Projects per year
Personal profile
Research interests
I am interested in understanding how the regenerative capacity is governed in the nervous system. In the lab, we use combinatorial approaches including next-generation sequencing, molecular biology and fluorescence imaging to study the epitranscriptomic mechanisms in neural repair and human pathologies at different stages of development. In particular, we are interested in the m6A RNA methylation in regulating RNA trafficking, localization and translation, as well as how dysfunction of these mechanisms could be linked to brain disorders. The long-term goal is to use knowledge obtained from these analyses to guide therapeutic approaches for treatment of injuries, stroke and neurodegenerative diseases.
Research Area Keywords
- Neurosciences
- Systems Medicine & Bioinformatics
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Systems-wide analysis of oxidative stress-responsive m6A epitranscriptome
6/15/20 → 3/31/25
Project: Federal Funding Agencies
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Ablation of BATF Alleviates Transplant Rejection via Abrogating the Effector Differentiation and Memory Responses of CD8+ T Cells
Li, S., Zou, D., Chen, W., Cheng, Y., Britz, G. W., Weng, Y. L. & Liu, Z., Apr 19 2022, In: Frontiers in immunology. 13, 882721.Research output: Contribution to journal › Article › peer-review
Open Access -
METTL3 inhibition reduces N6-methyladenosine levels and prevents allogeneic CD4+ T-cell responses
Li, S., Zou, D., Chen, W., Britz, G. W., Liu, Z. & Weng, Y. L., Oct 2022, In: Immunology and Cell Biology. 100, 9, p. 718-730 13 p.Research output: Contribution to journal › Article › peer-review
Open Access -
A contemporary review of therapeutic and regenerative management of intracerebral hemorrhage
Sadaf, H., Desai, V. R., Misra, V., Golanov, E., Hegde, M. L., Villapol, S., Karmonik, C., Regnier-Golanov, A., Sayenko, D., Horner, P. J., Krencik, R., Weng, Y. L., Vahidy, F. S. & Britz, G. W., Nov 2021, In: Annals of Clinical and Translational Neurology. 8, 11, p. 2211-2221 11 p.Research output: Contribution to journal › Review article › peer-review
Open Access2 Scopus citations -
An EGFR signature predicts cell line and patient sensitivity to multiple tyrosine kinase inhibitors
Cheng, C., Zhao, Y., Schaafsma, E., Weng, Y. L. & Amos, C., Nov 1 2020, In: International Journal of Cancer. 147, 9, p. 2621-2633 13 p.Research output: Contribution to journal › Article › peer-review
8 Scopus citations -
Knocking Out Non-muscle Myosin II in Retinal Ganglion Cells Promotes Long-Distance Optic Nerve Regeneration
Wang, X. W., Yang, S. G., Zhang, C., Hu, M. W., Qian, J., Ma, J. J., Zhang, Y., Yang, B. B., Weng, Y. L., Ming, G. L., Kosanam, A. R., Saijilafu & Zhou, F. Q., Apr 21 2020, In: Cell Reports. 31, 3, 107537.Research output: Contribution to journal › Article › peer-review
Open Access21 Scopus citations