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  Transforming triple negative breast cancer treatment through intratumoral immunotherapy via nanofluidic drug eluting seed

  Grattoni, A.

  8/1/20 → 7/31/23

  Project: Federal Funding Agencies

• Outcome-Driven Approach to Minimize the Risks of Facial Distortion Following CMF Surgery

  Xia, J. J. & Gateno, J.

  8/1/20 → 7/31/25

  Project: Federal Funding Agencies

• M15-736

  Ondo, W. G. & Waln, O.

  7/28/20 → …

  Project: Clinical Trial

• Massachusetts General Hospital Healey Center for ALS - Healey ALS Platform Trial

  Appel, S. H., Greene, E. P., Shroff, S. & Thonhoff, J. R.

  7/24/20 → 12/31/22

  Project: Non Profit

• HEALEY ALS Platform Trial - Regimen-Specific Appendix A - For 0.3mh/kg SC zilucoplan administered once daily and placebo

  Appel, S. H., Greene, E. P., Liao, B., Shroff, S. & Thonhoff, J. R.

  7/24/20 → 7/23/25

  Project: Non Profit

• HEALEY ALS Platform Trial - Regimen-Specific Appendix C - For CNM-Au8

  Appel, S. H., Greene, E. P., Liao, B., Shroff, S. & Thonhoff, J. R.

  7/24/20 → 7/23/25

  Project: Non Profit

• HEALEY ALS Platform Trial - Regimen-Specific Appendix B - For verdiperstat (also known as BHV-3241)

  Appel, S. H., Greene, E. P., Liao, B., Shroff, S. & Thonhoff, J. R.

  7/24/20 → 7/23/25

  Project: Non Profit

• TSS and Upper Limb Robotics

  Sayenko, D. & Horner, P. J.

  7/24/20 → …

  Project: Clinical Trial

• To study the EMT contributions in tumor metastasis and chemoresisitance by using lineage tracing models

  Wong, S. T. & Sheng, J.

  7/17/20 → 6/30/21

  Project: Federal Funding Agencies

• Medpace - MAU868-201

  Gaber, A. O., Knight, R. J., Saharia, A. & Yi, S.

  7/16/20 → …

  Project: Clinical Trial

• Reversal of Heart Failure: Role of Vascular Recovery

  Cooke, J. P., Chen, K., Meng, S. & Youker, K. A.

  7/15/20 → 3/31/24

  Project: Federal Funding Agencies

• EPIGENETIC REPROGRAMMING TO GENERATE NOVEL CHONDRO-OSSEOUS STEM CELLS FOR BONE TISSUE ENGINEERING

  Davis, B.

  7/15/20 → 6/30/22

  Project: Federal Funding Agencies

• Neuro-Afib Study - Retrospective Phase (Phase I)

  Gadhia, R. R.

  7/13/20 → 7/12/45

  Project: Non Profit

• Clazakizumab - COVID-19

  Al-Saadi, M. A., Gaber, A. O., Goodarzi, A., Graviss, E. A., Moore, L. W., Swan, J. T., Yau, S. W., Youssef, J. G. & Zahiruddin, F.

  7/8/20 → …

  Project: Clinical Trial

• SH-PORTICO NG

  Kleiman, N., Faza, N., Gadhia, R. R., Goel, S., Little, S. H., Reardon, M. J. & Volpi, J. J.

  7/8/20 → …

  Project: Clinical Trial

• A Phase 2 Open-label Study of Brentuximab Vedotin in Front-line Therapy of Hodgkin Lymphoma (HL) an dCD30-expressing Peripheral T-cell Lymphoma (PTCL) in Older Patients or Patients With Significant Comorbidities Ineligible for Standard Chemotherapy

  Pingali, S. R., Darcourt, J., Petkova, J. & Rice, L.

  7/8/20 → …

  Project: Clinical Trial

• A Phase 2, Multicenter, Single-arm Study of Retreatment With Brentuximab Vedotin in Subjects With Relapsed or Refractory Classic Hodgkin Lymphoma (cHL) or CD30-expressing Peripheral T Cell Lymphoma (PTCL)

  Pingali, S. R., Abdelrahim, M., Bernicker, E. H., Chang, J. C., Darcourt, J., Heyne, K., Niravath, P. A., Petkova, J., Randhawa, J., Rice, L. & Singh, M.

  7/8/20 → …

  Project: Clinical Trial

• Evaluation of the Portico¿ NG Transcatheter Aortic Valve in High and Extreme Risk Patients with Symptomatic Severe Aortic Stenosis (ABT-CIP-10297)

  Kleiman, N., Gadhia, R. R., Goel, S., Reardon, M. J. & Volpi, J. J.

  7/6/20 → 7/5/45

  Project: Non Profit

• SH-XyloCor XC001

  Al-Mallah, M., Kleiman, N. & Shah, A. R.

  7/2/20 → …

  Project: Clinical Trial

• An Open-label, Randomized, Controlled Phase 3 Study of Enfortumab Vedotin in Combination With Pembrolizumab With or Without Chemotherapy, Versus Chemotherapy Alone in Previously Untreated Locally Advanced or Metastatic Urothelial Cancer

  Darcourt, J., Singh, M. & Zhang, J.

  7/2/20 → …

  Project: Clinical Trial

• Targeting novel checkpoint regulator to control viral myocarditis

  Xing, J., Cooke, J. P., Li, X. C. & Zhang, Z.

  7/1/20 → 6/30/23

  Project: Non Profit

• Synchrony: Holistic Program for Veterans

  Madan, A. & Fowler, C.

  7/1/20 → 6/30/21

  Project: Non Profit

• Elucidating the role(s) of cytoplasmic capping in the response to oxidative stress in vascular endothelial cells

  Kiss, D. L.

  7/1/20 → 6/30/23

  Project: Non Profit

• A Novel Non-Invasive Approach for Regaining Self-Assisted Standing after Spinal Cord Injury: Combining Transcutaneous Spinal Stimulation and Functional Electrical Stimulation

  Sayenko, D.

  7/1/20 → 6/30/22

  Project: Non Profit

• Integrating imaging mass cytometry with spatial transcriptomics and single-cell RNA-seq for understanding of drug resistance in ovarian cancer

  Wong, S. T.

  7/1/20 → 6/30/21

  Project: State

• Transcriptional Control of Gliogenesis in the CNS

  Cykowski, M. D.

  7/1/20 → 6/30/21

  Project: Federal Funding Agencies

• Remote controlled nanochannel implant for tunable drug delivery

  Grattoni, A.

  7/1/20 → 10/1/21

  Project: Federal Funding Agencies

• Phase 3 Multicenter, Double-Blind, randomized, placebo-controlled trail of Infigratinib for the Adjuvant Treatment of Subjects with Invasive Urothelial Carcinoma with Susceptible FGFR3 Genetic Alterations (PROOF 302)

  Satkunasivam, R., Darcourt, J., Singh, M. & Zhang, J.

  6/26/20 → …

  Project: Clinical Trial

• AOCT - I-MAB Phase 1b2 study of TJ003234 in Subjects with Severe COVID 19

  Gotur, D. B., Hsu, S. H., Moran, D., Perez, K. K. & Sanchez Leon, R.

  6/26/20 → …

  Project: Clinical Trial

• SH-PROTECTED TAVR

  Kleiman, N., Goel, S., Reardon, M. J. & Volpi, J. J.

  6/24/20 → …

  Project: Clinical Trial

• Gingival Bacteria in AD - GAIN Trial

  Masdeu, J. C., Faridar, A. & Nakawah, M. O.

  6/17/20 → …

  Project: Clinical Trial

• A Randomized, Double-Blind, Phase III Clinical Trial of Neoadjuvant Chemotherapy With Atezolizumab or Placebo in Patients With Triple-Negative Breast Cancer Followed by Adjuvant Continuation of Atezolizumab or Placebo

  Niravath, P. A., Abdelrahim, M., Arentz, C., Chang, J. C., Darcourt, J., Geyer, C. E., Heyne, K. & Singh, M.

  6/16/20 → …

  Project: Clinical Trial

• CMR for COVID Patients

  Shah, D. J., Graviss, E. A., Malahfji, M., Nasir, K. & Yang, E. Y.

  6/16/20 → …

  Project: Clinical Trial

• Systems-wide analysis of oxidative stress-responsive m6A epitranscriptome

  Weng, Y. & Krencik, R. C.

  6/15/20 → 3/31/25

  Project: Federal Funding Agencies

• HOPE Part 2 - Heron

  Swan, J. T., Caplan, R. E., Gaber, A. O. & Moore, L. W.

  6/5/20 → …

  Project: Clinical Trial

• Convergent AI for Precise Breast Cancer Risk Assessment

  Wong, S. T., Chang, J. C. & Ensor, Jr., J. E.

  6/1/20 → 5/31/25

  Project: Federal Funding Agencies

• Influence of pre-analytical factors in glioblastoma MGMT promoter methylation biomarker assay

  Rostomily, R. C., Mitra, S. & Powell, S. Z.

  6/1/20 → 5/31/25

  Project: Federal Funding Agencies

• Phase III Trial of Docetaxel vs. Docetaxel and Radium-223 for Metastatic Castration-Resistant Prostate Cancer (mCRPC)

  Darcourt, J., Heyne, K., Singh, M. & Zhang, J.

  5/27/20 → …

  Project: Clinical Trial

• A Phase III, Multicenter, Open-Label, Extension Clinical Trial to Demonstrate the Effectiveness and Safety of Liposomal Cyclosporine A (L-CsA) Inhalation Solution Delivered via the PARI Investigational eFlow® Device plus Standard of Care in the Treatment of Bronchiolitis Obliterans Syndrome in Patients post Single or Double Lung Transplantation (BT-L-CsA-303-FU (BOSTON-3))

  Goodarzi, A., Yau, S. W. & Youssef, J. G.

  5/27/20 → …

  Project: Clinical Trial

• AOCT-ALXN-Efficacy and Safety Study of IV Ravulizumab in Patients with COVID-19 Severe Pneumonia

  Khoshnevis, M. R.

  5/27/20 → …

  Project: Clinical Trial

• Prospective Sudden Cardiac Death Risk Stratification Using Cardiac MRI and Echocardiography Machine Learning in Mitral Valve Prolapse.

  Shah, D. J.

  5/26/20 → 4/30/25

  Project: Federal Funding Agencies

• A Randomized, Double-Blind, Phase III Trial of Paclitaxel/Trastuzumab/Pertuzumab With Atezolizumab or Placebo in First-Line HER2-Positive Metastatic Breast Cancer

  Chang, J. C., Darcourt, J., Geyer, C. E. & Niravath, P. A.

  5/19/20 → …

  Project: Clinical Trial

• SH-AltaValve.

  Chang, S., Faza, N., Goel, S., Kleiman, N., Lawrie, G. M., Little, S. H. & Reardon, M. J.

  5/19/20 → …

  Project: Clinical Trial

• A Phase 1a/b Dose-Escalation Study Followed by Expansion Cohorts of NGM120, a GFRAL Antagonist Monoclonal Antibody Blocking GDF15 Signaling, in Subjects With Advanced Solid Tumors and Pancreatic Cancer Using Combination Therapy

  Singh, M., Abdelrahim, M., Beinart, G. & Heyne, K.

  5/18/20 → …

  Project: Clinical Trial

• Evaluation of immune responses to CD44-targeted nanovectors for designing a novel anti-tuberculosis host-directed therapy

  Godin, B., Jagannath, C. & Leonard, F.

  5/1/20 → 4/30/22

  Project: Federal Funding Agencies

• A Phase 2, Multicenter, Open-label, Safety and Efficacy Study of XERMELO® (Telotristat Ethyl) Plus First-line Chemotherapy in Patients With Locally Advanced, Unresectable, Recurrent or Metastatic Biliary Tract Cancer (BTC)

  Abdelrahim, M., Bernicker, E. H., Chang, J. C., Darcourt, J., Heyne, K., Niravath, P. A., Singh, M. & Zhang, J.

  4/27/20 → …

  Project: Clinical Trial

• A PILOT RANDOMIZED CONTROLLED TRIAL OF DE NOVO BELATACEPT-BASED IMMUNOSUPPRESSION IN LUNG TRANSPLANTATION

  Goodarzi, A. & Yau, S. W.

  4/23/20 → …

  Project: Clinical Trial

• Voice Rest Adherence After Phonomicrosurgery

  Yiu, Y.

  4/20/20 → 3/31/23

  Project: Federal Funding Agencies

• DOD - Dehisced-Wound

  Rupert, P.

  4/16/20 → …

  Project: Clinical Trial

• Biodegradability and Biocompatiblity of a Shape Memory Polymer Wrap to Improve Saphenous Vein Graft Patency in Peripheral and Coronary Artery Bypass Grafting Surgeries

  Peden, E. K., Cooke, J. P. & Karmonik, C.

  4/15/20 → 10/31/21

  Project: Federal Funding Agencies