Personal profile

During her postdoctoral training, Dr. Zhao conducted research on amyotrophic lateral sclerosis (ALS) or Lou Gehrig’s disease. She investigated the roles of glutamate-mediated cytotoxicity, immune-mediated injury, and oxidative stress in motor neuron death. She also investigated the potential for a new phospholipid agent, VP025, to inhibit immune activation and protect motor neurons from injury. After completing her postdoctoral fellowship, Dr. Zhao joined the Methodist Hospital Research Institute as a scientist in the Department of Neurology.

Research interests

Research interests

Amyotrophic lateral sclerosis (ALS), commonly known as Lou Gehrig’s disease, is a progressive neurodegenerative disease that attacks motor neurons in the brain and spinal cord. Dr. Zhao is interested in the underlying mechanisms of neuroinflammation on motor neuron death and relevant therapeutic targets. Current research efforts aim to understand the roles of microglia/monocytes and T-cells on immune-mediated injury and repair in ALS. Dr. Zhao is investigating the neuroprotective potential of regulatory immune cells as new therapeutic options for ALS. Gene mutations on SOD1, TDP-43, and C9ORF72 have been linked to ALS. Dr. Zhao is also interested in the pathology of various mutant proteins as well as abnormal peptides, and how they affect interactions among motor neurons, microglia, and T-cells in ALS.

Keywords

    Free-text keywords

  • ALS, Lou Gehrig’s disease, Immune Suppression, Inflammation, Neuroprotection, Neurocytotoxicity

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Amyotrophic Lateral Sclerosis
Concept: Amyotrophic Lateral Sclerosis
Weight: 100%
Domain: Medicine & Life Sciences
Microglia
Concept: Microglia
Weight: 60%
Domain: Medicine & Life Sciences
Motor Neurons
Concept: Motor Neurons
Weight: 60%
Domain: Medicine & Life Sciences
Regulatory T-Lymphocytes
Concept: Regulatory T-Lymphocytes
Weight: 41%
Domain: Medicine & Life Sciences
Disease Progression
Concept: Disease Progression
Weight: 21%
Domain: Medicine & Life Sciences
Wounds and Injuries
Concept: Wounds and Injuries
Weight: 16%
Domain: Medicine & Life Sciences
T-Lymphocytes
Concept: T-Lymphocytes
Weight: 16%
Domain: Medicine & Life Sciences
Neurodegenerative Diseases
Concept: Neurodegenerative Diseases
Weight: 15%
Domain: Medicine & Life Sciences
Interleukin-4
Concept: Interleukin-4
Weight: 10%
Domain: Medicine & Life Sciences
Intracranial Vasospasm
Concept: Intracranial Vasospasm
Weight: 10%
Domain: Medicine & Life Sciences
Research OutputsResearch Output authored by Weihua Zhao is tagged with the concept

Journals

Experimental Neurology

ISSNs: 0014-4886

Academic Press

Journal

3

Journal of Neurochemistry

ISSNs: 0022-3042

Wiley

Journal

2

EMBO Molecular Medicine

ISSNs: 1757-4676

Additional searchable ISSN (Electronic): 1757-4684

Wiley

Journal

2

Proceedings of the National Academy of Sciences of the United States of America

ISSNs: 0027-8424

Journal

2

JAMA Neurology

ISSNs: 2168-6149

American Medical Association

Journal

2
has published Research OutputsResearch Output by Weihua Zhao

Research Network

Visualization: Institutional Network

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Weihua Zhao

Visualization: Co-author Network

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Weihua Zhao

Shared Pub. Internal Organizations

Houston Methodist Hospital

Organizational unit: Schools & Hospitals

30

Department of Pathology & Genomic Medicine

Organizational unit: Departments

2
2

Nantz National Alzheimer Center

Organizational unit: Programs

1
has Research OutputsResearch Output by Weihua Zhao

Shared Pub. External Organizations

Houston Methodist Research Institute

External organization: Unknown

19

Shanghai Jiao Tong University

External organization: Academic

4

Baylor College of Medicine

External organization: Academic

3

Cedars-Sinai Medical Center

External organization: Medical

2

Univ of Florida

External organization: Unknown

2
has Research OutputsResearch Output by Weihua Zhao

Shared Pub. Internal co-authors

has co-authored Research OutputsResearch Output with Weihua Zhao

Shared Pub. External co-authors

Jenny S. Henkel

External person

16

Jinghong Wang

External person

8

Shixiang Wen

External person

8

Qin Xiao

External person

4

Albert A. Yen

External person

3
has co-authored Research OutputsResearch Output with Weihua Zhao

ID: 2285798