Stephen H. Little, MD

Personal profile

Dr. Little, a cardiologist with the Houston Methodist DeBakey Heart & Vascular Center, is medical director of The Valve Clinic – a multidisciplinary medical clinic focused on the assessment and treatment of complex valvular heart disease. He also serves as Director of the Houston Methodist Valve Institute and is director of the Cardiovascular Hemodynamics Imaging Laboratory (CHIL).

Dr. Little’s recent research activities and peer-reviewed publications have focused on novel use of 3-D echocardiography for the quantification of native and prosthetic valve dysfunction as well as imaging guidance for percutaneous structural heart interventions. His team has created a robust in vitro flow system for multimodality functional valve imaging under tailored hemodynamic conditions. In collaboration with research scientists and mathematicians, Dr. Little’s research group creates complex heart valve constructs to address an increasingly important clinical need - To improve our understanding of heart valve dysfunction by employing multimodality imaging to better characterize and quantify these complex intra- cardiac flow conditions.

He received his medical degree from McMaster University and completed post graduate training in internal medicine and cardiology at the University of Western Ontario. Dr. Little completed research fellowships in echocardiography at the University of Ottawa Heart Institute and at Baylor College of Medicine, Houston. He is a fellow of the Royal College of Physicians and Surgeons of Canada, the American College of Cardiology, and the American Society of Echocardiography. Dr. Little serves on the Board of Directors for the American Society of Echocardiography as well as on ASE committees for Industry Relations, Public Relations, and writing groups.

Dr. Little has given more than 100 invited lectures nationally and internationally. He is an associate professor of clinical Medicine at Weill Cornell Medical College, and adjunct associate professor at Rice University, Dept. of Bioengineering.

Research interests

After completing sub-specialty Cardiology training (Royal College of Physicians and Surgeon of Canada), Dr. Little completed a postdoctoral fellowship in echocardiography at the Ottawa Heart Institute. He then completed a second postdoctoral fellowship, under the supervision of Dr. W. Zoghbi at Baylor College of Medicine, Houston.  As an assistant  professor  in Canada, he continued to develop novel  strategies to visualize  the prosthetic valve function using 3D transesophageal echocardiography.  In 2007 he was recruited back to Houston to join the Cardiovascular Imaging Institute of the Methodist DeBakey Heart & Vascular Center. As medical director of the MDHVC Heart Valve Clinic, and as a cardiologist interpreting ~3000 patient echocardiograms/year, he has established research programs based on the multi-modality imaging of native and prosthetic valves. Over the last five years, he also leads a team to create a robust in vitro flow system to simulate simple and complex heart valve constructs. As a natural extension of his interest in valve disease and my expertise in 3D imaging, his research group has recently begun collaborations with research scientists and mathematicians to address an increasingly important clinical need - To improve our understanding of heart valve dysfunction by employing multimodality imaging to better characterize and quantity these complex intra- cardiac flow conditions.

Keywords

    Research Area Keywords

  • Heart & Vascular
  • Imaging & Radiology
  • Clinical Translation & Trials
  • Clinical Care

    Free-text keywords

  • Valvular disease, Mitral regurgitation, Echocardiography

Fingerprint

Mitral Valve Insufficiency
Concept: Mitral Valve Insufficiency
Weight: 100%
Domain: Medicine & Life Sciences
Mitral Valve
Concept: Mitral Valve
Weight: 71%
Domain: Medicine & Life Sciences
Three-Dimensional Echocardiography
Concept: Three-Dimensional Echocardiography
Weight: 68%
Domain: Medicine & Life Sciences
Doppler Color Echocardiography
Concept: Doppler Color Echocardiography
Weight: 62%
Domain: Medicine & Life Sciences
Transesophageal Echocardiography
Concept: Transesophageal Echocardiography
Weight: 52%
Domain: Medicine & Life Sciences
Heart Valve Prosthesis Implantation
Concept: Heart Valve Prosthesis Implantation
Weight: 42%
Domain: Medicine & Life Sciences
Aortic Valve
Concept: Aortic Valve
Weight: 41%
Domain: Medicine & Life Sciences
Echocardiography
Concept: Echocardiography
Weight: 39%
Domain: Medicine & Life Sciences
Aortic Valve Stenosis
Concept: Aortic Valve Stenosis
Weight: 28%
Domain: Medicine & Life Sciences
Heart Valves
Concept: Heart Valves
Weight: 25%
Domain: Medicine & Life Sciences
Research OutputsResearch Output authored by Stephen H. Little is tagged with the concept

Journals

Methodist DeBakey Cardiovascular Journal

ISSNs: 1947-6094

Additional searchable ISSN (Electronic): 1947-6108

Methodist DeBakey Heart & Vascular Center, United States

Journal

20

Journal of the American Society of Echocardiography

ISSNs: 0894-7317

Mosby Inc.

Journal

12

JACC: Cardiovascular Imaging

ISSNs: 1936-878X

Additional searchable ISSN (Electronic): 1876-7591

Elsevier

Journal

12

Annals of Biomedical Engineering

ISSNs: 0090-6964

Additional searchable ISSN (Electronic): 1573-9686

Springer Netherlands

Journal

6

Journal of the American College of Cardiology.

ISSNs: 0735-1097

Elsevier

Journal

5
has published Research OutputsResearch Output by Stephen H. Little

Research Network

Visualization: Institutional Network

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Stephen H. Little

Visualization: Co-author Network

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Stephen H. Little

Shared Pub. Internal Organizations

Department of Cardiovascular Surgery

Organizational unit: Departments

28
14

Center for Cardiovascular Regeneration

Organizational unit: Programs

8

Center for Outcomes Research

Organizational unit: Programs

4

Department of Anesthesiology & Critical Care

Organizational unit: Departments

1
has Research OutputsResearch Output by Stephen H. Little

Shared Pub. External Organizations

Houston Methodist Research Institute

External organization: Unknown

42

Rice University

External organization: Academic

8

Baylor College of Medicine

External organization: Unknown

7

University of Houston

External organization: Unknown

7

University of California

External organization: Unknown

6
has Research OutputsResearch Output by Stephen H. Little

Shared Pub. Internal co-authors

has co-authored Research OutputsResearch Output with Stephen H. Little

Shared Pub. External co-authors

Dimitrios Maragiannis

External person

14

Stephen R. Igo

External person

11

Eleonora Avenatti

External person

10

Marti McCulloch

External person

7

Sagit Ben Zekry

External person

7
has co-authored Research OutputsResearch Output with Stephen H. Little

ID: 2282390