Personal profile

Dr. Mitra had a brillient academic career at Calcutta University, India from which he received MS in Biochemitry in 1959.After earning a Ph.D. from the University of Wisconsin in 1964, Dr. Mitra did postdoctoral research in Arthur Kornberg’s laboratory at Stanford Medical School. He then returned to India to join Bose Institute, Calcutta, as an assistant professor in 1966, and became an associate professor in 1971. He came back to the U.S. in 1971 to join the Biology Division of Oak Ridge National Laboratory as a senior research investigator and subsequently became leader of the Nucleic Acid Enzymology Group. He also served as an adjunct professor of the University of Tennessee Graduate School of Biomedical Sciences. Dr. Mitra moved to the newly created Sealy Center for Molecular Science at the University of Texas Medical Branch (UTMB), Galveston, TX in 1992 as professor of Biochemistry & Molecular Biology, and later as senior scientist in the Sealy Center for Molecular Medicine. After his retirement from UTMB in 2013, he joined Houston Methodist Research Institute as a full member in Radiation Oncology. He was elected a fellow of AAAS in 1989 and as a fellow of the Japan Society for Promotion of Science, participating in lecture tours in Japan in 1991, 1999, and 2008.He was awarded Mark Brothers of Indiana Prize in 2009. Dr. Mitra has been continuously funded by NIH since 1982 and has been serving on various NIH and other  review panels.

Research interests

Working in the broad area of genome damage, its repair, and its influence in carcinogenesis and cancer therapy, Dr. Mitra has made several seminal discoveries during his tenure at Oak Ridge National Laboratory, including the characterization of the E. coli repair protein for the mutagenic DNA base O-6 methylguanine produced by mutagens and anticancer alkylating agents, the naming of the repair protein MGMT, and the cloning of human MGMT. More recently, Dr. Mitra’s group characterized a new family of DNA repair proteins that they named NEILs for oxidative genome damage. The recent research focus of Dr. Mitra’s group is enhancement of chemo/radiation sensitivity of tumor cells using targeted DNA repair inhibitors. After the early studies on MGMT inhibition, his current research aims to identify inhibitors for repair pathways for oxidative/radiation damage.

Keywords

    Research Area Keywords

  • Cancer

    Free-text keywords

  • Genome damage, Repair, Cancer mechanisms, Cancer therapy

External positions

Adjunct Prof of Cell Mol Biol, Texas A&M University

Sep 1 2015Aug 31 2016

Adjunct Professor of Biochemistry & M ol Biol., UTMB

Sep 1 2013Aug 31 2016

Fingerprint

DNA
Concept: DNA
Weight: 100%
Domain: Medicine & Life Sciences
DNA Repair
Concept: DNA Repair
Weight: 98%
Domain: Medicine & Life Sciences
DNA Glycosylases
Concept: DNA Glycosylases
Weight: 97%
Domain: Medicine & Life Sciences
DNA-(Apurinic or Apyrimidinic Site) Lyase
Concept: DNA-(Apurinic or Apyrimidinic Site) Lyase
Weight: 71%
Domain: Medicine & Life Sciences
Methyltransferases
Concept: Methyltransferases
Weight: 65%
Domain: Medicine & Life Sciences
Repair
Concept: Repair
Weight: 60%
Domain: Chemical Compounds
Genes
Concept: Genes
Weight: 41%
Domain: Chemical Compounds
Escherichia coli
Concept: Escherichia coli
Weight: 38%
Domain: Medicine & Life Sciences
DNA Damage
Concept: DNA Damage
Weight: 38%
Domain: Medicine & Life Sciences
Genome
Concept: Genome
Weight: 35%
Domain: Medicine & Life Sciences
Research OutputsResearch Output authored by Sankar Mitra is tagged with the concept

Journals

The Journal of biological chemistry

ISSNs: 0021-9258

American Society for Biochemistry and Molecular Biology Inc.

Journal

30

Nucleic acids research

ISSNs: 0305-1048, 1362-4962

Additional searchable ISSN (Electronic): 1362-4962

Oxford University Press

Journal

18

Carcinogenesis

ISSNs: 0143-3334

Oxford University Press

Journal

17

Proceedings of the National Academy of Sciences of the United States of America

ISSNs: 0027-8424

Journal

12

Biochemistry

ISSNs: 0006-2960

American Chemical Society

Journal

11
has published Research OutputsResearch Output by Sankar Mitra

Research Network

Visualization: Institutional Network

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Sankar Mitra

Visualization: Co-author Network

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Sankar Mitra

Shared Pub. Internal Organizations

Neurosciences Research Program

Organizational unit: Programs

33

Department of Nanomedicine

Organizational unit: Departments

1

Houston Methodist Hospital

Organizational unit: Schools & Hospitals

1
has Research OutputsResearch Output by Sankar Mitra

Shared Pub. External Organizations

UT Medical Branch at Galveston

External organization: Unknown

122

Oak Ridge National Laboratory

External organization: Unknown

30

University of Tennessee-Oak Ridge Graduate School of Biomedical Sciences

External organization: Unknown

22

The University of Texas Health Science Center at San Antonio

External organization: Unknown

6

National Institute of Environmental Health Sciences

External organization: Unknown

6
has Research OutputsResearch Output by Sankar Mitra

Shared Pub. Internal co-authors

has co-authored Research OutputsResearch Output with Sankar Mitra

Shared Pub. External co-authors

Tapas K. Hazra

External person

57

Tadahide Izumi

External person

44

Istvan Boldogh

External person

41

Kishor K. Bhakat

External person

29

R. Roy

External person

23
has co-authored Research OutputsResearch Output with Sankar Mitra

ID: 2282686