Projects per year
Personal profile
Personal profile
Xian C. Li, MD, PhD, is a Professor of Immunology in Surgery at Weill Cornell Medical College of Cornell University in New York and director of the Immunobiology & Transplant Science Center at Houston Methodist Hospital in Houston Texas. He also serves as the vice chair of research in the Department of Surgery and holds the Max & Lillie Frosch Centennial Chair in Transplant Research at Houston Methodist.
Dr. Li’s research focuses on the fundamental mechanisms that govern transplant rejection and transplant tolerance as well as clinical translation of basic lab discoveries, with the overarching goal of developing new and innovative therapies for transplant patients. Dr. Li is a highly accomplished scientist, with over 250 papers published in areas of transplantation and immunology, including papers in high impact journals, e.g., Lancet, Science, Nature Medicine, Nature Immunology, Immunity, etc. He has made substantial contributions to the transplant community and is therefore recognized with many awards, elected memberships, and leadership roles. He received multiple awards from the American Society of Transplantation (AST), including AST Young Investigator Award, AST Career Development Award, AST/Wyeth Achievement Award, and the prestigious AST Established Investigator Award (basic science). Dr. Li also received the President’s Award for Transformative Excellence at Houston Methodist. Dr. Li has chaired and organized numerous national and international conferences and has been routinely invited to speak about his research by leading academic institutions worldwide. Dr. Li’s research has been continuously funded by the NIH for more than 20 years; he has 10 patents filed and granted in areas of tolerance, graft rejection, and regulatory cells.
Dr. Xian Li is an active member of multiple professional societies in which he has served in various capacities. He is an elected member of the American Society for Clinical Investigation (ASCI), an honorary society for physician scientists. Dr. Li is now a standing member of AST, AAI (American Association of Immunologists), TTS (The Transplantation Society), ILTS (International Liver Transplantation Society), a member of Faculty 1000 in Immunology. He has served on the AST basic science advisory council, chair of AST Vascularized Composite-tissue Allotransplantation committee, chair of AST Grants Executive Committee, chair of American Transplant Congress Joint Executive Planning Committee, and chair of the American Transplant Congress 2018, one of the largest gatherings of transplant professionals. He has served as a standing member for NIH study sections, including the Cellular and Molecular Immunology (CMI), Transplantation, Tolerance and Tumor immunology (TTT), and Immunobiology of Transplantation & Alloimmunity (ITA) study sections, as well as Department of Defense (DoD) and Immune Tolerance Network (ITN) grant review panels. He has served on the editorial boards of multiple scientific journals including J Immunol, Am J Transplant, Cell Mol Immunol, Front Immunol, Transplantation. He was also the section editor for Am J Transplant (Literature Watch) and now is the deputy editor for the journal Transplantation.
Dr. Xian Li completed his medical training in China and then joined the Multi-Organ Transplant Program at University of Western Ontario in London, Canada, where Dr. Li further completed his PhD training in pathology. He finished his postdoctoral fellowship training at University of Toronto and Harvard Medical School. Before moving to Houston Methodist Hospital in 2013, he was an associate professor of medicine at Harvard Medical School and deputy director of the Transplant Research Center at Brigham & Women’s Hospital in Boston, Massachusetts.
Education/Academic qualification
Postdoctoral Fellowship, Harvard University
MD, Qingdao Medical School, Qingdao, China
Postdoctoral Fellowship, University of Toronto
Research Fellowship, University of Western Ontario
Immunology, PhD, Western University, London, Canada
Divisions
- Abdominal Transplant
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Collaborations and top research areas from the last five years
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Modulation of innate immune cells to create transplant tolerance
Li, X. C. (PI)
7/1/24 → 5/31/29
Project: Federal Funding Agencies
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Modulation of chromatin dynamics to promote transplant survival
Li, X. C. (PI)
12/6/23 → 10/31/28
Project: Federal Funding Agencies
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Studies of a new checkpoint regulator in the control of intestinal inflammation
Zhang, Z. (PI) & Li, X. C. (Key Personnel)
6/7/21 → 5/31/26
Project: Federal Funding Agencies
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Control of dysfunctional Tregs
Li, X. C. (PI) & Xiao, J. (Key Personnel)
2/1/14 → 1/31/27
Project: Federal Funding Agencies
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Development of T Regulatory Cells and Their Association With Outcomes Following Liver Transplantation
Ghobrial, R. M. (PI), Connor, A. A. (Key Personnel), Graviss, E. A. (Key Personnel), Li, X. C. (Key Personnel), Mobley, C. M. (Key Personnel), Moore, L. W. (Key Personnel), Rizk, E. (Key Personnel), Saharia, A. (Key Personnel), Simon, C. J. (Key Personnel), Uosef, A. (Key Personnel) & Xiao, J. (Key Personnel)
12/3/13 → …
Project: Clinical Trial
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Beyond T-cell subsets: stemness and adaptation redefining immunity and immunotherapy
Zou, D., Li, X. C. & Chen, W., 2025, (Accepted/In press) In: Cellular and Molecular Immunology. 22, 9, p. 957-974 18 p.Research output: Contribution to journal › Review article › peer-review
2 Scopus citations -
Epigenetically modulating macrophage subpopulations to promote long-term allograft survival in a mouse heart transplant model
Su, X., Deng, G., Sun, S., Wang, G., Hennessy-Strahs, S., Li, J., Wen, M., Mao, Z., Ghobrial, R. M., Xiao, X., Chen, W. & Li, X. C., Oct 2025, In: American Journal of Transplantation. 25, 10, p. 2067-2081 15 p.Research output: Contribution to journal › Article › peer-review
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In Real Estate as in the Protective Effect of Regulatory T Cells: It Is Location, Location, and Location
Zou, D. & Li, X. C., 2025, (Accepted/In press) In: Transplantation.Research output: Contribution to journal › Comment/debate › peer-review
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IRF4 expression by NK precursors predetermines exhaustion of NK cells during tumor metastasis
Zhang, X., Yin, Z., Wu, J., Xiang, X., Zou, D., Wang, G., Fu, J., Lan, P., Minze, L. J., Li, X. C. & Chen, W., Jul 2025, In: Nature immunology. 26, 7, p. 1062-1073 12 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Outcomes for Early Liver Transplantation for Alcohol-associated Liver Disease in High-acuity Liver Transplant Recipients with Alcohol Use Disorder
Meinders, A. M., Connor, A. A., Ontiveros, J., Elaileh, A., Patel, K., Todd, J., Nottage, D. L., Brombosz, E. W., Moore, L. W., Simon, C. J., Cheah, Y. L., Hobeika, M. J., Mobley, C. M., Saharia, A., Basra, T., Kodali, S., Victor, D. W., Lee, B. P., Terrault, N. & Li, X. C. & 2 others, , Mar 20 2025, In: Transplantation Direct. 11, 4, p. e1776 e1776.Research output: Contribution to journal › Article › peer-review
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