Projects per year
Personal profile
Personal profile
Yi-Lan Weng earned his bachelor’s degree in Chemistry and Life Science from National Tsing Hua University (Taiwan) in 1999 and his master’s degree in Biochemistry from National Yang-Ming University (Taiwan) in 2001. He received his PhD in Neuroscience at Case Western Reserve University (CWRU) in 2011 where he focused on cellular and molecular mechanisms of axon targeting and regeneration. While at CWRU, he helped to design a specific peptide that blocked protein tyrosine phosphatase-sigma signal transduction, successfully restored serotonergic innervation to the spinal cord in rats, and facilitated functional recovery of both locomotor and urinary systems following spinal cord injury. During his postdoctoral training at Johns Hopkins University, Dr. Weng developed a serial of innovative next-generation sequencing approaches and experimental methods to elucidate roles of DNA and RNA epigenetics in determining regenerative capacity. His findings have been published in the most prestigious journals, including Nature, Nature Neuroscience, and Neuron. In 2018, Dr. Weng joined the Center for Neuroregeneration at HMRI as an Assistant Professor. Dr. Weng’s research investigates the epitranscriptomic regulation of neuronal function.
Research interests
I am interested in understanding how the regenerative capacity is governed in the nervous system. In the lab, we use combinatorial approaches including next-generation sequencing, molecular biology and fluorescence imaging to study the epitranscriptomic mechanisms in neural repair and human pathologies at different stages of development. In particular, we are interested in the m6A RNA methylation in regulating RNA trafficking, localization and translation, as well as how dysfunction of these mechanisms could be linked to brain disorders. The long-term goal is to use knowledge obtained from these analyses to guide therapeutic approaches for treatment of injuries, stroke and neurodegenerative diseases.
Education/Academic qualification
Neuroscience, Postdoctoral Associate, John Hopkins
Award Date: Jul 1 2017
Neuroscience, PhD, Case Western Reserve University
Award Date: May 1 2011
Biochemistry, MS, National Yang Ming Chiao Tung University
Award Date: May 1 2001
Chemistry, BS, National Tsing Hua University
Award Date: May 1 1999
External positions
Assistant Professor of Neuroscience in Neurological Surgery, Weill Cornell Medicine
May 2019 → …
Research Area Keywords
- Neurosciences
- Systems Medicine & Bioinformatics
Free-text keywords
- Regeneration
- Stroke
- Neurodegenerative disease
- Spinal cord
- synaptic transmission
- axon
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Collaborations and top research areas from the last five years
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Systems-wide analysis of oxidative stress-responsive m6A epitranscriptome
Weng, Y.-L. (PI) & Krencik, R. C. (Key Personnel)
6/15/20 → 3/31/26
Project: Federal Funding Agencies
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Neuromodulation and the Neuroimmune Axis of Repair
Horner, P. J. (PI) & Weng, Y.-L. (Key Personnel)
7/31/21 → 7/30/24
Project: Non Profit
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2019 NARSAD Young Investigator Grant- 28235
Weng, Y.-L. (PI) & Horner, P. J. (Key Personnel)
1/15/20 → 1/14/22
Project: Non Profit
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Biochemical profiling and structural basis of ADAR1-mediated RNA editing
Deng, X., Sun, L., Zhang, M., Basavaraj, R., Wang, J., Weng, Y. L. & Gao, Y., Apr 3 2025, In: Molecular Cell. 85, 7, p. 1381-1394.e6Research output: Contribution to journal › Article › peer-review
Open Access -
Epigenetic and epitranscriptomic regulation of axon regeneration
Cheng, Y., Song, H., Ming, G. L. & Weng, Y. L., Apr 2023, In: Molecular Psychiatry. 28, 4, p. 1440-1450 11 p.Research output: Contribution to journal › Review article › peer-review
Open Access10 Scopus citations -
Exploring the brain epitranscriptome: perspectives from the NSAS summit
Lee, S. M., Koo, B., Carré, C., Fischer, A., He, C., Kumar, A., Liu, K., Meyer, K. D., Ming, G. L., Peng, J., Roignant, J. Y., Storkebaum, E., Sun, S., De Pietri Tonelli, D., Wang, Y., Weng, Y. L., Pulvirenti, L., Shi, Y., Yoon, K. J. & Song, H., 2023, In: Frontiers in Neuroscience. 17, 1291446.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Random Forest model reveals the interaction between N6-methyladenosine modifications and RNA-binding proteins
Hong, W., Zhao, Y., Weng, Y. L. & Cheng, C., Mar 17 2023, In: iScience. 26, 3, p. 106250 106250.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Ablation of BATF Alleviates Transplant Rejection via Abrogating the Effector Differentiation and Memory Responses of CD8+ T Cells
Li, S., Zou, D., Chen, W., Cheng, Y., Britz, G. W., Weng, Y. L. & Liu, Z., Apr 19 2022, In: Frontiers in immunology. 13, p. 882721 882721.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations