A Randomized, Open-label, Phase II Study of Canakinumab or Pembrolizumab as Monotherapy or in Combination as Neoadjuvant Therapy in Subjects With Resectable Non-small Cell Lung Cancer (CANOPY-N)

  Bernicker, E. H., Barrios, R., Chan, E. Y., Chang, J. C., Darcourt, J., Heyne, K., Kim, M. P., Niravath, P. A., Singh, M. & Zhang, J.

  4/9/20 → …

  Project: Clinical Trial

• ABBV-8E12 Anti-tau Antibody in AD - Extension Study

  Masdeu, J. C., Faridar, A. & Nakawah, M. O.

  4/9/20 → …

  Project: Clinical Trial

• Intraoperative Analytics and Enhanced Patient Outcomes

  4/5/20 → 5/4/21

  Project: Federal Funding Agencies

• Novel carbon nanozyme mechanisms for traumatic brain injury therapy

  Hegde, M.

  4/1/20 → 3/31/25

  Project: Federal Funding Agencies

• Myotonic Dystrophy Compilation of Clinical Findings

  Greene, E. P., Appel, S. H., Ashizawa, T., Mathuria, N., Shroff, S. & Thonhoff, J. R.

  4/1/20 → …

  Project: Clinical Trial

• U.S. Study to Protect Brain Health through Lifestyle Intervention to Reduce Risk:Neuroimaging Ancillary Study

  Masdeu, J. C.

  4/1/20 → 9/30/21

  Project: Federal Funding Agencies

• Takeda - TAK-018-2001

  Abraham, B. P. & Glassner, K.

  3/27/20 → …

  Project: Clinical Trial

• LEAP-012 - MERCK (7902-012, Site No. 0784) Safety and Efficacy of Lenvatinib (E7080 / MK-7902) With Pembrolizumab (MK-3475) in Combination With Transarterial Chemoembolization (TACE) in Participants With Incurable / Non-metastatic Hepatocellular Carcinoma (MK-7902-012 / E7080-G000-318 / LEAP-012)

  Ghobrial, R. M., Abdelrahim, M., Gibbs, J. M., Heyne, K., Shetty, A. & Victor, III, D. W.

  3/27/20 → …

  Project: Clinical Trial

• AOCT - COVID-19 Plasma Donation

  Salazar, E., Castillo, B., Chen, J. & Leveque, C.

  3/26/20 → …

  Project: Clinical Trial

• AOCT - Convalescent Plasma - COVID-19

  Salazar, E., Ashraf, M., Castillo, B., Chen, J., Leveque, C. & Perez, K. K.

  3/26/20 → …

  Project: Clinical Trial

• A Pilot Randomized Controlled Trial of De Novo Belatacept-Based Immunosuppression in Lung Transplantation

  3/26/20 → 3/25/45

  Project: Non Profit

• Phase 2, Open-Label Safety and Efficacy Study of Telisotuzumab Vedotin (ABBV-399) in Subjects With Previously Treated c-Met+ Non-Small Cell Lung Cancer

  Bernicker, E. H., Darcourt, J., Heyne, K., Singh, M. & Templeton, S.

  3/24/20 → …

  Project: Clinical Trial

• Receptive Music Approach to Improve Agitation in Hospitalized Dementia Patients

  3/23/20 → 6/30/21

  Project: Non Profit

• Building Resilience in Caregivers of Trauma Survivors

  Fowler, C.

  3/15/20 → 9/29/21

  Project: Federal Funding Agencies

• Clinical Validation of the InterVenn Ovarian CAncer Liquid Biopsy (VOCAL)

  Kamat, A. A., Alaniz, A., Suri, A. & Zaid, T.

  3/12/20 → …

  Project: Clinical Trial

• Under EdWorkplace Violence Against Nurses Prevention Grant Program

  3/11/20 → 8/31/21

  Project: State

• Exercise Intervention for Strong and Fit Pediatric Fontan Patients (StrongFitFontan)

  Cooke, J. P.

  3/10/20 → 2/28/25

  Project: Federal Funding Agencies

• ALLIANCE A221602: OLANZAPINEWITH ORWITHOUT FOSAPREPITANT FOR THE PREVENTION OF CHEMOTHERAPY INDUCED NAUSEA AND VOMITING (CINV) IN PATIENTS RECEIVING HIGHLY EMETOGENIC CHEMOTHERAPY (HEC): A PHASE III RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL

  Darcourt, J., Bernicker, E. H., Chang, J. C., Geyer, C. E., Heyne, K., Niravath, P. A. & Randhawa, J.

  3/6/20 → 3/5/45

  Project: Non Profit

• INTEGRATION OF IMMUNOTHERAPY INTO ADJUVANT THERAPY FOR RESECTED NSCLC: ALCHEMIST CHEMO-IO (ACCIO)

  Bernicker, E. H. & Zhang, J.

  3/6/20 → 3/5/45

  Project: Non Profit

• CTSU - IRB SUBMISSIONA Phase III Trial To Evaluate The Efficacy Of The Addition Of Inotuzumab Ozogamicin (A Conjugated Anti-Cd22 Monoclonal Antibody) To Frontline Therapy In Young Adults (Ages 18-39 Years) With Newly Diagnosed Precursor B-Cell ALL.

  Randhawa, J., Abdelrahim, M., Bernicker, E. H., Chang, J. C., Heyne, K., Niravath, P. A., Singh, M., Zhang, J. & Patel, T.

  3/6/20 → 3/5/45

  Project: Non Profit

• Molecular mechanism of streptococcal adaptation to host nutritional defenses

  Kumaraswami, M. & Olsen, R. J.

  2/25/20 → 1/31/25

  Project: Federal Funding Agencies

• Multicenter Phase II Trial of Durvalumab (MEDI4736) With Trastuzumab and Pertuzumab Combination in HER2-Enriched and HER2-Amplified Breast Cancer (DTP Trial)

  Chang, J. C., Darcourt, J., Geyer, C. E. & Niravath, P. A.

  2/21/20 → …

  Project: Clinical Trial

• Treatment of Autoimmune Psychosis

  Masdeu, J. C., Faridar, A., Nakawah, M. O., Pascual, B. & Weinstein, B.

  2/20/20 → …

  Project: Clinical Trial

• Systematic identification of astrocyte-tumor crosstalk regulating brain metastatic tumors

  Wong, S. T., Zhao, H., Rostomily, R. C. & Sheng, J.

  2/15/20 → 1/31/25

  Project: Federal Funding Agencies