Wenhao Chen, PhD

Associate Professor of Transplant Immunology in Surgery, Academic Institute
Associate Member, Research Institute
Immunobiology & Transplant Science Center
Department of Surgery
J.C. Walter Jr. Transplant Center
Houston Methodist
Weill Cornell Medical College

Source: Scopus
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Personal profile

Dr. Wenhao Chen earned his Ph.D. in Biomedical Science from the University of Toronto in 2006. He held faculty appointments at the University of Toledo College of Medicine in Toledo, Ohio and Baylor College of Medicine in Houston, Texas before becoming a member of Houston Methodist Research Institute in 2013. As a member of the Transplantation Immunology Program, Dr. Chen studies the cellular and molecular mechanisms underlying immune tolerance. He has published more than 40 original papers and review articles in high-impact scientific journals.

Research interests

Dr. Chen’s research interests are to define the molecular mechanisms by which immune cells reject the transplanted organs or cause autoimmune type 1 diabetes and develop novel strategies to selectively abrogate undesired immune responses against self-islets or transplanted organs.

Education/Academic qualification

Immunology, Postdoctoral Associate, Baylor College of Medicine

Transplantation Immunology, Postdoctoral Fellowship, University of Texas Health Science Center at Houston

Immunology, Postdoctoral Fellowship, University of Toronto

Biomedical Science, PhD, University of Toronto

Free-text keywords

Transplantation
Type 1 diabetes
T cell
Immune tolerance

Research Area Keywords

Transplantation

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3 Finished

IRF4-dependent T-cell effector programs in governing transplant outcomes
Chen, W. & Li, X. C.
5/1/18 → 4/30/23
Project: Federal Funding Agencies
Evaluating IRF4 in Kidney Transplant Allograft Biopsies A Single Center, Prospective Study Evaluating IRF4 in kidney transplant allograft biopsies
Yi, S., Chen, W., Gaber, A. O. & Knight, R. J.
Project: Clinical Trial
Defining Immunology Frailty as a Predictor of Human Liver Allograft Recipient Futility
Lunsford, K. E., Chen, W., Eagar, T. N., Ghobrial, R. M., Graviss, E. A., Gupte, A. A., Hamilton, D. J. & Li, X. C.
4/10/19 → 8/31/19
Project: Federal Funding Agencies
Identification of the intracellular regulators involved in establishing T-cell tolerance to cardiac allografts
Chen, W. & Li, X. C.
American Heart Association
9/9/13 → 6/30/15
Project: Non Profit
Modulation of the T cell synapse induces deletional peripheral tolerance in transplantation
Chen, W.
Fondation de la Recherche en Transplant
9/1/13 → 5/31/18
Project: Non Profit

1863 Citations
22 h-Index
58 Article
8 Review article
3 Chapter
1 Editorial

Fingolimod (FTY720) prevents chronic rejection of rodent cardiac allografts through inhibition of the RhoA pathway
Chen, W., Chen, W., Chen, S., Uosef, A., Ghobrial, R. M. & Kloc, M., Apr 2021, In : Transplant Immunology. 65, 101347.
Research output: Contribution to journal › Article
2 Scopus citations
Adoptive CD8⁺ T cell therapy generates immunological memory to inhibit melanoma metastasis
Fu, J., Yu, A., Tang, J., He, B. & Chen, W., 2020, In : American Journal of Translational Research. 12, 11, p. 7262-7274 13 p.
Research output: Contribution to journal › Article
Epigenetically modifying the Foxp3 locus for generation of stable antigen-specific Tregs as cellular therapeutics
Chen, S., Zhang, L., Ying, Y., Wang, Y., Arnold, P. R., Wang, G., Li, J., Ghobrial, R. M., Chen, W., Xiao, X. & Li, X. C., Sep 1 2020, In : American Journal of Transplantation. 20, 9, p. 2366-2379 14 p.
Research output: Contribution to journal › Article
1 Scopus citations
Interferon regulatory factor 4 deficiency in CD8⁺ T cells abrogates terminal effector differentiation and promotes transplant acceptance
Zou, D., Fu, J., Guo, Z. & Chen, W., Dec 2020, In : Immunology. 161, 4, p. 364-379 16 p.
Research output: Contribution to journal › Article
PIRs mediate innate myeloid cell memory to nonself MHC molecules
Dai, H., Lan, P., Zhao, D., Abou-Daya, K., Liu, W., Chen, W., Friday, A. J., Williams, A. L., Sun, T., Chen, J., Chen, W., Mortin-Toth, S., Danska, J. S., Wiebe, C., Nickerson, P., Li, T., Mathews, L. R., Turnquist, H. R., Nicotra, M. L., Gingras, S. & 6 others, Takayama, E., Kubagawa, H., Shlomchik, M. J., Oberbarnscheidt, M. H., Li, X. C. & Lakkis, F. G., Jun 5 2020, In : Science. 368, 6495, p. 1122-1127 6 p.
Research output: Contribution to journal › Article
13 Scopus citations