Research interests

I am interested in understanding how the regenerative capacity is governed in the nervous system. In the lab, we use combinatorial approaches including next-generation sequencing, molecular biology and fluorescence imaging to study the epitranscriptomic mechanisms in neural repair and human pathologies at different stages of development. In particular, we are interested in the m6A RNA methylation in regulating RNA trafficking, localization and translation, as well as how dysfunction of these mechanisms could be linked to brain disorders. The long-term goal is to use knowledge obtained from these analyses to guide therapeutic approaches for treatment of injuries, stroke and neurodegenerative diseases.

Keywords

    Research Area Keywords

  • Neurosciences
  • Systems Medicine & Bioinformatics

Fingerprint

Epigenomics
Concept: Epigenomics
Weight: 100%
Domain: Medicine & Life Sciences
Regeneration
Concept: Regeneration
Weight: 68%
Domain: Medicine & Life Sciences
Neurons
Concept: Neurons
Weight: 67%
Domain: Medicine & Life Sciences
Axons
Concept: Axons
Weight: 57%
Domain: Medicine & Life Sciences
Methylation
Concept: Methylation
Weight: 57%
Domain: Medicine & Life Sciences
Class 2 Receptor-Like Protein Tyrosine Phosphatases
Concept: Class 2 Receptor-Like Protein Tyrosine Phosphatases
Weight: 52%
Domain: Medicine & Life Sciences
Nervous System
Concept: Nervous System
Weight: 51%
Domain: Medicine & Life Sciences
RNA
Concept: RNA
Weight: 50%
Domain: Medicine & Life Sciences
DNA
Concept: DNA
Weight: 40%
Domain: Medicine & Life Sciences
Messenger RNA
Concept: Messenger RNA
Weight: 38%
Domain: Medicine & Life Sciences
Research OutputsResearch Output authored by Yi-Lan Weng is tagged with the concept

Research outputs

m6A facilitates hippocampus-dependent learning and memory through YTHDF1

Research output: Contribution to journalArticle

An Intrinsic Epigenetic Barrier for Functional Axon Regeneration

Research output: Contribution to journalArticle

Epigenetic regulation of axonal regenerative capacity

Research output: Contribution to journalReview article

Journals

Neuron

ISSNs: 0896-6273

Additional searchable ISSN (Electronic): 1097-4199

Cell Press

Journal

3

Nature

ISSNs: 0028-0836, 0000-0000, 0000-0000, 1465-7392

Journal

2

Journal of Neuroscience

ISSNs: 0270-6474

Society for Neuroscience

Journal

1

Neurotherapeutics

ISSNs: 1933-7213

Additional searchable ISSN (Electronic): 1878-7479

Springer New York

Journal

1

Nature Neuroscience

ISSNs: 1097-6256

Nature Publishing Group

Journal

1
has published Research OutputsResearch Output by Yi-Lan Weng

Research Network

Visualization: Institutional Network

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Yi-Lan Weng

Visualization: Co-author Network

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Yi-Lan Weng

Shared Pub. Internal Organizations

Stanley H. Appel Department of Neurology

Organizational unit: Departments

3
has Research OutputsResearch Output by Yi-Lan Weng

Shared Pub. External Organizations

Johns Hopkins University

External organization: Academic

4

School of Medicine

External organization: Unknown

3

Univ. of Pennsylvania Sch. of Med.

External organization: Unknown

2

University of Chicago

External organization: Unknown

2

University of Chicago

External organization: Unknown

2
has Research OutputsResearch Output by Yi-Lan Weng

Shared Pub. External co-authors

Hongjun Song

External person

5

Guo-Li Ming

External person

5

Ran Ran Liu

External person

4

Jessica Joseph

External person

3

Jessica Cassin

External person

2
has co-authored Research OutputsResearch Output with Yi-Lan Weng

ID: 40357825