Personal profile

Dr. Pandita earned his Ph.D. in Cytogenetics from Panjab University in 1980. He held faculty appointments at Columbia University in New York, Washington University in St.  Louis, Missouri, and The University of Texas Southwestern Medical Center in Dallas, Texas before becoming a member of the Houston Methodist Research Institute in 2014.  As a member of the Cancer Research Program, he directs a research program focusing on DNA repair and radiotherapy.  Dr. Pandita was elected the Fellow of the American Association of Advancement of Science in 2013. He has also been a member of several NIH study sections and review boards. He is the past Chairman of A-T Workshop 2012 (ATW2012) International meeting. Dr. Pandita serves on the editorial board for the journals Cancer Research, Genomic Integrity, BMC Genomics, and served as a chartered member of the CMAD NIH Study Section.

Research interests

Dr. Pandita's research employs radiation genetics and biology to study the relationships between DNA sequence, chromatin structure and sensitivity to IR. The long-term goal of the research projects is to understand the mechanistic role of chromatin structure in regulating the cell survival response to IR-induced DNA damage. This knowledge base will be used by the laboratory to develop clinically relevant methods to increase tumor cell response to IR-based therapies while decreasing injury to adjacent, normal tissue.

Dr. Pandita's main areas of research are the following:
-To define, at the chromatin level, the function of H4K16ac in DNA DSB repair.
-To determine the role of ATM dependent MOF phosphorylation in the cellular response to IR.
-To determine the pathobiology of mutant mice defective for MOF T392 phosphorylation in order to test the hypothesis that Mof plays a critical role in oncogenic transformation in vivo.
-To determine the mechanisitic basis for enhanced tumor cell radiosensitivity following HP1β loss or hyperthermia.

Keywords

    Free-text keywords

  • DNA damage response, DNA DSB repair, Radiation signaling, Telomere metabolism, Chromatin structure

    Research Area Keywords

  • Imaging & Radiology
  • Cancer

Fingerprint

Ataxia Telangiectasia
Concept: Ataxia Telangiectasia
Weight: 100%
Domain: Medicine & Life Sciences
DNA Damage
Concept: DNA Damage
Weight: 94%
Domain: Medicine & Life Sciences
Telomere
Concept: Telomere
Weight: 86%
Domain: Medicine & Life Sciences
Ionizing Radiation
Concept: Ionizing Radiation
Weight: 84%
Domain: Medicine & Life Sciences
Double-Stranded DNA Breaks
Concept: Double-Stranded DNA Breaks
Weight: 58%
Domain: Medicine & Life Sciences
Genomic Instability
Concept: Genomic Instability
Weight: 57%
Domain: Medicine & Life Sciences
DNA Repair
Concept: DNA Repair
Weight: 55%
Domain: Medicine & Life Sciences
Telomerase
Concept: Telomerase
Weight: 49%
Domain: Medicine & Life Sciences
Chromatin
Concept: Chromatin
Weight: 44%
Domain: Medicine & Life Sciences
Chromosomes
Concept: Chromosomes
Weight: 41%
Domain: Medicine & Life Sciences
Research OutputsResearch Output authored by Tej K. Pandita is tagged with the concept

Journals

Molecular and Cellular Biology

ISSNs: 0270-7306

American Society for Microbiology

Journal

19

Oncogene

ISSNs: 0950-9232

Additional searchable ISSN (Electronic): 1476-5594

Nature Publishing Group

Journal

13

Radiation Research

ISSNs: 0033-7587

Radiation Research Society

Journal

11

Cancer Research

ISSNs: 0008-5472

American Association for Cancer Research Inc.

Journal

10

Proceedings of the National Academy of Sciences of the United States of America

ISSNs: 0027-8424

Journal

7
has published Research OutputsResearch Output by Tej K. Pandita

Research Network

Visualization: Institutional Network

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Tej K. Pandita

Visualization: Co-author Network

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Tej K. Pandita

Shared Pub. Internal Organizations

Houston Methodist Hospital

Organizational unit: Schools & Hospitals

9

Neurosciences Research Program

Organizational unit: Programs

4

Department of Medicine

Organizational unit: Departments

2

Department of Nanomedicine

Organizational unit: Departments

2

Stanley H. Appel Department of Neurology

Organizational unit: Departments

1
has Research OutputsResearch Output by Tej K. Pandita

Shared Pub. External Organizations

Washington Univ. School of Medicine

External organization: Unknown

46

VA North Texas Care System

External organization: Unknown

27

Columbia University, College of Physicians and Surgeons

External organization: Unknown

21

Columbia University in the City of New York

External organization: Unknown

20

Houston Methodist Research Institute

External organization: Unknown

18
has Research OutputsResearch Output by Tej K. Pandita

Shared Pub. Internal co-authors

has co-authored Research OutputsResearch Output with Tej K. Pandita

Shared Pub. External co-authors

Raj K. Pandita

External person

36

Girdhar G. Sharma

External person

20

Arun Gupta

External person

19

Raj K. Pandita

External person

16

S. Dhar

External person

14
has co-authored Research OutputsResearch Output with Tej K. Pandita

ID: 2283159