Personal profile

Vivek Mittal is the director of the Neuberger Berman Foundation Lung Cancer Laboratory and an associate professor of Cell and Developmental Biology in the cardiothoracic surgery department at Weill Cornell Medical College in New York.

Previously, Dr. Mittal held faculty appointments at Cold Spring Harbor Laboratory and State University of New York, Stony Brook. Dr. Mittal speaks at public engagements to diverse audiences around the world and has produced several patents and authored articles in leading journals including Science, Nature, Cancer Cell, PNAS, and other leading peer-reviewed journals and text books. He contributes to NIH study sections and has chaired sessions at prominent national conferences and symposiums. His research is supported by funds from the National Cancer Institute and private foundations.

As a director of research at the Lung Cancer Center, Dr. Mittal oversees the development of future research themes and educational activities to ensure their concordance with the overall translational mission of the Center. He created a state-of-the art Biobank at Weill Cornell Medical College as a repository for biospecimens from lung cancer, other thoracic malignancies, and benign diseases.

Dr. Mittal is committed to the mentoring of the clinical fellows and faculty in basic research, which is a critical part of the training of the next generation of translational researchers. He is an active teacher and mentor, organizing focus groups and supervising a problem based learning course for medical students. He mentors graduate students, postdoctoral fellows, surgical fellows and junior faculty. He is also dedicated to interviewing candidates for admission to the M.D. and Ph.D. program, and recruitment of junior faculty.

Research interests

Research in Dr. Mittal’s lab studies de novo lung carcinogenesis, as well as the initiation and progression of metastatic lesions derived from extrapulmonary neoplasms. The program integrates clinical and basic science to foster innovative research for the prevention, detection, and treatment of cancer.

A major aim of his research is to understand cancer cell intrinsic and extrinsic programs that regulate tumor growth and metastasis. Cancer cell intrinsic programs include aberrant signaling pathways, which are investigated at several levels of regulation including transcriptional, epigenetic, and small regulatory RNAs. Cancer cell extrinsic programs include the contribution of the tumor microenvironment. The heterotypic reciprocal signaling between the stromal cells and tumor epithelial compartments that contribute to tumor progression can be unraveled by dissecting the complexity of various stromal cell types that comprise the microenvironment. Dr. Mittal is interested in understanding how these two programs are integrated to regulate key tumorigenic processes including angiogenesis, inflammation, epithelial to mesenchymal transition, therapeutic resistance, metastasis initiation and progression.

Dr. Mittal’s research has produced novel stromal targets for prognosis and drug design. A major goal of this ongoing work is to collaborate with clinicians to rapidly validate additional molecular research findings in preclinical and clinical studies, and determine if they have diagnostic and therapeutic potential for clinical use.

Key contributions include:
-First demonstration that endothelial progenitor cells promote angiogenesis necessary for the formation of lethal macrometastases (Science, 2008).
-First demonstration that myeloid cells induce mesenchymal to epithelial transition that promotes breast cancer metastasis to the lungs (Cancer Research, 2012).
-Discovered microRNA-708, which is epigenetically silenced during metastatic progression in breast cancer (Cancer Cell, 2013 in press). Currently, the potential of miR-708 as a therapeutic against triple negative breast cancer is being evaluated.
-Have identified a novel mechanism, whereby metastasis-incompetent tumors generate metastasis-suppressive niches that inhibit metastasis (in review, Cancer Discovery).
-Analysis of fresh clinical samples have led to the discovery of novel stromal targets of prognostic and therapeutic value in lung cancer.

Keywords

    Free-text keywords

  • Lung cancer, Breast cancer, Tumor microenvironment, Epigenome, microRNA, Mouse models, Genomics

    Research Area Keywords

  • Systems Medicine & Bioinformatics

Fingerprint

Neoplasms
Concept: Neoplasms
Weight: 100%
Domain: Medicine & Life Sciences
Neoplasm Metastasis
Concept: Neoplasm Metastasis
Weight: 83%
Domain: Medicine & Life Sciences
Epithelial-Mesenchymal Transition
Concept: Epithelial-Mesenchymal Transition
Weight: 62%
Domain: Medicine & Life Sciences
Breast Neoplasms
Concept: Breast Neoplasms
Weight: 51%
Domain: Medicine & Life Sciences
Bone Marrow
Concept: Bone Marrow
Weight: 50%
Domain: Medicine & Life Sciences
Lung Neoplasms
Concept: Lung Neoplasms
Weight: 44%
Domain: Medicine & Life Sciences
Tumor Microenvironment
Concept: Tumor Microenvironment
Weight: 37%
Domain: Medicine & Life Sciences
Entamoeba histolytica
Concept: Entamoeba histolytica
Weight: 34%
Domain: Medicine & Life Sciences
Lung
Concept: Lung
Weight: 34%
Domain: Medicine & Life Sciences
Small Nuclear RNA
Concept: Small Nuclear RNA
Weight: 27%
Domain: Medicine & Life Sciences
Research OutputsResearch Output authored by Vivek Mittal is tagged with the concept

Research outputs

Nanoparticle delivery of miR-708 mimetic impairs breast cancer metastasis

Research output: Contribution to journalArticle

The lung microenvironment: an important regulator of tumour growth and metastasis

Research output: Contribution to journalReview article

Epithelial Mesenchymal Transition in Tumor Metastasis

Research output: Contribution to journalArticle

Metastatic tumor cells – genotypes and phenotypes

Research output: Contribution to journalArticle

Journals

Proceedings of the National Academy of Sciences of the United States of America

ISSNs: 0027-8424

Journal

8

Cancer Research

ISSNs: 0008-5472

American Association for Cancer Research Inc.

Journal

5

Nature

ISSNs: 0028-0836, 0000-0000, 0000-0000, 1465-7392

Journal

5

PLoS ONE

Additional searchable ISSN (Electronic): 1932-6203

Public Library of Science

Journal

4

The Journal of biological chemistry

ISSNs: 0021-9258

American Society for Biochemistry and Molecular Biology Inc.

Journal

3
has published Research OutputsResearch Output by Vivek Mittal

Research Network

Visualization: Institutional Network

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Vivek Mittal

Visualization: Co-author Network

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Vivek Mittal

Shared Pub. Internal Organizations

Institute for Academic Medicine

Organizational unit: Institutes

8

Weill Cornell Medical College

Organizational unit: Schools & Hospitals

8

Houston Methodist Hospital

Organizational unit: Schools & Hospitals

4

Department of Urology

Organizational unit: Departments

3

Cores, Biostatistics and Bioinformatics

Organizational unit: Programs

2
has Research OutputsResearch Output by Vivek Mittal

Shared Pub. External Organizations

Weill Medical College of Cornell University

External organization: Unknown

27

Cold Spring Harbor Laboratory

External organization: Unknown

19

Memorial Sloan-Kettering Cancer Center

External organization: Unknown

12

Jawaharlal Nehru University

External organization: Unknown

6

State University of New York at Stony Brook

External organization: Unknown

6
has Research OutputsResearch Output by Vivek Mittal

Shared Pub. Internal co-authors

has co-authored Research OutputsResearch Output with Vivek Mittal

Shared Pub. External co-authors

Dingcheng Gao

External person

22

Nasser K. Altorki

External person

13

Daniel J. Nolan

External person

13

Robert Benezra

External person

11

S. Rafii

External person

10
has co-authored Research OutputsResearch Output with Vivek Mittal

ID: 2282723