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  Safety, Pharmacokinetics (PK), and Efficacy of ONC-392 as a Single Agent and in Combination with Pembrolizumab in Advanced Solid Tumors and NSCLC: An Open Label Phase IA/IB Study

  Chang, J. C. & Niravath, P. A.

  12/2/22 → …

  Project: Clinical Trial

• Targeting Sodium Hydrogen Exchanger 6 to Improve the Efficacy of Chemotherapy and Immunotherapy for Multiple Myeloma

  Yang, J.

  12/1/22 → 11/30/24

  Project: State

• SENTINEL-1: A Feasibility Study of Fluorescence Enhanced Pelvic Lymph Node DeTection Using Intravesical HexamiNolevulinate HCl Dye for PatiEnts with Muscle-Invasive BLadder Cancer

  Satkunasivam, R.

  12/1/22 → …

  Project: Clinical Trial

• Targeting Nitric Oxide Synthase (NOS) pathway to remodel obesity induced tumor inflammation in patients with TNBC

  Chang, J. C.

  12/1/22 → 11/30/24

  Project: State

• A Phase III, Randomized, Open-Label, Multicenter Study Evaluating the Efficacy and Safety of Adjuvant Giredestrant Compared with Physician's Choice of Adjuvant Endocrine Monotherapy in Patients with Estrogen Receptor-Positive, Her2-Negative Early Breast Cancer

  Chang, J. C. & Niravath, P. A.

  11/21/22 → …

  Project: Clinical Trial

• A Phase I Dose Escalation and Dose Expansion and Phase II Monotherapy Open-label, First-in-Human, Multicenter Study of OP-1250 in Adult Subjects with Advanced and/or Metastatic Hormone Receptor (HR)-positive, HER2-negative Breast Cancer

  Niravath, P. A. & Chang, J. C.

  11/8/22 → …

  Project: Clinical Trial

• Docetaxel Chemotherapy and Pembrolizumab Plus Interleukin-12 Gene Therapy in Triple Negative Breast Cancer (INTEGRAL)

  Chang, J. C., Niravath, P. A. & Venta, L. A.

  10/31/22 → …

  Project: Clinical Trial

• A Phase 2a, Double-Blind, Randomized, Active Controlled, Parallel Group Study Evaluating the Efficacy, Safety, and Tolerability of Bezafibrate Administered in Combination with Obeticholic Acid in Subjects with Primary Biliary Cholangitis

  Victor, III, D. W. & Kodali, S.

  10/14/22 → …

  Project: Clinical Trial

• A Phase 2, Randomized, Double-Blind, Double-Dummy, Placebo-Controlled Study Evaluating the Safety and Efficacy of Semaglutide, and the Fixed-Dose Combination of Cilofexor and Firsocostat, Alone and in Combination, in Subjects With Compensated Cirrhosis (F4) Due to Nonalcoholic Steatohepatitis (NASH)

  Victor, III, D. W. & Kodali, S.

  10/11/22 → …

  Project: Clinical Trial

• BI 1425-0003 - Phase IIa - Crohn's Study - A Phase IIa, randomised, double-blind, placebo-controlled trial to evaluate the safety, efficacy, pharmacokinetics and pharmacodynamics of BI 706321 orally administered for 12 weeks in patients with Crohn`s Disease (CD) receiving ustekinumab induction treatment

  Abraham, B. P., Fan, C. & Glassner, K.

  10/3/22 → …

  Project: Clinical Trial

• CRISPR-Based Genome Editing of Ribosomal Protein L39 (RPL39) for Personalized Metaplastic Breast Cancer therapy

  Rosato, R. R.

  10/1/22 → 9/30/23

  Project: State

• Exploring ER?mRNA-based therapy in aggressive forms of breast cancer

  Thomas, C.

  10/1/22 → 9/30/23

  Project: State

• Engineered enzymes for enhanced mRNA vaccine production

  Gollihar, J. D.

  10/1/22 → 9/30/23

  Project: State

• Non-Invasive Brainstem Modulation for the Treatment of Non-Motor Symptoms in Parkinson?s Disease: A Randomized Controlled Trial (RCT) and an Open Label Extension (OLE) Study

  Ondo, W. G. & Waln, O.

  10/1/22 → …

  Project: Clinical Trial

• A Multi-Center, Real-World Evidence Registry to Assess Outcomes for the Long-Term Impact of Catheter Ablation for Atrial Fibrillation: DYNAMIC AF Registry

  9/30/22 → …

  Project: Clinical Trial

• A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Dose Range Finding Clinical Trial to Evaluate the Tolerability, Safety, and Efficacy of PRAX-944 in the Treatment of Adults with Essential Tremor

  Waln, O. & Billnitzer, A.

  9/28/22 → …

  Project: Clinical Trial

• Safety and Effectiveness Study of the Zenflow Spring System - A Minimally Invasive Treatment for LUTS Associated With BPH

  Gonzalez, R. & Starke, N. R.

  9/27/22 → …

  Project: Clinical Trial

• Intranasal Delivery of Telomerase Reverse Transcriptase mRNA for Therapy of Traumatic Brain Injury

  Godin, B.

  9/26/22 → 8/31/24

  Project: Federal Funding Agencies

• Relationship of the Human Astrocyte Matrisome with Synaptic Networks

  Krencik, R. C.

  9/23/22 → 7/31/27

  Project: Federal Funding Agencies

• Malleable Treatment - the Tactra Erectile Restoration Study (It MATTERS)

  Starke, N. R.

  9/23/22 → …

  Project: Clinical Trial

• A Prospective Study Evaluating the Clinical Outcomes of Ventral Hernias Treated Robotically With OviTex Reinforced Tissue Matrix

  Oviedo, R. J.

  9/23/22 → …

  Project: Clinical Trial

• A Phase 3 Open-Label, Randomized Study of Fixed Duration Pirtobrutinib (LOXO-305) Plus Venetoclax and Rituximab Versus Venetoclax and Rituximab in Previously Treated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (BRUIN CLL-322)

  Shah, S., Ganguly, S., Petkova, J., Pingali, S. R. & Rice, L.

  9/21/22 → …

  Project: Clinical Trial

• Validation of a novel 3D culture platform for TNBC treatment selection

  Yun, K.

  9/20/22 → 8/31/27

  Project: Federal Funding Agencies

• A Randomized, Double-blind, Phase III Study, Comparing NIS793 in Combination With Gemcitabine and Nab-paclitaxel Versus (vs.) Placebo Combined With Gemcitabine and Nab-paclitaxel for First Line Treatment of Metastatic Pancreatic Ductal Adenocarcinoma

  Abdelrahim, M., Heyne, K. & Singh, M.

  9/20/22 → …

  Project: Clinical Trial

• The Hancock Jaffe Surgical Antireflux Venous Valve Endoprosthesis (SAVVE) Study

  Peden, E. K., Le, L., Rahimi, M. & Roy, T.

  9/19/22 → …

  Project: Clinical Trial

• Cephea Mitral Valve System for Treatment of MR EFS Abbott

  Goel, S., Faza, N., Kleiman, N., Little, S. H., Reardon, M. J. & Yousefzai, R.

  9/19/22 → …

  Project: Clinical Trial

• Eradication of Escaped Variant Tumor Cells for Cancer Immunotherapy

  Lu, Y.

  9/15/22 → 8/31/26

  Project: Federal Funding Agencies

• LEAFLEX EFS for Severe Aortic Stenosis Pi-Cardia A Prospective, Multicenter, Non-Randomized, Single-Arm, Open-Label Clinical Study to Demonstrate the Safety and Performance of the Leaflex Performer

  Goel, S., Faza, N., Kleiman, N., Little, S. H. & Reardon, M. J.

  9/15/22 → …

  Project: Clinical Trial

• Open Label Study of Pitolisant (Wakix) as Adjunct Therapy for Subjects with Refractory Restless Legs Syndrome

  Ondo, W. G. & Waln, O.

  9/15/22 → …

  Project: Clinical Trial

• Vascularized NICHE with local immunosuppression for cell replacement for Type 1 diabetes

  Grattoni, A.

  9/12/22 → 5/31/27

  Project: Federal Funding Agencies

• Novel Targeted Therapeutics for Breast Cancer

  Ozpolat, B.

  9/1/22 → 6/30/25

  Project: Federal Funding Agencies

• Virtual Reality-Based Cognitive Intervention For The Prevention of Delirium & Cognitive Impairment In Geriatric Surgical Patients

  Faisal, H.

  9/1/22 → 8/31/24

  Project: Federal Funding Agencies

• Sexual Assault Nurse Examiner (SANE) expansion - Baytown Hospital

  9/1/22 → 8/31/23

  Project: State

• Sexual Assault Nurse Examiner (SANE) expansion - TMC

  9/1/22 → 8/31/23

  Project: State

• RESONANCE Registry of the Natural History of Recurrent PeriCarditis (Kiniksa)

  Shah, D. J.

  9/1/22 → …

  Project: Clinical Trial

• Type 1 Hydrolyzed Collagen (T1HC) * impact on the reduction of groin wound complications in vascular surgery

  Rahimi, M., Le, L., Lumsden, A. B., Peden, E. K. & Roy, T.

  8/30/22 → …

  Project: Clinical Trial

• Multilevel Intervention Strategies to Transform Kidney Care and Improve Pursuit of Transplant in an Integrated Healthcare Delivery System

  Waterman, A. D.

  8/15/22 → 7/31/23

  Project: Federal Funding Agencies

• A Phase IIa randomized, double-blind, placebo-controlled study of the effects of L-serine on Mild Cognitive Impairment (MCI)

  Roman, G. C., Masdeu, J. C. & Pascual, B.

  8/11/22 → …

  Project: Clinical Trial

• CY 6031 Phase 3 - To Evaluate CK3773274 in patients with oHCM, LVOT Cytokinetics, Inc.

  Nagueh, S., Buergler, J., Chamsi-Pasha, M. A. & Kurrelmeyer, K. M.

  8/10/22 → …

  Project: Clinical Trial

• A Phase 2b, 12-week, Double-blind, Placebo-controlled, Randomized, Parallel-group, Multicenter Study of the Safety and Efficacy of JZP385 in the Treatment of Adults with Moderate to Severe Essential Tremor

  Waln, O. & Ondo, W. G.

  8/8/22 → …

  Project: Clinical Trial

• HANSA - Kidney Imlifidase-Renal Function in Highly Sensitized Patients 1 Year After Desensitization With Imlifidase Prior to DD Kidney Tx

  Gaber, A. O., Knight, R. J. & Yi, S.

  8/4/22 → …

  Project: Clinical Trial

• AstroCapsules: A Novel Tool to Detect and Modulate the Neurotrauma Microenvironment

  Krencik, R. C.

  8/1/22 → 7/31/24

  Project: Non Profit

• Integrating in vivo and in silico models of prostate cancer-bone metastasis to overcome anti-tumor therapy resistance

  Casarin, S.

  8/1/22 → 7/31/23

  Project: Federal Funding Agencies

• Hydroponic Vegetable Gardening_Quality of Life in Cancer PatientsCaregivers_TAMU Grow It Yourself: The Effect of Hydroponic Vegetable Gardening on Improving Quality of Life in Cancer Patients and Their Caregivers

  Bernicker, E. H. & Satkunasivam, R.

  7/28/22 → …

  Project: Clinical Trial

• JAGUAR Trial: ObJective Analysis to GaUge EVAR Outcomes Through Randomization

  Lumsden, A. B., Le, L., Peden, E. K. & Rahimi, M.

  7/27/22 → …

  Project: Clinical Trial

• An Open-label, Multicenter Trial of the Safety, Tolerability, and Pharmacokinetic/Pharmacodynamic Profile of M1774 in Participants With Metastatic or Locally Advanced Unresectable Solid Tumors (DDRiver Solid Tumors 301)

  Singh, M., Abdelrahim, M., Bernicker, E. H., Heyne, K., Niravath, P. A. & Zhang, J.

  7/25/22 → …

  Project: Clinical Trial

• A Phase 2b, Dose-Ranging, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study of Rodatristat Ethyl in Patients with Pulmonary Arterial Hypertension (ELEVATE 2)

  Sahay, S. & Safdar, Z.

  7/21/22 → …

  Project: Clinical Trial

• Open Label, Multi-center, Phase 1b/2 Clinical Trial to Evaluate the Safety and Efficacy of Autologous CAR BCMA T Cells (CT053) in Patients With Relapsed and/or Refractory Multiple Myeloma (LUMMICAR STUDY 2)

  Ganguly, S., Petkova, J., Pingali, S. R. & Shah, S.

  7/14/22 → …

  Project: Clinical Trial

• POR and Training Program on Multidrug-Resistant Organisms

  Arias, C. A.

  7/1/22 → 6/30/26

  Project: Federal Funding Agencies

• Vascularized Islet transplantation NICHE with local immunosuppression for the treatment of type 1 diabetes

  Grattoni, A.

  7/1/22 → 4/30/26

  Project: Federal Funding Agencies