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Personal profile
Personal profile
Dr. Wenhao Chen earned his Ph.D. in Biomedical Science from the University of Toronto in 2006. He held faculty appointments at the University of Toledo College of Medicine in Toledo, Ohio and Baylor College of Medicine in Houston, Texas before becoming a member of Houston Methodist Research Institute in 2013. As a member of the Transplantation Immunology Program, Dr. Chen studies the cellular and molecular mechanisms underlying immune tolerance. He has published more than 40 original papers and review articles in high-impact scientific journals.
Research interests
Dr. Chen’s research interests are to define the molecular mechanisms by which immune cells reject the transplanted organs or cause autoimmune type 1 diabetes and develop novel strategies to selectively abrogate undesired immune responses against self-islets or transplanted organs.
Education/Academic qualification
Immunology, Postdoctoral Associate, Baylor College of Medicine
Transplantation Immunology, Postdoctoral Fellowship, University of Texas Health Science Center at Houston
Immunology, Postdoctoral Fellowship, University of Toronto
Biomedical Science, PhD, University of Toronto
Free-text keywords
- Transplantation
- Type 1 diabetes
- T cell
- Immune tolerance
Research Area Keywords
- Transplantation
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IRF4-dependent T-cell effector programs in governing transplant outcomes
5/1/18 → 4/30/23
Project: Federal Funding Agencies
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Defining Immunology Frailty as a Predictor of Human Liver Allograft Recipient Futility
Lunsford, K. E., Chen, W., Eagar, T. N., Ghobrial, R. M., Graviss, E. A., Gupte, A. A., Hamilton, D. J. & Li, X. C.
4/10/19 → 8/31/19
Project: Federal Funding Agencies
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Modulation of the T cell synapse induces deletional peripheral tolerance in transplantation
Fondation de la Recherche en Transplant
9/1/13 → 5/31/18
Project: Non Profit
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Fingolimod (FTY720) prevents chronic rejection of rodent cardiac allografts through inhibition of the RhoA pathway
Chen, W., Chen, W., Chen, S., Uosef, A., Ghobrial, R. M. & Kloc, M., Apr 2021, In: Transplant Immunology. 65, 101347.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Adoptive CD8+ T cell therapy generates immunological memory to inhibit melanoma metastasis
Fu, J., Yu, A., Tang, J., He, B. & Chen, W., 2020, In: American Journal of Translational Research. 12, 11, p. 7262-7274 13 p.Research output: Contribution to journal › Article › peer-review
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Epigenetically modifying the Foxp3 locus for generation of stable antigen-specific Tregs as cellular therapeutics
Chen, S., Zhang, L., Ying, Y., Wang, Y., Arnold, P. R., Wang, G., Li, J., Ghobrial, R. M., Chen, W., Xiao, X. & Li, X. C., Sep 1 2020, In: American Journal of Transplantation. 20, 9, p. 2366-2379 14 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Interferon regulatory factor 4 deficiency in CD8+ T cells abrogates terminal effector differentiation and promotes transplant acceptance
Zou, D., Fu, J., Guo, Z. & Chen, W., Dec 2020, In: Immunology. 161, 4, p. 364-379 16 p.Research output: Contribution to journal › Article › peer-review
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PIRs mediate innate myeloid cell memory to nonself MHC molecules
Dai, H., Lan, P., Zhao, D., Abou-Daya, K., Liu, W., Chen, W., Friday, A. J., Williams, A. L., Sun, T., Chen, J., Chen, W., Mortin-Toth, S., Danska, J. S., Wiebe, C., Nickerson, P., Li, T., Mathews, L. R., Turnquist, H. R., Nicotra, M. L., Gingras, S. & 6 others, , Jun 5 2020, In: Science. 368, 6495, p. 1122-1127 6 p.Research output: Contribution to journal › Article › peer-review
18 Scopus citations