Projects per year
Personal profile
Research interests
Vision - Dr. Casarin's Research focuses on the development of in silico models to guide pre-clinical and clinical research in a more robust and more effective fashion. Working side-by-side with biologist and clinicians, Dr. Casarin and his team aim to create data-integrated in silico platforms with the ultimate goal of prioritizing therapeutic approaches that will most likely succeed and de-prioritizing the ones that will most likely fail.
Active projects - The fields of interest of Dr. Casarin mostly include vascular, cancer, and transplants:
- Vascular: i) modeling of atherosclerotic plaque formation in superior femoral arteries; ii) modeling of restenosis phenomenon in vein graft bypasses during post-surgical vascular adaptation; iii) in silico platform to optimize the development of gene therapies to improve the life expectancy of vein graft bypasses
- Cancer: i) modeling of prostate cancer bone metastasis establishment, development, and response to therapeutic agents; ii) application of neural networks to the identification of cellular nuceli of interest in the phenomenon of foreign body response; iii) modeling of colon-rectal cancer development and metastatic spreading
- Transplant: clinical data-driven in silico platform to optimize the management of brain dead donor patients for solid organ transplantation.
Education/Academic qualification
Applied Mathematical Sciences, PhD, Mathematical Models in Computational Surgery, Université de La Rochelle
Nov 1 2013 → Jun 17 2017
Award Date: Jun 17 2017
Biomedical Engineering, MS, Politecnico Di Milano
Oct 1 2010 → Oct 3 2013
Award Date: Oct 3 2013
Biomedical Engineering, BS, Universita di Padova
Oct 1 2006 → Mar 26 2010
Award Date: Mar 26 2010
External positions
Adjunct Professor, University of La Rochelle
Mar 1 2022 → …
Research Area Keywords
- Transplantation
- Cancer
- Systems Medicine & Bioinformatics
- Heart & Vascular
- Immunobiology & Inflammation
Free-text keywords
- Computational Biology
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Collaborations and top research areas from the last five years
Projects
- 2 Finished
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Integrating in vivo and in silico models of prostate cancer-bone metastasis to overcome anti-tumor therapy resistance
8/1/22 → 7/31/24
Project: Federal Funding Agencies
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Translational and Computational Analysis of Dialysis Fistula Maturation Failure
9/1/20 → 8/31/23
Project: Federal Funding Agencies
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An agent-based model of cardiac allograft vasculopathy: toward a better understanding of chronic rejection dynamics
Serafini, E., Corti, A., Gallo, D., Chiastra, C., Li, X. C. & Casarin, S., 2023, In: Frontiers in Bioengineering and Biotechnology. 11, p. 1190409 1190409.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
A predictive multiscale model of in-stent restenosis in femoral arteries: linking haemodynamics and gene expression with an agent-based model of cellular dynamics
Corti, A., Colombo, M., Rozowsky, J. M., Casarin, S., He, Y., Carbonaro, D., Migliavacca, F., Matas, J. F. R., Berceli, S. A. & Chiastra, C., Mar 2022, In: Journal of the Royal Society Interface. 19, 188, p. 20210871 20210871.Research output: Contribution to journal › Article › peer-review
14 Scopus citations -
Deep Learning for Automated Analysis of Cellular and Extracellular Components of the Foreign Body Response in Multiphoton Microscopy Images
Sarti, M., Parlani, M., Diaz-Gomez, L., Mikos, A. G., Cerveri, P., Casarin, S. & Dondossola, E., Jan 25 2022, In: Frontiers in Bioengineering and Biotechnology. 9, p. 797555 797555.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Enhancing 223Ra Treatment Efficacy by Anti- β1 Integrin Targeting.
Paindelli, C., Casarin, S., Wang, F., Diaz-Gomez, L., Zhang, J., Mikos, A. G., Logothetis, C. J., Friedl, P. & Dondossola, E., Jul 1 2022, In: Journal of Nuclear Medicine. 63, 7, p. 1039-1045 7 p.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
Multiscale agent-based modeling of restenosis after percutaneous transluminal angioplasty: Effects of tissue damage and hemodynamics on cellular activity
Corti, A., Colombo, M., Migliavacca, F., Berceli, S. A., Casarin, S., Rodriguez Matas, J. F. & Chiastra, C., Aug 2022, In: Computers in Biology and Medicine. 147, p. 105753 105753.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations
Prizes
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Young Researcher Prize
Casarin, Stefano (Recipient), Oct 18 2019
Prize: Prize (including medals and awards)