Stephen T. Wong, PhD

Personal profile

Dr. Wong holds the John S. Dunn, Sr. Distinguished Endowed Chair in Biomedical Engineering; he is also a Professor of Radiology, Pathology, Laboratory Medicine, Neurology, and Neurosciences, the Associate Director of Translational Research at Methodist Cancer Center, and Chief of Medical Physics and Chief Research Information Officer at Houston Methodist Hospital. In addition, he serves as the Founding Director of the Ting Tsung and Wei Fong Chao Center for BRAIN (Bioinformatics Research and Imaging in the Neurosciences) and Founding Director of the Center for Modeling Cancer Development at Houston Methodist Research Institute. He also holds a dozen of other academic posts across institutions in Texas Medical Center as well as overseas universities and medical schools.

An internationally acclaimed bioengineer and imaging scientist, Dr. Stephen Wong has led teams that developed production automation for first very large scale integration (VLSI) 1MB computer memory chip and the largest online brokerage trading system, and contributed to the first hospital-wide digital radiology image management system in US academic medical centers.

Dr. Wong has more than twenty years of research and management experience in industry and academia, including Hewlett-Packard, AT&T Bell Laboratories, the Japanese Fifth Generation Computer Systems Project, Philips Medical Systems and Royal Philips Electronics, Charles Schwab, University of California - San Francisco/Berkeley, Harvard University and Houston Methodist Hospital. He received his senior executive education from the MIT Sloan School of Management, Stanford University Graduate School of Business and Columbia University Graduate School of Business. He holds many patents and has published over 300 peer-reviewed papers and four books. He also serves on and chairs NIH study panels, conference program committees, and the editorial boards of twelve scientific journals. As an international authority, he is sought as a speaker on medical imaging, systems biology, healthcare IT, drug development, biophotonics, clinical neuroscience and other related topics.

Research interests

Dr. Wong's research focuses on understanding health and disease from a systems perspective in order to generate cost-effective strategies and solutions for disease management. His research approaches combine both experimental and high throughput biology with rigorous computational, bioinformatics, biophysics, and imaging methods to achieve a deep understanding of the functions of each component in biological systems and integration of them with multilevel systems analysis. For example, the consequences of genetic variation, cell-cell interactions and environmental factors are included to reflect the circumstances and microenvironments of the disease condition. Current research projects include pathway modeling and high throughput phenotyping approaches for target discovery and drug repurposing in combating neurological disorders and cancer, and for understanding the mechanisms of these diseases. Additional projects include reformulation of small molecule drugs using chemical biology approaches, the development of point-of-care molecular diagnosis and monitoring devices using biophotonics and nanotechnology techniques, and the development of label-free molecular image-guided cancer therapy platforms.


    Research Area Keywords

  • Cancer
  • Imaging & Radiology
  • Outcomes, Quality & Health Care Performance
  • Systems Medicine & Bioinformatics

    Free-text keywords

  • Biological and medical imaging, Bioinformatics , Systems biology, Drug repositioning, Drug combinations, Image-guided therapy, Translational biophotonics, Molecular imaging, Diagnosis, Mechanisms of cancer , Mechanisms of neurological disorders


Concept: Neoplasms
Weight: 100%
Domain: Medicine & Life Sciences
Imaging techniques
Concept: Imaging techniques
Weight: 98%
Domain: Engineering & Materials Science
Concept: Cells
Weight: 73%
Domain: Engineering & Materials Science
Microscopic examination
Concept: Microscopic examination
Weight: 67%
Domain: Engineering & Materials Science
Concept: Brain
Weight: 59%
Domain: Engineering & Materials Science
Concept: Neurons
Weight: 55%
Domain: Engineering & Materials Science
Concept: Microscopy
Weight: 55%
Domain: Medicine & Life Sciences
Concept: Genes
Weight: 54%
Domain: Engineering & Materials Science
Concept: Screening
Weight: 53%
Domain: Engineering & Materials Science
Breast Neoplasms
Concept: Breast Neoplasms
Weight: 52%
Domain: Medicine & Life Sciences
Research OutputsResearch Output authored by Stephen T. Wong is tagged with the concept


Computerized Medical Imaging and Graphics

ISSNs: 0895-6111

Additional searchable ISSN (Electronic): 1879-0771

Elsevier Limited




ISSNs: 1539-2791

Humana Press




ISSNs: 1053-8119

Additional searchable ISSN (Electronic): 1095-9572

Academic Press




ISSNs: 1367-4803

Additional searchable ISSN (Electronic): 1460-2059

Oxford University Press



Cancer Research

ISSNs: 0008-5472

American Association for Cancer Research Inc.


has published Research OutputsResearch Output by Stephen T. Wong

Research Network

Visualization: Institutional Network

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Stephen T. Wong

Visualization: Co-author Network

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Stephen T. Wong

Shared Pub. Internal Organizations

Houston Methodist Hospital

Organizational unit: Schools & Hospitals


Department of Neurosurgery

Organizational unit: Departments


Department of Radiology

Organizational unit: Departments


Department of Medicine

Organizational unit: Departments


Department of Pathology & Genomic Medicine

Organizational unit: Departments

has Research OutputsResearch Output by Stephen T. Wong

Shared Pub. External Organizations

Houston Methodist Research Institute

External organization: Unknown


Harvard Medical School

External organization: Unknown


Brigham and Women's Hospital

External organization: Unknown


University of California, San Francisco

External organization: Unknown


Northwestern Polytechnic University

External organization: Unknown

has Research OutputsResearch Output by Stephen T. Wong

Shared Pub. Internal co-authors

has co-authored Research OutputsResearch Output with Stephen T. Wong

Shared Pub. External co-authors

Xiaobo Zhou

External person


Lei Guo

External person


Tianming Liu

External person


Geoffrey S. Young

External person


Xiaoyin Xu

External person

has co-authored Research OutputsResearch Output with Stephen T. Wong

ID: 2285218