Projects per year
Personal profile
Personal profile
Dr. Wenhao Chen earned his Ph.D. in Biomedical Science from the University of Toronto in 2006. He held faculty appointments at the University of Toledo College of Medicine in Toledo, Ohio and Baylor College of Medicine in Houston, Texas before becoming a member of Houston Methodist Research Institute in 2013. As a member of the Transplantation Immunology Program, Dr. Chen studies the cellular and molecular mechanisms underlying immune tolerance. He has published more than 40 original papers and review articles in high-impact scientific journals.
Research interests
Dr. Chen’s research interests are to define the molecular mechanisms by which immune cells reject the transplanted organs or cause autoimmune type 1 diabetes and develop novel strategies to selectively abrogate undesired immune responses against self-islets or transplanted organs.
Education/Academic qualification
Immunology, Postdoctoral Associate, Baylor College of Medicine
Transplantation Immunology, Postdoctoral Fellowship, University of Texas Health Science Center at Houston
Immunology, Postdoctoral Fellowship, University of Toronto
Biomedical Science, PhD, University of Toronto
Divisions
- Abdominal Transplant
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Collaborations and top research areas from the last five years
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LDHA-dependent T-cell effector programs in heart transplantation
Chen, W. (PI)
8/7/25 → 7/31/26
Project: Federal Funding Agencies
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Evaluating IRF4 in Kidney Transplant Allograft Biopsies A Single Center, Prospective Study Evaluating IRF4 in kidney transplant allograft biopsies
Yi, S. (PI), Chen, W. (Key Personnel), Gaber, A. O. (Key Personnel) & Moore, L. W. (Key Personnel)
Project: Clinical Trial
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Impact of Irreversible T Cell Dysfunction on Transplant Outcomes
Chen, W. (PI)
1/12/24 → 12/31/24
Project: Federal Funding Agencies
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Defining Immunology Frailty as a Predictor of Human Liver Allograft Recipient Futility
Chen, W. (Key Personnel), Eagar, T. N. (Key Personnel), Ghobrial, R. M. (Key Personnel), Graviss, E. A. (Key Personnel), Gupte, A. A. (Key Personnel), Hamilton, D. J. (Key Personnel) & Li, X. C. (Key Personnel)
4/10/19 → 8/31/19
Project: Federal Funding Agencies
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IRF4-dependent T-cell effector programs in governing transplant outcomes
Chen, W. (PI) & Li, X. C. (Key Personnel)
5/1/18 → 1/11/24
Project: Federal Funding Agencies
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Beyond T-cell subsets: stemness and adaptation redefining immunity and immunotherapy
Zou, D., Li, X. C. & Chen, W., 2025, (Accepted/In press) In: Cellular and Molecular Immunology. 22, 9, p. 957-974 18 p.Research output: Contribution to journal › Review article › peer-review
2 Scopus citations -
Epigenetically modulating macrophage subpopulations to promote long-term allograft survival in a mouse heart transplant model
Su, X., Deng, G., Sun, S., Wang, G., Hennessy-Strahs, S., Li, J., Wen, M., Mao, Z., Ghobrial, R. M., Xiao, X., Chen, W. & Li, X. C., Oct 2025, In: American Journal of Transplantation. 25, 10, p. 2067-2081 15 p.Research output: Contribution to journal › Article › peer-review
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IRF4 expression by NK precursors predetermines exhaustion of NK cells during tumor metastasis
Zhang, X., Yin, Z., Wu, J., Xiang, X., Zou, D., Wang, G., Fu, J., Lan, P., Minze, L. J., Li, X. C. & Chen, W., Jul 2025, In: Nature immunology. 26, 7, p. 1062-1073 12 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Transient Anti-TCRβ mAb Treatment Induces CD4+ T Cell Exhaustion and Prolongs Survival in a Mouse Model of Systemic Lupus Erythematosus
Gonzalez, N. M., Zou, D., Zeng, Z., Feng, F. X., Zhang, X., Sannes, C., Gu, A., Zu, Y. & Chen, W., Feb 2025, In: Immunology. 174, 2, p. 239-246 8 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Aerobic glycolysis enables the effector differentiation potential of stem-like CD4+ T cells to combat cancer
Zou, D., Zhang, X., Li, S., Xiao, X., Gonzalez, N. M., Minze, L. J., Li, X. C. & Chen, W., May 2024, In: Cellular and Molecular Immunology. 21, 5, p. 527-529 3 p.Research output: Contribution to journal › Letter › peer-review
2 Scopus citations
Prizes
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Presidential Award - Peer Reviewed Publication
Chen, W. (Recipient), 2023
Prize: Prize (including medals and awards)
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Presidential Award - Peer Reviewed Publication
Chen, W. (Recipient), Oct 14 2025
Prize: Prize (including medals and awards)