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Yi-Lan Weng, PhD

  • 516 Citations
  • 8 h-Index
20112020

Research output per year

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Personal profile

Research interests

I am interested in understanding how the regenerative capacity is governed in the nervous system. In the lab, we use combinatorial approaches including next-generation sequencing, molecular biology and fluorescence imaging to study the epitranscriptomic mechanisms in neural repair and human pathologies at different stages of development. In particular, we are interested in the m6A RNA methylation in regulating RNA trafficking, localization and translation, as well as how dysfunction of these mechanisms could be linked to brain disorders. The long-term goal is to use knowledge obtained from these analyses to guide therapeutic approaches for treatment of injuries, stroke and neurodegenerative diseases.

Research Area Keywords

  • Neurosciences
  • Systems Medicine & Bioinformatics

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Projects

Systems-wide analysis of oxidative stress-responsive m6A epitranscriptome

Weng, Y. & Krencik, R. C.

6/15/20 → 3/31/25

Project: Federal Funding Agencies

2019 NARSAD Young Investigator Grant- 28235

Weng, Y. & Horner, P. J.

1/15/20 → 1/14/22

Project: Non Profit

Research Output

  • 516 Citations
  • 8 h-Index
  • 9 Article
  • 2 Review article

An EGFR signature predicts cell line and patient sensitivity to multiple tyrosine kinase inhibitors

Cheng, C., Zhao, Y., Schaafsma, E., Weng, Y-L. & Amos, C., Jan 1 2020, In : International Journal of Cancer.

Research output: Contribution to journal › Article

    • Knocking Out Non-muscle Myosin II in Retinal Ganglion Cells Promotes Long-Distance Optic Nerve Regeneration

    Wang, X. W., Yang, S. G., Zhang, C., Hu, M. W., Qian, J., Ma, J. J., Zhang, Y., Yang, B. B., Weng, Y. L., Ming, G. L., Kosanam, A. R., Saijilafu & Zhou, F. Q., Apr 21 2020, In : Cell Reports. 31, 3, 107537.

    Research output: Contribution to journal › Article

    • 2 Scopus citations

    m6A mRNA Methylation Is Essential for Oligodendrocyte Maturation and CNS Myelination

    Xu, H., Dzhashiashvili, Y., Shah, A., Kunjamma, R. B., Weng, Y. L., Elbaz, B., Fei, Q., Jones, J. S., Li, Y. I., Zhuang, X., Ming, G. L., He, C. & Popko, B., Jan 22 2020, In : Neuron. 105, 2, p. 293-309.e5

    Research output: Contribution to journal › Article

    • 2 Scopus citations

    Epitranscriptomic m6A Regulation of Axon Regeneration in the Adult Mammalian Nervous System

    Weng, Y-L., Wang, X., An, R., Cassin, J., Vissers, C., Liu, Y., Liu, Y., Xu, T., Wang, X., Wong, S. Z. H., Joseph, J., Dore, L. C., Dong, Q., Zheng, W., Jin, P., Wu, H., Shen, B., Zhuang, X., He, C., Liu, K. & 2 others, Song, H. & Ming, G-L., Jan 17 2018, In : Neuron. 97, 2, p. 313-325.e6

    Research output: Contribution to journal › Article

    • 76 Scopus citations

    m6A facilitates hippocampus-dependent learning and memory through YTHDF1

    Shi, H., Zhang, X., Weng, Y. L., Lu, Z., Liu, Y., Lu, Z., Li, J., Hao, P., Zhang, Y., Zhang, F., Wu, Y., Delgado, J. Y., Su, Y., Patel, M. J., Cao, X., Shen, B., Huang, X., Ming, G. L., Zhuang, X., Song, H. & 2 others, He, C. & Zhou, T., Nov 8 2018, In : Nature. 563, 7730, p. 249-253 5 p.

    Research output: Contribution to journal › Article

    • 57 Scopus citations