Projects per year
Personal profile
Personal profile
Dr. Wang is an expert at the forefront of research in the fields of computational biology, modeling-aided drug target discovery, biophysical modeling of drug transport, and multiscale cancer modeling. Dr. Wang has developed expertise in both computational and translational research, and has successfully acted as an intermediary, catalyst, and team leader at the intersection of mathematics/engineering and the biology/medical fields. This intermediary role between medical and mathematical fields is of particular importance, facilitating discoveries that are only possible through a joining of these distinct but important research fields.
Research interests
Dr. Wang’s research spans a broad spectrum of applied mathematics, probability modeling, and systems biology and medicine. Dr. Wang’s research focuses on integrating mathematical, physical, and statistical methods with experimental investigations and patient data analysis to quantitatively study tumor progression and invasion, to help improve prediction of treatment efficacy and optimize treatment planning. Furthermore, he has been developing practical mathematical tools that can potentially be used by doctors in the clinic to predict the outcome for each individual patient prior to actual treatment.
External positions
Associate Professor of Research in Physiology and Biophysics, Weill Cornell Medical College
Dec 12 2019 → …
Research Area Keywords
- Cancer
- Imaging & Radiology
- Nanomedicine
- Precision Medicine
- Regenerative Medicine
- Systems Medicine & Bioinformatics
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Nanoparticle delivery of miRNA-based therapeutics to overcome clinical challenges in triple negative breast cancer
3/4/21 → 2/28/26
Project: Federal Funding Agencies
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miR-155 targeted therapeutics for precision medicine in lung cancer
8/3/18 → 7/31/23
Project: Federal Funding Agencies
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A Targeted Nanomedicine Prototype Against Enzalutamide-resistant Prostate Cancer
8/1/18 → 7/31/23
Project: Federal Funding Agencies
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Imaging and Molecular correlates of progression in cystic neoplasms of the pancreas
9/1/18 → 8/31/21
Project: Federal Funding Agencies
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A new multiscale methodology and application to tumor growth modeling
7/1/18 → 5/31/20
Project: Federal Funding Agencies
Research output
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Dedifferentiation-mediated stem cell niche maintenance in early-stage ductal carcinoma in situ progression: insights from a multiscale modeling study
Butner, J. D., Dogra, P., Chung, C., Ruiz-Ramírez, J., Nizzero, S., Plodinec, M., Li, X., Pan, P-Y., Chen, S-H., Cristini, V., Ozpolat, B., Calin, G. A. & Wang, Z., May 21 2022, In: Cell death & disease. 13, 5, p. 485Research output: Contribution to journal › Article › peer-review
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Genetic and Structural Analysis of SARS-CoV-2 Spike Protein for Universal Epitope Selection
Markosian, C., Staquicini, D. I., Dogra, P., Dodero-Rojas, E., Lubin, J. H., Tang, F. H. F., Smith, T. L., Contessoto, V. G., Libutti, S. K., Wang, Z., Cristini, V., Khare, S. D., Whitford, P. C., Burley, S. K., Onuchic, J. N., Pasqualini, R. & Arap, W., May 3 2022, (E-pub ahead of print) In: Molecular Biology and Evolution.Research output: Contribution to journal › Article › peer-review
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Translational Modeling Identifies Synergy between Nanoparticle-Delivered miRNA-22 and Standard-of-Care Drugs in Triple-Negative Breast Cancer
Dogra, P., Ramírez, J. R., Butner, J. D., Peláez, M. J., Chung, C., Hooda-Nehra, A., Pasqualini, R., Arap, W., Cristini, V., Calin, G. A., Ozpolat, B. & Wang, Z., Mar 16 2022, (E-pub ahead of print) In: Pharmaceutical Research.Research output: Contribution to journal › Article › peer-review
Open Access -
A mathematical model for the quantification of a patient’s sensitivity to checkpoint inhibitors and long-term tumour burden
Butner, J. D., Wang, Z., Elganainy, D., Al Feghali, K. A., Plodinec, M., Calin, G. A., Dogra, P., Nizzero, S., Ruiz-Ramírez, J., Martin, G. V., Tawbi, H. A., Chung, C., Koay, E. J., Welsh, J. W., Hong, D. S. & Cristini, V., Apr 2021, In: Nature Biomedical Engineering. 5, 4, p. 297-308 12 p.Research output: Contribution to journal › Article › peer-review
8 Scopus citations -
A mathematical model to estimate chemotherapy concentration at the tumor-site and predict therapy response in colorectal cancer patients with liver metastases
Anaya, D. A., Dogra, P., Wang, Z., Haider, M., Ehab, J., Jeong, D. K., Ghayouri, M., Lauwers, G. Y., Thomas, K., Kim, R., Butner, J. D., Nizzero, S., Ramírez, J. R., Plodinec, M., Sidman, R. L., Cavenee, W. K., Pasqualini, R., Arap, W., Fleming, J. B. & Cristini, V., Jan 25 2021, In: Cancers. 13, 3, p. 1-18 18 p., 444.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations
Prizes
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2019 Travel award for the Biophysical Society Annual Meeting
Wang, Zhihui (Recipient), Mar 2019
Prize: Prize (including medals and awards)
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A Multiscale Agent-Based Model of Ductal Carcinoma in Situ
Butner, J. (Recipient) & Wang, Zhihui (Recipient), May 2020
Prize: Other distinction
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A multiscale mathematical model to study nanomedicine delivery in solid tumors
Dogra, Prashant (Recipient) & Wang, Zhihui (Recipient), Nov 2019
Prize: Other distinction
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