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Personal profile
Dr. Xuewu Liu worked as an engineer in the optics industry for two years before undertaking postdoctoral training at the Indiana Center for Biological Microscopy at IUPUI Indianapolis. He then joined Ohio State University as a senior research associate in nanomedicine. He was appointed assistant professor of nanomedicine and biomedical engineering at the University of Texas Health Science Center in Houston in 2006. In 2010, Dr. Liu joined to The Methodist Hospital Research Institute, to direct the nanoengineering core.
Dr. Xuewu Liu is a leading scientist in silicon nanotechnology, with extensive experience in materials science, optics, microfabrication and nanomedicine. He directs research and development of silicon based biomedical nanotechnology, and coordinates a nanoengineering team to support biomedical research at the institute levels. The nanomedicine platforms he has developed include porous silicon particles, nanowire barcodes, an implantable nanochannel delivery system, nanowire enhanced nanofluidic devices, and nanoporous proteomic chips. Dr. Liu had been issued 8 US patents, and published over 100 peer-reviewed journal papers, of which >20 were highlighted as journal cover articles.
Research interests
Dr. Liu’s research focus is the development of silicon based nanotechnology platforms for prevention, diagnosis and treatment of human disease. His current interests include mass production of porous silicon particles, surface chemistry of porous silicon, nanowire theranostic platforms, multifunctional nanoparticles, and microfluidics devices for isolation and analysis of exosomes.
Education/Academic qualification
Postdoctoral Associate, Heart and Lung Research Institute
Biological Microscopy, Postdoctoral Associate, Indiana Center for Biological Microscopy, Indianapolis, IN
Nuclear Physics, MS, Jilin University
Physics, PhD, Kent State University
Research Area Keywords
- Nanomedicine
- Cancer
Free-text keywords
- Silicon nanotechnology
- Drug delivery nanoparticles
- Theranostics
- Biological microfluidics
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Projects
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A tunable nanofluidic drug delivery platform for in vivo research
4/15/18 → 1/31/22
Project: Federal Funding Agencies
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Center for Immunotherapeutic Transport Oncophysics
Shen, H., Herzog, T., Kojic, M., Li, Z., Liu, X., Schrefler, B. A., Tasciotti, E., Wang, R. & Ziemys, A.
8/29/16 → 7/31/21
Project: Federal Funding Agencies
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Tumor vasculature-targeted nanotherapeutics for DNA damage response
Shen, H., Jenkins, N. A., Liu, X. & Mitra, S.
12/1/15 → 5/31/21
Project: Federal Funding Agencies
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A Nanodrug for the Cure of Metastatic Breast Cancer
Shen, H., Chang, J. C., Ensor, Jr., J. E. & Liu, X.
7/15/17 → 2/29/20
Project: Federal Funding Agencies
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Identification of novel immune targets and neoantigens for development of immunotherapy for breast cancer
Wang, R., Chang, J. C., Liu, X. & Wang, H.
12/1/16 → 11/30/19
Project: State
Research Output
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An injectable nanoparticle generator enhances delivery of cancer therapeutics
Xu, R., Zhang, G., Mai, J., Deng, X., Segura-Ibarra, V., Wu, S., Shen, J., Liu, H., Hu, Z., Chen, L., Huang, Y., Koay, E., Huang, Y., Liu, J., Ensor, J. E., Blanco, E., Liu, X., Ferrari, M. & Shen, H., Apr 1 2016, In : Nature Biotechnology. 34, 4, p. 414-418 5 p.Research output: Contribution to journal › Article
173 Scopus citations -
Biocompatible PLGA-mesoporous silicon microspheres for the controlled release of bmp-2 for bone augmentation
Minardi, S., Fernandez-Moure, J. S., Fan, D., Murphy, M. B., Yazdi, I. K., Liu, X., Weiner, B. K. & Tasciotti, E., Feb 2020, In : Pharmaceutics. 12, 2, 118.Research output: Contribution to journal › Article
5 Scopus citations -
Design and in vitro characterization of multistage silicon-PLGA budesonide particles for inflammatory bowel disease
Leonard, F., Srinivasan, S., Liu, X., Collnot, E. M., Ferrari, M., Lehr, C. M. & Godin, B., Jun 1 2020, In : European Journal of Pharmaceutics and Biopharmaceutics. 151, p. 61-72 12 p.Research output: Contribution to journal › Article
1 Scopus citations -
Electrostatically gated nanofluidic membrane for ultra-low power controlled drug delivery
Di Trani, N., Silvestri, A., Sizovs, A., Wang, Y., Erm, D. R., Demarchi, D., Liu, X. & Grattoni, A., May 7 2020, In : Lab on a Chip. 20, 9, p. 1562-1576 15 p.Research output: Contribution to journal › Article
4 Scopus citations -
Enhanced thermal effect of plasmonic nanostructures confined in discoidal porous silicon particles
Zhang, D., Wu, H. J., Zhou, X., Qi, R., Xu, L., Guo, Y. & Liu, X., Aug 20 2020, In : RSC Advances. 10, 51, p. 30840-30847 8 p.Research output: Contribution to journal › Article
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