Projects per year
Personal profile
Personal profile
Dr. Wenhao Chen earned his Ph.D. in Biomedical Science from the University of Toronto in 2006. He held faculty appointments at the University of Toledo College of Medicine in Toledo, Ohio and Baylor College of Medicine in Houston, Texas before becoming a member of Houston Methodist Research Institute in 2013. As a member of the Transplantation Immunology Program, Dr. Chen studies the cellular and molecular mechanisms underlying immune tolerance. He has published more than 40 original papers and review articles in high-impact scientific journals.
Research interests
Dr. Chen’s research interests are to define the molecular mechanisms by which immune cells reject the transplanted organs or cause autoimmune type 1 diabetes and develop novel strategies to selectively abrogate undesired immune responses against self-islets or transplanted organs.
Education/Academic qualification
Immunology, Postdoctoral Associate, Baylor College of Medicine
Transplantation Immunology, Postdoctoral Fellowship, McGovern Medical School at UTHealth
Immunology, Postdoctoral Fellowship, University of Toronto
Biomedical Science, PhD, University of Toronto
Free-text keywords
- Transplantation
- Type 1 diabetes
- T cell
- Immune tolerance
Research Area Keywords
- Transplantation
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Projects
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IRF4-dependent T-cell effector programs in governing transplant outcomes
5/1/18 → 4/30/23
Project: Federal Funding Agencies
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Defining Immunology Frailty as a Predictor of Human Liver Allograft Recipient Futility
Lunsford, K. E., Chen, W., Eagar, T. N., Ghobrial, R. M., Graviss, E. A., Gupte, A. A., Hamilton, D. J. & Li, X. C.
4/10/19 → 8/31/19
Project: Federal Funding Agencies
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Modulation of the T cell synapse induces deletional peripheral tolerance in transplantation
Fondation de la Recherche en Transplant
9/1/13 → 5/31/18
Project: Non Profit
Research Output
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Epigenetically modifying the Foxp3 locus for generation of stable antigen-specific Tregs as cellular therapeutics
Chen, S., Zhang, L., Ying, Y., Wang, Y., Arnold, P. R., Wang, G., Li, J., Ghobrial, R. M., Chen, W., Xiao, X. & Li, X. C., Sep 1 2020, In : American Journal of Transplantation. 20, 9, p. 2366-2379 14 p.Research output: Contribution to journal › Article
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PIRs mediate innate myeloid cell memory to nonself MHC molecules
Dai, H., Lan, P., Zhao, D., Abou-Daya, K., Liu, W., Chen, W., Friday, A. J., Williams, A. L., Sun, T., Chen, J., Chen, W., Mortin-Toth, S., Danska, J. S., Wiebe, C., Nickerson, P., Li, T., Mathews, L. R., Turnquist, H. R., Nicotra, M. L., Gingras, S. & 6 others, , Jun 5 2020, In : Science. 368, 6495, p. 1122-1127 6 p.Research output: Contribution to journal › Article
3 Scopus citations -
T cell exhaustion is associated with antigen abundance and promotes transplant acceptance
Zou, D., Dai, Y., Zhang, X., Wang, G., Xiao, X., Jia, P., Li, X. C., Guo, Z. & Chen, W., Mar 17 2020, In : American Journal of Transplantation. 20, 9, p. 2540-2550 11 p.Research output: Contribution to journal › Article
1 Scopus citations -
T follicular helper and memory cell responses and the mTOR pathway in murine heart transplantation
Xie, A., Yan, H., Fu, J., He, A., Xiao, X., Li, X. C. & Chen, W., Feb 2020, In : Journal of Heart and Lung Transplantation. 39, 2, p. 134-144 11 p.Research output: Contribution to journal › Article
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Ablation of interferon regulatory factor 4 in T cells induces “memory” of transplant tolerance that is irreversible by immune checkpoint blockade
Zhang, H., Wu, J., Zou, D., Xiao, X., Yan, H., Li, X. C. & Chen, W., Mar 2019, In : American Journal of Transplantation. 19, 3, p. 884-893 10 p.Research output: Contribution to journal › Article
4 Scopus citations