Research outputs

  1. 2019
  2. Piperine attenuates cognitive impairment in an experimental mouse model of sporadic Alzheimer's disease

    Wang, C., Cai, Z., Wang, W., Wei, M., Kou, D., Li, T., Yang, Z., Guo, H., Le, W. & Li, S., Aug 1 2019, In : Journal of Nutritional Biochemistry. 70, p. 147-155 9 p.

    Research output: Contribution to journalArticle

  3. Distinct Connectivity and Functionality of Aldehyde Dehydrogenase 1a1-Positive Nigrostriatal Dopaminergic Neurons in Motor Learning

    Wu, J., Kung, J., Dong, J., Chang, L., Xie, C., Habib, A., Hawes, S., Yang, N., Chen, V., Liu, Z., Evans, R., Liang, B., Sun, L., Ding, J., Yu, J., Saez-Atienzar, S., Tang, B., Khaliq, Z., Lin, D. T., Le, W. & 1 othersCai, H., Jul 30 2019, In : Cell Reports. 28, 5, p. 1167-1181.e7

    Research output: Contribution to journalArticle

  4. 帕金森病患者尸检迷走神经病理和肠道神经炎症分析

    Yang, Z., Sun, L., Kou, D., Li, T., Sun, Z. & Le, W., May 8 2019, In : Chinese Journal of Neurology. 52, 5, p. 387-393 7 p.

    Research output: Contribution to journalArticle

  5. ALDH1A1 regulates postsynaptic μ–opioid receptor expression in dorsal striatal projection neurons and mitigates dyskinesia through transsynaptic retinoic acid signaling

    Pan, J., Yu, J., Sun, L., Xie, C., Chang, L., Wu, J., Hawes, S., Saez–Atienzar, S., Zheng, W., Kung, J., Ding, J., Le, W., Chen, S. & Cai, H., Mar 5 2019, In : Scientific Reports. 9, 1, 3602.

    Research output: Contribution to journalArticle

  6. Altered Expression Levels of MicroRNA-132 and Nurr1 in Peripheral Blood of Parkinson's Disease: Potential Disease Biomarkers

    Yang, Z., Li, T., Li, S., Wei, M., Qi, H., Shen, B., Chang, R. C. C., Le, W. & Piao, F., Feb 28 2019, In : ACS Chemical Neuroscience.

    Research output: Contribution to journalArticle

  7. Graphene oxide nanocolloids induce autophagy-lysosome dysfunction in mouse embryonic stem cells

    Wei, M., Fu, Z., Wang, C., Zheng, W., Li, S. & Le, W., Feb 1 2019, In : Journal of Biomedical Nanotechnology. 15, 2, p. 340-351 12 p.

    Research output: Contribution to journalArticle

  8. Recent advances and perspectives of metabolomics-based investigations in Parkinson's disease

    Shao, Y. & Le, W., Jan 11 2019, In : Molecular neurodegeneration. 14, 1, 3.

    Research output: Contribution to journalArticle

  9. Alteration in sleep architecture and electroencephalogram as an early sign of Alzheimer's disease preceding the disease pathology and cognitive decline

    Zhang, F., Zhong, R., Li, S., Fu, Z., Wang, R., Wang, T., Huang, Z. & Le, W., Jan 1 2019, In : Alzheimer's and Dementia.

    Research output: Contribution to journalArticle

  10. Clinical and radiological characteristics of restless legs syndrome following acute lacunar infarction

    Tuo, H., Tian, Z., Ma, X., Cui, Y., Xue, Y., Che, J., Xu, C., Chen, K., Zhang, Y., Zhang, L., Bi, H., Le, W. & Ondo, W. G., Jan 1 2019, In : Sleep Medicine. 53, p. 81-87 7 p.

    Research output: Contribution to journalArticle

  11. Exercise and Parkinson's disease

    Xu, X., Fu, Z. & Le, W., Jan 1 2019, International Review of Neurobiology. Academic Press, (International Review of Neurobiology).

    Research output: Chapter in Book/Report/Conference proceedingChapter

  12. Therapeutic effects of hirsutella sinensis on the disease onset and progression of amyotrophic lateral sclerosis in SOD1G93A transgenic mouse model

    Shang, H. Y., Zhang, J. J., Fu, Z. F., Liu, Y. F., Li, S., Chen, S. & Le, W., Jan 1 2019, In : CNS Neuroscience and Therapeutics.

    Research output: Contribution to journalArticle

  13. 2018
  14. Dynamic changes of CX3CL1/CX3CR1 axis during microglial activation and motor neuron loss in the spinal cord of ALS mouse model

    Zhang, J., Liu, Y., Liu, X., Li, S., Cheng, C., Chen, S. & Le, W., Dec 21 2018, In : Translational Neurodegeneration. 7, 1, 35.

    Research output: Contribution to journalArticle

  15. Fingerprint analysis of Huolingshengji Formula and its neuroprotective effects in SOD1G93A mouse model of amyotrophic lateral sclerosis

    Zhou, Q., Wang, Y., Zhang, J., Shao, Y., Li, S., Wang, Y., Cai, H., Feng, Y. & Le, W., Dec 1 2018, In : Scientific Reports. 8, 1, 1668.

    Research output: Contribution to journalArticle

  16. Recent advances in microfluidic models for cancer metastasis research

    Xu, H., Liu, X. & Le, W., Aug 1 2018, In : TrAC - Trends in Analytical Chemistry. 105, p. 1-6 6 p.

    Research output: Contribution to journalReview article

  17. Impacts of acute hypoxia on Alzheimer's disease-like pathologies in APPswe/PS1dE9 mice and their wild type littermates

    Zhang, F., Zhong, R., Qi, H., Li, S., Cheng, C., Liu, X., Liu, Y. & Le, W., May 9 2018, In : Frontiers in Neuroscience. 12, MAY, 314.

    Research output: Contribution to journalArticle

  18. Potential biomarkers of Parkinson's disease revealed by plasma metabolic profiling

    Zhao, H., Wang, C., Zhao, N., Li, W., Yang, Z., Liu, X., Le, W. & Zhang, X., Apr 1 2018, In : Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 1081-1082, p. 101-108 8 p.

    Research output: Contribution to journalArticle

  19. Distinct disruptions in Land's cycle remodeling of glycerophosphocholines in murine cortex mark symptomatic onset and progression in two Alzheimer's disease mouse models

    Granger, M. W., Liu, H., Fowler, C. F., Blanchard, A. P., Taylor, M. W., Sherman, S. P. M., Xu, H., Le, W. & Bennett, S. A. L., Jan 1 2018, (Accepted/In press) In : Journal of Neurochemistry.

    Research output: Contribution to journalArticle

  20. Pathological Impacts of Chronic Hypoxia on Alzheimer's Disease

    Zhang, F., Niu, L., Li, S. & Le, W., Jan 1 2018, (Accepted/In press) In : ACS Chemical Neuroscience.

    Research output: Contribution to journalArticle

  21. Targeting the MIR-665-3p-ATG4B-Autophagy axis relieves inflammation and apoptosis in intestinal ischemia/reperfusion

    Li, Z., Wang, G., Feng, D., Zu, G., Li, Y., Shi, X., Zhao, Y., Jing, H., Ning, S., Le, W., Yao, J. & Tian, X., Jan 1 2018, In : Cell Death and Disease. 9, 5, 483.

    Research output: Contribution to journalArticle

  22. Repurposing carbamazepine for the treatment of amyotrophic lateral sclerosis in SOD1-G93A mouse model

    Zhang, J. J., Zhou, Q. M., Chen, S. & Le, W., 2018, (Accepted/In press) In : CNS Neuroscience and Therapeutics.

    Research output: Contribution to journalArticle

  23. 2017
  24. An insight review of autophagy biology and neurodegenerative diseases: machinery, mechanisms and regulation

    Li, S. & Le, W., Nov 27 2017, (Accepted/In press) In : Science China Life Sciences. p. 1-3 3 p.

    Research output: Contribution to journalArticle

  25. Nanomaterials modulate stem cell differentiation: biological interaction and underlying mechanisms

    Wei, M., Li, S. & Le, W., Oct 25 2017, In : Journal of nanobiotechnology. 15, 1, 1 p.

    Research output: Contribution to journalReview article

  26. Biomarker Discovery in Parkinson’s Disease: Present Challenges and Future Opportunities

    Li, S. & Le, W., Sep 21 2017, (Accepted/In press) In : Neuroscience Bulletin. p. 1-2 2 p.

    Research output: Contribution to journalArticle

  27. Milestones of Parkinson’s Disease Research: 200 Years of History and Beyond

    Li, S. & Le, W., Sep 11 2017, (Accepted/In press) In : Neuroscience Bulletin. p. 1-5 5 p.

    Research output: Contribution to journalArticle

  28. Can Biomarkers Help the Early Diagnosis of Parkinson’s Disease?

    Le, W., Dong, J., Li, S. & Korczyn, A. D., Sep 2 2017, (Accepted/In press) In : Neuroscience Bulletin. p. 1-8 8 p.

    Research output: Contribution to journalArticle

  29. Acute hypoxia induced an imbalanced M1/M2 activation of microglia through NF-κB signaling in Alzheimer's disease mice and wild-type littermates

    Zhang, F., Zhong, R., Li, S., Fu, Z., Cheng, C., Cai, H. & Le, W., Aug 25 2017, In : Frontiers in Aging Neuroscience. 9, AUG, 282.

    Research output: Contribution to journalArticle

  30. Activation of DRD5 (dopamine receptor D5) inhibits tumor growth by autophagic cell death

    Leng, Z. G., Lin, S. J., Wu, Z. R., Guo, Y. H., Cai, L., Shang, H. B., Tang, H., Xue, Y. J., Lou, M. Q., Zhao, W., Le, W., Zhao, W. G., Zhang, X. & Wu, Z. B., Aug 3 2017, (Accepted/In press) In : Autophagy. p. 1-16 16 p.

    Research output: Contribution to journalArticle

  31. Tiny But Mighty: Promising Roles of MicroRNAs in the Diagnosis and Treatment of Parkinson’s Disease

    Wang, Y., Yang, Z. & Le, W., Jul 31 2017, (Accepted/In press) In : Neuroscience Bulletin. p. 1-9 9 p.

    Research output: Contribution to journalArticle

  32. Diagnostic accuracy of tablet-based software for the detection of concussion

    Yang, S., Flores, B., Magal, R., Harris, K., Gross, J., Ewbank, A., Davenport, S., Ormachea, P., Nasser, W., Le, W., Peacock, W. F., Katz, Y. & Eagleman, D. M., Jul 1 2017, In : PLoS ONE. 12, 7, e0179352.

    Research output: Contribution to journalArticle

  33. Gold nanoparticles enhance the differentiation of embryonic stem cells into dopaminergic neurons via mTOR/p70S6K pathway

    Wei, M., Li, S., Yang, Z., Zheng, W. & Le, W., Jun 1 2017, In : Nanomedicine. 12, 11, p. 1305-1317 13 p.

    Research output: Contribution to journalArticle

  34. The missing link between sleep disorders and age-related dementia: recent evidence and plausible mechanisms

    Zhang, F., Zhong, R., Li, S., Chang, R. C. C. & Le, W., Feb 10 2017, (Accepted/In press) In : Journal of Neural Transmission. p. 1-10 10 p.

    Research output: Contribution to journalArticle

  35. Autophagy in neurodegenerative diseases: Pathogenesis and therapy

    Guo, F., Liu, X., Cai, H. & Le, W., 2017, (Accepted/In press) In : Brain Pathology.

    Research output: Contribution to journalArticle

  36. Early pathogenic event of Alzheimer's disease documented in iPSCs from patients with PSEN1 mutations

    Yang, J., Zhao, H., Ma, Y., Shi, G., Song, J., Tang, Y., Li, S., Li, T., Liu, N., Tang, F., Gu, J., Zhang, L., Zhang, Z., Zhang, X., Jin, Y. & Le, W., 2017, In : Oncotarget. 8, 5, p. 7900-7913 14 p.

    Research output: Contribution to journalArticle

  37. n-butylidenephthalide treatment prolongs life span and attenuates motor neuron loss in SOD1G93A mouse model of amyotrophic lateral sclerosis

    Zhou, Q. M., Zhang, J. J., Li, S., Chen, S. & Le, W., 2017, (Accepted/In press) In : CNS Neuroscience and Therapeutics.

    Research output: Contribution to journalArticle

  38. 2016
  39. A Central Role for Phosphorylated p38α in Linking Proteasome Inhibition-Induced Apoptosis and Autophagy

    Guo, F., He, X. B., Li, S. & Le, W., Nov 10 2016, (Accepted/In press) In : Molecular neurobiology. p. 1-13 13 p.

    Research output: Contribution to journalArticle

  40. Protective microglia and their regulation in Parkinson’s disease

    Le, W., Wu, J. & Tang, Y., Sep 21 2016, In : Frontiers in Molecular Neuroscience. 9, SEP2016, 89.

    Research output: Contribution to journalReview article

  41. Therapies for Parkinson’s diseases: alternatives to current pharmacological interventions

    Li, S., Dong, J., Cheng, C. & Le, W., Aug 11 2016, (Accepted/In press) In : Journal of Neural Transmission. p. 1-21 21 p.

    Research output: Contribution to journalArticle

  42. The recommendations of Chinese Parkinson's disease and movement disorder society consensus on therapeutic management of Parkinson's disease

    Chen, S., Chan, P., Sun, S., Chen, H., Zhang, B., Le, W., Liu, C., Peng, G., Tang, B., Wang, L., Cheng, Y., Shao, M., Liu, Z., Wang, Z., Chen, X., Wang, M., Wan, X., Shang, H., Liu, Y., Xu, P. & 6 othersWang, J., Feng, T., Chen, X., Hu, X., Xie, A. & Xiao, Q., Jun 30 2016, In : Translational Neurodegeneration. 5, 1, 12.

    Research output: Contribution to journalReview article

  43. Nanomaterial-modulated autophagy: Underlying mechanisms and functional consequences

    Zheng, W., Wei, M., Li, S. & Le, W., Jun 1 2016, In : Nanomedicine. 11, 11, p. 1417-1430 14 p.

    Research output: Contribution to journalArticle

  44. Induced pluripotent stem cells in Alzheimer's disease: Applications for disease modeling and cell-replacement therapy

    Yang, J., Li, S., He, X. B., Cheng, C. & Le, W., May 17 2016, In : Molecular Neurodegeneration. 11, 1, 39.

    Research output: Contribution to journalArticle

  45. Current pharmaceutical treatments and alternative therapies of parkinson’s disease

    Dong, J., Cui, Y., Li, S. & Le, W., May 1 2016, In : Current Neuropharmacology. 14, 4, p. 339-355 17 p.

    Research output: Contribution to journalArticle

  46. Current therapy of drugs in amyotrophic lateral sclerosis

    Lu, H., Le, W., Xie, Y. Y. & Wang, X. P., May 1 2016, In : Current Neuropharmacology. 14, 4, p. 314-321 8 p.

    Research output: Contribution to journalArticle

  47. Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases

    Tang, Y. & Le, W., Mar 1 2016, In : Molecular neurobiology. 53, 2, p. 1181-1194 14 p.

    Research output: Contribution to journalArticle

  48. Chronic Sleep Deprivation Exacerbates Learning-Memory Disability and Alzheimer's Disease-Like Pathologies in AβPPswe/PS1Delta;E9 Mice

    Qiu, H., Zhong, R., Liu, H., Zhang, F., Li, S. & Le, W., Feb 2 2016, In : Journal of Alzheimer's Disease. 50, 3, p. 669-685 17 p.

    Research output: Contribution to journalArticle

  49. Chronic hypoxia facilitates Alzheimer's disease through demethylation of γ-secretase by downregulating DNA methyltransferase 3b

    Liu, H., Qiu, H., Yang, J., Ni, J. & Le, W., Feb 1 2016, In : Alzheimer's and Dementia. 12, 2, p. 130-143 14 p.

    Research output: Contribution to journalArticle

  50. Corrigendum to "A quantitative approach to developing Parkinsonian monkeys (Macaca fascicularis) with intracerebroventricular 1-methyl-4-phenylpyridinium injections" [J. Neurosci. Methods 251 (2015) 99-107]

    Li, H., Lei, X., Huang, B., Rizak, J. D., Yang, L., Yang, S., Wu, J., Lü, L., Wang, J., Yan, T., Li, H., Wang, Z., Hu, Y., Le, W., Deng, X., Huang, T., Li, J., Xu, L., Zhang, B. & Hu, X., Jan 30 2016, In : Journal of Neuroscience Methods. 258, p. 135 1 p.

    Research output: Contribution to journalArticle

  51. Erratum: 1-methyl-4-phenylpyridinium stereotactic infusion completely and specifically ablated the nigrostriatal dopaminergic pathway in Rhesus Macaque (PLoS ONE (2016) 11:1 (e0147094)

    Lei, X., Li, H., Huang, B., Rizak, J., Li, L., Xu, L., Liu, L., Wu, J., Lü, L., Wang, Z., Hu, Y., Le, W., Deng, X., Li, J., Yao, Y., Xu, L., Hu, X. & Zhang, B., Jan 8 2016, In : PLoS ONE. 11, 1, e0147094.

    Research output: Contribution to journalArticle

  52. Double-Edged Roles of Nitric Oxide Signaling on APP Processing and Amyloid-β Production In Vitro: Preliminary Evidence from Sodium Nitroprusside

    Cai, Z. X., Guo, H. S., Wang, C., Wei, M., Cheng, C., Yang, Z. F., Chen, Y. W., Le, W. D. & Li, S., Jan 1 2016, In : Neurotoxicity Research. 29, 1, p. 21-34 14 p.

    Research output: Contribution to journalArticle

  53. miR-29 regulates Tet1 expression and contributes to early differentiation of mouse ESCs

    Cui, Y., Li, T., Yang, D., Li, S. & Le, W., 2016, In : Oncotarget. 7, 40, p. 64932-64941 10 p.

    Research output: Contribution to journalArticle

  54. Nurr1-Based Therapies for Parkinson's Disease

    Dong, J., Li, S., Mo, J. L., Cai, H. B. & Le, W. D., 2016, (Accepted/In press) In : CNS Neuroscience and Therapeutics.

    Research output: Contribution to journalArticle

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