• 18011 Citations
  • 68 h-Index
1987 …2020

Research output per year

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Personal profile

Personal profile

Dr. Le received his Bachelor’s degree from Suzhou Medical College in 1978, and his doctoral degree from Shanghai 2nd Medical University in 1988. He did postdoctoral training at Baylor College of Medicine starting in 1989. He was promoted to Assistant Professor in 1993, Associate Professor in 2000 and Professor in 2005 at Baylor College of Medicine. He has published over 185 SCI papers in peer review journals and 7 scientific books. He has been awarded 26 research grants including 3 NIH R0-1 awards, grants from Michael Fox Foundation, APDA, PDF and NPA. Recently, he received two grant awards from the Helis Foundation to support Parkinson’s disease research. He is a reviewer committee member of NIH, VA, INSERM, Singapore Academy of Science, and the Chinese Nature Science Foundation. He is an editorial board member of six international journals including Autophagy, Neurodegenerative Disease, and is the Academic Editor of Plos One and J Alzheimer’s Disease.

Research interests

Dr. Le is a neurologist/neuroscientist with research interest in the cellular and molecular basis of neuronal injury in these neurodegenerative diseases. Dr. Le’s research program focuses on defining the molecular mechanisms and pathological pathways of three major neurodegenerative diseases (Parkinson’s disease [PD], Alzheimers’s disease, and ALS). Recently he pioneered a linkage study of transcription factors regulating CNS development and neurodegenerative disorders.

Education/Academic qualification

Neurology, Postdoctoral Fellowship, Baylor College of Medicine

Medicine, MS, Shanghai 2nd Medical University

PhD, Shanghai 2nd Medical University

External positions

Dalian Medical University

Free-text keywords

  • Neurodegenerative diseases
  • Parkinson’s Disease
  • Alzheimer
  • ALS

Research Area Keywords

  • Neurosciences

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Research Output

Activation of dopamine receptor D1 inhibits glioblastoma tumorigenicity by regulating autophagic activity

Yang, K., Wei, M., Yang, Z., Fu, Z., Xu, R., Cheng, C., Chen, X., Chen, S., Dammer, E. & Le, W., Jan 1 2020, In : Cellular Oncology.

Research output: Contribution to journalArticle

  • Autophagy and Alzheimer's Disease

    Chen, S., Zhou, Q., Ni, Y. & Le, W., Jan 1 2020, In : Advances in experimental medicine and biology. 1207, p. 3-19 17 p.

    Research output: Contribution to journalArticle

  • Autophagy and Motor Neuron Diseases

    Zhang, X., Yang, K. & Le, W., Jan 1 2020, In : Advances in experimental medicine and biology. 1207, p. 53-74 22 p.

    Research output: Contribution to journalArticle

  • B-Cell Receptor-Associated Protein 31 Negatively Regulates the Expression of Monoamine Oxidase A Via R1

    Jia, C. C., Li, G., Jiang, R., Liu, X., Yuan, Q., Le, W., Hou, Y. & Wang, B., Apr 30 2020, In : Frontiers in Molecular Biosciences. 7, 64.

    Research output: Contribution to journalArticle

  • Correction to: Parkinson's disease-related Leucine-rich repeat kinase 2 modulates nuclear morphology and genomic stability in striatal projection neurons during aging

    Chen, X., Xie, C., Tian, W., Sun, L., Zheng, W., Hawes, S., Chang, L., Kung, J., Ding, J., Chen, S., Le, W. & Cai, H., Mar 16 2020, In : Molecular Neurodegeneration. 15, 1, 22.

    Research output: Contribution to journalArticle