Projects per year
Personal profile
Personal profile
Dr. Eagar received his PhD in immunology and molecular pathogenesis from the Northwestern University Medical School in Chicago in 2001. He then completed an immunology fellowship at the University of California at San Francisco and an HLA fellowship at Houston Methodist Hospital. Dr. Eagar was an assistant professor in the Department of Pathology and Immunology at The University of Texas Southwestern Medical Center in Dallas before joining the Department of Pathology and Genomic Medicine here in 2013.
Research interests
Dr. Eagar is board certified in histocompatibility by the American Board of Histocompatibility and Immunogenetics. His research interests include identifying immune processes involved in the pathogenesis of multiple sclerosis and transplant rejection, with a focus on finding novel regulatory pathways involved in T cell activation that might be harnessed for therapeutic intervention.
Research Area Keywords
- Infectious Disease & Pathology
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Projects
- 2 Finished
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Defining Immunology Frailty as a Predictor of Human Liver Allograft Recipient Futility
Lunsford, K. E., Chen, W., Eagar, T. N., Ghobrial, R. M., Graviss, E. A., Gupte, A. A., Hamilton, D. J. & Li, X. C.
4/10/19 → 8/31/19
Project: Federal Funding Agencies
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Modulating B and T cell functions in EAE through gamma secretase and Notch
Natl Inst of Neuro Disorders and Stroke
8/1/13 → 5/31/18
Project: Federal Funding Agencies
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CD11c+CD88+CD317+ myeloid cells are critical mediators of persistent CNS autoimmunity
Manouchehri, N., Hussain, R. Z., Cravens, P. D., Esaulova, E., Artyomov, M. N., Edelson, B. T., Wu, G. F., Cross, A. H., Doelger, R., Loof, N., Eagar, T. N., Forsthuber, T. G., Calvier, L., Herz, J. & Stüve, O., Apr 6 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 14, e2014492118.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Limited window for donation of convalescent plasma with high live-virus neutralizing antibody titers for COVID-19 immunotherapy
Gontu, A., Srinivasan, S., Salazar, E., Nair, M. S., Nissly, R. H., Greenawalt, D., Bird, I. M., Herzog, C. M., Ferrari, M. J., Poojary, I., Katani, R., Lindner, S. E., Minns, A. M., Rossi, R., Christensen, P. A., Castillo, B., Chen, J., Eagar, T. N., Yi, X., Zhao, P. & 7 others, , Feb 24 2021, In: Communications Biology. 4, 1, 267.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Significantly Decreased Mortality in a Large Cohort of Coronavirus Disease 2019 (COVID-19) Patients Transfused Early with Convalescent Plasma Containing High-Titer Anti–Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Spike Protein IgG
Salazar, E., Christensen, P. A., Graviss, E. A., Nguyen, D. T., Castillo, B., Chen, J., Lopez, B. V., Eagar, T. N., Yi, X., Zhao, P., Rogers, J., Shehabeldin, A., Joseph, D., Masud, F., Leveque, C., Olsen, R. J., Bernard, D. W., Gollihar, J. & Musser, J. M., Jan 2021, In: American Journal of Pathology. 191, 1, p. 90-107 18 p.Research output: Contribution to journal › Article › peer-review
Open Access28 Scopus citations -
Convalescent plasma anti–SARS-CoV-2 spike protein ectodomain and receptor-binding domain IgG correlate with virus neutralization
Salazar, E., Kuchipudi, S. V., Christensen, P. A., Eagar, T., Yi, X., Zhao, P., Jin, Z., Long, S. W., Olsen, R. J., Chen, J., Castillo, B., Leveque, C., Towers, D., Lavinder, J., Gollihar, J., Cardona, J., Ippolito, G., Nissly, R., Bird, I., Greenawalt, D. & 14 others, , Dec 1 2020, In: Journal of Clinical Investigation. 130, 12, p. 6728-6738 11 p.Research output: Contribution to journal › Article › peer-review
Open Access31 Scopus citations -
Limitations of cell-lineage-specific non-dynamic gene recombination in CD11c.Cre+ITGA4fl/fl mice
Manouchehri, N., Hussain, R. Z., Cravens, P. D., Doelger, R., Greenberg, B. M., Okuda, D. T., Forsthuber, T. G., Eagar, T. N. & Stüve, O., Jul 15 2020, In: Journal of Neuroimmunology. 344, 577245.Research output: Contribution to journal › Article › peer-review
1 Scopus citations