Projects per year
Personal profile
Personal profile
Dr. Xuewu Liu got his Ph.D. in 2002, then undertook a postdoctoral training at the Indiana Center for Biological Microscopy at IUPUI Indianapolis. In 2003, he joined Ohio State University as a senior research associate in nanomedicine. He was appointed assistant professor of nanomedicine and biomedical engineering at the University of Texas Health Science Center in Houston in 2006. In 2010, Dr. Liu joined to The Methodist Hospital Research Institute, to direct the nanoengineering core.
Dr. Xuewu Liu is a leading scientist in silicon nanotechnology. With over 20 years of experience in silicon microfabrication, nanomaterials, microfluidics, and cancer nanotechnology, Dr. Liu has been leading the effort in the research and development of silicon-based nanomedicine platforms, and coordinates a nanoengineering team to support biomedical research at the institute levels. The nanomedicine platforms he developed include porous silicon nanovectors for drug delivery, multifunctional nanoparticles, nanochannel membranes for drug implants, nanostructure enhanced microfluidic devices, injectable nanoparticulate scavengers, and nanoporous assay for diagnostic biomarkers. Dr. Liu had published 150 peer-reviewed journal papers, and issued 10 US patents. He is intensively involved in the researches on targeted cancer therapy, in vitro and in vivo studies of particles-cells interaction, implanted drug delivery, microfluidic analysis of exosomes, and particulate cytokine scavengers for immune regulation. As the director of nanoengineering, he led the cleanroom microfabrication and the development of in-house nanofabrication capabilities in the Houston Methodist cGMP facility. His current active researches focus on microfluidic study of platelet-mediated tumor metastasis, injectable cytokine scavenging for immune modulation, and microfluidic cell manipulation for the study of intracellular interaction at single cell level.
Research interests
Dr. Liu’s research focus is the development of silicon based nanotechnology platforms for prevention, diagnosis and treatment of human disease. His current interests include microfluidic study of platelet-mediated tumor metastasis, injectable cytokine scavenging for immune modulation, and microfluidic cell manipulation for the study of intracellular interaction at single cell level.
Education/Academic qualification
Postdoctoral Associate, Heart and Lung Research Institute
May 4 2003 → Apr 30 2006
Biological Microscopy, Postdoctoral Associate, Indiana Center for Biological Microscopy, Indianapolis, IN
Nuclear Physics, MS, Jilin University
Physics, PhD, Kent State University
Research Area Keywords
- Nanomedicine
- Cancer
Free-text keywords
- Silicon nanotechnology
- Drug delivery nanoparticles
- Theranostics
- Biological microfluidics
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Collaborations and top research areas from the last five years
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Biophysical roles of pre-metastatic niche evolution on transport of circulating tumor cells
Liu, X. (PI) & Qin, L. (PI)
2/15/20 → 1/31/26
Project: Federal Funding Agencies
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Elucidate the effect of biophysical properties evolution in sentinel lymph node of breast cancer on initiating lung metastasis using novel ultrasound poroelastography
Liu, X. (PI)
2/1/21 → 1/31/25
Project: Federal Funding Agencies
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A tunable nanofluidic drug delivery platform for in vivo research
Grattoni, A. (PI) & Liu, X. (PI)
4/15/18 → 1/31/23
Project: Federal Funding Agencies
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A Nanodrug for the Cure of Metastatic Breast Cancer
Chang, J. C. (Project Director), Ensor, Jr., J. E. (Key Personnel) & Liu, X. (Key Personnel)
7/15/17 → 3/1/20
Project: Federal Funding Agencies
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Identification of novel immune targets and neoantigens for development of immunotherapy for breast cancer
Wang, R. (PI), Chang, J. C. (Key Personnel) & Liu, X. (Key Personnel)
12/1/16 → 11/30/19
Project: State
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An injectable nanoparticle generator enhances delivery of cancer therapeutics
Xu, R., Zhang, G., Mai, J., Deng, X., Segura-Ibarra, V., Wu, S., Shen, J., Liu, H., Hu, Z., Chen, L., Huang, Y., Koay, E., Huang, Y., Liu, J., Ensor, J. E., Blanco, E., Liu, X., Ferrari, M. & Shen, H., Apr 1 2016, In: Nature Biotechnology. 34, 4, p. 414-418 5 p.Research output: Contribution to journal › Article › peer-review
249 Scopus citations -
A parametric study of motion and attachment to capillary walls of circulating tumor cells (CTCs) interacting with non-activated and activated platelets
Simic, V., Nikolic, A., Ning, S., Milosevic, M., Leonard, F., Liu, X. & Kojic, M., Jun 2025, In: Computer Methods and Programs in Biomedicine. 264, 108699.Research output: Contribution to journal › Article › peer-review
Open Access -
Engineered built-in electric Fields in Cu0/CuOx nanozyme-decorated silicon nanodisks for the degradation of phenols and dyes
Huang, S., Zhang, T., Hong, S., Zhang, D., Zhao, Y., Li, M., Wang, Y., Liu, X., Guo, Y. & Xu, L., Jan 6 2025, (Accepted/In press) In: Nano Research.Research output: Contribution to journal › Article › peer-review
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Correction: Multivalent Presentation of MPL by Porous Silicon Microparticles Favors T Helper 1 Polarization Enhancing the Anti-Tumor Efficacy of Doxorubicin Nanoliposomes
Meraz, I. M., Hearnden, C. H., Liu, X., Yang, M., Williams, L., Savage, D. J., Gu, J., Rhudy, J. R., Yokoi, K., Lavelle, E. C. & Serda, R. E., 2024, In: PLoS ONE. 19, 11, p. e0314577Research output: Contribution to journal › Article › peer-review
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Nanofluidic delivery implant sustains localization and maximizes efficacy of intratumoral immunotherapy
Liu, H. C., Di Trani, N., Conte, M., Nguyen, D. C., Jokonya, S., Wu, A., Vander Pol, R., Joubert, A. L., Facchi, I., Wood, A. M., Ho, J., Pesaresi, F., Cauda, V., Chen, S. H., Liu, X., Stayton, P. S., Chua, C. Y. X. & Grattoni, A., Jun 2024, In: Nano Today. 56, 102258.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations