Personal profile

After earning his PhD in Molecular Biology in 1995 from Northwestern University, Dr. Beres completed post-doctoral fellowships at Baylor College of Medicine and the National Institute of Allergy and Infectious Diseases. Dr. Beres joined the Houston Methodist Research Institute HMRI at its inception in 2006, where he is currently a Full Research Member, Research Institute, Professor, Academic Institute, and Director of Microbial Informatics for the Center for Molecular and Translational Human Infectious Disease Research. Dr. Beres’s research focuses on employing bacterial whole-genome sequencing to understand human infectious diseases caused by microbial pathogens, including Streptococcus pyogenes, Staphylococcus aureus, and Klebsiella pneumoniae.

Research interests

The primary focus of Dr. Beres’s research is identifying the genetic/genomic basis for intrinsic differences and adaptive changes in the pathogenic behavior of human bacterial infections. Over the last 17 years, Dr. Beres has used bacterial pathogen whole-genome sequencing and related genome-scale strategies on populations of hundreds to thousands of human clinical isolates to obtain initial genomic assessments. Dr. Beres has then used DNA sequencing to further analyze strain-to-strain variation in gene content and RNA/cDNA sequencing for genome-wide gene transcriptome assessment. Dr. Beres is one of few specialists who has focused particularly on the human bacterial pathogen S. pyogenes, colloquially referred to as the “flesh-eating” bacteria. Dr. Beres’s research has contributed 40 of 166 (24%) of the complete genome sequences for S. pyogenes that are currently in the National Center Biotechnology Information GenBank database.

One prominent theme of Dr. Beres’s research has been the use of population pathogenomics to determine the molecular genetic underpinnings responsible for the epidemic shifts of different S. pyogenes genotypes that are responsible for severe invasive infections with high human morbidity and mortality. One important discovery of his research is that recurrent epidemic waves of type emm3 S. pyogenes stemmed from the emergence of newly evolved strains with enhanced fitness, and not from recycling of the same clone responsible for the preceding wave. Similarly, his analysis of 3,615 samples of type emm1 S. pyogenes obtained from global sources found that only four molecular genetic events were responsible for the pandemic of severe invasive infections worldwide. He also discovered that an emm89 S. pyogenes epidemic clone evolved through a complex series of multiple horizontal-transfer genetic recombination events, one of which was virtually identical to the recombination event responsible for triggering the pandemic of invasive infections caused by the emm1 strain. These three studies are some of the largest population pathogenomic infectious disease investigations that have been conducted.

Keywords

    Research Area Keywords

  • Infectious Disease & Pathology

Fingerprint

Streptococcus
Concept: Streptococcus
Weight: 100%
Domain: Medicine & Life Sciences
Genome
Concept: Genome
Weight: 53%
Domain: Medicine & Life Sciences
Virulence
Concept: Virulence
Weight: 39%
Domain: Medicine & Life Sciences
Infection
Concept: Infection
Weight: 32%
Domain: Medicine & Life Sciences
Genes
Concept: Genes
Weight: 31%
Domain: Medicine & Life Sciences
Streptococcus pyogenes
Concept: Streptococcus pyogenes
Weight: 30%
Domain: Medicine & Life Sciences
Pharyngitis
Concept: Pharyngitis
Weight: 23%
Domain: Medicine & Life Sciences
Virulence Factors
Concept: Virulence Factors
Weight: 18%
Domain: Medicine & Life Sciences
Necrotizing Fasciitis
Concept: Necrotizing Fasciitis
Weight: 15%
Domain: Medicine & Life Sciences
Prophages
Concept: Prophages
Weight: 14%
Domain: Medicine & Life Sciences
Research OutputsResearch Output authored by Stephen B. Beres is tagged with the concept

Journals

Proceedings of the National Academy of Sciences of the United States of America

ISSNs: 0027-8424

Journal

8

Journal of Infectious Diseases

ISSNs: 0022-1899

Oxford University Press

Journal

5

Infection and Immunity

ISSNs: 0019-9567

American Society for Microbiology

Journal

5

mBio

ISSNs: 2161-2129

Additional searchable ISSN (Electronic): 2150-7511

American Society for Microbiology

Journal

4

PLoS ONE

Additional searchable ISSN (Electronic): 1932-6203

Public Library of Science

Journal

3
has published Research OutputsResearch Output by Stephen B. Beres

Research Network

Visualization: Institutional Network

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Stephen B. Beres

Visualization: Co-author Network

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Stephen B. Beres

Shared Pub. Internal Organizations

50

Weill Cornell Medical College

Organizational unit: Schools & Hospitals

50

Houston Methodist Hospital

Organizational unit: Schools & Hospitals

49

Center for Bioenergetics

Organizational unit: Programs

1

Department of Medicine

Organizational unit: Departments

1
has Research OutputsResearch Output by Stephen B. Beres

Shared Pub. External Organizations

Houston Methodist Research Institute

External organization: Unknown

21

National Institutes of Health

External organization: Government

12

Baylor College of Medicine

External organization: Academic

12

University of Toronto

External organization: Unknown

8

Mount Sinai Hospital of University of Tortonto

External organization: Unknown

5
has Research OutputsResearch Output by Stephen B. Beres

Shared Pub. Internal co-authors

has co-authored Research OutputsResearch Output with Stephen B. Beres

Shared Pub. External co-authors

Concepcion C. Cantu

External person

11

Anthony R. Flores

External person

11

Nahuel Fittipaldi

External person

10

Frank R. DeLeo

External person

9

Waleed Nasser

External person

7
has co-authored Research OutputsResearch Output with Stephen B. Beres

ID: 2283388