Projects per year
Personal profile
Research interests
I am interested in understanding how the regenerative capacity is governed in the nervous system. In the lab, we use combinatorial approaches including next-generation sequencing, molecular biology and fluorescence imaging to study the epitranscriptomic mechanisms in neural repair and human pathologies at different stages of development. In particular, we are interested in the m6A RNA methylation in regulating RNA trafficking, localization and translation, as well as how dysfunction of these mechanisms could be linked to brain disorders. The long-term goal is to use knowledge obtained from these analyses to guide therapeutic approaches for treatment of injuries, stroke and neurodegenerative diseases.
Research Area Keywords
- Neurosciences
- Systems Medicine & Bioinformatics
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Projects
- 3 Active
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Systems-wide analysis of oxidative stress-responsive m6A epitranscriptome
6/15/20 → 3/31/25
Project: Federal Funding Agencies
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An EGFR signature predicts cell line and patient sensitivity to multiple tyrosine kinase inhibitors
Cheng, C., Zhao, Y., Schaafsma, E., Weng, Y. L. & Amos, C., Nov 1 2020, In: International Journal of Cancer. 147, 9, p. 2621-2633 13 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Knocking Out Non-muscle Myosin II in Retinal Ganglion Cells Promotes Long-Distance Optic Nerve Regeneration
Wang, X. W., Yang, S. G., Zhang, C., Hu, M. W., Qian, J., Ma, J. J., Zhang, Y., Yang, B. B., Weng, Y. L., Ming, G. L., Kosanam, A. R., Saijilafu & Zhou, F. Q., Apr 21 2020, In: Cell Reports. 31, 3, 107537.Research output: Contribution to journal › Article › peer-review
11 Scopus citations -
m6A mRNA Methylation Is Essential for Oligodendrocyte Maturation and CNS Myelination
Xu, H., Dzhashiashvili, Y., Shah, A., Kunjamma, R. B., Weng, Y. L., Elbaz, B., Fei, Q., Jones, J. S., Li, Y. I., Zhuang, X., Ming, G. L., He, C. & Popko, B., Jan 22 2020, In: Neuron. 105, 2, p. 293-309.e5Research output: Contribution to journal › Article › peer-review
29 Scopus citations -
Epitranscriptomic m6A Regulation of Axon Regeneration in the Adult Mammalian Nervous System
Weng, Y-L., Wang, X., An, R., Cassin, J., Vissers, C., Liu, Y., Liu, Y., Xu, T., Wang, X., Wong, S. Z. H., Joseph, J., Dore, L. C., Dong, Q., Zheng, W., Jin, P., Wu, H., Shen, B., Zhuang, X., He, C., Liu, K. & 2 others, , Jan 17 2018, In: Neuron. 97, 2, p. 313-325.e6Research output: Contribution to journal › Article › peer-review
127 Scopus citations -
m6A facilitates hippocampus-dependent learning and memory through YTHDF1
Shi, H., Zhang, X., Weng, Y. L., Lu, Z., Liu, Y., Lu, Z., Li, J., Hao, P., Zhang, Y., Zhang, F., Wu, Y., Delgado, J. Y., Su, Y., Patel, M. J., Cao, X., Shen, B., Huang, X., Ming, G. L., Zhuang, X., Song, H. & 2 others, , Nov 8 2018, In: Nature. 563, 7730, p. 249-253 5 p.Research output: Contribution to journal › Article › peer-review
149 Scopus citations