Projects per year
Personal profile
Personal profile
Dr. Little is a cardiologist with the Houston Methodist DeBakey Heart & Vascular Center and program director of the Cardiovascular Fellowship. In addition, he is director of Structural Heart for the Houston Methodist Hospital System, and medical director of the Valve Clinic. He also serves as director of the Cardiovascular Hemodynamics Imaging Laboratory (CHIL).
After completing sub-specialty Cardiology training at the Royal College of Physicians and Surgeon of Canada, Dr. Little completed a postdoctoral fellowship in echocardiography at the Ottawa Heart Institute. He then completed a postdoctoral fellowship, under the supervision of Dr. W. Zoghbi at Baylor College of Medicine, Houston. In 2007 he was recruited back to Houston to join the Cardiovascular Imaging Institute of Houston Methodist DeBakey Heart & Vascular Center.
He is a fellow of the Royal College of Physicians and Surgeons of Canada, the American College of Cardiology, and the American Society of Echocardiography. For the American Society of Echocardiography, Dr. Little served on the Board of Directors, was chair of the guidelines committee, and is the current vice-president.
Dr. Little has given more than 150 invited lectures nationally and internationally. He is an associate professor of clinical Medicine at Weill Cornell Medical College, and adjunct associate professor at Rice University, Dept. of Bioengineering.
Research interests
Dr. Little’s recent research activities and peer-reviewed publications have focused on novel use of 3D echocardiography for the quantification of native and prosthetic valve dysfunction as well as imaging guidance for percutaneous structural heart interventions. His team has created a robust in vitro flow system for multimodality functional valve imaging under tailored hemodynamic conditions.
As principal investigator, Dr. Little leads Houston Methodists participation in the international Triluminate Clinical Trial of catheter-based therapy for tricuspid valve regurgitation and participates as a co-investigator in multiple other structural heart trials at Houston Methodist.
Education/Academic qualification
Echocardiography, Clinical Fellowship, Baylor College of Medicine
Jul 1 2004 → Jun 1 2005
Award Date: Jun 1 2005
Internal Medicine, Residency, Western University
Jul 1 1997 → Jun 1 2003
Award Date: Jun 1 2003
MD, McMaster University School of Medicine
Sep 1 1994 → May 1 1997
Award Date: May 1 1997
External positions
Associate Professor of Clinical Medicine, Weill Cornell Medical College
Jun 1 2014 → …Adjunct Associate Professor, Rice University
May 1 2014 → …Research Area Keywords
- Heart & Vascular
- Imaging & Radiology
- Clinical Translation & Trials
- Clinical Care
Free-text keywords
- Valvular disease
- Mitral regurgitation
- Echocardiography
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Projects
Tricuspid Valve Regurgitation Patient Preference Survey ICON
Reardon, M. J., Faza, N., Kleiman, N. & Little, S. H.
9/24/20 → …
Project: Clinical Trial
IMAG-BioVentrix Revivent TC System for Ventricular Aneurysms BioVentrix
Shah, D. J., Chang, S., Faza, N., Little, S. H., Nabi, F., Reardon, M. J. & Yang, E. Y.
9/17/20 → …
Project: Clinical Trial
CHIL-Triluminate
Little, S. H., Faza, N., Kleiman, N. & Reardon, M. J.
9/2/20 → …
Project: Clinical Trial
SH-PORTICO NG
Kleiman, N., Faza, N., Gadhia, R. R., Little, S. H., Reardon, M. J. & Volpi, J. J.
7/8/20 → …
Project: Clinical Trial
SH-AltaValve.
Faza, N., Kleiman, N., Lawrie, G. M., Little, S. H., Mahmarian, J. J. & Reardon, M. J.
5/19/20 → …
Project: Clinical Trial
Research Output
3D Printing, Computational Modeling, and Artificial Intelligence for Structural Heart Disease
Wang, D. D., Qian, Z., Vukicevic, M., Engelhardt, S., Kheradvar, A., Zhang, C., Little, S. H., Verjans, J., Comaniciu, D., O'Neill, W. W. & Vannan, M. A., Aug 25 2020, In : JACC: Cardiovascular Imaging.Research output: Contribution to journal › Review article
Functional assessment of bioprosthetic mitral valves by cardiovascular magnetic resonance: An in vitro validation and comparison to Doppler echocardiography
Maragiannis, D., Jackson, M. S., Autry, K., Flores Arredondo, J. H., Aggeli, C., Tousoulis, D., Zoghbi, W. A., Shah, D. J. & Little, S. H., Jul 30 2020, In : Journal of Cardiovascular Magnetic Resonance. 22, 1, 55.Research output: Contribution to journal › Article
Imaging Guidance for Transcatheter Mitral Valve Intervention on Prosthetic Valves, Rings, and Annular Calcification
Little, S. H., Bapat, V., Blanke, P., Guerrero, M., Rajagopal, V. & Siegel, R., 2020, (Accepted/In press) In : JACC: Cardiovascular Imaging.Research output: Contribution to journal › Review article
Impact of Stroke Volume Index and Left Ventricular Ejection Fraction on Mortality After Aortic Valve Replacement
Ito, S., Nkomo, V. T., Orsinelli, D. A., Lin, G., Cavalcante, J., Popma, J. J., Adams, D. H., Checuti, S. J., Deeb, G. M., Boulware, M., Huang, J., Little, S. H., Cohen, S. A., Reardon, M. J. & Oh, J. K., Jan 2020, In : Mayo Clinic Proceedings. 95, 1, p. 69-76 8 p.Research output: Contribution to journal › Article
1
Scopus
citations
Intentional bioprosthetic tricuspid valve fracture to facilitate transcatheter valve-in-valve deployment
Karahalios, B., Breinholt, J. P., Little, S. H. & Huie Lin, C., Jan 1 2020, In : Catheterization and Cardiovascular Interventions.Research output: Contribution to journal › Article
Prizes
Figure of the month in JACC imaging
Vukicevic, Marija (Recipient) & Little, Stephen H. (Recipient), Feb 1 2017
Prize: Other distinction
File
Siemens Healthineers Research Collaboration grant contest winners
Little, Stephen H. (Recipient) & Vukicevic, Marija (Recipient), Mar 6 2018
Prize: Other distinction