Research outputs

  1. 2019
  2. Motor neuron disease-associated loss of nuclear TDP-43 is linked to DNA double-strand break repair defects

    Mitra, J., Guerrero, E. N., Hegde, P. M., Liachko, N. F., Wang, H., Vasquez, V., Gao, J., Pandey, A., Paul Taylor, J., Kraemer, B. C., Wu, P., Boldogh, I., Garruto, R. M., Mitra, S., Rao, K. S. & Hegde, M., Jan 1 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 10, p. 4696-4705 10 p.

    Research output: Contribution to journalArticle

  3. 2018
  4. Mutant FUS causes DNA ligation defects to inhibit oxidative damage repair in Amyotrophic Lateral Sclerosis

    Wang, H., Guo, W., Mitra, J., Hegde, P. M., Vandoorne, T., Eckelmann, B. J., Mitra, S., Tomkinson, A. E., Van Den Bosch, L. & Hegde, M. L., Sep 11 2018, In : Nature communications. 9, 1, 3683.

    Research output: Contribution to journalArticle

  5. SMAD4 gene mutation renders pancreatic cancer resistance to radiotherapy through promotion of autophagy

    Wang, F., Xia, X., Yang, C., Shen, J., Mai, J., Kim, H. C., Kirui, D., Kang, Y., Fleming, J. B., Koay, E. J., Mitra, S., Ferrari, M. & Shen, H., Jul 1 2018, In : Clinical Cancer Research. 24, 13, p. 3176-3185 10 p.

    Research output: Contribution to journalArticle

  6. Acetylation of oxidized base repair-initiating NEIL1 DNA glycosylase required for chromatin-bound repair complex formation in the human genome increases cellular resistance to oxidative stress

    Sengupta, S., Yang, C., Hegde, M. L., Hegde, P. M., Mitra, J., Pandey, A., Dutta, A., Datarwala, A. T., Bhakat, K. K. & Mitra, S., Apr 17 2018, In : DNA Repair. 66-67, p. 1-10 10 p.

    Research output: Contribution to journalArticle

  7. 2017
  8. Pre-Replicative Repair of Oxidized Bases Maintains Fidelity in Mammalian Genomes: The Cowcatcher Role of NEIL1 DNA Glycosylase

    Rangaswamy, S., Pandey, A., Mitra, S. & Hegde, M. L., Jun 30 2017, In : Genes. 8, 7

    Research output: Contribution to journalArticle

  9. DNA damage responses in central nervous system and age-associated neurodegeneration

    Hegde, M. L., Bohr, V. A. & Mitra, S., Jan 1 2017, In : Mechanisms of Ageing and Development. 161, p. 1-3 3 p.

    Research output: Contribution to journalEditorial

  10. Aurora kinase B dependent phosphorylation of 53BP1 is required for resolving merotelic kinetochore-microtubule attachment errors during mitosis

    Wang, H., Peng, B., Pandita, R. K., Engler, D. A., Matsunami, R. K., Xu, X., Hegde, P. M., Butler, E. B., Pandita, T. K., Mitra, S., Xu, B. & Hegde, M. L., 2017, In : Oncotarget. 8, 30, p. 48671-48687 17 p.

    Research output: Contribution to journalArticle

  11. Chromatin-Bound Oxidized α-Synuclein Causes Strand Breaks in Neuronal Genomes in in vitro Models of Parkinson's Disease

    Vasquez, V., Mitra, J., Hegde, P. M., Pandey, A., Sengupta, S., Mitra, S., Rao, S. K. & Hegde, M. L., 2017, In : Journal of Alzheimer's Disease. 60, s1, p. S133-S150

    Research output: Contribution to journalArticle

  12. 2016
  13. Microhomology-mediated end joining is activated in irradiated human cells due to phosphorylation-dependent formation of the XRCC1 repair complex

    Dutta, A., Eckelmann, B., Adhikari, S., Ahmed, K. M., Sengupta, S., Pandey, A., Hegde, P. M., Tsai, M-S., Tainer, J. A., Weinfeld, M., Hegde, M. L. & Mitra, S., Dec 19 2016, In : Nucleic acids research. 45, 5, p. 2585-2599 15 p.

    Research output: Contribution to journalArticle

  14. Regulation of oxidized base damage repair by chromatin assembly factor 1 subunit A

    Yang, C., Sengupta, S., Hegde, P. M., Mitra, J., Jiang, S., Holey, B., Sarker, A. H., Tsai, M-S., Hegde, M. L. & Mitra, S., Oct 27 2016, In : Nucleic acids research. 45, 2, p. 739-748 10 p.

    Research output: Contribution to journalArticle

  15. Chronic oxidative damage together with genome repair deficiency in the neurons is a double whammy for neurodegeneration: Is damage response signaling a potential therapeutic target?

    Wang, H., Dharmalingam, P., Vasquez, V., Mitra, J., Boldogh, I., Rao, K. S., Kent, T. A., Mitra, S. & Hegde, M. L., Sep 20 2016, In : Mechanisms of Ageing and Development.

    Research output: Contribution to journalArticle

  16. Depletion of tyrosyl DNA phosphodiesterase 2 activity enhances etoposide-mediated double-strand break formation and cell killing

    Kont, Y. S., Dutta, A., Mallisetty, A., Mathew, J., Minas, T., Kraus, C., Dhopeshwarkar, P., Kallakury, B., Mitra, S., Üren, A. & Adhikari, S., Jul 1 2016, In : DNA Repair. 43, p. 38-47 10 p.

    Research output: Contribution to journalArticle

  17. 8-Oxoguanine DNA glycosylase1-driven DNA repair-A paradoxical role in lung aging

    German, P., Saenz, D., Szaniszlo, P., Aguilera-Aguirre, L., Pan, L., Hegde, M. L., Bacsi, A., Hajas, G., Radak, Z., Ba, X., Mitra, S., Papaconstantinou, J. & Boldogh, I., Jun 21 2016, In : Mechanisms of Ageing and Development.

    Research output: Contribution to journalArticle

  18. Scaffold attachment factor A (SAF-A) and Ku temporally regulate repair of radiation-induced clustered genome lesions

    Hegde, M. L., Dutta, A., Yang, C., Mantha, A. K., Hegde, P. M., Pandey, A., Sengupta, S., Yu, Y., Calsou, P., Chen, D., Lees-Miller, S. P. & Mitra, S., Jun 9 2016, In : Oncotarget.

    Research output: Contribution to journalArticle

  19. 2015
  20. Increased human AP endonuclease 1 level confers protection against the paternal age effect in mice

    Sanchez, J. R., Reddick, T. L., Perez, M., Centonze, V. E., Mitra, S., Izumi, T., McMahan, C. A. & Walter, C. A., Sep 1 2015, In : Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 779, p. 124-133 10 p.

    Research output: Contribution to journalArticle

  21. The C-terminal Domain (CTD) of Human DNA Glycosylase NEIL1 Is Required for Forming BERosome Repair Complex with DNA Replication Proteins at the Replicating Genome: Dominant negative function of the CTD

    Hegde, P. M., Dutta, A., Sengupta, S., Mitra, J., Adhikari, S., Tomkinson, A. E., Li, G. M., Boldogh, I., Hazra, T. K., Mitra, S. & Hegde, M. L., Aug 21 2015, In : Journal of Biological Chemistry. 290, 34, p. 20919-20933 15 p.

    Research output: Contribution to journalArticle

  22. Norepinephrine Reduces Reactive Oxygen Species (ROS) and DNA Damage in Ovarian Surface Epithelial Cells

    Patel, P. R., Hegde, M. L., Theruvathu, J., Mitra, S. A., Boldogh, I. & Sowers, L., Jul 15 2015, In : Journal of Bioanalysis & Biomedicine. 7, 3, p. 75-80 6 p.

    Research output: Contribution to journalArticle

  23. New paradigms in the repair of oxidative damage in human genome: Mechanisms ensuring repair of mutagenic base lesions during replication and involvement of accessory proteins

    Dutta, A., Yang, C., Sengupta, S., Mitra, S. & Hegde, M. L., May 1 2015, In : Cellular and Molecular Life Sciences. 72, 9, p. 1679-1698 20 p.

    Research output: Contribution to journalArticle

  24. Revisiting Metal Toxicity in Neurodegenerative Diseases and Stroke: Therapeutic Potential

    Mitra, J., Vasquez, V., Hegde, P. M., Boldogh, I., Mitra, S., Kent, T. A., Rao, K. S. & Hegde, M. L., Feb 27 2015, In : Neurological Research and Therapy. 1, 2

    Research output: Contribution to journalArticle

  25. A Perspective on Chromosomal Double Strand Break Markers in Mammalian Cells

    Wang, H., Adhikari, S., Butler, E. B., Pandita, T. K., Mitra, S. & Hegde, M. L., Jan 24 2015, In : Jacobs Journal of Radiation Oncology. 1, 1:003.

    Research output: Contribution to journalArticle

  26. 2014
  27. Opposing roles of mitochondrial and nuclear PARP1 in the regulation of mitochondrial and nuclear DNA integrity: Implications for the regulation of mitochondrial function

    Szczesny, B., Brunyanszki, A., Olah, G., Mitra, S. & Szabo, C., Dec 1 2014, In : Nucleic acids research. 42, 21, p. 13161-13173 13 p.

    Research output: Contribution to journalArticle

  28. Innate inflammation induced by the 8-oxoguanine DNA glycosylase-1-KRAS-NF-κB pathway

    Aguilera-Aguirre, L., Bacsi, A., Radak, Z., Hazra, T. K., Mitra, S., Sur, S., Brasier, A. R., Ba, X. & Boldogh, I., Jan 1 2014, In : Journal of Immunology. 193, 9, p. 4643-4653 11 p.

    Research output: Contribution to journalArticle

  29. Oxidative stress: An essential factor in the pathogenesis of gastrointestinal mucosal diseases

    Bhattacharyya, A., Chattopadhyay, R., Mitra, S. & Crowe, S. E., Jan 1 2014, In : Physiological Reviews. 94, 2, p. 329-354 26 p.

    Research output: Contribution to journalArticle

  30. New perspectives on oxidized genome damage and repair inhibition by pro-oxidant metals in neurological diseases

    Mitra, J., Guerrero, E. N., Hegde, P. M., Wang, H., Boldogh, I., Rao, K. S. H., Mitra, S. & Hegde, M., 2014, In : Biomolecules. 4, 3, p. 678-703 26 p.

    Research output: Contribution to journalArticle

  31. 2013
  32. Systems approaches to modeling chronic mucosal inflammation

    Kalita, M., Tian, B., Gao, B., Choudhary, S., Wood, T. G., Carmical, J. R., Boldogh, I., Mitra, S., Minna, J. D. & Brasier, A. R., Nov 18 2013, In : BioMed Research International. 2013, 505864.

    Research output: Contribution to journalArticle

  33. Deficiency in Repair of the Mitochondrial Genome Sensitizes Proliferating Myoblasts to Oxidative Damage

    Szczesny, B., Olah, G., Walker, D. K., Volpi, E., Rasmussen, B. B., Szabo, C. & Mitra, S., Sep 16 2013, In : PLoS ONE. 8, 9, e75201.

    Research output: Contribution to journalArticle

  34. Prereplicative repair of oxidized bases in the human genome is mediated by NEIL1 DNA glycosylase together with replication proteins

    Hegde, M., Hegde, P. M., Bellot, L. J., Mandal, S. M., Hazra, T. K., Li, G. M., Boldogh, I., Tomkinson, A. E. & Mitra, S., Aug 13 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 33

    Research output: Contribution to journalArticle

  35. Dual Regulatory Roles of Human AP-Endonuclease (APE1/Ref-1) in CDKN1A/p21 Expression

    Sengupta, S., Mitra, S. & Bhakat, K. K., Jul 16 2013, In : PLoS ONE. 8, 7, e68467.

    Research output: Contribution to journalArticle

  36. The disordered C-terminal domain of human DNA glycosylase NEIL1 contributes to its stability via intramolecular interactions

    Hegde, M., Tsutakawa, S. E., Hegde, P. M., Holthauzen, L. M. F., Li, J., Oezguen, N., Hilser, V. J., Tainer, J. A. & Mitra, S., Jul 10 2013, In : Journal of molecular biology. 425, 13, p. 2359-2371 13 p.

    Research output: Contribution to journalArticle

  37. Conserved structural chemistry for incision activity in structurally non-homologous apurinic/apyrimidinic endonuclease APE1 and endonuclease IV DNA repair enzymes

    Tsutakawa, S. E., Shin, D. S., Mol, C. D., Izumi, T., Arvai, A. S., Mantha, A. K., Szczesny, B., Ivanov, I. N., Hosfield, D. J., Maiti, B., Pique, M. E., Frankel, K. A., Hitomi, K., Cunningham, R. P., Mitra, S. & Tainer, J. A., Mar 22 2013, In : Journal of Biological Chemistry. 288, 12, p. 8445-8455 11 p.

    Research output: Contribution to journalArticle

  38. 2012
  39. The interaction between polynucleotide kinase phosphatase and the DNA repair protein XRCC1 is critical for repair of DNA alkylation damage and stable association at DNA damage sites

    Della-Maria, J., Hegde, M. L., McNeill, D. R., Matsumoto, Y., Tsai, M. S., Ellenberger, T., Wilson, D. M., Mitra, S. & Tomkinson, A. E., Nov 9 2012, In : Journal of Biological Chemistry. 287, 46, p. 39233-39244 12 p.

    Research output: Contribution to journalArticle

  40. Enhancement of NEIL1 protein-initiated oxidized DNA base excision repair by heterogeneous nuclear ribonucleoprotein U (hnRNP-U) via direct interaction

    Hegde, M., Banerjee, S., Hegde, P. M., Bellot, L. J., Hazra, T. K., Boldogh, I. & Mitra, S., Oct 5 2012, In : Journal of Biological Chemistry. 287, 41, p. 34202-34211 10 p.

    Research output: Contribution to journalArticle

  41. Oxidized base damage and single-strand break repair in mammalian genomes: Role of disordered regions and posttranslational modifications in early enzymes

    Hegde, M., Izumi, T. & Mitra, S., Jul 3 2012, In : Progress in Molecular Biology and Translational Science. 110, p. 123-153 31 p.

    Research output: Contribution to journalArticle

  42. Activation of Ras signaling pathway by 8-oxoguanine DNA glycosylase bound to its excision product, 8-oxoguanine

    Boldogh, I., Hajas, G., Aguilera-Aguirre, L., Hegde, M., Radak, Z., Bacsi, A., Sur, S., Hazra, T. K. & Mitra, S., Jun 15 2012, In : Journal of Biological Chemistry. 287, 25, p. 20769-20773 5 p.

    Research output: Contribution to journalArticle

  43. Proteomic study of amyloid beta (25-35) peptide exposure to neuronal cells: Impact on APE1/Ref-1's protein-protein interaction

    Mantha, A. K., Dhiman, M., Taglialatela, G., Perez-Polo, R. J. & Mitra, S., Jun 1 2012, In : Journal of Neuroscience Research. 90, 6, p. 1230-1239 10 p.

    Research output: Contribution to journalArticle

  44. Regulation of mouse-renin gene by apurinic/apyrimidinic-endonuclease 1 (APE1/Ref-1) via recruitment of histone deacetylase 1 corepressor complex

    Sengupta, S., Chattopadhyay, R., Mantha, A. K., Mitra, S. & Bhakat, K. K., May 1 2012, In : Journal of Hypertension. 30, 5, p. 917-925 9 p.

    Research output: Contribution to journalArticle

  45. Oxidative genome damage and its repair: Implications in aging and neurodegenerative diseases

    Hegde, M., Mantha, A. K., Hazra, T. K., Bhakat, K. K., Mitra, S. & Szczesny, B., Apr 1 2012, In : Mechanisms of Ageing and Development. 133, 4, p. 157-168 12 p.

    Research output: Contribution to journalArticle

  46. Human DNA glycosylase NEIL1's interactions with downstream repair proteins is critical for efficient repair of oxidized DNA base damage and enhanced cell survival

    Hegde, M., Hegde, P. M., Arijit, D., Boldogh, I. & Mitra, S., 2012, In : Biomolecules. 2, 4, p. 564-578 15 p.

    Research output: Contribution to journalArticle

  47. 2011
  48. Does evening sun increase the risk of skin cancer?

    Mitra, S., Nov 22 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 47, p. 18857-18858 2 p.

    Research output: Contribution to journalArticle

  49. Impaired integrity of DNA after recovery from inflammation causes persistent dysfunction of colonic smooth muscle

    Choi, K., Chen, J., Mitra, S. & Sarna, S. K., Oct 1 2011, In : Gastroenterology. 141, 4

    Research output: Contribution to journalArticle

  50. Apoptosis induced by persistent single-strand breaks in mitochondrial genome: Critical role of EXOG (5′-exo/endonuclease) in their repair

    Tann, A. W., Boldogh, I., Meiss, G., Qian, W., Van Houten, B., Mitra, S. & Szczesny, B., Sep 16 2011, In : Journal of Biological Chemistry. 286, 37, p. 31975-31983 9 p.

    Research output: Contribution to journalArticle

  51. Fen1 mutations that specifically disrupt its interaction with PCNA cause aneuploidy-associated cancer

    Zheng, L., Dai, H., Hegde, M., Zhou, M., Guo, Z., Wu, X., Wu, J., Su, L., Zhong, X., Mitra, S., Huang, Q., Kernstine, K. H., Pfeifer, G. P. & Shen, B., Jul 1 2011, In : Cell Research. 21, 7, p. 1052-1067 16 p.

    Research output: Contribution to journalArticle

  52. Oxidative genome damage and its repair in neurodegenerative diseases: Function of transition metals as a double-edged sword

    Hegde, M., Hegde, P. M., Rao, K. S. & Mitra, S., May 10 2011, In : Journal of Alzheimer's Disease. 24, SUPPL. 2, p. 183-198 16 p.

    Research output: Contribution to journalArticle

  53. Obesity and hepatosteatosis in mice with enhanced oxidative DNA damage processing in mitochondria

    Zhang, H., Xie, C., Spencer, H. J., Zuo, C., Higuchi, M., Ranganathan, G., Kern, P. A., Chou, M. W., Huang, Q., Szczesny, B., Mitra, S., Watson, A. J., Margison, G. P. & Fan, C. Y., Apr 1 2011, In : American Journal of Pathology. 178, 4, p. 1715-1727 13 p.

    Research output: Contribution to journalArticle

  54. Preferential repair of oxidized base damage in the transcribed genes of mammalian cells

    Banerjee, D., Mandal, S. M., Das, A., Hegde, M., Das, S., Bhakat, K. K., Boldogh, I., Sarkar, P. S., Mitra, S. & Hazra, T. K., Feb 25 2011, In : Journal of Biological Chemistry. 286, 8, p. 6006-6016 11 p.

    Research output: Contribution to journalArticle

  55. Human AP endonuclease (APE1/Ref-1) and its acetylation regulate YB-1-p300 recruitment and RNA polymerase II loading in the drug-induced activation of multidrug resistance gene MDR1

    Sengupta, S., Mantha, A. K., Mitra, S. & Bhakat, K. K., Jan 27 2011, In : Oncogene. 30, 4, p. 482-493 12 p.

    Research output: Contribution to journalArticle

  56. 2010
  57. Functions of disordered regions in mammalian early base excision repair proteins

    Hegde, M., Hazra, T. K. & Mitra, S., Nov 1 2010, In : Cellular and Molecular Life Sciences. 67, 21, p. 3573-3587 15 p.

    Research output: Contribution to journalArticle

  58. Specific inhibition of NEIL-initiated repair of oxidized base damage in human genome by copper and iron: Potential etiological linkage to neurodegenerative diseases

    Hegde, M., Hegde, P. M., Holthauzen, L. M. F., Hazra, T. K., Rao, K. S. J. & Mitra, S., Sep 10 2010, In : Journal of Biological Chemistry. 285, 37, p. 28812-28825 14 p.

    Research output: Contribution to journalArticle

  59. RPA physically interacts with the human DNA glycosylase NEIL1 to regulate excision of oxidative DNA base damage in primer-template structures

    Theriot, C. A., Hegde, M., Hazra, T. K. & Mitra, S., Jun 4 2010, In : DNA Repair. 9, 6, p. 643-652 10 p.

    Research output: Contribution to journalArticle

  60. Age- and tissue-specific changes in mitochondrial and nuclear DNA base excision repair activity in mice: Susceptibility of skeletal muscles to oxidative injury

    Szczesny, B., Tann, A. W. & Mitra, S., May 1 2010, In : Mechanisms of Ageing and Development. 131, 5, p. 330-337 8 p.

    Research output: Contribution to journalArticle

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ID: 2282686