Research outputs

  1. 2019
  2. The mechanistic study behind suppression of GVHD while retaining GVL activities by myeloid-derived suppressor cells

    Zhang, J., Chen, H-M., Ma, G., Zhou, Z., Raulet, D., Rivera, A. L., Chen, S-H. & Pan, P-Y., Aug 1 2019, In : Leukemia. 33, 8, p. 2078-2089 12 p.

    Research output: Contribution to journalArticle

  3. 2018
  4. Blocking immunoinhibitory receptor LILRB2 reprograms tumor-associated myeloid cells and promotes antitumor immunity

    Chen, H-M., van der Touw, W., Wang, Y. S., Kang, K., Mai, S., Zhang, J., Alsina-Beauchamp, D., Duty, J. A., Mungamuri, S. K., Zhang, B., Moran, T., Flavell, R., Aaronson, S., Hu, H-M., Arase, H., Ramanathan, S., Flores, R., Pan, P-Y. & Chen, S-H., Dec 3 2018, In : The Journal of clinical investigation. 128, 12, p. 5647-5662 16 p.

    Research output: Contribution to journalArticle

  5. Glatiramer acetate enhances myeloid-derived suppressor cell function via recognition of paired Ig-like receptor B

    Van Der Touw, W., Kang, K., Luan, Y., Ma, G., Mai, S., Qin, L., Bian, G., Zhang, R., Mungamuri, S. K., Hu, H. M., Zhang, C. C., Aaronson, S. A., Feldmann, M., Yang, W. C., Chen, S-H. & Pan, P-Y., Sep 15 2018, In : Journal of Immunology. 201, 6, p. 1727-1734 8 p.

    Research output: Contribution to journalArticle

  6. 2017
  7. Leukocyte immunoglobulin-like receptors in human diseases: An overview of their distribution, function, and potential application for immunotherapies

    Zhang, J., Mai, S., Chen, H-M., Kang, K., Li, X. C., Chen, S. H. & Pan, P. Y., Aug 1 2017, In : Journal of Leukocyte Biology. 102, 2, p. 351-360 10 p.

    Research output: Contribution to journalReview article

  8. LILRB receptor-mediated regulation of myeloid cell maturation and function

    van der Touw, W., Chen, H-M., Pan, P-Y. & Chen, S-H., Jun 21 2017, (Accepted/In press) In : Cancer Immunology, Immunotherapy. p. 1-9 9 p.

    Research output: Contribution to journalArticle

  9. 2016
  10. Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards

    Bronte, V., Brandau, S., Chen, S-H., Colombo, M. P., Frey, A. B., Greten, T. F., Mandruzzato, S., Murray, P. J., Ochoa, A., Ostrand-Rosenberg, S., Rodriguez, P. C., Sica, A., Umansky, V., Vonderheide, R. H. & Gabrilovich, D. I., Jul 6 2016, In : Nature Communications. 7, 12150.

    Research output: Contribution to journalReview article

  11. 5-Fluorouracil targets thymidylate synthase in the selective suppression of TH17 cell differentiation

    Wang, J., Peng, L., Zhang, R., Zheng, Z., Chen, C., Cheung, K. L., Cui, M., Bian, G., Xu, F., Chiang, D., Hu, Y., Chen, Y., Lu, G., Yang, J., Zhang, H., Yang, J., Zhu, H., Chen, S-H., Liu, K., Zhou, M. M. & 4 othersSikora, A. G., Li, L., Jiang, B. & Xiong, H., Apr 12 2016, In : Oncotarget. 7, 15, p. 19312-19326 15 p.

    Research output: Contribution to journalArticle

  12. 2015
  13. Myeloid-derived suppressor cells as an immune parameter in patients with concurrent sunitinib and stereotactic body radiotherapy

    Chen, H-M., Ma, G., Gildener-Leapman, N., Eisenstein, S., Coakley, B. A., Ozao, J., Mandeli, J., Divino, C., Schwartz, M., Sung, M., Ferris, R., Kao, J., Wang, L. H., Pan, P-Y., Ko, E. C. & Chen, S-H., Sep 15 2015, In : Clinical Cancer Research. 21, 18, p. 4073-4085 13 p.

    Research output: Contribution to journalArticle

  14. DC-SIGN+ Macrophages Control the Induction of Transplantation Tolerance

    Conde, P., Rodriguez, M., van der Touw, W., Jimenez, A., Burns, M., Miller, J., Brahmachary, M., Chen, H-M., Boros, P., Rausell-Palamos, F., Yun, T. J., Riquelme, P., Rastrojo, A., Aguado, B., Stein-Streilein, J., Tanaka, M., Zhou, L., Zhang, J., Lowary, T. L., Ginhoux, F. & 12 othersPark, C. G., Cheong, C., Brody, J., Turley, S. J., Lira, S. A., Bronte, V., Gordon, S., Heeger, P. S., Merad, M., Hutchinson, J., Chen, S-H. & Ochando, J., Jun 16 2015, In : Immunity. 42, 6, p. 1143-1158 16 p.

    Research output: Contribution to journalArticle

  15. 2014
  16. Immunizations with hepatitis B viral antigens and a TLR7/8 agonist adjuvant induce antigen-specific immune responses in HBV-transgenic mice

    Wang, Y., Chen, K., Wu, Z., Liu, Y., Liu, S., Zou, Z., Chen, S-H. & Qu, C., Dec 1 2014, In : International Journal of Infectious Diseases. 29, p. 31-36 6 p.

    Research output: Contribution to journalArticle

  17. Concurrent sunitinib and stereotactic body radiotherapy for patients with oligometastases: Final report of a prospective clinical trial

    Kao, J., Chen, C. T., Tong, C. C. L., Packer, S. H., Schwartz, M., Chen, S-H. & Sung, M. W., Jan 1 2014, In : Targeted Oncology. 9, 2, p. 145-153 9 p.

    Research output: Contribution to journalArticle

  18. 2013
  19. Myeloid-derived suppressor cells as a trojan horse: A cellular vehicle for the delivery of oncolytic viruses

    Pan, P-Y., Chen, H-M. & Chen, S-H., Oct 22 2013, In : OncoImmunology. 2, 8, e25083.

    Research output: Contribution to journalArticle

  20. Myeloid-derived suppressor cells as a vehicle for tumor-specific oncolytic viral therapy

    Eisenstein, S., Coakley, B. A., Briley-Saebo, K., Ma, G., Chen, H-M., Meseck, M., Ward, S., Divino, C., Woo, S., Chen, S-H. & Pan, P-Y., Aug 15 2013, In : Cancer Research. 73, 16, p. 5003-5015 13 p.

    Research output: Contribution to journalArticle

  21. T cell-derived inducible nitric oxide synthase switches offth17 cell differentiation

    Yang, J., Zhang, R., Lu, G., Shen, Y., Peng, L., Zhu, C., Cui, M., Wang, W., Arnaboldi, P., Tang, M., Gupta, M., Qi, C. F., Jayaraman, P., Zhu, H., Jiang, B., Chen, S-H., He, J. C., Ting, A. T., Zhou, M. M., Kuchroo, V. K. & 4 othersMorse, H. C., Ozato, K., Sikora, A. G. & Xiong, H., Jul 1 2013, In : Journal of Experimental Medicine. 210, 7, p. 1447-1462 16 p.

    Research output: Contribution to journalArticle

  22. Polarization and reprogramming of myeloid-derived suppressor cells

    Yang, W. C., Ma, G., Chen, S-H. & Pan, P-Y., Jun 1 2013, In : Journal of molecular cell biology. 5, 3, p. 207-209 3 p.

    Research output: Contribution to journalReview article

  23. Lymphatic vasculature mediates macrophage reverse cholesterol transport in mice

    Martel, C., Li, W., Fulp, B., Platt, A. M., Gautier, E. L., Westerterp, M., Bittman, R., Tall, A. R., Chen, S-H., Thomas, M. J., Kreisel, D., Swartz, M. A., Sorci-Thomas, M. G. & Randolph, G. J., Apr 1 2013, In : Journal of Clinical Investigation. 123, 4, p. 1571-1579 9 p.

    Research output: Contribution to journalArticle

  24. Programming of MDSC: New opportunities for targeted therapy

    Svider, P., Chen, S-H., Sikora, A. G. & Yang, W. C., Jan 1 2013, The Tumor Immunoenvironment. Springer Netherlands, Vol. 9789400762176. p. 567-584 18 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

  25. 2012
  26. Myeloid-derived suppressor cells in transplantation and cancer

    Ochando, J. C. & Chen, S-H., Dec 1 2012, In : Immunologic Research. 54, 1-3, p. 275-285 11 p.

    Research output: Contribution to journalReview article

  27. Erratum: Inhibitory receptors bind ANGPTLs and support blood stem cells and leukaemia development (Nature (2012) 485 (656-660) DOI: 10.1038/nature11095)

    Zheng, J., Umikawa, M., Cui, C., Li, J., Chen, X., Zhang, C., Huynh, H., Kang, X., Silvany, R., Wan, X., Ye, J., Cant, A. P., Chen, S-H., Wang, H. Y., Sally Ward, E. & Zhang, C. C., Aug 30 2012, In : Nature. 488, 7413, 1 p.

    Research output: Contribution to journalComment/debate

  28. Γ-H2AX kinetics as a novel approach to high content screening for small molecule radiosensitizers

    Fu, S., Yang, Y., Tirtha, D., Yen, Y., Zhou, B. S., Zhou, M. M., Ohlmeyer, M., Ko, E. C., Cagan, R., Rosenstein, B. S., Chen, S-H. & Kao, J., Jun 29 2012, In : PloS one. 7, 6, e38465.

    Research output: Contribution to journalArticle

  29. Phase II trial of concurrent sunitinib and image-guided radiotherapy for oligometastases

    Tong, C. C. L., Ko, E. C., Sung, M. W., Cesaretti, J. A., Stock, R. G., Packer, S. H., Forsythe, K., Genden, E. M., Schwartz, M., Lau, K. H. V., Galsky, M., Ozao-Choy, J., Chen, S-H. & Kao, J., Jun 27 2012, In : PloS one. 7, 6, e36979.

    Research output: Contribution to journalArticle

  30. Tumor-expressed inducible nitric oxide synthase controls induction of functional myeloid-derived suppressor cells through modulation of vascular endothelial growth factor release

    Jayaraman, P., Parikh, F., Lopez-Rivera, E., Hailemichael, Y., Clark, A., Ma, G., Cannan, D., Ramacher, M., Kato, M., Overwijk, W. W., Chen, S-H., Umansky, V. Y. & Sikora, A. G., Jun 1 2012, In : Journal of Immunology. 188, 11, p. 5365-5376 12 p.

    Research output: Contribution to journalArticle

  31. R-Ras is required for murine dendritic cell maturation and CD4 + T-cell priming

    Singh, G., Hashimoto, D., Yan, X., Helft, J., Park, P. J. Y., Ma, G., Qiao, R. F., Kennedy, C. R., Chen, S-H., Merad, M. & Chan, A. M., Feb 16 2012, In : Blood. 119, 7, p. 1693-1701 9 p.

    Research output: Contribution to journalArticle

  32. Inhibitory receptors bind ANGPTLs and support blood stem cells and leukaemia development

    Zheng, J., Umikawa, M., Cui, C., Li, J., Chen, X., Zhang, C., Hyunh, H., Kang, X., Silvany, R., Wan, X., Ye, J., Cantó, A. P., Chen, S-H., Wang, H. Y., Ward, E. S. & Zhang, C. C., Jan 1 2012, In : Nature. 485, 7400, p. 656-660 5 p.

    Research output: Contribution to journalArticle

  33. Myeloid-derived suppressive cells and their regulatory mechanisms in cancer

    Ma, G., Pan, P-Y. & Chen, S-H., Jan 1 2012, Innate Immune Regulation and Cancer Immunotherapy. Springer New York, p. 231-250 20 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

  34. 2011
  35. DNA vaccines delivered by human papillomavirus pseudovirions as a promising approach for generating antigen-specific CD8+ T cell immunity

    Peng, S., Ma, B., Chen, S-H., Hung, C. F. & Wu, T. C., Jul 28 2011, In : Cell and Bioscience. 1, 1, 26.

    Research output: Contribution to journalArticle

  36. Erratum: Phase 1 study of concurrent sunitinib and image-guided radiotherapy followed by maintenance sunitinib for patients with oligometastases (Cancer (2009) 115 (3571-80))

    Kao, J., Packer, S., Vu, H. L., Schwartz, M. E., Sung, M. W., Stock, R. G., Lo, Y. C., Huang, D., Chen, S-H. & Cesaretti, J. A., Jun 15 2011, In : Cancer. 117, 12, 1 p.

    Research output: Contribution to journalComment/debate

  37. Paired immunoglobin-like receptor-B regulates the suppressive function and fate of myeloid-derived suppressor cells

    Ma, G., Pan, P-Y., Eisenstein, S., Divino, C. M., Lowell, C. A., Takai, T. & Chen, S-H., Mar 25 2011, In : Immunity. 34, 3, p. 385-395 11 p.

    Research output: Contribution to journalArticle

  38. Targeting immune suppressing myeloid-derived suppressor cells in oncology

    Kao, J., Ko, E. C., Eisenstein, S., Sikora, A. G., Fu, S. & Chen, S-H., Jan 1 2011, In : Critical Reviews in Oncology/Hematology. 77, 1, p. 12-19 8 p.

    Research output: Contribution to journalReview article

  39. A functional recombinant human 4-1BB ligand for immune costimulatory therapy of cancer

    Meseck, M., Huang, T., Ma, G., Wang, G., Chen, S. H. & Woo, S. L. C., 2011, In : Journal of Immunotherapy. 34, 2, p. 175-182 8 p.

    Research output: Contribution to journalArticle

  40. 2010
  41. Myeloid-derived suppressor cells prevent type 1 diabetes in murine models

    Yin, B., Ma, G., Yen, C. Y., Zhou, Z., Wang, G. X., Divino, C. M., Casares, S., Chen, S-H., Yang, W. C. & Pan, P-Y., Nov 15 2010, In : Journal of Immunology. 185, 10, p. 5828-5834 7 p.

    Research output: Contribution to journalArticle

  42. Myeloid-derived suppressor cells: Natural regulators for transplant tolerance

    Boros, P., Ochando, J. C., Chen, S-H. & Bromberg, J. S., Nov 1 2010, In : Human Immunology. 71, 11, p. 1061-1066 6 p.

    Research output: Contribution to journalReview article

  43. Monocytic suppressive cells mediate cardiovascular transplantation tolerance in mice

    Garcia, M. R., Ledgerwood, L., Yang, Y., Xu, J., Lal, G., Burrell, B., Ma, G., Hashimoto, D., Li, Y., Boros, P., Grisotto, M., Van Rooijen, N., Matesanz, R., Tacke, F., Ginhoux, F., Ding, Y., Chen, S-H., Randolph, G., Merad, M., Bromberg, J. S. & 1 othersOchando, J. C., Jul 1 2010, In : Journal of Clinical Investigation. 120, 7, p. 2486-2496 11 p.

    Research output: Contribution to journalArticle

  44. Development and function of myeloid-derived suppressor cells generated from mouse embryonic and hematopoietic stem cells

    Zhou, Z., French, D. L., Ma, G., Eisenstein, S., Chen, Y., Divino, C. M., Keller, G., Chen, S-H. & Pan, P-Y., Mar 31 2010, In : STEM CELLS. 28, 3, p. 620-632 13 p.

    Research output: Contribution to journalArticle

  45. Immune stimulatory receptor CD40 is required for T-cell suppression and T regulatory cell activation mediated by myeloid-derived suppressor cells in cancer

    Pan, P-Y., Ma, G., Weber, K. J., Ozao-Choy, J., Wang, G., Yin, B., Divino, C. M. & Chen, S-H., Jan 1 2010, In : Cancer Research. 70, 1, p. 99-108 10 p.

    Research output: Contribution to journalArticle

  46. 2009
  47. Phase 1 study of concurrent sunitinib and image-guided radiotherapy followed by maintenance sunitinib for patients with oligometastases: Acute toxicity and preliminary response

    Kao, J., Packer, S., Ha, L. V., Schwartz, M. E., Sung, M. W., Stock, R. G., Lo, Y. C., Huang, D., Chen, S-H. & Cesaretti, J. A., Aug 1 2009, In : Cancer. 115, 15, p. 3571-3580 10 p.

    Research output: Contribution to journalArticle

  48. The novel role of tyrosine kinase inhibitor in the reversal of immune suppression and modulation of tumor microenvironment for immune-based cancer therapies

    Ozao-Choy, J., Ge, M., Kao, J., Wang, G. X., Meseck, M., Sung, M., Schwartz, M., Divino, C. M., Pan, P-Y. & Chen, S-H., Mar 15 2009, In : Cancer Research. 69, 6, p. 2514-2522 9 p.

    Research output: Contribution to journalArticle

  49. 2008
  50. Interleukin 10 suppresses Th17 cytokines secreted by macrophages and T cells

    Gu, Y., Yang, J., Ouyang, X., Liu, W., Li, H., Yang, J., Bromberg, J., Chen, S-H., Mayer, L., Unkeless, J. C. & Xiong, H., Jul 1 2008, In : European Journal of Immunology. 38, 7, p. 1807-1813 7 p.

    Research output: Contribution to journalArticle

  51. Advancements in immune tolerance

    Pan, P-Y., Ozao, J., Zhou, Z. & Chen, S-H., Jan 14 2008, In : Advanced Drug Delivery Reviews. 60, 2, p. 91-105 15 p.

    Research output: Contribution to journalReview article

  52. Reversion of immune tolerance in advanced malignancy: Modulation of myeloid-derived suppressor cell development by blockade of stem-cell factor function

    Pan, P-Y., Wang, G. X., Yin, B., Ozao, J., Ku, T., Divino, C. M. & Chen, S-H., Jan 1 2008, In : Blood. 111, 1, p. 219-228 10 p.

    Research output: Contribution to journalArticle

  53. 2007
  54. The terminology issue for myeloid-derived suppressor cells [1]

    Gabrilovich, D. I., Bronte, V., Chen, S-H., Colombo, M. P., Ochoa, A., Ostrand-Rosenberg, S. & Schreiber, H., Jan 1 2007, In : Cancer Research. 67, 1, 1 p.

    Research output: Contribution to journalLetter

  55. 2006
  56. Gr-1+CD115+ immature myeloid suppressor cells mediate the development of tumor-induced T regulatory cells and T-cell anergy in tumor-bearing host

    Huang, B., Pan, P-Y., Li, Q., Sato, A. I., Levy, D. E., Bromberg, J., Divino, C. M. & Chen, S-H., Jan 15 2006, In : Cancer Research. 66, 2, p. 1123-1131 9 p.

    Research output: Contribution to journalArticle

  57. 2005
  58. Erratum: Toll-like receptors on tumor cells facilitate evasion of immune surveillance (Cancer Research (June 15, 2005) 65 (5009-5014))

    Huang, B., Zhao, J., Li, H., He, K. L., Chen, Y., Chen, S-H., Mayer, L., Unkeless, J. C. & Xiong, H., Oct 1 2005, In : Cancer Research. 65, 19, 1 p.

    Research output: Contribution to journalComment/debate

  59. The systemic administration of Ig-4-1BB ligand in combination with IL-12 gene transfer eradicates hepatic colon carcinoma

    Xu, D. P., Sauter, B. V., Huang, T. G., Meseck, M., Woo, S. L. C. & Chen, S-H., Oct 1 2005, In : Gene Therapy. 12, 20, p. 1526-1533 8 p.

    Research output: Contribution to journalArticle

  60. 2004
  61. NK and CD8+ T cell-mediated eradication of poorly immunogenic B16-F10 melanoma by the combined action of IL-12 gene therapy and 4-1BB costimulation

    Xu, D., Gu, P., Pan, P-Y., Li, Q., Sato, A. I. & Chen, S-H., Apr 20 2004, In : International Journal of Cancer. 109, 4, p. 499-506 8 p.

    Research output: Contribution to journalArticle

  62. Regulation of Dendritic Cell Function by NK Cells: Mechanisms Underlying the Synergism in the Combination Therapy of IL-12 and 4-1BB Activation

    Pan, P-Y., Gu, P., Li, Q., Xu, D., Weber, K. & Chen, S-H., Apr 15 2004, In : Journal of Immunology. 172, 8, p. 4779-4789 11 p.

    Research output: Contribution to journalArticle

  63. Role of Immature Myeloid Gr-1+ Cells in the Development of Antitumor Immunity

    Li, Q., Pan, P-Y., Gu, P., Xu, D. & Chen, S-H., Feb 1 2004, In : Cancer Research. 64, 3, p. 1130-1139 10 p.

    Research output: Contribution to journalArticle

  64. In situ recruitment of antigen-presenting cells by intratumoral GM-CSF gene delivery

    Pan, P-Y., Li, Y., Li, Q., Gu, P., Martinet, O., Thung, S. & Chen, S-H., Jan 1 2004, In : Cancer Immunology, Immunotherapy. 53, 1, p. 17-25 9 p.

    Research output: Contribution to journalArticle

  65. 2003
  66. IFN-γ sensitization of prostate cancer cells to Fas-mediated death: A gene therapy approach

    Selleck, W. A., Canfield, S. E., Hassen, W. A., Meseck, M., Kuzmin, A. I., Eisensmith, R. C., Chen, S-H. & Hall, S. J., Feb 1 2003, In : Molecular Therapy. 7, 2, p. 185-192 8 p.

    Research output: Contribution to journalArticle

  67. 2002
  68. OX40 ligation enhances primary and memory cytotoxic T lymphocyte responses in an immunotherapy for hepatic colon metastases

    Pan, P-Y., Zang, Y., Weber, K., Meseck, M. L. & Chen, S-H., Oct 1 2002, In : Molecular Therapy. 6, 4, p. 528-536 9 p.

    Research output: Contribution to journalArticle

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