Research outputs

  1. 2019
  2. Human Bone Marrow Endothelial Progenitor Cell Transplantation into Symptomatic ALS Mice Delays Disease Progression and Increases Motor Neuron Survival by Repairing Blood-Spinal Cord Barrier

    Garbuzova-Davis, S., Kurien, C., Haller, E., Eve, D. J., Navarro, S., Steiner, G., Mahendrasah, A., Hailu, S., Khatib, M., Boccio, K. J., Borlongan, C. V., Van Loveren, H. R., Appel, S. H. & Sanberg, P. R., Mar 27 2019, In : Scientific Reports. 9, 1, 5280.

    Research output: Contribution to journalArticle

  3. Immune dysregulation in amyotrophic lateral sclerosis: mechanisms and emerging therapies

    Beers, D. & Appel, S. H., Feb 1 2019, In : The Lancet Neurology. 18, 2, p. 211-220 10 p.

    Research output: Contribution to journalReview article

  4. Head-to-head comparison of 11C-PBR28 and 11C-ER176 for quantification of the translocator protein in the human brain

    Zanotti Fregonara, P., Pascual, M. B., Veronese, M., Yu, M. M., Beers, D., Appel, S. H. & Masdeu, J. C., Jan 1 2019, In : European Journal of Nuclear Medicine and Molecular Imaging.

    Research output: Contribution to journalArticle

  5. 2018
  6. Functional alterations of myeloid cells during the course of Alzheimer's disease

    Thome, A. D., Faridar, A., Beers, D. R., Thonhoff, J. R., Zhao, W., Wen, S., Pascual, B., Masdeu, J. C. & Appel, S. H., Nov 13 2018, In : Molecular Neurodegeneration. 13, 1, p. 61 1 p.

    Research output: Contribution to journalArticle

  7. Neuroinflammatory mechanisms in amyotrophic lateral sclerosis pathogenesis

    Thonhoff, J. R., Simpson, E. P. & Appel, S. H., Oct 1 2018, In : Current Opinion in Neurology. 31, 5, p. 635-639 5 p.

    Research output: Contribution to journalArticle

  8. Transplantation of human bone marrow stem cells into symptomatic ALS mice enhanced structural and functional blood-spinal cord barrier repair

    Garbuzova-Davis, S., Haller, E., Navarro, S., Besong, T. E., Boccio, K. J., Hailu, S., Khatib, M., Sanberg, P. R., Appel, S. H. & Borlongan, C. V., Aug 30 2018, In : Experimental Neurology.

    Research output: Contribution to journalArticle

  9. Head-to-head comparison of 11C-PBR28 and 18F-GE180 for quantification of the translocator protein in the human brain

    Zanotti-Fregonara, P., Pascual, B., Rizzo, G., Yu, M., Pal, N., Beers, D., Carter, R., Appel, S. H., Atassi, N. & Masdeu, J. C., Aug 1 2018, In : Journal of Nuclear Medicine. 59, 8, p. 1260-1266 7 p.

    Research output: Contribution to journalArticle

  10. Expanded autologous regulatory T-lymphocyte infusions in ALS

    Thonhoff, J. R., Beers, D. R., Zhao, W., Pleitez, M., Simpson, E. P., Berry, J. D., Cudkowicz, M. E. & Appel, S. H., Jul 1 2018, In : Neurology - Neuroimmunology Neuroinflammation. 5, 4

    Research output: Contribution to journalArticle

  11. Expanded autologous regulatory T-lymphocyte infusions in ALS A phase I, first-in-human study

    Thonhoff, J. R., Beers, D. R., Zhao, W., Pleitez, M., Simpson, E. P., Berry, J. D., Cudkowicz, M. E. & Appel, S. H., Jul 1 2018, In : Neurology: Neuroimmunology and NeuroInflammation. 5, 4, p. e465 e465.

    Research output: Contribution to journalArticle

  12. The role of regulatory T lymphocytes in amyotrophic lateral sclerosis

    Beers, D., Zhao, W. & Appel, S. H., Jun 1 2018, In : JAMA Neurology. 75, 6, p. 656-658 3 p.

    Research output: Contribution to journalEditorial

  13. Phosphorylated TDP-43 (pTDP-43) aggregates in the axial skeletal muscle of patients with sporadic and familial amyotrophic lateral sclerosis

    Cykowski, M. D., Powell, S. Z-E., Appel, J. W., Arumanayagam, A. S., Rivera, A. L. & Appel, S. H., Apr 13 2018, In : Acta neuropathologica communications. 6, 1, 1 p.

    Research output: Contribution to journalArticle

  14. Genome-wide Analyses Identify KIF5A as a Novel ALS Gene

    ITALSGEN Consortium, Genomic Translation for ALS Care (GTAC) Consortium, ALS Sequencing Consortium, NYGC ALS Consortium, Answer ALS Foundation, Clinical Research in ALS and Related Disorders for Therapeutic Development (CReATe) Consortium, SLAGEN Consortium, French ALS Consortium & Project MinE ALS Sequencing Consortium, Mar 21 2018, In : Neuron. 97, 6, p. 1268-1283.e6

    Research output: Contribution to journalArticle

  15. An open label study of a novel immunosuppression intervention for the treatment of amyotrophic lateral sclerosis

    Fournier, C. N., Schoenfeld, D., Berry, J. D., Cudkowicz, M. E., Chan, J., Quinn, C., Brown, R. H., Salameh, J. S., Tansey, M. G., Beers, D., Appel, S. H. & Glass, J. D., Jan 4 2018, (Accepted/In press) In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. p. 1-8 8 p.

    Research output: Contribution to journalArticle

  16. 2017
  17. Phase IIa trial of fingolimod for amyotrophic lateral sclerosis demonstrates acceptable acute safety and tolerability

    Berry, J. D., Paganoni, S., Atassi, N., Macklin, E. A., Goyal, N., Rivner, M., Simpson, E. P., Appel, S. H., Grasso, D. L., Mejia, N. I., Mateen, F., Gill, A., Vieira, F., Tassinari, V. & Perrin, S., Dec 1 2017, In : Muscle and Nerve. 56, 6, p. 1077-1084 8 p.

    Research output: Contribution to journalArticle

  18. Introduction to supplement: the current status of treatment for ALS

    Miller, R. G. & Appel, S. H., Oct 31 2017, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 18, p. 1-4 4 p.

    Research output: Contribution to journalArticle

  19. Characterization of Gene Expression Phenotype in Amyotrophic Lateral Sclerosis Monocytes

    Zhao, W., Beers, D. R., Hooten, K. G., Sieglaff, D. H., Zhang, A., Kalyana-Sundaram, S., Traini, C. M., Halsey, W. S., Hughes, A. M., Sathe, G. M., Livi, G. P., Fan, G. H. & Appel, S. H., Jun 1 2017, In : JAMA Neurology. 74, 6, p. 677-685 9 p.

    Research output: Contribution to journalArticle

  20. Serum C-Reactive Protein as a Prognostic Biomarker in Amyotrophic Lateral Sclerosis

    Lunetta, C., Lizio, A., Maestri, E., Sansone, V. A., Mora, G., Miller, R. G., Appel, S. H. & Chiò, A., Jun 1 2017, In : JAMA Neurology. 74, 6, p. 660-667 8 p.

    Research output: Contribution to journalArticle

  21. Pyrimethamine Significantly Lowers CSF/SOD1 in ALS Patients With SOD1 Mutations

    Lange, D. J., Shahbazi, M., Silani, V., Ludolph, A. C., Weishaupt, J. H., Ajroud-Driss, S., Fields, K. G., Remanan, R., Appel, S. H., Morelli, C., Doretti, A., Maderna, L., Messina, S., Weiland, U., Marklund, S. L. & Andersen, P. M., May 8 2017, In : Annals of Neurology.

    Research output: Contribution to journalArticle

  22. Clinical Significance of TDP-43 Neuropathology in Amyotrophic Lateral Sclerosis

    Cykowski, M. D., Powell, S. Z., Peterson, L. E., Appel, J. W., Rivera, A. L., Takei, H., Chang, E. & Appel, S. H., May 1 2017, In : Journal of neuropathology and experimental neurology. 76, 5, p. 402-413 12 p.

    Research output: Contribution to journalArticle

  23. ALS patients' regulatory T lymphocytes are dysfunctional, and correlate with disease progression rate and severity

    Beers, D. R., Zhao, W., Wang, J., Zhang, X., Wen, S., Neal, D., Thonhoff, J. R., Alsuliman, A. S., Shpall, E. J., Rezvani, K. & Appel, S. H., Mar 9 2017, In : JCI Insight. 2, 5, p. e89530

    Research output: Contribution to journalArticle

  24. TDP-43 Depletion in Microglia Promotes Amyloid Clearance but Also Induces Synapse Loss

    Paolicelli, R. C., Jawaid, A., Henstridge, C. M., Valeri, A., Merlini, M., Robinson, J. L., Lee, E. B., Rose, J., Appel, S. H., Lee, V. M. Y., Trojanowski, J. Q., Spires-Jones, T., Schulz, P. E. & Rajendran, L., 2017, (Accepted/In press) In : Neuron.

    Research output: Contribution to journalArticle

  25. 2016
  26. A robust, good manufacturing practice–compliant, clinical-scale procedure to generate regulatory T cells from patients with amyotrophic lateral sclerosis for adoptive cell therapy

    Alsuliman, A., Appel, S. H., Beers, D. R., Basar, R., Shaim, H., Kaur, I., Zulovich, J., Yvon, E., Muftuoglu, M., Imahashi, N., Kondo, K., Liu, E., Shpall, E. J. & Rezvani, K., Oct 1 2016, In : Cytotherapy. 18, 10, p. 1312-1324 13 p.

    Research output: Contribution to journalArticle

  27. Stem cells in amyotrophic lateral sclerosis: Ready for prime time?

    Appel, S. H. & Armon, C., Jul 26 2016, In : Neurology. 87, 4, p. 348-349 2 p.

    Research output: Contribution to journalArticle

  28. Defining SOD1 ALS natural history to guide therapeutic clinical trial design

    Bali, T., Self, W., Liu, J., Siddique, T., Wang, L. H., Bird, T. D., Ratti, E., Atassi, N., Boylan, K. B., Glass, J. D., Maragakis, N. J., Caress, J. B., McCluskey, L. F., Appel, S. H., Wymer, J. P., Gibson, S., Zinman, L., Mozaffar, T., Callaghan, B., McVey, A. L. & 7 othersJockel-Balsarotti, J., Allred, P., Fisher, E. R., Lopate, G., Pestronk, A., Cudkowicz, M. E. & Miller, T. M., Jun 3 2016, (Accepted/In press) In : Journal of Neurology, Neurosurgery and Psychiatry.

    Research output: Contribution to journalArticle

  29. Amyotrophic lateral sclerosis

    Simpson, E. P. & Appel, S. H., Jan 1 2016, Neuroimmune Pharmacology. Springer International Publishing, p. 493-502 10 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

  30. The immune system continues to knock at the ALS door

    Staff, N. P. & Appel, S. H., 2016, (Accepted/In press) In : Neuromuscular Disorders. 26, 6, p. 335-336 2 p.

    Research output: Contribution to journalEditorial

  31. 2015
  32. TDP-43 activates microglia through NF-κB and NLRP3 inflammasome

    Zhao, W., Beers, D. R., Bell, S., Wang, J., Wen, S., Baloh, R. H. & Appel, S. H., Nov 1 2015, In : Experimental Neurology. 273, p. 24-35 12 p.

    Research output: Contribution to journalArticle

  33. Randomized phase 2 trial of NP001-a novel immune regulator: Safety and early efficacy in ALS

    Miller, R. G., Block, G., Katz, J. S., Barohn, R. J., Gopalakrishnan, V., Cudkowicz, M., Zhang, J. R., McGrath, M. S., Ludington, E., Appel, S. H. & Azhir, A., Jun 1 2015, In : Neurology: Neuroimmunology and NeuroInflammation. 2, 3, p. e100

    Research output: Contribution to journalArticle

  34. Protective and Toxic Neuroinflammation in Amyotrophic Lateral Sclerosis

    Hooten, K. G., Beers, D., Zhao, W. & Appel, S. H., Apr 1 2015, In : Neurotherapeutics. 12, 2, p. 364-375 12 p.

    Research output: Contribution to journalArticle

  35. Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways

    Cirulli, E. T., Lasseigne, B. N., Petrovski, S., Sapp, P. C., Dion, P. A., Leblond, C. S., Couthouis, J., Lu, Y-F., Wang, Q., Krueger, B. J., Ren, Z., Keebler, J., Han, Y., Levy, S. E., Boone, B. E., Wimbish, J. R., Waite, L. L., Jones, A. L., Carulli, J. P., Day-Williams, A. G. & 31 othersStaropoli, J. F., Xin, W. W., Chesi, A., Raphael, A. R., McKenna-Yasek, D., Cady, J., Vianney de Jong, J. M. B., Kenna, K. P., Smith, B. N., Topp, S., Miller, J., Gkazi, A., Al-Chalabi, A., van den Berg, L. H., Veldink, J., Silani, V., Ticozzi, N., Shaw, C. E., Baloh, R. H., Appel, S., Simpson, E., Lagier-Tourenne, C., Pulst, S. M., Gibson, S., Trojanowski, J. Q., Elman, L., McCluskey, L., Grossman, M., Shneider, N. A., Chung, W. K. & FALS Sequencing Consortium, Mar 27 2015, In : Science (New York, N.Y.). 347, 6229, p. 1436-41 6 p.

    Research output: Contribution to journalArticle

  36. The Role of Regulatory T Cells and Microglia in Amyotrophic Lateral Sclerosis

    Beers, D., Zhao, W., Hooten, K. G. & Appel, S. H., Mar 6 2015, Neuroinflammation: New Insights into Beneficial and Detrimental Functions. David, S. (ed.). Wiley, p. 235-249 15 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

  37. 2014
  38. Role of Inflammation in Neurodegenerative Diseases

    Appel, S. H., Beers, D. & Zhao, W., Dec 3 2014, Neurobiology of Brain Disorders: Biological Basis of Neurological and Psychiatric Disorders. Elsevier, p. 380-395 16 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

  39. Neuroimmunology of Amyotrophic Lateral Sclerosis

    Henkel, J. S., Beers, D., Zhao, W. & Appel, S. H., Jun 3 2014, Neuroinflammation and CNS Disorders. Wiley, p. 185-209 25 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

  40. Foreword

    Appel, S. H., May 1 2014, In : Unknown Journal. p. vii-x

    Research output: Contribution to journalArticle

  41. An open-label multicenter study to assess the safety of dextromethorphan/quinidine in patients with pseudobulbar affect associated with a range of underlying neurological conditions

    Pattee, G. L., Wymer, J. P., Lomen-Hoerth, C., Appel, S. H., Formella, A. E. & Pope, L. E., Jan 1 2014, In : Current Medical Research and Opinion. 30, 11, p. 2255-2265 11 p.

    Research output: Contribution to journalArticle

  42. Correction to: 'Seeking a measure of clinically meaningful change in ALS'

    McElhiney, M., Rabkin, J. G., Goetz, R., Katz, J., Miller, R. G., Forshew, D. A., David, W., Cudkowicz, M., Glass, J. D., Appel, S. H., Simpson, E. P. & Mitsumoto, H., Jan 1 2014, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 15, 7-8

    Research output: Contribution to journalArticle

  43. Seeking a measure of clinically meaningful change in ALS

    Mcelhiney, M., Rabkin, J. G., Goetz, R., Katz, J., Miller, R. G., Forshew, D. A., David, W., Cudkowicz, M., Glass, J. D., Appel, S. H., Simpson, E. P. & Mitsumoto, H., Jan 1 2014, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 15, 5-6, p. 398-405 8 p.

    Research output: Contribution to journalArticle

  44. TREM2 variant p.R47H as a risk factor for sporadic amyotrophic lateral sclerosis

    Cady, J., Koval, E. D., Benitez, B. A., Zaidman, C., Jockel-Balsarotti, J., Allred, P., Baloh, R. H., Ravits, J., Simpson, E., Appel, S. H., Pestronk, A., Goate, A. M., Miller, T. M., Cruchaga, C. & Harms, M. B., Jan 1 2014, In : JAMA Neurology. 71, 4, p. 449-453 5 p.

    Research output: Contribution to journalArticle

  45. TDP-43 pathology in the basal forebrain and hypothalamus of patients with amyotrophic lateral sclerosis

    Cykowski, M. D., Takei, H., Schulz, P. E., Appel, S. H. & Powell, S. Z., 2014, In : Acta neuropathologica communications. 2, p. 171

    Research output: Contribution to journalArticle

  46. 2013
  47. A tribute to Jenny S. Henkel, Ph.D. (1955-2013)

    Appel, S. H., Sep 1 2013, In : Journal of Neuroimmune Pharmacology. 8, 4, p. 757-1047 291 p.

    Research output: Contribution to journalArticle

  48. Immune-mediated mechanisms in the pathoprogression of amyotrophic lateral sclerosis

    Zhao, W., Beers, D. & Appel, S. H., Sep 1 2013, In : Journal of Neuroimmune Pharmacology. 8, 4, p. 888-899 12 p.

    Research output: Contribution to journalArticle

  49. An antisense oligonucleotide against SOD1 delivered intrathecally for patients with SOD1 familial amyotrophic lateral sclerosis: A phase 1, randomised, first-in-man study

    Miller, T. M., Pestronk, A., David, W., Rothstein, J., Simpson, E. P., Appel, S. H., Andres, P. L., Mahoney, K., Allred, P., Alexander, K., Ostrow, L. W., Schoenfeld, D., Macklin, E. A., Norris, D. A., Manousakis, G., Crisp, M., Smith, R., Bennett, C. F., Bishop, K. M. & Cudkowicz, M. E., May 1 2013, In : The Lancet Neurology. 12, 5, p. 435-442 8 p.

    Research output: Contribution to journalArticle

  50. Deciphering amyotrophic lateral sclerosis: What phenotype, neuropathology and genetics are telling us about pathogenesis

    Ravits, J., Appel, S., Baloh, R. H., Barohn, R., Rix Brooks, B., Elman, L., Floeter, M. K., Henderson, C., Lomen-Hoerth, C., MacKlis, J. D., McCluskey, L., Mitsumoto, H., Przedborski, S., Rothstein, J., Trojanowski, J. Q., Van Den Berg, L. H. & Ringel, S., May 1 2013, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 14, SUPPL1, p. 5-18 14 p.

    Research output: Contribution to journalArticle

  51. Erratum: Regulatory T-lymphocytes mediate amyotrophic lateral sclerosis progression and survival [EMBO Mol Med 5, 1] DOI: 10.1002/emmm.201201544

    Henkel, J. S., Beers, D., Wen, S., Rivera, A. L., Toennis, K. M., Appel, J. E., Zhao, W., Moore, D. H., Powell, S. Z-E. & Appel, S. H., Feb 1 2013, In : EMBO Molecular Medicine. 5, 2

    Research output: Contribution to journalArticle

  52. Blood-spinal cord barrier breakdown and pericyte reductions in amyotrophic lateral sclerosis

    Winkler, E. A., Sengillo, J. D., Sullivan, J. S., Henkel, J. S., Appel, S. H. & Zlokovic, B. V., Jan 1 2013, In : Acta Neuropathologica. 125, 1, p. 111-120 10 p.

    Research output: Contribution to journalArticle

  53. Regulatory T-lymphocytes mediate amyotrophic lateral sclerosis progression and survival

    Henkel, J. S., Beers, D., Wen, S., Rivera, A. L., Toennis, K. M., Appel, J. E., Zhao, W., Moore, D. H., Powell, S. Z-E. & Appel, S. H., Jan 1 2013, In : EMBO Molecular Medicine. 5, 1, p. 64-79 16 p.

    Research output: Contribution to journalArticle

  54. 2012
  55. Regulatory T lymphocytes from ALS mice suppress microglia and effector T lymphocytes through different cytokine-mediated mechanisms

    Zhao, W., Beers, D., Liao, B., Henkel, J. S. & Appel, S. H., Dec 1 2012, In : Neurobiology of Disease. 48, 3, p. 418-428 11 p.

    Research output: Contribution to journalArticle

  56. Amyotrophic lateral sclerosis, frontotemporal lobar dementia, and p62; A functional convergence?

    Appel, S. H. & Rowland, L. P., Oct 9 2012, In : Neurology. 79, 15, p. 1526-1527 2 p.

    Research output: Contribution to journalArticle

  57. Transformation from a neuroprotective to a neurotoxic microglial phenotype in a mouse model of ALS

    Liao, B., Zhao, W., Beers, D., Henkel, J. S. & Appel, S. H., Sep 1 2012, In : Experimental Neurology. 237, 1, p. 147-152 6 p.

    Research output: Contribution to journalArticle

Previous 1 2 3 4 5 6 7 8 Next

ID: 2286839