Vision - Dr. Casarin's Research focuses on the development of in silico models to guide pre-clinical and clinical Research in a more robust and more effectivr fashion. Working side-by-side wit biologist and clinicians, Dr. Casarin and his team am to create data-integrated in silico platforms with the ultimate goal of prioritizing thrapeturic approaches that will most likely succeed and de-prioritizing the ones that will most liley fail.

Active projects - The fields of interest of Dr. Casarin mostly include vascular, cancer, and transplants:

1. Vascular: i) modeling of atherosclerotic plaque formation in superior femoral arteries; ii) modeling of restenosis phenomenon in vein graft bypasses during post-surgical vascular adaptation; iii) in silico platform to optimize the development of gene therapies to improve the life expectancy of vein graft bypasses
2. Cancer: i) modeling of prostate cancer bone metastasis establishment, development, and response to therapeutic agents; ii) application of neural networks to the identification of cellular nuceli of interest in the phenomenon of foreign body response; iii) modeling of colon-rectal cancer development and metastatic spreading
3. Transplant: clinical data-driven in silico platform to optimize the management of brain dead donor patients for solid organ transplantation.