Personal profile

Dr. Zeenat Safdar is an Associate Professor of Medicine at the Institute of Academic Medicine, Director of Clinical Research and Pulmonary Hypertension Program at the Houston Methodist Hospital Lung Center in Houston, Texas. She is also an Adjunct Associate Professor of Medicine at Baylor College of Medicine.

Dr. Safdar serves as a Chair of Young Council at Pulmonary Vascular Research Institute, Pulmonology Chair at the Pulmonary Hypertension Association Online University, and National Chair at PHA on the Road program. She serves as Registries and Databases Workforce leader at PH council of International Society of Heart Lung Transplantation (ISHLT).

Dr. Safdar is a Fellow of the American College of Physicians, American College of Chest Physicians (CHEST), and Pulmonary Vascular Research Institute. She is a member of the PH Council of International Society of Heart Lung Transplant, American Thoracic Society and Texas Medical Association.

She has been invited to serve as the session facilitator, presenter, and abstract reviewer and selector at the International Conference of the ATS, CHEST and ISHLT. Dr. Safdar has served as an invited reviewer for the American Journal of Respiratory and Critical Care Medicine, Respiratory Medicine and Therapeutic Advances in Respiratory Disease and serves as a member of the editorial board of several journals.

Research interests

Dr. Safdar’s principal area of interest is Pulmonary Arterial Hypertension (PAH), specifically translational research, clinical research and clinical trials. Her recent research has focused on the contribution of renin-angiotensin-aldosterone system to the pathophysiology of PAH. She is the principal and co-investigator of several ongoing clinical trials including

  • REATA - a phase 2 dose-ranging study of efficacy and safety of Bardoxolone Methyl in PAH
  • LIBERTY - a phase 2 study of Ubenimex in patient with PAH
  • TRANSIT-1 - a study to Assess the Tolerability and the Safety of the Transition From Inhaled Treprostinil to Oral Selexipag in PAH
  • Chronic ThromboEmbolic Pulmonary Hypertension registry
  • TRITON - The Efficacy and Safety of Initial Triple Versus Initial Dual Oral Combination Therapy in Patients With Newly Diagnosed PAH
  • RIN-PH - Safety and Efficacy of Inhaled Treprostinil in Adult PH With ILD Including CPFE

 The Houston Methodist Hospital Pulmonary Hypertension program also provides expert care for patients with idiopathic pulmonary fibrosis (IPF). As a Director of the IPF program, she serves as a lead investigator of several ongoing IPF clinical trials including 

  • RIFF study - a phase 2 randomized placebo-controlled clinical study to assess the safety and efficacy of Lebrikizumab in IPF
  • RAINIER study - a phase 2 multicenter study to assess the efficacy and safety of Simtuzamab in IPF

 She was the site investigator of several complete IPF clinical trials such as

  • ARTEMIS-IPF - ambrisentan for IPF
  • ARTEMIS-PH - ambrisentan in PH associated with IPF
  • MUSIC - macitentan for IPF

 Dr. Safdar is the recipient of a K23 grant from the National Institute of Health (NIH) and several other grants from non-profit organizations.  Her research has been published in prominent, high impact journals.

Keywords

    Research Area Keywords

  • Clinical Translation & Trials
  • Clinical Care

    Free-text keywords

  • Pulmonary Arterial Hypertension (PAH), Idiopathic Pulmonary Fibrosis (IPF), Pulmonary disease

Fingerprint

Pulmonary Hypertension
Concept: Pulmonary Hypertension
Weight: 100%
Domain: Medicine & Life Sciences
Lung
Concept: Lung
Weight: 22%
Domain: Medicine & Life Sciences
Idiopathic Pulmonary Fibrosis
Concept: Idiopathic Pulmonary Fibrosis
Weight: 17%
Domain: Medicine & Life Sciences
Therapeutics
Concept: Therapeutics
Weight: 12%
Domain: Medicine & Life Sciences
Hemoptysis
Concept: Hemoptysis
Weight: 12%
Domain: Medicine & Life Sciences
Epoprostenol
Concept: Epoprostenol
Weight: 12%
Domain: Medicine & Life Sciences
Pulmonary Artery
Concept: Pulmonary Artery
Weight: 10%
Domain: Medicine & Life Sciences
Thorax
Concept: Thorax
Weight: 8%
Domain: Medicine & Life Sciences
Heart Diseases
Concept: Heart Diseases
Weight: 8%
Domain: Medicine & Life Sciences
Hypertension
Concept: Hypertension
Weight: 7%
Domain: Medicine & Life Sciences
Research OutputsResearch Output authored by Zeenat Safdar is tagged with the concept

Journals

Therapeutic advances in respiratory disease

ISSNs: 1753-4658

Additional searchable ISSN (Electronic): 1753-4666

SAGE Publications Ltd

Journal

4

Pulm Circ

ISSNs: 2045-8932

Additional searchable ISSN (Electronic): 2045-8940

SAGE Publications Inc.

Scopus rating (2018): CiteScore 2.15 SJR 0.851 SNIP 0.627

Journal

3

Respiratory Medicine

ISSNs: 0954-6111

W.B. Saunders Ltd

Journal

2

Liver Transplantation

ISSNs: 1527-6465

Additional searchable ISSN (Electronic): 1527-6473

Wiley

Journal

2

European Respiratory Journal

ISSNs: 0903-1936

Additional searchable ISSN (Electronic): 1399-3003

European Respiratory Society

Scopus rating (2018): CiteScore 4.82 SJR 3.925 SNIP 2.397

Journal

2
has published Research OutputsResearch Output by Zeenat Safdar

Research Network

Visualization: Institutional Network

Click on a line in the diagram to see collaboration details.

Click icons to see information about the content.

Zeenat Safdar

Visualization: Co-author Network

Click on a line in the diagram to see collaboration details.

Click icons to see information about the content.

Zeenat Safdar

Shared Pub. Internal Organizations

has Research OutputsResearch Output by Zeenat Safdar

Shared Pub. External Organizations

Baylor College of Medicine

External organization: Unknown

12

VA North Texas Care System

External organization: Unknown

3

University of Alabama at Birmingham

External organization: Unknown

3

Cleveland Clinic Foundation

External organization: Unknown

3

Alfred Hospital

External organization: Medical

2
has Research OutputsResearch Output by Zeenat Safdar

Shared Pub. Internal co-authors

has co-authored Research OutputsResearch Output with Zeenat Safdar

Shared Pub. External co-authors

Joao de Andrade

External person

3

Shelley Shapiro

External person

3

Jahar Bhattacharya

External person

3

I. Ben-Dov

External person

2

Y. Schwarz

External person

2
has co-authored Research OutputsResearch Output with Zeenat Safdar

ID: 27341190