Personal profile

After obtaining his MD and PhD degrees, Dr. Zu attended the University of Connecticut Health Center as a postdoctoral fellow and later remained there as an assistant professor. He then spent four years in pathology residency training at New York University, followed by a two-year hematopathology fellowship at the National Cancer Institute of the National Institutes of Health. Dr. Zu joined the Department of Pathology and Genomic Medicine at Houston Methodist Hospital in 2004, where he currently serves as the Medical Director of the Hematopathology Section. He is also Professor of Pathology and Laboratory Medicine at the Weill Cornell Medical College of Cornell University. In addition to his clinical responsibilities, Dr. Zu is also the Director of the Cancer Pathology research laboratory at the Houston Methodist Research Institute. These combined positions enable him to address clinically-driven questions. As a physician-scientist, Dr. Zu has pioneered the translation of the oligonucleotide aptamers and nanotechnology into clinical applications, and his research is currently funded by multiple NIH and CPRIT grants.

Research interests

Dr. Zu's clinical interests include diagnosis of hematopoietic and lymphoid disorders. His research centers on the development of novel diagnostics and treatments for these disorders. His laboratory was the first to use aptamer probes to enhance the diagnostic capabilities of multi-color flow cytometry amd immunohistochemical staining, and for rapid detection of circulating tumor cells in whole blood samples. By combining nanotechnology with aptamer technology, Dr. Zu's laboratory is also developing new multi-functional nanomedicine for specific tumor imaging and targeted therapy of several cancer types, including lymphomas, multiple myeloma, pancreatic cancer, breast cancer, prostate cancer, ovarian cancer, and hepatocellular (liver) carcinoma. Other directions of his laboratory include studies on the role of cancer stem cells in the development of multiple myeloma and elucidating the molecular mechanisms underlying the myelodysplastic syndrome.

Keywords

    Research Area Keywords

  • Infectious Disease & Pathology
  • Nanomedicine
  • Cancer

    Free-text keywords

  • Aptamer technology, Nanomedicine, Early cancer detection, Targeted cancer therapy

Fingerprint

Lymphoma, Large B-Cell, Diffuse
Concept: Lymphoma, Large B-Cell, Diffuse
Weight: 100%
Domain: Medicine & Life Sciences
Lymphoma
Concept: Lymphoma
Weight: 38%
Domain: Medicine & Life Sciences
Neoplasms
Concept: Neoplasms
Weight: 38%
Domain: Medicine & Life Sciences
Cells
Concept: Cells
Weight: 33%
Domain: Chemical Compounds
B-Lymphocytes
Concept: B-Lymphocytes
Weight: 25%
Domain: Medicine & Life Sciences
Nucleotide Aptamers
Concept: Nucleotide Aptamers
Weight: 23%
Domain: Medicine & Life Sciences
p38 Mitogen-Activated Protein Kinases
Concept: p38 Mitogen-Activated Protein Kinases
Weight: 22%
Domain: Medicine & Life Sciences
Anaplastic Large-Cell Lymphoma
Concept: Anaplastic Large-Cell Lymphoma
Weight: 22%
Domain: Medicine & Life Sciences
Germinal Center
Concept: Germinal Center
Weight: 21%
Domain: Medicine & Life Sciences
B-Cell Lymphoma
Concept: B-Cell Lymphoma
Weight: 21%
Domain: Medicine & Life Sciences
Research OutputsResearch Output authored by Youli Zu is tagged with the concept

Journals

Blood

ISSNs: 0006-4971

American Society of Hematology

Journal

8

Leukemia

ISSNs: 0887-6924

Nature Publishing Group

Journal

6

Archives of Pathology and Laboratory Medicine

ISSNs: 0003-9985, 1543-2165, 0363-0153

Additional searchable ISSN (Electronic): 1543-2165

College of American Pathologists

Journal

6

Oncotarget

Additional searchable ISSN (Electronic): 1949-2553

Impact Journals

Journal

6

The Journal of biological chemistry

ISSNs: 0021-9258

American Society for Biochemistry and Molecular Biology Inc.

Journal

4
has published Research OutputsResearch Output by Youli Zu

Research Network

Visualization: Institutional Network

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Youli Zu

Visualization: Co-author Network

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Youli Zu

Shared Pub. Internal Organizations

21

Department of Medicine

Organizational unit: Departments

9

Department of Nanomedicine

Organizational unit: Departments

7

Cancer Center

Organizational unit: Centers of Excellence

4

Department of Radiology

Organizational unit: Departments

3
has Research OutputsResearch Output by Youli Zu

Shared Pub. External Organizations

University of Texas M. D. Anderson Cancer Center

External organization: Unknown

31

Houston Methodist Research Institute

External organization: Unknown

31

Weill Medical College of Cornell University

External organization: Unknown

30

Cleveland Clinic Foundation

External organization: Unknown

20

Gundersen Lutheran Medical Center

External organization: Unknown

19
has Research OutputsResearch Output by Youli Zu

Shared Pub. Internal co-authors

has co-authored Research OutputsResearch Output with Youli Zu

Shared Pub. External co-authors

Carlo Visco

External person

26

Maurilio Ponzoni

External person

26

Miguel A. Piris

External person

26

Andrés J M Ferreri

External person

25

Karen Dybkær

External person

25
has co-authored Research OutputsResearch Output with Youli Zu

ID: 2285879