Research outputs

  1. 2019
  2. Nanoparticle delivery of miR-708 mimetic impairs breast cancer metastasis

    Ramchandani, D., Lee, S. K., Yomtoubian, S., Han, M. S., Tung, C. H. & Mittal, V., Mar 1 2019, In : Molecular Cancer Therapeutics. 18, 3, p. 579-591 13 p.

    Research output: Contribution to journalArticle

  3. The lung microenvironment: an important regulator of tumour growth and metastasis

    Altorki, N. K., Markowitz, G. J., Gao, D., Port, J. L., Saxena, A., Stiles, B., McGraw, T. & Mittal, V., Jan 1 2019, In : Nature Reviews Cancer. 19, 1, p. 9-31 23 p.

    Research output: Contribution to journalReview article

  4. 2018
  5. Immune reprogramming via PD-1 inhibition enhances early-stage lung cancer survival

    Markowitz, G. J., Havel, L. S., Crowley, M. J., Ban, Y., Lee, S. B., Thalappillil, J. S., Narula, N., Bhinder, B., Elemento, O., Wong, S. T., Gao, D., Altorki, N. K. & Mittal, V., Jul 12 2018, In : JCI insight. 3, 13

    Research output: Contribution to journalArticle

  6. Epithelial Mesenchymal Transition in Tumor Metastasis

    Mittal, V., Jan 24 2018, In : Annual Review of Pathology: Mechanisms of Disease. 13, p. 395-412 18 p.

    Research output: Contribution to journalArticle

  7. Metastatic tumor cells – genotypes and phenotypes

    Gao, D., Mittal, V., Ban, Y., Lourenco, A. R., Yomtoubian, S. & Lee, S., 2018, (Accepted/In press) In : Frontiers in Biology.

    Research output: Contribution to journalArticle

  8. 2017
  9. Targeting the vascular and perivascular niches as a regenerative therapy for lung and liver fibrosis

    Cao, Z., Ye, T., Sun, Y., Ji, G., Shido, K., Chen, Y., Luo, L., Na, F., Li, X., Huang, Z., Ko, J. L., Mittal, V., Qiao, L., Chen, C., Martinez, F. J., Rafii, S. & Ding, B. S., Aug 30 2017, In : Science Translational Medicine. 9, 405, aai8710.

    Research output: Contribution to journalArticle

  10. Regulation of tumor progression and metastasis by bone marrow-derived microenvironments

    El Rayes, T., Gao, D., Altorki, N. K., Cox, T. R., Erler, J. T. & Mittal, V., Aug 2 2017, Biomarkers of the Tumor Microenvironment: Basic Studies and Practical Applications. Springer International Publishing, p. 303-328 26 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

  11. Fischer et al. reply

    Fischer, K. R., Altorki, N. K., Mittal, V. & Gao, D., Jul 5 2017, In : Nature. 547, 7661, p. E1-E6 6 p.

    Research output: Contribution to journalArticle

  12. The nuclear transport receptor Importin-11 is a tumor suppressor that maintains PTEN protein

    Chen, M., Nowak, D. G., Narula, N., Robinson, B., Watrud, K., Ambrico, A., Herzka, T. M., Zeeman, M. E., Minderer, M., Zheng, W., Ebbesen, S. H., Plafker, K. S., Stahlhut, C., Wang, V. M. Y., Wills, L., Nasar, A., Castillo-Martin, M., Cordon-Cardo, C., Wilkinson, J. E., Powers, S. & 6 othersSordella, R., Altorki, N. K., Mittal, V., Stiles, B. M., Plafker, S. M. & Trotman, L. C., Mar 6 2017, In : The Journal of cell biology. 216, 3, p. 641-656 16 p.

    Research output: Contribution to journalArticle

  13. Influencing the tumor microenvironment: A Phase II study of copper depletion using tetrathiomolybdate in patients with breast cancer at high risk for recurrence and in preclinical models of lung metastases

    Chan, N., Willis, A., Kornhauser, N., Mward, M., Lee, S. B., Nackos, E., Seo, B. R., Chuang, E., Cigler, T., Moore, A., Donovan, D., Cobham, M. V., Fitzpatrick, V., Schneider, S., Wiener, A., Guillaume-Abraham, J., Aljom, E., Zelkowitz, R., Warren, J. D., Lane, M. E. & 3 othersFischbach, C., Mittal, V. & Vahdat, L., Feb 1 2017, In : Clinical Cancer Research. 23, 3, p. 666-676 11 p.

    Research output: Contribution to journalArticle

  14. Matrix Metalloproteinase 14 promotes lung cancer by cleavage of Heparin-Binding EGF-like Growth Factor

    Stawowczyk, M., Wellenstein, M. D., Lee, S. B., Yomtoubian, S., Durrans, A., Choi, H., Narula, N., Altorki, N. K., Gao, D. & Mittal, V., 2017, In : Neoplasia (United States). 19, 2, p. 55-64 10 p.

    Research output: Contribution to journalArticle

  15. 2016
  16. Epithelial mesenchymal transition in aggressive lung cancers

    Mittal, V., Oct 1 2016, Advances in Experimental Medicine and Biology. Springer New York, Vol. 890. p. 37-56 20 p. (Advances in Experimental Medicine and Biology; vol. 890).

    Research output: Chapter in Book/Report/Conference proceedingChapter

  17. The microenvironment of lung cancer and therapeutic implications

    Mittal, V., El Rayes, T., Narula, N., McGraw, T. E., Altorki, N. K. & Barcellos-Hoff, M. H., Oct 1 2016, Advances in Experimental Medicine and Biology. Springer New York, Vol. 890. p. 75-110 36 p. (Advances in Experimental Medicine and Biology; vol. 890).

    Research output: Chapter in Book/Report/Conference proceedingChapter

  18. In Vivo Visualization and Characterization of Epithelial-Mesenchymal Transition in Breast Tumors

    Zhao, Z., Zhu, X., Cui, K., Mancuso, J., Federley, R., Fischer, K., Teng, G. J., Mittal, V., Gao, D., Zhao, H. & Wong, S. T., Apr 15 2016, In : Cancer Research. 76, 8, p. 2094-2104 11 p.

    Research output: Contribution to journalArticle

  19. Development of a prosaposin-derived therapeutic cyclic peptide that targets ovarian cancer via the tumor microenvironment

    Wang, S., Blois, A., El Rayes, T., Liu, J. F., Hirsch, M. S., Gravdal, K., Palakurthi, S., Bielenberg, D. R., Akslen, L. A., Drapkin, R., Mittal, V. & Watnick, R. S., Mar 9 2016, In : Science Translational Medicine. 8, 329, 329ra34.

    Research output: Contribution to journalArticle

  20. Cancer cell CCL5 mediates bone marrow independent angiogenesis in breast cancer

    Sax, M. J., Gasch, C., Athota, V. R., Freeman, R., Rasighaemi, P., Westcott, D. E., Day, C. J., Nikolic, I., Elsworth, B., Wei, M., Rogers, K., Swarbrick, A., Mittal, V., Pouliot, N. & Mellick, A. S., 2016, In : Oncotarget. 7, 51, p. 85437-85449 13 p.

    Research output: Contribution to journalArticle

  21. Expression of the receptor for hyaluronic acid mediated motility (RHAMM) is associated with poor prognosis and metastasis in non-small cell lung carcinoma

    Wang, D., Narula, N., Azzopardi, S., Smith, R. S., Nasar, A., Altorki, N. K., Mittal, V., Somwar, R., Stiles, B. M. & Nancy Du, Y. C., 2016, In : Oncotarget. 7, 26, p. 39957-39969 13 p.

    Research output: Contribution to journalArticle

  22. 2015
  23. Lung inflammation promotes metastasis through neutrophil protease-mediated degradation of Tsp-1

    Rayes, T. E., Catena, R., Lee, S., Stawowczyk, M., Joshi, N., Fischbach, C., Powell, C. A., Dannenberg, A., Altorki, N. K., Gao, D. & Mittal, V., Dec 29 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 52, p. 16000-16005 6 p.

    Research output: Contribution to journalArticle

  24. Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance

    Fischer, K. R., Durrans, A., Lee, S., Sheng, J., Li, F., Wong, S. T. C., Choi, H., El Rayes, T., Ryu, S., Troeger, J., Schwabe, R. F., Vahdat, L. T., Altorki, N. K., Mittal, V. & Gao, D., Nov 26 2015, In : Nature. 527, 7579, p. 472-6 5 p.

    Research output: Contribution to journalArticle

  25. Identification of reprogrammed myeloid cell transcriptomes in NSCLC

    Durrans, A., Gao, D., Gupta, R., Fischer, K. R., Choi, H., El Rayes, T., Ryu, S., Nasar, A., Spinelli, C. F., Andrews, W., Elemento, O., Nolan, D., Stiles, B., Rafii, S., Narula, N., Davuluri, R., Altorki, N. K. & Mittal, V., Jun 5 2015, In : PLoS ONE. 10, 6, e0129123.

    Research output: Contribution to journalArticle

  26. Transcriptome Analysis of Individual Stromal Cell Populations Identifies Stroma-Tumor Crosstalk in Mouse Lung Cancer Model

    Choi, H., Sheng, J., Gao, D., Li, F., Durrans, A., Ryu, S., Lee, S. B., Narula, N., Rafii, S., Elemento, O., Altorki, N., Wong, S. T. & Mittal, V., Feb 24 2015, In : Cell Reports. 10, 7, p. 1187-1201 15 p.

    Research output: Contribution to journalArticle

  27. Inflammation and lung cancer: The link to angiogenesis

    Ei Rayes, T., Catena, R., Rafii, S., Altorki, N. & Mittal, V., Jan 1 2015, Inflammation and Lung Cancer. Springer New York, p. 137-159 23 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

  28. Signal transduction in tumor angiogenesis

    Hla, T., Altorki, N. & Mittal, V., Jan 1 2015, Molecular Oncology: Causes of Cancer and Targets for Treatment. Cambridge University Press, p. 861-871 11 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

  29. 2014
  30. EMT process in bone metastasis

    Gao, D., Thompson, E. W. & Mittal, V., Aug 27 2014, Bone Cancer: Primary Bone Cancers and Bone Metastases: Second Edition. Elsevier, p. 451-459 9 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

  31. ID proteins regulate diverse aspects of cancer progression and provide novel therapeutic opportunities

    Nair, R., Teo, W. S., Mittal, V. & Swarbrick, A., Jan 1 2014, In : Molecular Therapy. 22, 8, p. 1407-1415 9 p.

    Research output: Contribution to journalArticle

  32. Targeting RPL39 and MLF2 reduces tumor initiation and metastasis in breast cancer by inhibiting nitric oxide synthase signaling

    Dave, B., Granados-Principal, S., Zhu, R., Benz, S., Rabizadeh, S., Soon-Shiong, P., Yu, K. D., Shao, Z., Li, X., Gilcrease, M., Lai, Z., Chen, Y., Huang, T. H. M., Shen, H., Liu, X., Ferrari, M., Zhan, M., Wong, S. T. C., Kumaraswami, M., Mittal, V. & 3 othersChen, X., Gross, S. S. & Chang, J. C., Jan 1 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 24, p. 8838-8843 6 p.

    Research output: Contribution to journalArticle

  33. Vascular contribution to metastasis

    Sax, M., Plummer, P. N., Mittal, V. & Mellick, A. S., Jan 1 2014, In : Cancer Forum. 38, 2, p. 103-107 5 p.

    Research output: Contribution to journalArticle

  34. 2013
  35. Tetrathiomolybdate-associated copper depletion decreases circulating endothelial progenitor cells in women with breast cancer at high risk of relapse

    Jain, S., Cohen, J., Ward, M. M., Kornhauser, N., Chuang, E., Cigler, T., Moore, A., Donovan, D., Lam, C., Cobham, M. V., Schneider, S., Hurtado Rúa, S. M., Benkert, S., Mathijsen Greenwood, C., Zelkowitz, R., Warren, J. D., Lane, M. E., Mittal, V., Rafii, S. & Vahdat, L. T., Jun 1 2013, In : Annals of Oncology. 24, 6, p. 1491-1498 8 p.

    Research output: Contribution to journalArticle

  36. Delivery of gene silencing agents for breast cancer therapy

    Shen, H., Mittal, V., Ferrari, M. & Chang, J. C., May 8 2013, In : Breast Cancer Research. 15, 3, 205.

    Research output: Contribution to journalArticle

  37. Bone marrow-derived Gr1+ cells can generate a metastasis-resistant microenvironment via induced secretion of thrombospondin-1

    Catena, R., Bhattacharya, N., El Rayes, T., Wang, S., Choi, H., Gao, D., Ryu, S., Joshi, N., Bielenberg, D., Lee, S. B., Haukaas, S. A., Gravdal, K., Halvorsen, O. J., Akslen, L. A., Watnick, R. S. & Mittal, V., May 1 2013, In : Cancer Discovery. 3, 5, p. 578-589 12 p.

    Research output: Contribution to journalArticle

  38. Suppression of miRNA-708 by Polycomb Group Promotes Metastases by Calcium-Induced Cell Migration

    Ryu, S., McDonnell, K., Choi, H., Gao, D., Hahn, M., Joshi, N., Park, S. M., Catena, R., Do, Y., Brazin, J., Vahdat, L. T., Silver, R. B. & Mittal, V., Jan 14 2013, In : Cancer Cell. 23, 1, p. 63-76 14 p.

    Research output: Contribution to journalArticle

  39. MicroRNAs regulate tumor angiogenesis modulated by endothelial progenitor cells

    Plummer, P. N., Freeman, R., Taft, R. J., Vider, J., Sax, M., Umer, B. A., Gao, D., Johns, C., Mattick, J. S., Wilton, S. D., Ferro, V., McMillan, N. A. J., Swarbrick, A., Mittal, V. & Mellick, A. S., Jan 1 2013, In : Cancer Research. 73, 1, p. 341-352 12 p.

    Research output: Contribution to journalArticle

  40. 2012
  41. Microenvironmental regulation of epithelial-mesenchymal transitionsin cancer

    Gao, D., Vahdat, L. T., Wong, S. T., Chang, J. C. & Mittal, V., Oct 1 2012, In : Cancer Research. 72, 19, p. 4883-4889 7 p.

    Research output: Contribution to journalArticle

  42. Tumor microenvironment regulates epithelial-mesenchymal transitions in metastasis

    Gao, D. & Mittal, V., Jul 1 2012, In : Expert Review of Anticancer Therapy. 12, 7, p. 857-859 3 p.

    Research output: Contribution to journalArticle

  43. Myeloid progenitor cells in the premetastatic lung promote metastases by inducing mesenchymal to epithelial transition

    Gao, D., Joshi, N., Choi, H., Ryu, S., Hahn, M., Catena, R., Sadik, H., Argani, P., Wagner, P., Vahdat, L. T., Port, J. L., Stiles, B., Sukumar, S., Altorki, N. K., Rafii, S. & Mittal, V., Mar 15 2012, In : Cancer Research. 72, 6, p. 1384-1394 11 p.

    Research output: Contribution to journalArticle

  44. Incremental increase in VEGFR1 + hematopoietic progenitor cells and VEGFR2 + endothelial progenitor cells predicts relapse and lack of tumor response in breast cancer patients

    Jain, S., Ward, M. M., O'Loughlin, J., Boeck, M., Wiener, N., Chuang, E., Cigler, T., Moore, A., Donovan, D., Lam, C., Cobham, M. V., Schneider, S., Christos, P., Baergen, R. N., Swistel, A., Lane, M. E., Mittal, V., Rafii, S. & Vahdat, L. T., Feb 1 2012, In : Breast Cancer Research and Treatment. 132, 1, p. 235-242 8 p.

    Research output: Contribution to journalArticle

  45. Epithelial-mesenchymal transition, cancer stem cells and treatment resistance

    Dave, B., Mittal, V., Tan, N. M. & Chang, J. C., Jan 19 2012, In : Breast Cancer Research. 14, 1, 202.

    Research output: Contribution to journalArticle

  46. 2011
  47. Discovery of novel human breast cancer micrornas from deep sequencing data by analysis of pri-microrna secondary structures

    Ryu, S., Joshi, N., McDonnell, K., Woo, J., Choi, H., Gao, D., McCombie, W. R. & Mittal, V., Feb 18 2011, In : PLoS ONE. 6, 2, e16403.

    Research output: Contribution to journalArticle

  48. 2010
  49. Inductive angiocrine signals from sinusoidal endothelium are required for liver regeneration

    Ding, B. S., Nolan, D. J., Butler, J. M., James, D., Babazadeh, A. O., Rosenwaks, Z., Mittal, V., Kobayashi, H., Shido, K., Lyden, D., Sato, T. N., Rabbany, S. Y. & Rafii, S., Nov 11 2010, In : Nature. 468, 7321, p. 310-315 6 p.

    Research output: Contribution to journalArticle

  50. Using the transcription factor inhibitor of DNA binding 1 to selectively target endothelial progenitor cells offers novel strategies to inhibit tumor angiogenesis and growth

    Mellick, A. S., Plummer, P. N., Nolan, D. J., Gao, D., Bambino, K., Hahn, M., Catena, R., Turner, V., McDonnell, K., Benezra, R., Brink, R., Swarbrick, A. & Mittal, V., Sep 15 2010, In : Cancer Research. 70, 18, p. 7273-7282 10 p.

    Research output: Contribution to journalArticle

  51. TGF-β IL-6 axis mediates selective and adaptive mechanisms of resistance to molecular targeted therapy in lung cancer

    Yao, Z., Fenoglio, S., Gao, D. C., Camiolo, M., Stiles, B., Lindsted, T., Schlederer, M., Johns, C., Altorki, N., Mittal, V., Kenner, L. & Sordella, R., Aug 31 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 35, p. 15535-15540 6 p.

    Research output: Contribution to journalArticle

  52. Inhibition of neovascularization to simultaneously ameliorate graft-vs-host disease and decrease tumor growth

    Penack, O., Henke, E., Suh, D., King, C. G., Smith, O. M., Na, I. K., Holland, A. M., Ghosh, A., Lu, S. X., Jenq, R. R., Liu, C., Murphy, G. F., Lu, T. T., May, C., Scheinberg, D. A., Gao, D. C., Mittal, V., Heller, G., Benezra, R. & Van Den Brink, M. R. M., Jun 1 2010, In : Journal of the National Cancer Institute. 102, 12, p. 894-908 15 p.

    Research output: Contribution to journalArticle

  53. Stem cells: Metabolism regulates differentiation

    McGraw, T. E. & Mittal, V., Mar 1 2010, In : Nature Chemical Biology. 6, 3, p. 176-177 2 p.

    Research output: Contribution to journalArticle

  54. 2009
  55. Bone marrow-derived endothelial progenitor cells contribute to the angiogenic switch in tumor growth and metastatic progression

    Gao, D., Nolan, D., McDonnell, K., Vahdat, L., Benezra, R., Altorki, N. & Mittal, V., Aug 1 2009, In : Biochimica et Biophysica Acta - Reviews on Cancer. 1796, 1, p. 33-40 8 p.

    Research output: Contribution to journalArticle

  56. The role of bone-marrow-derived cells in tumor growth, metastasis initiation and progression

    Gao, D. & Mittal, V., Aug 1 2009, In : Trends in Molecular Medicine. 15, 8, p. 333-343 11 p.

    Research output: Contribution to journalArticle

  57. Engraftment and Reconstitution of Hematopoiesis Is Dependent on VEGFR2-Mediated Regeneration of Sinusoidal Endothelial Cells

    Hooper, A. T., Butler, J. M., Nolan, D. J., Kranz, A., Iida, K., Kobayashi, M., Kopp, H. G., Shido, K., Petit, I., Yanger, K., James, D., Witte, L., Zhu, Z., Wu, Y., Pytowski, B., Rosenwaks, Z., Mittal, V., Sato, T. N. & Rafii, S., Mar 6 2009, In : Cell Stem Cell. 4, 3, p. 263-274 12 p.

    Research output: Contribution to journalArticle

  58. 2008
  59. Endothelial progenitor cells are cellular hubs essential for neoangiogenesis of certain aggressive adenocarcinomas and metastatic transition but not adenomas

    Kerbel, R. S., Benezra, R., Lyden, D. C., Hattori, K., Heissig, B., Nolan, D. J., Mittal, V., Shaked, Y., Dias, S., Bertolini, F. & Rafii, S., Aug 26 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 34

    Research output: Contribution to journalArticle

  60. Endothelial progenitor cells control the angiogenic switch in mouse lung metastasis

    Gao, D., Nolan, D. J., Mellick, A. S., Bambino, K., McDonnell, K. & Mittal, V., Jan 11 2008, In : Science. 319, 5860, p. 195-198 4 p.

    Research output: Contribution to journalArticle

  61. 2007
  62. Id1 restrains p21 expression to control endothelial progenitor cell formation

    Ciarrocchi, A., Jankovic, V., Shaked, Y., Nolan, D. J., Mittal, V., Kerbel, R. S., Nimer, S. D. & Benezra, R., Dec 19 2007, In : PLoS ONE. 2, 12, e1338.

    Research output: Contribution to journalArticle

  63. ID genes mediate tumor reinitiation during breast cancer lung metastasis

    Gupta, G. P., Perk, J., Acharyya, S., De Candia, P., Mittal, V., Todorova-Manova, K., Gerald, W. L., Brogi, E., Benezra, R. & Massagué, J., Dec 4 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 49, p. 19506-19511 6 p.

    Research output: Contribution to journalArticle

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