Projects per year
Personal profile
Research interests
Vision - Dr. Casarin's Research focuses on the development of in silico models to guide pre-clinical and clinical research in a more robust and more effective fashion. Working side-by-side with biologist and clinicians, Dr. Casarin and his team aim to create data-integrated in silico platforms with the ultimate goal of prioritizing therapeutic approaches that will most likely succeed and de-prioritizing the ones that will most likely fail.
Active projects - The fields of interest of Dr. Casarin mostly include vascular, cancer, and transplants:
- Vascular: i) modeling of atherosclerotic plaque formation in superior femoral arteries; ii) modeling of restenosis phenomenon in vein graft bypasses during post-surgical vascular adaptation; iii) in silico platform to optimize the development of gene therapies to improve the life expectancy of vein graft bypasses
- Cancer: i) modeling of prostate cancer bone metastasis establishment, development, and response to therapeutic agents; ii) application of neural networks to the identification of cellular nuceli of interest in the phenomenon of foreign body response; iii) modeling of colon-rectal cancer development and metastatic spreading
- Transplant: clinical data-driven in silico platform to optimize the management of brain dead donor patients for solid organ transplantation.
Education/Academic qualification
Applied Mathematical Sciences, PhD, Université de La Rochelle
Nov 1 2013 → Jun 17 2017
Award Date: Jun 17 2017
Biomedical Engineering, MS, Politecnico Di Milano
Oct 1 2010 → Oct 3 2013
Award Date: Oct 3 2013
Biomedical Engineering, BS, Universita di Padova
Oct 1 2006 → Mar 26 2010
Award Date: Mar 26 2010
Research Area Keywords
- Transplantation
- Cancer
- Systems Medicine & Bioinformatics
- Heart & Vascular
- Immunobiology & Inflammation
Free-text keywords
- Computational Biology
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Projects
- 1 Active
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Translational and Computational Analysis of Dialysis Fistula Maturation Failure
9/1/20 → 8/31/23
Project: Federal Funding Agencies
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A predictive multiscale model of in-stent restenosis in femoral arteries: linking haemodynamics and gene expression with an agent-based model of cellular dynamics
Corti, A., Colombo, M., Rozowsky, J. M., Casarin, S., He, Y., Carbonaro, D., Migliavacca, F., Matas, J. F. R., Berceli, S. A. & Chiastra, C., 2022, In: Journal of the Royal Society Interface. 19, 188, 20210871.Research output: Contribution to journal › Article › peer-review
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Deep Learning for Automated Analysis of Cellular and Extracellular Components of the Foreign Body Response in Multiphoton Microscopy Images
Sarti, M., Parlani, M., Diaz-Gomez, L., Mikos, A. G., Cerveri, P., Casarin, S. & Dondossola, E., Jan 25 2022, In: Frontiers in Bioengineering and Biotechnology. 9, 797555.Research output: Contribution to journal › Article › peer-review
Open Access -
Baseline local hemodynamics as predictor of lumen remodeling at 1-year follow-up in stented superficial femoral arteries
Colombo, M., He, Y., Corti, A., Gallo, D., Casarin, S., Rozowsky, J. M., Migliavacca, F., Berceli, S. & Chiastra, C., Dec 2021, In: Scientific Reports. 11, 1, 1613.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
Enhancing Radium 223 treatment efficacy by anti-beta 1 integrin targeting
Paindelli, C., Casarin, S., Feng, W., Gomez, L-D., Zhang, J., Mikos, A. G., Logothetis, C. J., Friedl, P. & Dondossola, E., Oct 2021, In: Journal of Nuclear Medicine.Research output: Contribution to journal › Article › peer-review
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In silico deceased donor intervention research: A potential accelerant for progress
Hobeika, M. J., Casarin, S., Saharia, A., Mobley, C., Yi, S., McMillan, R., Mark Ghobrial, R. & Gaber, A. O., Jun 2021, In: American Journal of Transplantation. 21, 6, p. 2231-2239 9 p.Research output: Contribution to journal › Article › peer-review
Prizes
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Young Researcher Prize
Casarin, Stefano (Recipient), Oct 18 2019
Prize: Prize (including medals and awards)