Projects per year
Personal profile
Personal profile
Dr. Wenhao Chen earned his Ph.D. in Biomedical Science from the University of Toronto in 2006. He held faculty appointments at the University of Toledo College of Medicine in Toledo, Ohio and Baylor College of Medicine in Houston, Texas before becoming a member of Houston Methodist Research Institute in 2013. As a member of the Transplantation Immunology Program, Dr. Chen studies the cellular and molecular mechanisms underlying immune tolerance. He has published more than 40 original papers and review articles in high-impact scientific journals.
Research interests
Dr. Chen’s research interests are to define the molecular mechanisms by which immune cells reject the transplanted organs or cause autoimmune type 1 diabetes and develop novel strategies to selectively abrogate undesired immune responses against self-islets or transplanted organs.
Education/Academic qualification
Immunology, Postdoctoral Associate, Baylor College of Medicine
Transplantation Immunology, Postdoctoral Fellowship, University of Texas Health Science Center at Houston
Immunology, Postdoctoral Fellowship, University of Toronto
Biomedical Science, PhD, University of Toronto
Research Area Keywords
- Transplantation
Free-text keywords
- Transplantation
- Type 1 diabetes
- T cell
- Immune tolerance
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IRF4-dependent T-cell effector programs in governing transplant outcomes
5/1/18 → 4/30/23
Project: Federal Funding Agencies
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Defining Immunology Frailty as a Predictor of Human Liver Allograft Recipient Futility
Chen, W., Eagar, T. N., Ghobrial, R. M., Graviss, E. A., Gupte, A. A., Hamilton, D. J. & Li, X. C.
4/10/19 → 8/31/19
Project: Federal Funding Agencies
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Modulation of the T cell synapse induces deletional peripheral tolerance in transplantation
Fondation de la Recherche en Transplant
9/1/13 → 5/31/18
Project: Non Profit
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Ablation of BATF Alleviates Transplant Rejection via Abrogating the Effector Differentiation and Memory Responses of CD8+ T Cells
Li, S., Zou, D., Chen, W., Cheng, Y., Britz, G. W., Weng, Y. L. & Liu, Z., Apr 19 2022, In: Frontiers in immunology. 13, 882721.Research output: Contribution to journal › Article › peer-review
Open Access -
Genetically targeting the BATF family transcription factors BATF and BATF3 in the mouse abrogates effector T cell activities and enables long-term heart allograft survival
Wang, Y., Xiao, X., Kong, G., Wen, M., Wang, G., Ghobrial, R. M., Dong, N., Chen, W. & Li, X. C., Feb 2022, In: American Journal of Transplantation. 22, 2, p. 414-426 13 p.Research output: Contribution to journal › Article › peer-review
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Association of CXCR6 with COVID-19 severity: delineating the host genetic factors in transcriptomic regulation
Dai, Y., Wang, J., Jeong, H. H., Chen, W., Jia, P. & Zhao, Z., Sep 2021, In: Human genetics. 140, 9, p. 1313-1328 16 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Fingolimod (FTY720) prevents chronic rejection of rodent cardiac allografts through inhibition of the RhoA pathway
Chen, W., Chen, W., Chen, S., Uosef, A., Ghobrial, R. M. & Kloc, M., Apr 2021, In: Transplant Immunology. 65, 101347.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
IRF4 ablation in B cells abrogates allogeneic B cell responses and prevents chronic transplant rejection
Wang, G., Zou, D., Wang, Y., Gonzalez, N. M., Yi, S. G., Li, X. C., Chen, W. & Gaber, A. O., Oct 2021, In: Journal of Heart and Lung Transplantation. 40, 10, p. 1122-1132 11 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations