Personal profile

Stanley H. Appel, M.D. is the Peggy and Gary Edwards Distinguished Endowed Chair for the Treatment and Research of ALS, Department of Neurology, Neurological Institute, Houston Methodist Hospital and Professor of Neurology at Weill Medical College of Cornell University. He was previously Chair of the Department of Neurology at Baylor College of Medicine as well as Chief of the Neurology division and the James B. Duke Professor of Medicine at Duke University Medical Center, North Carolina. Dr. Appel is a native of Massachusetts and received his Bachelor Degree at Harvard University and his Medical Degree from Columbia College of Physicians and Surgeons. He is Director of the MDA/ALS Research and Clinical Center at the Methodist Neurological Institute, and past Director of a National Institute of Aging Alzheimer’s Disease Research Center.

Dr. Appel is a member of numerous professional societies and committees, and is the author of 15 published books and over 350 articles on topics such as ALS, neuromuscular disease, Alzheimer’s Disease, and Parkinson’s Disease. He has received a number of awards for his accomplishments in Neurology and Biochemistry, including the Gold Medal Award in 1997 from Columbia College of Physicians and Surgeons for “Distinguished Achievements in Medicine”, the Sheila Essey Award in 2003 from the American Academy of Neurology for “outstanding research in Amyotrophic Lateral Sclerosis”, Elected Fellow of the American Association for the Advancement of Science in recognition of the “dedication and commitment to advancing science and serving society” in 2003, Baylor College of Medicine Alumni Association Distinguished Faculty Award in 2004, MDA’s Wings Over Wall Street Diamond Award in 2004, Texas Neurological Society Lifetime Achievement Award in 2005 and the Forbes Norris Award for “compassion and love for humanity in research and treatment in patients with ALS” from the International Alliance of ALS/MND Associations in 2005, and the Museum District Business Alliance Award in recognition of his commitment to research, patient care, and education, 2007, and the recipient of the Houston Academy of Medicine 2008 John P. McGovern Compleat Physician Award. He is also named 2008 Best of the Best Physicians by the Medical Journal Houston.

Research interests

Research in Dr. Appel’s laboratory has focused on developing new insights into neurodegenerative diseases with primary emphasis on ALS. His studies of mutant SOD transgenic mice have documented that neuroinflammation and activated microglia are neuroprotective during early stages of disease and cytotoxic during late stages of disease. The early stages start within motor neurons and appear cell-autonomous, whereas later stages involve innate immune glia and are non-cell autonomous.These two stages appear to be modulated by peripheral Tcells that enter the CNS at sites of neuronal injury; Th2 and regulatory Tcells are increased in early stages and appear to provide neuroprotection, while Th1 Tcells are increased in later stages and mediate cytotoxicity. Transplantation of ALS mice with regulatory Tcells prolonged disease duration by more than 80%. Our comparable studies in human ALS have employed PCR techniques to confirm the presence of activated microglia and to demonstrate the presence of CD4 Tcells as well as immature and mature dendritic cells and enhanced chemokine signaling. Our laboratory was the first to document that regulatory T lymphocytes modulate disease progression in ALS patients. More specifically, regulatory T lymphocytes are decreased in ALS patients that progress at a faster rate; the levels of Treg may thus serve as a biomarker of rates of disease progression. His current efforts are focused on enhancing the protective immunity of Treg cells and anti-inflammatory microglia, and decreasing the proinflammatory immunity of Th1 effector lymphocytes and proinflammatory microglia.

Keywords

    Research Area Keywords

  • Neurosciences
  • Regenerative Medicine

    Free-text keywords

  • Neurodegenerative diseases, Amyotrophic Lateral Sclerosis, Alzheimer’s disease, Parkinson’s disease, Neuromuscular disorders

Fingerprint

Amyotrophic Lateral Sclerosis
Concept: Amyotrophic Lateral Sclerosis
Weight: 100%
Domain: Medicine & Life Sciences
Motor Neurons
Concept: Motor Neurons
Weight: 55%
Domain: Medicine & Life Sciences
Cholinergic Receptors
Concept: Cholinergic Receptors
Weight: 23%
Domain: Medicine & Life Sciences
Microglia
Concept: Microglia
Weight: 16%
Domain: Medicine & Life Sciences
Spinal Cord
Concept: Spinal Cord
Weight: 16%
Domain: Medicine & Life Sciences
Myasthenia Gravis
Concept: Myasthenia Gravis
Weight: 15%
Domain: Medicine & Life Sciences
Skeletal Muscle
Concept: Skeletal Muscle
Weight: 15%
Domain: Medicine & Life Sciences
Calcium
Concept: Calcium
Weight: 14%
Domain: Medicine & Life Sciences
Muscular Dystrophies
Concept: Muscular Dystrophies
Weight: 14%
Domain: Medicine & Life Sciences
Immunoglobulin G
Concept: Immunoglobulin G
Weight: 14%
Domain: Medicine & Life Sciences
Research OutputsResearch Output authored by Stanley H. Appel is tagged with the concept

Journals

Neurology

ISSNs: 0028-3878, 1526-632X

Lippincott Williams and Wilkins

Journal

30

Journal of Neurochemistry

ISSNs: 0022-3042

Wiley

Journal

21

Annals of Neurology

ISSNs: 0364-5134

Wiley

Journal

19

Experimental Neurology

ISSNs: 0014-4886

Academic Press

Journal

15

Archives of Neurology

ISSNs: 0003-9942

American Medical Association

Journal

14
has published Research OutputsResearch Output by Stanley H. Appel

Research Network

Visualization: Institutional Network

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Stanley H. Appel

Visualization: Co-author Network

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Stanley H. Appel

Shared Pub. Internal Organizations

5

Department of Pathology & Genomic Medicine

Organizational unit: Departments

4

Houston Methodist Sugar Land Hospital

Organizational unit: Schools & Hospitals

1

Nantz National Alzheimer Center

Organizational unit: Programs

1

Center for Outcomes Research

Organizational unit: Programs

1
has Research OutputsResearch Output by Stanley H. Appel

Shared Pub. External Organizations

Baylor College of Medicine

External organization: Unknown

163

Duke University Medical Center

External organization: Unknown

34

Biological Research Center at Hungarian Academy of Sciences

External organization: Unknown

17

Albert Szent-Györgyi Med. Sch.

External organization: Unknown

13

Massachusetts General Hospital

External organization: Unknown

7
has Research OutputsResearch Output by Stanley H. Appel

Shared Pub. Internal co-authors

has co-authored Research OutputsResearch Output with Stanley H. Appel

Shared Pub. External co-authors

R. Glenn Smith

External person

47

József Engelhardt

External person

35

Jenny S. Henkel

External person

28

László Siklós

External person

23

E. Stefani

External person

23
has co-authored Research OutputsResearch Output with Stanley H. Appel

ID: 2286839