Stanley H. Appel, MD

Projects

Projects per year 2005 2010 2015 2018 2020 2021 2038

• 5 Not started
• 11 Active
• 19 Finished

Projects per year

Search results

• Active

  Tregs in AD clinical trial A Phase II Clinical Trial of Interleukin-2 (IL-2) in Patients with Mild to Moderate Alzheimer's Disease Progress

  Faridar, A., Appel, S. H., Masdeu, J. C. & Pascual, B.

  9/9/21 → …

  Project: Clinical Trial

• Regulatory T cells as a novel therapeutic target in Alzheimer's Disease

  Appel, S. H., Faridar, A. & Masdeu, J. C.

  8/1/21 → 12/31/24

  Project: Non Profit

• HEALEY ALS Platform Trial - Regimen-Specific Appendix D - For pridopidine 45 mg oral capsule administered twice daily (BID) or its matching placebo.

  Appel, S. H., Shroff, S., Greene, E. P., Liao, B. & Thonhoff, J. R.

  6/29/21 → 7/23/25

  Project: Non Profit

• A Study of Biological Markers for the Nervous and Immune Systems and Free Radical Mediated Processes in Amyotrophic Lateral Sclerosis (ALS)

  Appel, S. H., Beers, D., Greene, E. P., Lai, E. C., Liao, B., Shroff, S., Thonhoff, J. R. & Zhao, W.

  8/13/20 → …

  Project: Clinical Trial

• HEALEY ALS Platform Trial - Regimen-Specific Appendix B - For verdiperstat (also known as BHV-3241)

  Appel, S. H., Shroff, S., Greene, E. P., Liao, B. & Thonhoff, J. R.

  7/24/20 → 7/23/25

  Project: Non Profit

• HEALEY ALS Platform Trial - Regimen-Specific Appendix A - For 0.3mh/kg SC zilucoplan administered once daily and placebo

  Appel, S. H., Shroff, S., Greene, E. P., Liao, B. & Thonhoff, J. R.

  7/24/20 → 7/23/25

  Project: Non Profit

• HEALEY ALS Platform Trial - Regimen-Specific Appendix C - For CNM-Au8

  Appel, S. H., Shroff, S., Greene, E. P., Liao, B. & Thonhoff, J. R.

  7/24/20 → 7/23/25

  Project: Non Profit

• Myotonic Dystrophy Compilation of Clinical Findings

  Greene, E. P., Appel, S. H., Ashizawa, T., Mathuria, N., Shroff, S. & Thonhoff, J. R.

  4/1/20 → …

  Project: Clinical Trial

• Neuromuscular Observational Research (MOVR) Data Hub Protocol

  Greene, E. P., Appel, S. H., Shroff, S. & Thonhoff, J. R.

  5/17/19 → …

  Project: Clinical Trial

• PBR28 PET

  Masdeu, J. C., Appel, S. H., Faridar, A., Karmonik, C., Nakawah, M. O. & Pascual, B.

  6/7/16 → …

  Project: Clinical Trial

• Phase IIa Double-Blind, Placebo-Controlled Study to Evaluate the Safety ofOral Fingolimod in Patients with ALS

  Greene, E. P., Appel, S. H. & Lai, E. C.

  Massachusetts General Hospital

  5/13/13 → 5/12/38

  Project: Non Profit

• Not started

  COMPILATIONS OF CLINICAL FINDINGS IN AMYOTROPHIC LATERAL SCLEROSIS

  Appel, S. H., Greene, E. P., Liao, B., Shroff, S. & Thonhoff, J. R.

  Project: Clinical Trial

• Safety and Efficacy Study of Ravulizumab in Adults With Generalized Myasthenia Gravis

  Greene, E. P., Appel, S. H., Liao, B., Shroff, S. & Thonhoff, J. R.

  Project: Clinical Trial

• IL2 Plus Abatacept in AD

  Faridar, A., Appel, S. H. & Masdeu, J. C.

  Project: Clinical Trial

• Genomic Translation for ALS Clinical Care

  Appel, S. H., Greene, E. P., Shroff, S. & Thonhoff, J. R.

  Project: Clinical Trial

• TRACK-ALS-001

  Masdeu, J. C., Appel, S. H., Nakawah, M. O., Pascual, B., Thonhoff, J. R. & Yu, M.

  Project: Clinical Trial

• Finished

  Massachusetts General Hospital Healey Center for ALS - Healey ALS Platform Trial

  Appel, S. H., Greene, E. P., Shroff, S. & Thonhoff, J. R.

  7/24/20 → 12/31/22

  Project: Non Profit

• Expanded Population of Regulatory T-Cells (EPAR T-Cells) for People with Amyotrophic Lateral Sclerosis (PALS)

  Appel, S. H.

  9/1/18 → 9/30/21

  Project: Non Profit

• T-Reg Leukapheresis_2.0_ALSAFAC_807

  Appel, S. H. & Thonhoff, J. R.

  8/1/18 → 1/31/22

  Project: Non Profit

• Selective neuronal vulnerability and resistance to pTDP-43 pathology in the primary motor and visual cortices of ALS patients

  Cykowski, M. D. & Appel, S. H.

  8/1/18 → 1/31/20

  Project: Non Profit

• Expanded Population of Regulatory T-Cells (EPAR T-Cells) for People with Amyotrophic Lateral Sclerosis (PALS)

  Appel, S. H.

  7/1/18 → 12/31/21

  Project: Non Profit

• Inflamatory and IPSC Markers and Models of ALS

  Appel, S. H. & Zhao, W.

  2/1/18 → 2/1/19

  Project: Non Profit

• Genomic Translation for ALS Care

  Appel, S. H., Greene, E. P., Shroff, S. & Thonhoff, J. R.

  10/1/15 → 9/30/19

  Project: Non Profit

• A PILOT TRIAL OF THE SAFETY, TOLERABILITY AND PHARMACOKINETICS OF EXPANED AND INFUSED T-REGULATORY CELLS WITH IL-2 DELIVERED BY INTRAVENOUS INFUSION IN SUBJECTS WITH ALS

  Appel, S. H. & Greene, E. P.

  ALS Association

  6/1/15 → 6/1/17

  Project: Non Profit

• TRACK-ALS

  Masdeu, J. C., Appel, S. H., Lee, D. Y., Pascual, B. & Yu, M.

  ALS Association

  1/1/15 → 7/31/17

  Project: Non Profit

• Immune Mechanisms in Amyotrophic Lateral Sclerosis

  Appel, S. H., Beers, D. & Zhao, W.

  Muscular Dystrophy Association

  5/1/14 → 4/30/17

  Project: Non Profit

• Blocking TLR-Activation of Regulatory T cells Slows Disease in ALS

  Appel, S. H., Beers, D. & Zhao, W.

  Natl Inst of Neuro Disorders and Stroke

  3/15/13 → 8/31/15

  Project: Federal Funding Agencies

• CD4+ CD25+ regulatory T cells as Potential Biomarkers of Pathogenesis and Response to Therapy in CIDP Patients

  Greene, E. P., Appel, S. H. & Lai, E. C.

  GBS/CIDP Foundation International

  8/22/12 → 6/30/14

  Project: Non Profit

• Infrastructure of a Small Screening Trial Consortium MDA ALS Clinical Research Network.

  Appel, S. H.

  California Pacific Medical Ctr Res Inst

  1/1/12 → 12/31/14

  Project: Non Profit

• Immune Mechanisms in Amyotrophic Lateral Sclerosis

  Appel, S. H.

  Muscular Dystrophy Association

  7/1/10 → 6/30/13

  Project: Non Profit

• Lowering of SOD1 in FALS with Pyrimethamine: Is Response Mutation Specific

  Appel, S. H.

  Hospital For Special Surgery

  4/1/10 → 6/30/13

  Project: Non Profit

• Using CD4+T Cells as a candidate therapy to slow disease progression in ALS

  Appel, S. H., Beers, D. & Zhao, W.

  Natl Inst of Neuro Disorders and Stroke

  2/15/10 → 4/30/12

  Project: Federal Funding Agencies

• Clinical Research Network Grant (MDA116573)

  Appel, S. H.

  Muscular Dystrophy Association

  8/1/08 → 3/31/12

  Project: Non Profit

• Immune mechanisms in amyotrophic lateral sclerosis

  Appel, S. H.

  Muscular Dystrophy Association

  7/1/07 → 6/30/10

  Project: Non Profit

• Phase III trial of Minocycline in ALS

  Appel, S. H.

  Columbia University

  7/1/05 → 5/31/07

  Project: Federal Funding Agencies