Research outputs

  1. 2019
  2. Tumor core biopsies adequately represent immune microenvironment of high-grade serous carcinoma

    Lara, O. D., Krishnan, S., Wang, Z., Corvigno, S., Zhong, Y., Lyons, Y., Dood, R., Hu, W., Qi, L., Liu, J., Coleman, R. L., Westin, S. N., Fleming, N. D., Cristini, V., Rao, A., Burks, J. & Sood, A. K., Nov 26 2019, In : Scientific reports. 9, 1, p. 17589

    Research output: Contribution to journalArticle

  3. A multiscale agent-based model of ductal carcinoma in situ

    Butner, J. D., Fuentes, D., Ozpolat, B., Calin, G. A., Zhou, X., Lowengrub, J., Cristini, V. & Wang, Z., Oct 8 2019, In : IEEE Transactions on Biomedical Engineering.

    Research output: Contribution to journalArticle

  4. Mathematical modeling in cancer nanomedicine: a review

    Dogra, P., Butner, J. D., Chuang, Y. L., Caserta, S., Goel, S., Brinker, C. J., Cristini, V. & Wang, Z., Jun 1 2019, In : Biomedical Microdevices. 21, 2, 40.

    Research output: Contribution to journalArticle

  5. Predicting breast cancer response to neoadjuvant chemotherapy based on tumor vascular features in needle biopsies

    Brocato, T. A., Brown-Glaberman, U., Wang, Z., Selwyn, R. G., Wilson, C. M., Wyckoff, E. F., Lomo, L. C., Saline, J. L., Hooda-Nehra, A., Pasqualini, R., Arap, W., Brinker, C. J. & Cristini, V., Mar 5 2019, In : JCI insight. 4, 8, e126518.

    Research output: Contribution to journalArticle

  6. Multiscale Modeling of Ductal Carcinoma In Situ

    Butner, J., Cristini, V. & Wang, Z., Feb 15 2019, In : Biophysical Journal. 116, 3, p. 322a 323 p.

    Research output: Contribution to journalArticle

  7. Size-Optimized Ultrasmall Porous Silica Nanoparticles Depict Vasculature-Based Differential Targeting in Triple Negative Breast Cancer

    Goel, S., Ferreira, C. A., Dogra, P., Yu, B., Kutyreff, C. J., Siamof, C. M., Engle, J. W., Barnhart, T. E., Cristini, V., Wang, Z. & Cai, W., Jan 1 2019, In : Small. 1903747.

    Research output: Contribution to journalArticle

  8. A Multiscale Mathematical Model to Study Nanomedicine Delivery in Solid Tumors

    Dogra, P., Chuang, Y-L., Butner, J., Ruiz-Ramirez, J., Cristini, V. & Wang, Z., 2019.

    Research output: Contribution to conferencePoster

  9. 2018
  10. A visually apparent and quantifiable CT imaging feature identifies biophysical subtypes of pancreatic ductal adenocarcinoma

    Koay, E. J., Lee, Y., Cristini, V., Lowengrub, J. S., Kang, Y., San Lucas, F. A., Hobbs, B. P., Ye, R., Elganainy, D., Almahariq, M., Amer, A. M., Yu, S., Chatterjee, D., Yan, H., Park, P. C., Rios Perez, M. V., Li, D., Garg, N., Reiss, K., Chauhan, A. & 18 othersZaid, M. M., Nikzad, N., Wolff, R. A., Javle, M., Varadhachary, G. R., Shroff, R. T., Das, P., Lee, J. E., Ferrari, M., Maitra, A., Taniguchi, C. M., Kim, M. P., Crane, C. H., Katz, M. H. G., Wang, H., Bhosale, P., Tamm, E. P. & Fleming, J. B., Dec 1 2018, In : Clinical Cancer Research. 24, 23, p. 5883-5894 12 p.

    Research output: Contribution to journalArticle

  11. Establishing the effects of mesoporous silica nanoparticle properties on in vivo disposition using imaging-based pharmacokinetics

    Dogra, P., Adolphi, N. L., Wang, Z., Lin, Y. S., Butler, K. S., Durfee, P. N., Croissant, J. G., Noureddine, A., Coker, E. N., Bearer, E. L., Cristini, V. & Brinker, C. J., Oct 31 2018, In : Nature Communications. 9, 1, 1 p., 4551.

    Research output: Contribution to journalArticle

  12. Understanding Ductal Carcinoma in Situ Invasion using a Multiscale Agent-Based Model

    Joseph Butner, D., Cristini, V. & Wang, Z., Oct 26 2018, 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2018. Institute of Electrical and Electronics Engineers Inc., Vol. 2018-July. p. 5846-5849 4 p. 8513542

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  13. Regenerative Medicine to Trump Cancer

    Corradetti, B., Dogra, P., Ferrari, M. & Cristini, V., Oct 11 2018, In : Open Access Government.

    Research output: Contribution to journalLetter

  14. Understanding the Connection between Nanoparticle Uptake and Cancer Treatment Efficacy using Mathematical Modeling

    Brocato, T. A., Coker, E. N., Durfee, P. N., Lin, Y. S., Townson, J., Wyckoff, E. F., Cristini, V., Brinker, C. J. & Wang, Z., May 24 2018, In : Scientific Reports. 8, 1, p. 7538 7538.

    Research output: Contribution to journalArticle

  15. 2017
  16. Development of a three dimensional, multiscale agent-based model of ductal carcinoma in situ

    Butner, J. D., Cristini, V. & Wang, Z., Sep 13 2017, 2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Smarter Technology for a Healthier World, EMBC 2017 - Proceedings. Institute of Electrical and Electronics Engineers Inc., p. 86-89 4 p. 8036769

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  17. 2016
  18. A hybrid agent-based model of the developing mammary terminal end bud

    Butner, J. D., Chuang, Y-L., Simbawa, E., Al-Fhaid, A. S., Mahmoud, S. R., Cristini, V. & Wang, Z., Oct 21 2016, In : Journal of Theoretical Biology. 407, p. 259-70 12 p.

    Research output: Contribution to journalArticle

  19. Development of a three dimensional, lattice-free multiscale model of the mammary terminal end bud

    Butner, J. D., Cristini, V. & Zhihui Wang, Aug 2016, In : Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference. 2016, p. 6134-6137 4 p.

    Research output: Contribution to journalArticle

  20. Theory and Experimental Validation of a Spatio-temporal Model of Chemotherapy Transport to Enhance Tumor Cell Kill

    Wang, Z., Kerketta, R., Chuang, Y. L., Dogra, P., Butner, J. D., Brocato, T. A., Day, A., Xu, R., Shen, H., Simbawa, E., AL-Fhaid, A. S., Mahmoud, S. R., Curley, S. A., Ferrari, M., Koay, E. J. & Cristini, V., Jun 1 2016, In : PLoS Computational Biology. 12, 6, e1004969.

    Research output: Contribution to journalArticle

  21. A Geometrically-Constrained Mathematical Model of Mammary Gland Ductal Elongation Reveals Novel Cellular Dynamics within the Terminal End Bud

    Paine, I., Chauviere, A., Landua, J., Sreekumar, A., Cristini, V., Rosen, J. & Lewis, M. T., Apr 2016, In : PLoS Computational Biology. 12, 4, p. e1004839

    Research output: Contribution to journalArticle

  22. Integrated nanotechnology platform for tumor-targeted multimodal imaging and therapeutic cargo release

    Hosoya, H., Dobroff, A. S., Driessen, W. H. P., Cristini, V., Brinker, L. M., Staquicini, F. I., Cardó-Vila, M., D'Angelo, S., Ferrara, F., Proneth, B., Lin, Y-S., Dunphy, D. R., Dogra, P., Melancon, M. P., Stafford, R. J., Miyazono, K., Gelovani, J. G., Kataoka, K., Brinker, C. J., Sidman, R. L. & 2 othersArap, W. & Pasqualini, R., Feb 16 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 7, p. 1877-82 6 p.

    Research output: Contribution to journalArticle

  23. 2015
  24. A modeling approach to study the normal mammary gland growth process

    Butner, J. D., Cristini, V. & Wang, Z., Aug 2015, In : Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference. 2015, p. 1444-7 4 p.

    Research output: Contribution to journalArticle

  25. Integrated PK-PD and agent-based modeling in oncology

    Wang, Z., Butner, J. D., Cristini, V. & Deisboeck, T. S., Mar 11 2015, In : Journal of Pharmacokinetics and Pharmacodynamics. 42, 2, p. 179-189 11 p.

    Research output: Contribution to journalReview article

  26. Simulating cancer growth with multiscale agent-based modeling

    Wang, Z., Butner, J. D., Kerketta, R., Cristini, V. & Deisboeck, T. S., Feb 1 2015, In : Seminars in Cancer Biology. 30, p. 70-78 9 p.

    Research output: Contribution to journalReview article

  27. Computational Approaches for Multiscale Modeling

    Wang, Z., Cristini, V. & Deisboeck, T. S., Jan 1 2015, Systems Cell Biology. Elsevier Inc., Vol. 4. p. 80-85 6 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

  28. Predictive Modeling of Drug Response in Non-Hodgkin's Lymphoma

    Frieboes, H. B., Smith, B. R., Wang, Z., Kotsuma, M., Ito, K., Day, A., Cahill, B., Flinders, C., Mumenthaler, S. M., Mallick, P., Simbawa, E., Al-Fhaid, A. S., Mahmoud, S. R., Gambhir, S. S. & Cristini, V., 2015, In : PLoS ONE. 10, 6, p. e0129433

    Research output: Contribution to journalArticle

  29. 2014
  30. Intra-tumoral heterogeneity of gemcitabine delivery and mass transport in human pancreatic cancer

    Koay, E. J., Baio, F. E., Ondari, A., Truty, M. J., Cristini, V., Thomas, R. M., Chen, R., Chatterjee, D., Kang, YA., Zhang, J., Court, L., Bhosale, P. R., Tamm, E. P., Qayyum, A., Crane, C. H., Javle, M., Katz, M. H., Gottumukkala, V. N., Rozner, M. A., Shen, H. & 10 othersLee, J. E., Wang, H., Chen, Y., Plunkett, W., Abbruzzese, J. L., Wolff, R. A., Maitra, A., Ferrari, M., Varadhachary, G. R. & Fleming, J. B., Dec 1 2014, In : Physical Biology. 11, 6, 065002.

    Research output: Contribution to journalArticle

  31. Development of a diffusion-based mathematical model for predicting chemotherapy effects

    Wang, Z., Kerketta, R., Chuang, Y. L. & Cristini, V., Nov 2 2014, 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2014. Institute of Electrical and Electronics Engineers Inc., p. 2480-2483 4 p. 6944125

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  32. Development of a sampling-based global sensitivity analysis workflow for multiscale computational cancer models

    Wang, Z., Deisboeck, T. S. & Cristini, V., Oct 1 2014, In : IET Systems Biology. 8, 5, p. 191-197 7 p.

    Research output: Contribution to journalArticle

  33. The effect of interstitial pressure on therapeutic agent transport: Coupling with the tumor blood and lymphatic vascular systems

    Wu, M., Frieboes, H. B., Chaplain, M. A. J., McDougall, S. R., Cristini, V. & Lowengrub, J. S., Aug 21 2014, In : Journal of Theoretical Biology. 355, p. 194-207 14 p.

    Research output: Contribution to journalArticle

  34. Understanding Drug Resistance in Breast Cancer with Mathematical Oncology

    Brocato, T., Dogra, P., Koay, E. J., Day, A., Chuang, Y-L., Wang, Z. & Cristini, V., Jun 1 2014, In : Current Breast Cancer Reports. 6, 2, p. 110-120 11 p.

    Research output: Contribution to journalArticle

  35. Transport properties of pancreatic cancer describe gemcitabine delivery and response

    Koay, E. J., Truty, M. J., Cristini, V., Thomas, R. M., Chen, R., Chatterjee, D., Kang, YAA., Bhosale, P. R., Tamm, E. P., Crane, C. H., Javle, M., Katz, M. H., Gottumukkala, V. N., Rozner, M. A., Shen, H., Lee, J. E., Wang, H., Chen, Y., Plunkett, W., Abbruzzese, J. L. & 4 othersWolff, R. A., Varadhachary, G. R., Ferrari, M. & Fleming, J. B., Apr 1 2014, In : Journal of Clinical Investigation. 124, 4, p. 1525-1536 12 p.

    Research output: Contribution to journalArticle

  36. Computational modeling of 3D tumor growth and angiogenesis for chemotherapy evaluation

    Tang, L., Van De Ven, A. L., Guo, D., Andasari, V., Cristini, V., Li, K. C. & Zhou, X., Jan 3 2014, In : PLoS ONE. 9, 1, e83962.

    Research output: Contribution to journalArticle

  37. Tumor vascular permeabilization using localized mild hyperthermia to improve macromolecule transport

    Kirui, D. K., Koay, E. J., Guo, X., Cristini, V., Shen, H. & Ferrari, M., Jan 1 2014, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 10, 7, p. 1487-1496 10 p.

    Research output: Contribution to journalArticle

  38. 2013
  39. Mechanistic modeling identifies drug-uptake history as predictor of tumor drug resistance and nano-carrier-mediated response

    Pascal, J., Ashley, C. E., Wang, Z., Brocato, T. A., Butner, J. D., Carnes, E. C., Koay, E. J., Brinker, C. J. & Cristini, V., Dec 23 2013, In : ACS Nano. 7, 12, p. 11174-11182 9 p.

    Research output: Contribution to journalArticle

  40. Mechanistic patient-specific predictive correlation of tumor drug response with microenvironment and perfusion measurements

    Pascal, J., Bearer, E. L., Wang, Z., Koay, E. J., Curley, S. A. & Cristini, V., Aug 27 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 35, p. 14266-14271 6 p.

    Research output: Contribution to journalArticle

  41. Impact of Diffusion Barriers to Small Cytotoxic Molecules on the Efficacy of Immunotherapy in Breast Cancer

    Das, H., Wang, Z., Niazi, M. K. K., Aggarwal, R., Lu, J., Kanji, S., Das, M., Joseph, M., Gurcan, M. & Cristini, V., Apr 19 2013, In : PLoS ONE. 8, 4, e61398.

    Research output: Contribution to journalArticle

  42. The effect of interstitial pressure on tumor growth: Coupling with the blood and lymphatic vascular systems

    Wu, M., Frieboes, H. B., McDougall, S. R., Chaplain, M. A. J., Cristini, V. & Lowengrub, J., Mar 7 2013, In : Journal of Theoretical Biology. 320, p. 131-151 21 p.

    Research output: Contribution to journalArticle

  43. A Computational Model for Predicting Nanoparticle Accumulation in Tumor Vasculature

    Frieboes, H. B., Wu, M., Lowengrub, J., Decuzzi, P. & Cristini, V., Feb 28 2013, In : PLoS ONE. 8, 2, e56876.

    Research output: Contribution to journalArticle

  44. An Integrated Computational/Experimental Model of Lymphoma Growth

    Frieboes, H. B., Smith, B. R., Chuang, Y. L., Ito, K., Roettgers, A. M., Gambhir, S. S. & Cristini, V., 2013, In : PLoS Computational Biology. 9, 3, e1003008.

    Research output: Contribution to journalArticle

  45. 2012
  46. Integrated intravital microscopy and mathematical modeling to optimize nanotherapeutics delivery to tumors

    Van De Ven, A. L., Wu, M., Lowengrub, J., McDougall, S. R., Chaplain, M. A. J., Cristini, V., Ferrari, M. & Frieboes, H. B., Dec 1 2012, In : AIP Advances. 2, 1, 011208.

    Research output: Contribution to journalArticle

  47. Effect of vascularization on glioma tumor growth

    Hatzikirou, H., Chauvière, A., Lowengrub, J., De Groot, J. & Cristini, V., Nov 1 2012, Modeling Tumor Vasculature: Molecular, Cellular, and Tissue Level Aspects and Implications. Springer New York, Vol. 9781461400523. p. 237-259 23 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

  48. Quantitative measurements and modeling of cargo-motor interactions during fast transport in the living axon

    Seamster, P. E., Loewenberg, M., Pascal, J., Chauviere, A., Gonzales, A., Cristini, V. & Bearer, E. L., Oct 2012, In : Physical Biology. 9, 5, 055005.

    Research output: Contribution to journalArticle

  49. Patient-calibrated agent-based modelling of ductal carcinoma in situ (DCIS): From microscopic measurements to macroscopic predictions of clinical progression

    Macklin, P., Edgerton, M. E., Thompson, A. M. & Cristini, V., May 21 2012, In : Journal of Theoretical Biology. 301, p. 122-140 19 p.

    Research output: Contribution to journalArticle

  50. Density-dependent quiescence in glioma invasion: Instability in a simple reaction-diffusion model for the migration/proliferation dichotomy

    Pham, K., Chauviere, A., Hatzikirou, H., Li, X., Byrne, H. M., Cristini, V. & Lowengrub, J., May 2012, In : Journal of Biological Dynamics. 6, SUPPL. 1, p. 54-71 18 p.

    Research output: Contribution to journalArticle

  51. Integrative physical oncology

    Hatzikirou, H., Chauviere, A., Bauer, A. L., Leier, A., Lewis, M. T., Macklin, P., Marquez-Lago, T. T., Bearer, E. L. & Cristini, V., Jan 2012, In : Wiley Interdisciplinary Reviews: Systems Biology and Medicine. 4, 1, p. 1-14 14 p.

    Research output: Contribution to journalArticle

  52. Dynamic density functional theory of solid tumor growth: Preliminary models

    Chauviere, A., Hatzikirou, H., Kevrekidis, I. G., Lowengrub, J. S. & Cristini, V., 2012, In : AIP Advances. 2, 1, 011210.

    Research output: Contribution to journalArticle

  53. 2011
  54. Multiscale cancer modeling

    Deisboeck, T. S., Wang, Z., MacKlin, P. & Cristini, V., Aug 15 2011, In : Annual Review of Biomedical Engineering. 13, p. 127-155 29 p.

    Research output: Contribution to journalArticle

  55. Correction: Physical oncology: A bench-to-bedside quantitative and predictive approach (Cancer Research (2011) 71, (298-302))

    Frieboes, H. B., Chaplain, M. A. J., Thompson, A. M., Bearer, E. L., Lowengrub, J. S. & Cristini, V., Mar 1 2011, In : Cancer Research. 71, 5, p. 2024 1 p.

    Research output: Contribution to journalComment/debate

  56. Physical oncology: A bench-to-bedside quantitative and predictive approach

    Frieboes, H. B., Chaplain, M. A. J., Thompson, A. M., Bearer, E. L., Lowengrub, J. S. & Cristini, V., Jan 15 2011, In : Cancer Research. 71, 2, p. 298-302 5 p.

    Research output: Contribution to journalReview article

  57. Predictions of tumour morphological stability and evaluation against experimental observations

    Pham, K., Frieboes, H. B., Cristini, V. & Lowengrub, J., Jan 6 2011, In : Journal of the Royal Society Interface. 8, 54, p. 16-29 14 p.

    Research output: Contribution to journalArticle

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