Research outputs

  1. 2019
  2. α4-integrin deficiency in B cells does not affect disease in a T-cell-mediated EAE disease model

    Hussain, R. Z., Cravens, P. D., Miller-Little, W. A., Doelger, R., Granados, V., Herndon, E., Okuda, D. T., Eagar, T. N. & Stüve, O., Jul 1 2019, In : Neurology: Neuroimmunology and NeuroInflammation. 6, 4, e563.

    Research output: Contribution to journalArticle

  3. 2018
  4. Presenilin1 regulates Th1 and Th17 effector responses but is not required for experimental autoimmune encephalomyelitis

    Cummings, M., Arumanayagam, A. C. S., Zhao, P., Kannanganat, S., Stuve, O., Karandikar, N. J. & Eagar, T. N., Aug 1 2018, In : PLoS ONE. 13, 8, e0200752.

    Research output: Contribution to journalArticle

  5. 2017
  6. The detrimental impact of persistent vs an isolated occurrence of de novo donor-specific antibodies on intermediate-term renal transplant outcomes

    Loucks-DeVos, J. M., Eagar, T. N., Gaber, A. O., Patel, S. J., Teeter, L. D., Graviss, E. A. & Knight, R. J., Aug 2017, In : Clinical Transplantation. 31, 8

    Research output: Contribution to journalArticle

  7. Early clearance vs persistence of de novo donor-specific antibodies following lung transplantation

    Islam, A. K., Sinha, N., DeVos, J. M., Kaleekal, T. S., Jyothula, S. S., Teeter, L. D., Nguyen, D. T. M., Eagar, T. N., Moore, L. W., Puppala, M., Wong, S. T. C., Knight, R. J., Frost, A. E., Graviss, E. A. & Osama Gaber, A., Jun 28 2017, In : Clinical Transplantation.

    Research output: Contribution to journalArticle

  8. 2016
  9. A single amino acid substitution prevents recognition of a dominant human aquaporin-4 determinant in the context of HLA-DRB1-03: 01 by a murine TCR

    Arellano, B., Hussain, R., Miller-Little, W. A., Herndon, E., Lambracht-Washington, D., Eagar, T. N., Lewis, R., Healey, D., Vernino, S., Greenberg, B. M. & Stüve, O., Apr 1 2016, In : PLoS ONE. 11, 4, e0152720.

    Research output: Contribution to journalArticle

  10. 2015
  11. T cell subsets and their signature cytokines in autoimmune and inflammatory diseases

    Raphael, I., Nalawade, S., Eagar, T. N. & Forsthuber, T. G., Jul 1 2015, In : Cytokine. 74, 1, p. 5-17 13 p.

    Research output: Contribution to journalArticle

  12. 2014
  13. Immune surveillance of the central nervous system in multiple sclerosis - Relevance for therapy and experimental models

    Hussain, R. Z., Hayardeny, L., Cravens, P. C., Yarovinsky, F., Eagar, T. N., Arellano, B., Deason, K., Castro-Rojas, C. & Stüve, O., Nov 15 2014, In : Journal of Neuroimmunology. 276, 1-2, p. 9-17 9 p.

    Research output: Contribution to journalArticle

  14. Testing effects of glatiramer acetate and fingolimod in an infectious model of CNS immune surveillance

    Castro-Rojas, C., Deason, K., Hussain, R. Z., Hayardeny, L., Cravens, P. C., Yarovinsky, F., Eagar, T. N., Arellano, B. & Stüve, O., Nov 15 2014, In : Journal of Neuroimmunology. 276, 1-2, p. 232-235 4 p.

    Research output: Contribution to journalArticle

  15. 2013
  16. A peptide prime-DNA boost immunization protocol provides significant benefits as a new generation Aβ42 DNA vaccine for Alzheimer disease

    Lambracht-Washington, D., Qu, B. X., Fu, M., Anderson, L. D., Eagar, T. N., Stüve, O. & Rosenberg, R. N., Jan 15 2013, In : Journal of Neuroimmunology. 254, 1-2, p. 63-68 6 p.

    Research output: Contribution to journalArticle

  17. 2012
  18. Parkinson's disease: A role for the immune system

    German, D. C., Eagar, T. N. & Sonsalla, P. K., 2012, In : Current Molecular Pharmacology. 5, 3, p. 340-349 10 p.

    Research output: Contribution to journalArticle

  19. 2011
  20. Lymph node-derived donor encephalitogenic CD4+ T cells in C57BL/6 mice adoptive transfer experimental autoimmune encephalomyelitis highly express GM-CSF and T-bet

    Cravens, P. D., Hussain, R. Z., Zacharias, T. E., Ben, L. H., Herndon, E., Vinnakota, R., Lambracht-Washington, D., Nessler, S., Zamvil, S. S., Eagar, T. N. & Stüve, O., Jun 24 2011, In : Journal of Neuroinflammation. 8, 73.

    Research output: Contribution to journalArticle

  21. DNA immunization against amyloid beta 42 has high potential as safe therapy for Alzheimer's disease as it diminishes antigen-specific Th1 and Th17 cell proliferation.

    Lambracht-Washington, D., Qu, B. X., Fu, M., Anderson, L. D., Stüve, O., Eagar, T. N. & Rosenberg, R. N., 2011, In : Cellular and Molecular Neurobiology. 31, 6, p. 867-874 8 p.

    Research output: Contribution to journalArticle

  22. Rituximab therapy reduces organ-specific T cell responses and ameliorates experimental autoimmune encephalomyelitis

    Monson, N. L., Cravens, P., Hussain, R., Harp, C. T., Cummings, M., Martin, M. D. P., Ben, L. H., Do, J., Lyons, J. A., Lovette-Racke, A., Cross, A. H., Racke, M. K., Stüve, O., Shlomchik, M. & Eagar, T. N., 2011, In : PLoS ONE. 6, 2, e17103.

    Research output: Contribution to journalArticle

  23. 2010
  24. Translational research in neurology and neuroscience 2010: Multiple sclerosis

    Stüve, O., Kieseier, B. C., Hemmer, B., Hartung, H. P., Awad, A., Frohman, E. M., Greenberg, B. M., Racke, M. K., Zamvil, S. S., Phillips, J. T., Gold, R., Chan, A., Zettl, U., Milo, R., Marder, E., Khan, O. & Eagar, T. N., Nov 2010, In : Archives of Neurology. 67, 11, p. 1307-1315 9 p.

    Research output: Contribution to journalArticle

  25. Memory B cells from a subset of treatment-naïve relapsing-remitting multiple sclerosis patients elicit CD4+ T-cell proliferation and IFN-γ production in response to myelin basic protein and myelin oligodendrocyte glycoprotein

    Harp, C. T., Ireland, S., Davis, L. S., Remington, G., Cassidy, B., Cravens, P. D., Stuve, O., Lovett-Racke, A. E., Eagar, T. N., Greenberg, B. M., Racke, M. K., Cowell, L. G., Karandikar, N. J., Frohman, E. M. & Monson, N. L., Oct 2010, In : European Journal of Immunology. 40, 10, p. 2942-2956 15 p.

    Research output: Contribution to journalArticle

  26. Analysis of three plasmid systems for use in DNA Aβ42 immunization as therapy for Alzheimer's disease

    Qu, B. X., Lambracht-Washington, D., Fu, M., Eagar, T. N., Stüve, O. & Rosenberg, R. N., Jul 2010, In : Vaccine. 28, 32, p. 5280-5287 8 p.

    Research output: Contribution to journalArticle

  27. Pharmacological prion protein silencing accelerates central nervous system autoimmune disease via T cell receptor signalling

    Hu, W., Nessler, S., Hemmer, B., Eagar, T. N., Kane, L. P., Leliveld, S. R., Müller-Schiffmann, A., Gocke, A. R., Lovett-Racke, A., Ben, L. H., Hussain, R. Z., Breil, A., Elliott, J. L., Puttaparthi, K., Cravens, P. D., Singh, M. P., Petsch, B., Stitz, L., Racke, M. K., Korth, C. & 1 othersStüve, O., Feb 2010, In : Brain. 133, 2, p. 375-388 14 p.

    Research output: Contribution to journalArticle

  28. Reversible alopecia associated with glatiramer acetate

    Pacheco, M. F., Jacobe, H., Eagar, T. N. & Stüve, O., 2010, In : Archives of Neurology. 67, 9, p. 1154 1 p.

    Research output: Contribution to journalArticle

  29. 2009
  30. Direct and consensual murine pupillary reflex metrics: Establishing normative values

    Hussain, R. Z., Hopkins, S. C., Frohman, E. M., Eagar, T. N., Cravens, P. C., Greenberg, B. M., Vernino, S. & Stüve, O., Dec 3 2009, In : Autonomic Neuroscience: Basic and Clinical. 151, 2, p. 164-167 4 p.

    Research output: Contribution to journalArticle

  31. Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR-induced stop signal.

    Fife, B. T., Pauken, K. E., Eagar, T. N., Obu, T., Wu, J., Tang, Q., Azuma, M., Krummel, M. F. & Bluestone, J. A., Nov 2009, In : Nature Immunology. 10, 11, p. 1185-1192 8 p.

    Research output: Contribution to journalArticle

  32. Depletion of B lymphocytes from cerebral perivascular spaces by rituximab

    Martin, M. D. P., Cravens, P. D., Winger, R., Kieseier, B. C., Cepok, S., Eagar, T. N., Zamvil, S. S., Weber, M. S., Frohman, E. M., Kleinschmidt-DeMasters, B. K., Montine, T. J., Hemmer, B., Marra, C. M. & Stüve, O., Aug 2009, In : Archives of Neurology. 66, 8, p. 1016-1020 5 p.

    Research output: Contribution to journalArticle

  33. 200 years after darwin

    Rosenberg, R. N., Stüve, O. & Eagar, T. N., Feb 11 2009, In : JAMA - Journal of the American Medical Association. 301, 6, p. 660-662 3 p.

    Research output: Contribution to journalArticle

  34. 200 years after darwin

    Rosenberg, R. N., Stüve, O. & Eagar, T. N., Feb 2009, In : Archives of Neurology. 66, 2, p. 153-155 3 p.

    Research output: Contribution to journalArticle

  35. Genetic polymorphism at codon 129 of the prion protein gene is not associated with multiple sclerosis

    Stüve, O., Korth, C., Gabatto, P., Cameron, E. M., Hu, W., Eagar, T. N., Monson, N. L., Frohman, E. M., Racke, M. K., Zabetian, C. P. & Oksenberg, J. R., Feb 2009, In : Archives of Neurology. 66, 2, p. 280-281 2 p.

    Research output: Contribution to journalArticle

  36. Quinpramine is a novel compound effective in ameliorating brain autoimmune disease

    Singh, M. P., Hörste, G. M. Z., Hu, W., Mausberg, A. K., Cravens, P. D., Eagar, T. N., Löber, S., Klingenstein, R., Gmeiner, P., Korth, C., Kieseier, B. C. & Stüve, O., Feb 2009, In : Experimental Neurology. 215, 2, p. 397-400 4 p.

    Research output: Contribution to journalArticle

  37. PEG minocycline-liposomes ameliorate CNS autoimmune disease

    Hu, W., Metselaar, J., Ben, L. H., Cravens, P. D., Singh, M. P., Frohman, E. M., Eagar, T. N., Racke, M. K., Kieseier, B. C. & Stüve, O., Jan 7 2009, In : PLoS ONE. 4, 1, e4151.

    Research output: Contribution to journalArticle

  38. DNA β-amyloid1-42 trimer immunization for alzheimer diseaseina wild-type mouse model

    Lambracht-Washington, D., Qu, B. X., Fu, M., Eagar, T. N., Stüve, O. & Rosenberg, R. N., 2009, In : JAMA - Journal of the American Medical Association. 302, 16, p. 1796-1802 7 p.

    Research output: Contribution to journalArticle

  39. 2008
  40. Decrease in the numbers of dendritic cells and CD4 + T cells in cerebral perivascular spaces due to natalizumab

    Del Pilar Martin, M., Cravens, P. D., Winger, R., Frohman, E. M., Racke, M. K., Eagar, T. N., Zamvil, S. S., Weber, M. S., Hemmer, B., Karandikar, N. J., Kleinschmidt-DeMasters, B. K. & Stüve, O., Dec 2008, In : Archives of Neurology. 65, 12, p. 1596-1603 8 p.

    Research output: Contribution to journalArticle

  41. Immunologic Mechanisms of Multiple Sclerosis

    Frohman, E. M., Eagar, T. N., Monson, N., Stuve, O. & Karandikar, N., Nov 2008, In : Neuroimaging Clinics of North America. 18, 4, p. 577-588 12 p.

    Research output: Contribution to journalArticle

  42. B cells, antibodies, and tertiary lymphoid tissue in MS brains

    Stüve, O. & Eagar, T. N., Sep 2008, In : The Lancet Neurology. 7, 9, p. 766-767 2 p.

    Research output: Contribution to journalArticle

  43. DNA-based vaccines: The future of multiple sclerosis therapy?

    Stüve, O., Cravens, P. D. & Eagar, T. N., Mar 2008, In : Expert Review of Neurotherapeutics. 8, 3, p. 351-360 10 p.

    Research output: Contribution to journalArticle

  44. Prion proteins: Physiological functions and role in neurological disorders

    Hu, W., Kieseier, B., Frohman, E., Eagar, T. N., Rosenberg, R. N., Hartung, H. P. & Stüve, O., Jan 15 2008, In : Journal of the neurological sciences. 264, 1-2, p. 1-8 8 p.

    Research output: Contribution to journalArticle

  45. 2007
  46. DNA plasmid vaccination for multiple sclerosis

    Stüve, O., Eagar, T. N., Frohman, E. M. & Cravens, P. D., Oct 2007, In : Archives of Neurology. 64, 10, p. 1385-1386 2 p.

    Research output: Contribution to journalArticle

  47. 2006
  48. Insulin-induced remission in new-onset NOD mice is maintained by the PD-1-PD-L1 pathway

    Fife, B. T., Guleria, I., Bupp, M. G., Eagar, T. N., Tang, Q., Bour-Jordan, H., Yagita, H., Azuma, M., Sayegh, M. H. & Bluestone, J. A., Nov 2006, In : Journal of Experimental Medicine. 203, 12, p. 2737-2747 11 p.

    Research output: Contribution to journalArticle

  49. 2005
  50. Differential induction of IgE-mediated anaphylaxis after soluble vs. cell-bound tolerogenic peptide therapy of autoimmune encephalomyelitis

    Smith, C. E., Eagar, T. N., Strominger, J. L. & Miller, S. D., Jul 5 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 27, p. 9595-9600 6 p.

    Research output: Contribution to journalArticle

  51. 2004
  52. CTLA-4 regulates expansion and differentiation of Th1 cells following induction of peripheral T cell tolerance

    Eagar, T. N., Turley, D. M., Padilla, J., Karandikar, N. J., Tan, L., Bluestone, J. A. & Miller, S. D., Jun 15 2004, In : Journal of Immunology. 172, 12, p. 7442-7450 9 p.

    Research output: Contribution to journalArticle

  53. Notch 1 signaling regulates peripheral T cell activation

    Eagar, T. N., Tang, Q., Wolfe, M., He, Y., Pear, W. S. & Bluestone, J. A., Apr 2004, In : Immunity. 20, 4, p. 407-415 9 p.

    Research output: Contribution to journalArticle

  54. 2002
  55. Functional activation of myelin-specific T cells by virus-induced molecular mimicry

    Olson, J. K., Eagar, T. N. & Miller, S. D., Sep 1 2002, In : Journal of Immunology. 169, 5, p. 2719-2726 8 p.

    Research output: Contribution to journalArticle

  56. The role of CTLA-4 in induction and maintenance of peripheral T cell tolerance

    Eagar, T. N., Karandikar, N. J., Bluestone, J. A. & Miller, S. D., 2002, In : European Journal of Immunology. 32, 4, p. 972-981 10 p.

    Research output: Contribution to journalArticle

  57. 2001
  58. Discordant effects of anti-VLA-4 treatment before and after onset of relapsing experimental autoimmune encephalomyelitis

    Theien, B. E., Vanderlugt, C. L., Eagar, T. N., Nickerson-Nutter, C., Nazareno, R., Kuchroo, V. K. & Miller, S. D., 2001, In : Journal of Clinical Investigation. 107, 8, p. 995-1006 12 p.

    Research output: Contribution to journalArticle

  59. Functional role of epitope spreading in the chronic pathogenesis of autoimmune and virus-induced demyelinating diseases

    Miller, S. D. & Eagar, T. N., 2001, In : Advances in Experimental Medicine and Biology. 490, p. 99-107 9 p.

    Research output: Contribution to journalArticle

  60. 2000
  61. CTLA-4 downregulates epitope spreading and mediates remission in relapsing experimental autoimmune encephalomyelitis

    Karandikar, N. J., Eagar, T. N., Vanderlugt, C. L., Bluestone, J. A. & Miller, S. D., Sep 22 2000, In : Journal of Neuroimmunology. 109, 2, p. 173-180 8 p.

    Research output: Contribution to journalArticle

  62. Pathologic role and temporal appearance of newly emerging autoepitopes in relapsing experimental autoimmune encephalomyelitis

    Vanderlugt, C. L., Neville, K. L., Nikcevich, K. M., Eagar, T. N., Bluestone, J. A. & Miller, S. D., Jan 15 2000, In : Journal of Immunology. 164, 2, p. 670-678 9 p.

    Research output: Contribution to journalArticle

  63. 1998
  64. The functional significance of epitope spreading and its regulation by co-stimulatory molecules

    Vanderlugt, C. L., Begolka, W. S., Neville, K. L., Katz-Levy, Y., Howard, L. M., Eagar, T. N., Bluestone, J. A. & Miller, S. D., Aug 1998, In : Immunological Reviews. 164, p. 63-72 10 p.

    Research output: Contribution to journalArticle

  65. Activation of antigen-specific T cells in vivo induced by tolerogenic encounter with antigen-coupled splenocytes

    Eagar, T. N., Tan, L. J., Leg, H., Barrett, T. & Miller, S. D., Mar 20 1998, In : FASEB Journal. 12, 5

    Research output: Contribution to journalArticle

  66. Tissue-specific up-regulation of B7-1 expression and function during the course of murine relapsing experimental autoimmune encephalomyelitis

    Karandikar, N. J., Vanderlugt, C. L., Eagar, T. N., Tan, L., Bluestone, J. A. & Miller, S. D., 1998, In : Journal of Immunology. 161, 1, p. 192-199 8 p.

    Research output: Contribution to journalArticle

ID: 12616794