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Wenhao Chen, PhD

  • 1757 Citations
  • 21 h-Index
19982020

Research output per year

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Personal profile

Personal profile

Dr. Wenhao Chen earned his Ph.D. in Biomedical Science from the University of Toronto in 2006. He held faculty appointments at the University of Toledo College of Medicine in Toledo, Ohio and Baylor College of Medicine in Houston, Texas before becoming a member of Houston Methodist Research Institute in 2013. As a member of the Transplantation Immunology Program, Dr. Chen studies the cellular and molecular mechanisms underlying immune tolerance. He has published more than 40 original papers and review articles in high-impact scientific journals.

Research interests

Dr. Chen’s research interests are to define the molecular mechanisms by which immune cells reject the transplanted organs or cause autoimmune type 1 diabetes and develop novel strategies to selectively abrogate undesired immune responses against self-islets or transplanted organs.

Education/Academic qualification

Immunology, Postdoctoral Associate, Baylor College of Medicine

Transplantation Immunology, Postdoctoral Fellowship, McGovern Medical School at UTHealth

Immunology, Postdoctoral Fellowship, University of Toronto

Biomedical Science, PhD, University of Toronto

Free-text keywords

  • Transplantation
  • Type 1 diabetes
  • T cell
  • Immune tolerance

Research Area Keywords

  • Transplantation

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Projects

IRF4-dependent T-cell effector programs in governing transplant outcomes

Chen, W. & Li, X. C.

5/1/18 → 4/30/23

Project: Federal Funding Agencies

Defining Immunology Frailty as a Predictor of Human Liver Allograft Recipient Futility

Lunsford, K. E., Chen, W., Eagar, T. N., Ghobrial, R. M., Graviss, E. A., Gupte, A. A., Hamilton, D. J. & Li, X. C.

4/10/19 → 8/31/19

Project: Federal Funding Agencies

Identification of the intracellular regulators involved in establishing T-cell tolerance to cardiac allografts

Chen, W. & Li, X. C.

American Heart Association

9/9/13 → 6/30/15

Project: Non Profit

Modulation of the T cell synapse induces deletional peripheral tolerance in transplantation

Chen, W.

Fondation de la Recherche en Transplant

9/1/13 → 5/31/18

Project: Non Profit

Research Output

  • 1757 Citations
  • 21 h-Index
  • 55 Article
  • 8 Review article
  • 3 Chapter
  • 1 Editorial

Epigenetically modifying the Foxp3 locus for generation of stable antigen-specific Tregs as cellular therapeutics

Chen, S., Zhang, L., Ying, Y., Wang, Y., Arnold, P. R., Wang, G., Li, J., Ghobrial, R. M., Chen, W., Xiao, X. & Li, X. C., Sep 1 2020, In : American Journal of Transplantation. 20, 9, p. 2366-2379 14 p.

Research output: Contribution to journal › Article

    • PIRs mediate innate myeloid cell memory to nonself MHC molecules

    Dai, H., Lan, P., Zhao, D., Abou-Daya, K., Liu, W., Chen, W., Friday, A. J., Williams, A. L., Sun, T., Chen, J., Chen, W., Mortin-Toth, S., Danska, J. S., Wiebe, C., Nickerson, P., Li, T., Mathews, L. R., Turnquist, H. R., Nicotra, M. L., Gingras, S. & 6 others, Takayama, E., Kubagawa, H., Shlomchik, M. J., Oberbarnscheidt, M. H., Li, X. C. & Lakkis, F. G., Jun 5 2020, In : Science (New York, N.Y.). 368, 6495, p. 1122-1127 6 p.

    Research output: Contribution to journal › Article

    • 3 Scopus citations

    T cell exhaustion is associated with antigen abundance and promotes transplant acceptance

    Zou, D., Dai, Y., Zhang, X., Wang, G., Xiao, X., Jia, P., Li, X. C., Guo, Z. & Chen, W., Mar 17 2020, In : American Journal of Transplantation. 20, 9, p. 2540-2550 11 p.

    Research output: Contribution to journal › Article

    • 1 Scopus citations

    T follicular helper and memory cell responses and the mTOR pathway in murine heart transplantation

    Xie, A., Yan, H., Fu, J., He, A., Xiao, X., Li, X. C. & Chen, W., Feb 1 2020, In : Journal of Heart and Lung Transplantation. 39, 2, p. 134-144 11 p.

    Research output: Contribution to journal › Article

    • Ablation of interferon regulatory factor 4 in T cells induces “memory” of transplant tolerance that is irreversible by immune checkpoint blockade

    Zhang, H., Wu, J., Zou, D., Xiao, X., Yan, H., Li, X. C. & Chen, W., Mar 2019, In : American Journal of Transplantation. 19, 3, p. 884-893 10 p.

    Research output: Contribution to journal › Article

    • 4 Scopus citations