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• A Phase III Randomized Placebo-Controlled Study to Examine the Efficacy and Safety of DAS181 for the Treatment of Lower Respiratory Tract Parainfluenza Infection in Immunocompromised Subjects

  Goodarzi, A., Yau, S. W. & Youssef, J. G.

  Project: Clinical Trial

• A Phase III Randomized, Placebo-Controlled Study of Pembrolizumab (MK-3475, NSC #776864)) in addition to Paclitaxel and Carboplatin for Measurable Stage III or IVA, Stage IVB or Recurrent Endometrial Cancer

  Kamat, A. A., Darcourt, J., Singh, M., Suri, A. & Zaid, T.

  3/1/19 → 2/28/25

  Project: Non Profit

• A Phase III Double-Blind Trial for Surgically Resected Early Stage Non-small Cell Lung Cancer: Crizotinib Versus Placebo for Patients With Tumors Harboring the Anaplastic Lymphoma Kinase (ALK) Fusion Protein

  Bernicker, E. H., Heyne, K., Singh, M. & Zhang, J.

  Project: Clinical Trial

• A Phase III, Randomized, Open-Label, Multicenter Study Evaluating the Efficacy and Safety of Adjuvant Giredestrant Compared with Physician's Choice of Adjuvant Endocrine Monotherapy in Patients with Estrogen Receptor-Positive, Her2-Negative Early Breast Cancer

  Chang, J. C. & Niravath, P. A.

  Project: Clinical Trial

• A Phase III, Open-Label, Randomized Study to Investigate the Efficacy and Safety of Atezolizumab (Anti-PD-L1 Antibody) Compared With Best Supportive Care Following Adjuvant Cisplatin-Based Chemotherapy in Patients With Completely Resected Stage IB-IIIA

  Bernicker, E. H., Heyne, K., Singh, M. & Zhang, J.

  Project: Clinical Trial

• A phase III, multicenter, randomized, study of atezolizumab/placebo administered in combination with paclitaxel, carboplatin, and bevacizumab to patients with newly-diagnosed stage III or stage IV ovarian, fallopian tube, or primary peritoneal cancer

  Kamat, A. A., Alaniz, A., Bernicker, E. H., Darcourt, J., Heyne, K., Singh, M., Suri, A. & Zaid, T.

  3/13/18 → 3/12/43

  Project: Non Profit

• A Phase III, Multicenter, Open-Label, Extension Clinical Trial to Demonstrate the Effectiveness and Safety of Liposomal Cyclosporine A (L-CsA) Inhalation Solution Delivered via the PARI Investigational eFlow® Device plus Standard of Care in the Treatment of Bronchiolitis Obliterans Syndrome in Patients post Single or Double Lung Transplantation (BT-L-CsA-303-FU (BOSTON-3))

  Goodarzi, A., Yau, S. W. & Youssef, J. G.

  5/27/20 → …

  Project: Clinical Trial

• A Phase III, Long-Term, Randomized, Double-blind, Placebo-controlled Trial of Troriluzole in Adult Subjects With Spinocerebellar Ataxia.

  Ashizawa, T. & Ondo, W. G.

  5/10/19 → …

  Project: Clinical Trial

• A Phase II Clinical tRial of neoADjuVant sAsanlimab and stereotaCtiC body radIatioN thErapy as an in situ vaccine for cisplatin-ineligible Muscle Invasive Bladder Cancer (RAD VACCINE MIBC)

  Satkunasivam, R., Chen, S., Esnaola, N. F., Farach, A. M., Teh, B. S. & Zhang, J.

  1/20/22 → …

  Project: Clinical Trial

• A Phase IIb/III, Randomized, Double-blind, Placebo-controlled Trial of Troriluzole in Adult Subjects With Spinocerebellar Ataxia

  Ashizawa, T., Ondo, W. G. & Waln, O.

  1/25/17 → …

  Project: Clinical Trial

• A Phase IIa randomized, double-blind, placebo-controlled study of the effects of L-serine on Mild Cognitive Impairment (MCI)

  Roman, G. C., Masdeu, J. C. & Pascual, M. B.

  8/11/22 → …

  Project: Clinical Trial

• A Phase II and Biomarker Study of Dual VEGF/PD-L1 Blockade in Neoadjuvant Setting in Resectable Hepatocellular Carcinoma Patients

  Ghobrial, R. M., Abdelrahim, M. & Kodali, S.

  4/1/21 → 3/31/26

  Project: Federal Funding Agencies

• A Phase IIa, randomised, double-blind, placebo-controlled trial to evaluate the safety, efficacy, pharmacokinetics and pharmacodynamics of BI 706321 orally administered for 12 weeks in patients with Crohn`s Disease (CD) receiving ustekinumab induction treatment

  Abraham, B. P. & Glassner, K.

  Project: Clinical Trial

• A Phase II/III Trial of Neoadjuvant FOLFOX w/ Selective Use of Combined Modality Chemoradiation versus Preoperative Combined Modality Chemoradiation for Locally Advanced Rectal Cancer Patients Undergoing Low Anterior Resection w/ Total Mesorectal Excisio

  Bernicker, E. H., Darcourt, J. & Singh, M.

  University of Michigan

  6/11/13 → 6/10/38

  Project: Non Profit

• A Phase I Dose Escalation and Dose Expansion and Phase II Monotherapy Open-label, First-in-Human, Multicenter Study of OP-1250 in Adult Subjects with Advanced and/or Metastatic Hormone Receptor (HR)-positive, HER2-negative Breast Cancer

  Niravath, P. A. & Chang, J. C.

  Project: Clinical Trial

• A Phase I/II Open-Label, Safety And Preliminary Efficacy Study Of MRx0518 In Combination With Pembrolizumab In Patients With Advanced Malignancies Who Have Progressed On PD-1/PD-L1 Inhibitors

  Bernicker, E. H., Heyne, K. & Zhang, J.

  Project: Clinical Trial

• A Phase 3 Open-Label, Randomized Study of Fixed Duration Pirtobrutinib (LOXO-305) Plus Venetoclax and Rituximab Versus Venetoclax and Rituximab in Previously Treated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (BRUIN CLL-322)

  Shah, S., Ganguly, S., Petkova, J., Pingali, S. R. & Rice, L.

  Project: Clinical Trial

• A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Compare the Efficacy and Safety of Sotatercept Versus Placebo When Added to Background Pulmonary Arterial Hypertension (PAH) Therapy for the Treatment of PAH_A011-11 (STELLAR)

  Safdar, Z. & Sahay, S.

  7/30/21 → …

  Project: Clinical Trial

• A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study Evaluating Efficacy and Safety of Rozanolixizumab in Adult Patients With Generalized Myasthenia Gravis

  Shroff, S., Appel, S. H., Greene, E. P. & Thonhoff, J. R.

  10/18/19 → …

  Project: Clinical Trial

• A Phase 3, Randomized, Controlled Study of Prophylactic and On-demand Treatment of cTTP With BAX 930 (rADAMTS13)

  Rice, L.

  1/3/20 → …

  Project: Clinical Trial

• A PHASE 3, MULTICENTER, RANDOMIZED, OPEN-LABEL, ACTIVE-CONTROLLED STUDY OF TRASTUZUMAB DERUXTECAN (T-DXd) VERSUS TRASTUZUMAB EMTANSINE (T-DM1) IN SUBJECTS WITH HIGH-RISK HER2 POSITIVE PRIMARY BREAST CANCER WHO HAVE RESIDUAL INVASIVE DISEASE IN BREAST OR AXILLARY LYMPH NODES FOLLOWING NEOADJUVANT THERAPY

  Chang, J. C. & Niravath, P. A.

  7/30/21 → …

  Project: Clinical Trial

• A PHASE 3, MULTICENTER, RANDOMIZED, OPEN-LABEL, ACTIVE-CONTROLLED STUDY OF TRASTUZUMAB DERUXTECAN (T-DXd) VERSUS TRASTUZUMAB EMTANSINE (T-DM1) IN SUBJECTS WITH HIGH-RISK HER2-POSITIVE PRIMARY BREAST CANCER WHO HAVE RESIDUAL INVASIVE DISEASE IN BREAST OR

  7/6/21 → 7/5/31

  Project: Non Profit

• A Phase 3, Double-Blind, Randomized, Placebo-Controlled, Parallel-Group, 27-Week Trial to Evaluate the Efficacy, Safety, and Tolerability of Two Fixed Doses of Tavapadon in Early Parkinson's Disease (TEMPO-1 TRIAL)

  Ondo, W. G. & Waln, O.

  8/6/20 → …

  Project: Clinical Trial

• A PHASE 2 STUDY OF FUTIBATINIB IN PATIENTS WITH SPECIFIC FGFR ABERRATIONS

  Abdelrahim, M., Heyne, K. & Singh, M.

  Project: Clinical Trial

• A Phase 2b, Dose-Ranging, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study of Rodatristat Ethyl in Patients with Pulmonary Arterial Hypertension (ELEVATE 2)

  Sahay, S. & Safdar, Z.

  7/21/22 → …

  Project: Clinical Trial

• A Phase 2b, 12-week, Double-blind, Placebo-controlled, Randomized, Parallel-group, Multicenter Study of the Safety and Efficacy of JZP385 in the Treatment of Adults with Moderate to Severe Essential Tremor

  Waln, O. & Ondo, W. G.

  Project: Clinical Trial

• A Phase 2a, Double-Blind, Randomized, Active Controlled, Parallel Group Study Evaluating the Efficacy, Safety, and Tolerability of Bezafibrate Administered in Combination with Obeticholic Acid in Subjects with Primary Biliary Cholangitis

  Victor, III, D. W. & Kodali, S.

  Project: Clinical Trial

• A Phase 2/3, Randomized, Double Blind, Placebo Controlled, Multicenter Study to Evaluate the Efficacy and Safety of FP-025 in Patients With Severe to Critical COVID 19 With Associated Acute Respiratory Distress Syndrome (ARDS)

  Zainab, A. & Hsu, S. H.

  Project: Clinical Trial

• A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study of K0706 in Subjects With Early Parkinson's Disease

  Ondo, W. G. & Waln, O.

  10/22/19 → …

  Project: Clinical Trial

• A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Dose Range Finding Clinical Trial to Evaluate the Tolerability, Safety, and Efficacy of PRAX-944 in the Treatment of Adults with Essential Tremor

  Waln, O. & Ondo, W. G.

  Project: Clinical Trial

• A Phase 2, Randomized, Double-Blind, Double-Dummy, Placebo-Controlled Study Evaluating the Safety and Efficacy of Semaglutide, and the Fixed-Dose Combination of Cilofexor and Firsocostat, Alone and in Combination, in Subjects With Compensated Cirrhosis (F4) Due to Nonalcoholic Steatohepatitis (NASH)

  Victor, III, D. W. & Kodali, S.

  Project: Clinical Trial

• A Phase 2, Multi-Cohort, Open-Label Study of Intratumoral Tavokinogene Telseplasmid Plus Electroporation in Combination with Intravenous Pembrolizumab Therapy with or without Chemotherapy in Patients with Inoperable Locally Advanced or Metastatic Triple Negative Breast Cancer

  Chang, J. C. & Niravath, P. A.

  Project: Clinical Trial

• A Phase 2, Double-Blind, Randomized, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Ravulizumab in Adult Participants With Proliferative Lupus Nephritis (LN) or Immunoglobulin A Nephropathy (IgAN)

  Project: Clinical Trial

• A Phase 1a/b Dose-Escalation Study Followed by Expansion Cohorts of NGM120, a GFRAL Antagonist Monoclonal Antibody Blocking GDF15 Signaling, in Subjects With Advanced Solid Tumors and Pancreatic Cancer Using Combination Therapy

  Singh, M., Abdelrahim, M., Beinart, G. & Heyne, K.

  5/18/20 → …

  Project: Clinical Trial

• A Phase 0, Investigator Initiated Study, Evaluating the Impact of Omega 3 Free Fatty Acid Supplementation on Aromatase in Obese Subjects (CTMS# 15-2100)

  Niravath, P. A., Chang, J. C. & Darcourt, J.

  12/1/16 → 11/30/18

  Project: Federal Funding Agencies

• APEX1 is a critical cytosolic molecule to sense self DNAs in autoimmune diseases

  Zhang, Z.

  Baylor Research Institute

  5/1/14 → 4/30/16

  Project: Federal Funding Agencies

• AOCT - Zephyr Valve Registry ZEVR

  Kopas, L.

  2/3/20 → …

  Project: Clinical Trial

• AOCT - Sugar Land - AEGIS-II

  Kleiman, N.

  11/1/19 → …

  Project: Clinical Trial

• AOCT - Phase3_MK4482-013_COVID-19

  Moran, D., Gotur, D. B. & Zahiruddin, F.

  9/15/21 → …

  Project: Clinical Trial

• AOCT - Phase 23_PF-07321332RITONAVIR_Low-Risk COVID-19_C4671002

  Youssef, J. G., Goodarzi, A., Yau, S. W. & Zahiruddin, F.

  10/21/21 → …

  Project: Clinical Trial

• AOCT - Intuitive da Vinci SP in Colorectal Surgical Procedures

  6/28/21 → …

  Project: Clinical Trial

• AOCT - DISRUPT - Exebacase

  Ashraf, M., Jaijakul, S. & Zainab, A.

  Project: Clinical Trial

• AOCT - COVID-19 Plasma Donation

  Castillo, B., Chen, J. & Leveque, C.

  3/26/20 → …

  Project: Clinical Trial

• AOCT - Convalescent Plasma - COVID-19

  Castillo, B., Ashraf, M., Chen, J. & Leveque, C.

  Project: Clinical Trial

• AOCT - ATLAS - Knee Study

  McCulloch, P.

  Project: Clinical Trial

• AOCT - Athena Study

  Friedman, J. D., Albright, S. & Ellsworth, IV, W. A.

  Project: Clinical Trial

• AOCT-A Phase 2b, Multi-Center, Randomized, Double-Blind, Placebo-Controlled Study with Open-Label Extension to Evaluate the Safety and Efficacy of ST266 Eye Drops in the Treatment of Persistent Corneal Epithelial Defects

  Pandit, R. & Queen, J. H.

  4/20/22 → …

  Project: Clinical Trial

• AOCT - Amulet IDE Study

  Valderrábano, M.

  Project: Clinical Trial

• An ultra-sensitive nanomagnetic sensor for the early detection of anaplactic large cell lymphoma

  Zu, Y.

  University of Houston

  5/1/15 → 2/28/19

  Project: State

• Antigen specificity, suppressive mechanism & regulation of CD4+ regulatory T cell

  Wang, R.

  National Cancer Institute

  2/17/12 → 7/31/13

  Project: Federal Funding Agencies