Thomas A. Kent, MD

  • 6087 Citations
  • 35 h-Index
1982 …2020

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

2020

Oxidized Activated Charcoal Nanoparticles as Catalytic Superoxide Dismutase Mimetics: Evidence for Direct Participation of an Intrinsic Radical

Wu, G., McHugh, E. A., Berka, V., Chen, W., Wang, Z., Beckham, J. L., Derry, P. J., Roy, T., Kent, T. A., Tour, J. M. & Tsai, A. L., Jul 24 2020, In : ACS Applied Nano Materials. 3, 7, p. 6962-6971 10 p.

Research output: Contribution to journalArticle

Pervasive Genomic Damage in Experimental Intracerebral Hemorrhage: Therapeutic Potential of a Mechanistic-Based Carbon Nanoparticle

Dharmalingam, P., Talakatta, G., Mitra, J., Wang, H., Derry, P. J., Nilewski, L. G., McHugh, E. A., Fabian, R. H., Mendoza, K., Vasquez, V., Hegde, P. M., Kakadiaris, E., Roy, T., Boldogh, I., Hegde, V. L., Mitra, S., Tour, J. M., Kent, T. A. & Hegde, M., Mar 24 2020, In : ACS Nano. 14, 3, p. 2827-2846 20 p.

Research output: Contribution to journalArticle

3 Scopus citations

Pulse pressure variability is associated with unfavorable outcomes in acute ischaemic stroke patients treated with intravenous thrombolysis

Katsanos, A. H., Alexandrov, A. V., Mandava, P., Köhrmann, M., Soinne, L., Barreto, A. D., Sharma, V. K., Mikulik, R., Muir, K. W., Rothlisberger, T., Grotta, J. C., Levi, C. R., Molina, C. A., Saqqur, M., Palaiodimou, L., Psaltopoulou, T., Vosko, M. R., Moreira, T., Fiebach, J. B., Rubiera, M. & 6 others, Sandset, E. C., de Havenon, A., Kent, T. A., Alexandrov, A. W., Schellinger, P. D. & Tsivgoulis, G., 2020, (Accepted/In press) In : European Journal of Neurology.

Research output: Contribution to journalArticle

Revisiting the intersection of amyloid, pathologically modified tau and iron in Alzheimer's disease from a ferroptosis perspective

Derry, P. J., Hegde, M. L., Jackson, G. R., Kayed, R., Tour, J. M., Kent, T. A. & Tsa, A-L., Jan 1 2020, In : Progress in Neurobiology. 184, p. 101716 101716.

Research output: Contribution to journalReview article

9 Scopus citations

Use of a bioengineered antioxidant in mouse models of metabolic syndrome

Griffin, D. M., Bitner, B. R., Criss, Z., Marcano, D., Berlin, J. M., Kent, T. A., Tour, J. M., Samson, S. L. & Pautler, R. G., Feb 1 2020, In : Expert Opinion on Investigational Drugs. 29, 2, p. 209-219 11 p.

Research output: Contribution to journalArticle

2019

Catalytic oxidation and reduction reactions of hydrophilic carbon clusters with NADH and cytochrome C: Features of an electron transport nanozyme

Derry, P. J., Nilewski, L. G., Sikkema, W. K. A., Mendoza, K., Jalilov, A., Berka, V., McHugh, E. A., Tsai, A. L., Tour, J. M. & Kent, T. A., Jun 14 2019, In : Nanoscale. 11, 22, p. 10791-10807 17 p.

Research output: Contribution to journalArticle

2 Scopus citations

Critical Comparison of the Superoxide Dismutase-like Activity of Carbon Antioxidant Nanozymes by Direct Superoxide Consumption Kinetic Measurements

Wu, G., Berka, V., Derry, P. J., Mendoza, K., Kakadiaris, E., Roy, T., Kent, T. A., Tour, J. M. & Tsai, A. L., Oct 22 2019, In : ACS Nano. 13, 10, p. 11203-11213 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

Endovascular equipoise shift in a phase III randomized clinical trial of sonothrombolysis for acute ischemic stroke

for the CLOTBUST-ER Trial Investigators, Jul 1 2019, In : Therapeutic Advances in Neurological Disorders. 12

Research output: Contribution to journalArticle

2 Scopus citations

Functional and Structural Improvement with a Catalytic Carbon Nano-Antioxidant in Experimental Traumatic Brain Injury Complicated by Hypotension and Resuscitation

Mendoza, K., Derry, P. J., Cherian, L. M., Garcia, R., Nilewski, L., Goodman, J. C., Mbye, L., Robertson, C. S., Tour, J. M. & Kent, T. A., Jul 1 2019, In : Journal of Neurotrauma. 36, 13, p. 2139-2146 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Highly Oxidized Graphene Quantum Dots from Coal as Efficient Antioxidants

Nilewski, L., Mendoza, K., Jalilov, A. S., Berka, V., Wu, G., Sikkema, W. K. A., Metzger, A., Ye, R., Zhang, R., Luong, D. X., Wang, T., McHugh, E., Derry, P. J., Samuel, E. L., Kent, T. A., Tsai, A. L. & Tour, J. M., May 8 2019, In : ACS Applied Materials and Interfaces. 11, 18, p. 16815-16821 7 p.

Research output: Contribution to journalArticle

9 Scopus citations

Pooled analysis suggests benefit of catheter-based hematoma removal for intracerebral hemorrhage

Mandava, P., Murthy, S. B., Shah, N., Samson, Y., Kimmel, M. & Kent, T. A., Apr 9 2019, In : Neurology. 92, 15, p. e1688-e1697

Research output: Contribution to journalArticle

1 Scopus citations

Safety and efficacy of sonothrombolysis for acute ischaemic stroke: a multicentre, double-blind, phase 3, randomised controlled trial

CLOTBUST-ER Trial Investigators, Apr 2019, In : The Lancet Neurology. 18, 4, p. 338-347 10 p.

Research output: Contribution to journalArticle

12 Scopus citations

Telemedicine in Prehospital Acute Stroke Care: An Expanding Infrastructure for Treatment and Research

Derry, P. J., Mandava, P. & Kent, T. A., Mar 19 2019, In : Journal of the American Heart Association. 8, 6, e012259.

Research output: Contribution to journalEditorial

2018

Efficacy of novel carbon nanoparticle antioxidant therapy in a severe model of Reversible middle cerebral artery stroke in acutely hyperglycemic rats

Fabian, R. H., Derry, P. J., Rea, H. C., Dalmeida, W. V., Nilewski, L. G., Sikkema, W. K. A., Mandava, P., Tsai, A. L., Mendoza, K., Berka, V., Tour, J. M. & Kent, T. A., Apr 9 2018, In : Frontiers in Neurology. 9, APR, 199.

Research output: Contribution to journalArticle

12 Scopus citations

Inability of positive phase II clinical trials of investigational treatments to subsequently predict positive phase III clinical trials in glioblastoma

Mandel, J. J., Yust-Katz, S., Patel, A. J., Cachia, D., Liu, DI., Park, M., Yuan, Y., Kent, T. A. & De Groot, J. F., Jan 1 2018, In : Neuro-oncology. 20, 1, p. 113-122 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

Rho Guanine Nucleotide Exchange Factor ARHGEF17 Is a Risk Gene for Intracranial Aneurysms

Yang, X., Li, J., Fang, Y., Zhang, Z., Jin, D., Chen, X., Zhao, Y., Li, M., Huan, L., Kent, T. A., Dong, J. F., Jiang, R., Yang, S., Jin, L., Zhang, J., Zhong, T. P. & Yu, F., Jul 1 2018, In : Circulation. Genomic and precision medicine. 11, 7, p. e002099

Research output: Contribution to journalArticle

6 Scopus citations

RIP1K Contributes to Neuronal and Astrocytic Cell Death in Ischemic Stroke via Activating Autophagic-lysosomal Pathway

Ni, Y., Gu, W. W., Liu, Z. H., Zhu, Y. M., Rong, J. G., Kent, T. A., Li, M., Qiao, S. G., An, J. Z. & Zhang, H. L., Feb 10 2018, In : Neuroscience. 371, p. 60-74 15 p.

Research output: Contribution to journalArticle

23 Scopus citations
2017

Correlating quantitative susceptibility mapping with cognitive decline in Alzheimer's disease

Derry, P. J. & Kent, T. A., Aug 1 2017, In : Brain. 140, 8, p. 2069-2072 4 p.

Research output: Contribution to journalComment/debate

5 Scopus citations

Emotion dysregulation as an underlying mechanism of impulsive aggression: Reviewing empirical data to inform treatments for veterans who perpetrate violence

Miles, S. R., Sharp, C., Tharp, A. T., Stanford, M. S., Stanley, M., Thompson, K. E. & Kent, T. A., May 1 2017, In : Aggression and Violent Behavior. 34, p. 147-153 7 p.

Research output: Contribution to journalReview article

7 Scopus citations

Hemorrhagic stroke and cerebral venous sinus thrombosis

Martini, S. R. & Kent, T. A., Jan 1 2017, Cardiology Secrets. Elsevier, p. 505-509 5 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Inhibition of autophagy blocks cathepsins-tBid-mitochondrial apoptotic signaling pathway via stabilization of lysosomal membrane in ischemic astrocytes

Zhou, X. Y., Luo, Y., Zhu, Y. M., Liu, Z. H., Kent, T. A., Rong, J. G., Li, W., Qiao, S. G., Li, M., Ni, Y., Ishidoh, K. & Zhang, H. L., 2017, In : Cell Death and Disease. 8, 2, e2618.

Research output: Contribution to journalArticle

30 Scopus citations

Ischemic stroke

Martini, S. R. & Kent, T. A., Jan 1 2017, Cardiology Secrets. Elsevier, p. 493-504 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Perylene Diimide as a Precise Graphene-like Superoxide Dismutase Mimetic

Jalilov, A. S., Nilewski, L. G., Berka, V., Zhang, C., Yakovenko, A. A., Wu, G., Kent, T. A., Tsai, A. L. & Tour, J. M., Feb 28 2017, In : ACS Nano. 11, 2, p. 2024-2032 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

Sevoflurane postconditioning attenuates reactive astrogliosis and glial scar formation after ischemia–reperfusion brain injury

Zhu, Y. M., Gao, X., Ni, Y., Li, W., Kent, T. A., Qiao, S. G., Wang, C., Xu, X. X. & Zhang, H. L., Jul 25 2017, In : Neuroscience. 356, p. 125-141 17 p.

Research output: Contribution to journalArticle

16 Scopus citations
2016

Biocompatibility of reduced graphene oxide nanoscaffolds following acute spinal cord injury in rats

Palejwala, A. H., Fridley, J. S., Mata, J. A., Samuel, E. L. G., Luerssen, T. G., Perlaky, L., Kent, T. A., Tour, J. M. & Jea, A., Jan 1 2016, In : Surgical Neurology International. 7, 1, 188905.

Research output: Contribution to journalArticle

18 Scopus citations

Cerebrovascular disease

Martini, S. R. & Kent, T. A., May 3 2016, Neurology Secrets: Sixth Edition. Elsevier Inc., p. 222-233 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Embracing Biological and Methodological Variance in a New Approach to Pre-Clinical Stroke Testing

Kent, T. A. & Mandava, P., Aug 1 2016, In : Translational Stroke Research. 7, 4, p. 274-283 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

Erratum to: The effect of a locally adapted, secondary stroke risk factor self-management program on medication adherence among veterans with stroke (Behav Med Pract Policy Res, 10.1007/s13142-015-0348-6)

Damush, T. M., Myers, L., Anderson, J. A., Yu, Z., Ofner, S., Nicholas, G., Kimmel, B., Schmid, A. A., Kent, T. A. & Williams, L. S., Sep 1 2016, In : Translational Behavioral Medicine. 6, 3, 1 p.

Research output: Contribution to journalComment/debate

Insulin resistance intervention after stroke trial of pioglitazone: Is this perhaps the end of the beginning?

Ntaios, G. & Kent, T. A., Jul 1 2016, In : Stroke. 47, 7, p. 1962-1964 3 p.

Research output: Contribution to journalShort survey

Mechanistic Study of the Conversion of Superoxide to Oxygen and Hydrogen Peroxide in Carbon Nanoparticles

Jalilov, A. S., Zhang, C., Samuel, E. L. G., Sikkema, W. K. A., Wu, G., Berka, V., Kent, T. A., Tsai, A. L. & Tour, J. M., Jun 22 2016, In : ACS Applied Materials and Interfaces. 8, 24, p. 15086-15092 7 p.

Research output: Contribution to journalArticle

18 Scopus citations

Single-session emotion regulation skills training to reduce aggression in combat veterans: A clinical innovation case study

Miles, S. R., Thompson, K. E., Stanley, M. A. & Kent, T. A., May 1 2016, In : Psychological Services. 13, 2, p. 170-177 8 p.

Research output: Contribution to journalArticle

4 Scopus citations

The effect of a locally adapted, secondary stroke risk factor self-management program on medication adherence among veterans with stroke/TIA

Damush, T. M., Myers, L., Anderson, J. A., Yu, Z., Ofner, S., Nicholas, G., Kimmel, B., Schmid, A. A., Kent, T. A. & Williams, L. S., Sep 1 2016, In : Translational Behavioral Medicine. 6, 3, p. 457-468 12 p.

Research output: Contribution to journalArticle

10 Scopus citations
2015

An Outcome Model for Intravenous rt-PA in Acute Ischemic Stroke

Mandava, P., Shah, S. D., Sarma, A. K. & Kent, T. A., Dec 1 2015, In : Translational Stroke Research. 6, 6, p. 451-457 7 p.

Research output: Contribution to journalArticle

10 Scopus citations

Carbon nanoparticles and oxidative stress: Could an injection stop brain damage in minutes?

Nilewski, L. G., Sikkema, W. K., Kent, T. A. & Tour, J. M., Jun 1 2015, In : Nanomedicine. 10, 11, p. 1677-1679 3 p.

Research output: Contribution to journalReview article

10 Scopus citations

Emotion dysregulation mediates the relationship between traumatic exposure and aggression in healthy young women

Miles, S. R., Tharp, A. T., Stanford, M. S., Sharp, C., Menefee, D. & Kent, T. A., Apr 1 2015, In : Personality and Individual Differences. 76, p. 222-227 6 p.

Research output: Contribution to journalArticle

9 Scopus citations

Highly efficient conversion of superoxide to oxygen using hydrophilic carbon clusters

Samuel, E. L. G., Marcano, D. C., Berka, V., Bitner, B. R., Wu, G., Potter, A., Fabian, R. H., Pautler, R. G., Kent, T. A., Tsai, A. L. & Tour, J. M., Feb 24 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 8, p. 2343-2348 6 p.

Research output: Contribution to journalArticle

70 Scopus citations

Improving early clinical trial phase identification of promising therapeutics

Kent, T. A., Shah, S. D. & Mandava, P., Jan 1 2015, In : Neurology. 85, 3, p. 274-283 10 p.

Research output: Contribution to journalReview article

6 Scopus citations

The prevalence of epilepsy and association with traumatic brain injury in veterans of the Afghanistan and Iraq wars

Pugh, M. J. V., Orman, J. A., Jaramillo, C. A., Salinsky, M. C., Eapen, B. C., Towne, A. R., Amuan, M. E., Roman, G., McNamee, S. D., Kent, T. A., McMillan, K. K., Hamid, H. & Grafman, J. H., Jan 21 2015, In : Journal of Head Trauma Rehabilitation. 30, 1, p. 29-37 9 p.

Research output: Contribution to journalArticle

26 Scopus citations

The Relationship Between Emotion Dysregulation and Impulsive Aggression in Veterans With Posttraumatic Stress Disorder Symptoms

Miles, S. R., Menefee, D. S., Wanner, J., Teten Tharp, A. & Kent, T. A., 2015, In : Journal of Interpersonal Violence. 31, 10, p. 1795-1816 22 p.

Research output: Contribution to journalArticle

40 Scopus citations
2014

Exploratory analysis of glyburide as a novel therapy for preventing brain swelling

Sheth, K. N., Taylor Kimberly, W., Elm, J. J., Kent, T. A., Yoo, A. J., Thomalla, G., Campbell, B., Donnan, G. A., Davis, S. M., Albers, G. W., Jacobson, S., Del Zoppo, G., Marc Simard, J., Stern, B. J. & Mandava, P., Aug 2014, In : Neurocritical Care. 21, 1, p. 43-51 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

Hydrophilic carbon clusters as therapeutic, high-capacity antioxidants

Samuel, E. L. G., Duong, M. L. T., Bitner, B. R., Marcano, D. C., Tour, J. M. & Kent, T. A., Oct 1 2014, In : Trends in Biotechnology. 32, 10, p. 501-505 5 p.

Research output: Contribution to journalReview article

17 Scopus citations

Hyperglycemia Worsens Outcome After rt-PA Primarily in the Large-Vessel Occlusive Stroke Subtype

Mandava, P., Martini, S. R., Munoz, M., Dalmeida, W., Sarma, A. K., Anderson, J. A., Fabian, R. H. & Kent, T. A., Aug 1 2014, In : Translational Stroke Research. 5, 4, p. 519-525 7 p.

Research output: Contribution to journalArticle

30 Scopus citations

Influence of racial differences on outcomes after thrombolytic therapy in acute ischemic stroke

Mishra, N. K., Mandava, P., Chen, C., Grotta, J., Lees, K. R., Kent, T. A., Alexandrov, A., Bath, P. W., Bluhmki, E., Claesson, L., Curram, J., Davis, S. M., Donnan, G., Diener, H. C., Fisher, M., Gregson, B., Grotta, J., Hacke, W., Hennerici, M. G., Hommel, M. & 10 others, Kaste, M., Lyden, P., Marler, J., Muir, K., Sacco, R., Shuaib, A., Teal, P., Wahlgren, N. G., Warach, S. & Weimar, C., Jul 1 2014, In : International Journal of Stroke. 9, 5, p. 613-617 5 p.

Research output: Contribution to journalArticle

4 Scopus citations

Pilot study of intravenous glyburide in patients with a large ischemic stroke

Sheth, K. N., Kimberly, W. T., Elm, J. J., Kent, T. A., Mandava, P., Yoo, A. J., Thomalla, G., Campbell, B., Donnan, G. A., Davis, S. M., Albers, G. W., Jacobson, S., Simard, J. M. & Stern, B. J., Jan 2014, In : Stroke. 45, 1, p. 281-283 3 p.

Research output: Contribution to journalArticle

54 Scopus citations
2013

A pilot test of videoconferencing to improve access to a stroke risk-reduction programme for Veterans

Anderson, J., Godwin, K. M., Petersen, N. J., Willson, P. & Kent, T. A., Dec 17 2013, In : Journal of Telemedicine and Telecare. 19, 3, p. 153-159 7 p.

Research output: Contribution to journalArticle

3 Scopus citations

Biocompatibility of pristine graphene for neuronal interface: Laboratory investigation

Sahni, D., Jea, A., Mata, J. A., Marcano, D. C., Sivaganesan, A., Berlin, J. M., Tatsui, C. E., Sun, Z., Luerssen, T. G., Meng, S., Kent, T. A. & Tour, J. M., May 1 2013, In : Journal of Neurosurgery: Pediatrics. 11, 5, p. 575-583 9 p.

Research output: Contribution to journalArticle

51 Scopus citations

Design of poly(ethylene glycol)-functionalized hydrophilic carbon clusters for targeted therapy of cerebrovascular dysfunction in mild traumatic brain injury

Marcano, D. C., Bitner, B. R., Berlin, J. M., Jarjour, J., Lee, J. M., Jacob, A., Fabian, R. H., Kent, T. A. & Tour, J. M., May 1 2013, In : Journal of Neurotrauma. 30, 9, p. 789-796 8 p.

Research output: Contribution to journalArticle

26 Scopus citations

Explicit consideration of baseline factors to assess recombinant tissue-type plasminogen activator response with respect to race and sex

Mandava, P., Murthy, S. B., Munoz, M., McGuire, D., Simon, R. P., Alexandrov, A. V., Albright, K. C., Boehme, A. K., Martin-Schild, S., Martini, S. & Kent, T. A., Jun 2013, In : Stroke. 44, 6, p. 1525-1531 7 p.

Research output: Contribution to journalArticle

10 Scopus citations

Quantification of Errors in Ordinal Outcome Scales Using Shannon Entropy: Effect on Sample Size Calculations

Mandava, P., Krumpelman, C. S., Shah, J. N., White, D. L. & Kent, T. A., Jul 5 2013, In : PLoS ONE. 8, 7, e67754.

Research output: Contribution to journalArticle

10 Scopus citations

Stroke and Transient Ischemic Attack

Martini, S. R. & Kent, T. A., May 1 2013, Cardiology Secrets: Fourth Edition. Elsevier, p. 433-443 11 p.

Research output: Chapter in Book/Report/Conference proceedingChapter