• 2495 Citations
  • 22 h-Index
20032020

Research output per year

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Personal profile

Personal profile

Dr. Zhiqiang Zhang earned his Ph.D. in Life Science from the University of Dalian University of Technology, Dalian, China, in 1999. He held faculty appointments at the University of Texas, MD Anderson Cancer Center, Houston Texas, and the Baylor research Institute, Baylor Institute for Immunology Research, Dallas, Texas, and  adjunct faculty appointment at Baylor University, Waco, Texas, before becoming a member of Houston Methodist Research Institute in 2014. As a member of the Research Institute Transplant Immunology Research Program, he directs a research program focusing on inflammation and virus infection. 

Research interests

Innate immunity plays a critical role in initiating immune response and pathogen clearance upon microbial infection. Using pattern recognition receptors, including intracellular receptors or cell surface receptors, immune cells sense and respond to pathogenic microbial infection. This triggers activation of various anti-pathogen signaling cascades leading to anti-microbial, type I interferon (IFN), and/or proinflammatory cytokine responses. Understanding the effect of various microbial infections on receptors and signaling pathways will provide molecular insights into the host defense machinery and potential therapeutic targets for treating microbial infection. In contrast, uncontrolled nucleic acid sensing, especially self-nucleic acid sensing, and excessive production of type 1 IFN and proinflammatory cytokines, have been implicated in the development of autoimmune diseases such as systemic lupus erythematosus (SLE). Knowing the self-nucleic acid sensing systems in immune cells will help us develop receptor antagonists as a new form of therapy for autoimmune diseases.

Studies conducted by Dr. Zhang ’s group indicate that many helicases are critical cytosolic sensors that recognize RNA, DNA, or c-di-GMP, triggering the IFN host immune response mediated by MAVS, TRIF, or STING. The anti-microbial pathogen activities of these helicases are regulated by protein ubiquitination. Further studies indicate that these helicases as well as the well-known IFI16, play little role in sensing neutrophil-derived mitochondrial DNA (mtDNA), which is the major inducer of IFN in SLE. Dr.
Zhang ’s group has:
i) Characterized DNA-binding proteins in monocyte. They expect to identify the cytosolic sensor to mtDNA.
ii) Screened all 70 members in the TRIM family and has found that at least 6 other TRIMs play important roles in regulating nucleic acid sensing.

Together, their studies will focus on revealing the unknown host defense mechanisms, autoimmune mechanisms, and ubiquitin-signaling pathways.

Education/Academic qualification

Postdoctoral Fellowship, Chinese Academy of Sciences

Biochemical Engineering, MS, Dalian Univ of Technology

Biochemical Engineering, PhD, Dalian Univ of Technology

Postdoctoral Fellowship, The Pennsylvania State University

Postdoctoral Fellowship, Tufts University

Research Area Keywords

  • Immunobiology & Inflammation

Free-text keywords

  • Autoimmune mechanisms
  • Virus infection
  • Type I interferon
  • Proinflammatory cytokine response

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Projects

Research Output

  • 2495 Citations
  • 22 h-Index
  • 33 Article
  • 1 Comment/debate

EphA2 phosphorylates NLRP3 and inhibits inflammasomes in airway epithelial cells

Zhang, A., Xing, J., Xia, T., Zhang, H., Fang, M., Li, S., Du, Y., Li, X. C., Zhang, Z. & Zeng, M-S., Apr 30 2020, In : EMBO Reports. p. e49666

Research output: Contribution to journalArticle

  • 1 Scopus citations

    Identification of the E3 ligase TRIM29 as a critical checkpoint regulator of NK cell functions

    Dou, Y., Xing, J., Kong, G., Wang, G., Lou, X., Xiao, X., Vivier, E., Li, X. C. & Zhang, Z., Aug 15 2019, In : Journal of immunology (Baltimore, Md. : 1950). 203, 4, p. 873-880 8 p.

    Research output: Contribution to journalArticle

  • 3 Scopus citations

    Ephrin receptor A2 is an epithelial cell receptor for Epstein-Barr virus entry

    Zhang, H., Li, Y., Wang, H. B., Zhang, A., Chen, M. L., Fang, Z. X., Dong, X. D., Li, S. B., Du, Y., Xiong, D., He, J. Y., Li, M. Z., Liu, Y. M., Zhou, A. J., Zhong, Q., Zeng, Y. X., Kieff, E., Zhang, Z., Gewurz, B. E., Zhao, B. & 1 others, Zeng, M. S., Feb 1 2018, In : Nature Microbiology. 3, 2, p. 164-171 8 p.

    Research output: Contribution to journalArticle

  • 44 Scopus citations

    Erratum to: Ephrin receptor A2 is an epithelial cell receptor for Epstein–Barr virus entry (Nature Microbiology, (2018), 3, 2, (164-171), 10.1038/s41564-017-0080-8)

    Zhang, H., Li, Y., Wang, H. B., Zhang, A., Chen, M. L., Fang, Z. X., Dong, X. D., Li, S. B., Du, Y., Xiong, D., He, J. Y., Li, M. Z., Liu, Y. M., Zhou, A. J., Zhong, Q., Zeng, Y. X., Kieff, E., Zhang, Z., Gewurz, B. E., Zhao, B. & 1 others, Zeng, M. S., Sep 1 2018, In : Nature Microbiology. 3, 9, 1 p.

    Research output: Contribution to journalComment/debate

  • 2 Scopus citations

    Human Semaphorin-4A drives Th2 responses by binding to receptor ILT-4

    Lu, N., Li, Y., Zhang, Z., Xing, J., Sun, Y., Yao, S. & Chen, L., Dec 1 2018, In : Nature Communications. 9, 1, 742.

    Research output: Contribution to journalArticle

  • 17 Scopus citations

    Prizes

    IAM Award for Excellence in Peer-Reviewed Publication

    Zhang, Zhiqiang (Recipient), Jun 7 2017

    Prize: Other distinction