Projects per year
Personal profile
Personal profile
Dr. Wang received his Ph.D. from the University of Georgia in 1992. After receiving his doctoral degree in Molecular Genetics, Dr. Wang expanded his field of expertise by training with Dr. James Mullins in the Department of Microbiology and Immunology at Stanford University School of Medicine. In 1994, Dr. Wang joined the Surgery Branch in the Center for Cancer Research at the National Cancer Institute (NCI) in Bethesda, Maryland where he worked with Branch Chief, Dr. Steve Rosenberg, who is a pioneer of cancer immunotherapy. In 1996, Dr. Wang was promoted to Senior Principal Investigator. During his tenure at the NCI, Dr. Wang made insightful discoveries on how immune cells recognize solid tumors through specific cancer antigens and published a landmark paper in Science on the development of a novel genetic approach to identify cancer antigens recognized by CD4+ T cells. In 2000, Dr. Wang was appointed Associate Professor at Baylor College of Medicine in the Center for Cell and Gene Therapy and the Department of Pathology and Immunology. He was promoted to full Professor in 2004. His lab studies novel mechanisms in tumor immunity and tolerance, innate immune regulation, regulatory T cell biology, inflammation, and epigenetics.
Throughout his career Dr. Wang has published over hundred papers in the top class of journals, including Science, Cell, Nature Biotechnology, Nature Immunology, Cell Metabolism and Immunity, and has over 20 patents. His work has been supported by many grants from NIH, DoD, American Cancer Society, Cancer Research Institute and CPRIT.
Research interests
Research interests in Dr. Wang's laboratory include
- cancer immunotherapy,
- immune regulation in infectious and tumor immunity;
- innate immune signaling and inflammation in diseases, 3) epigenetic reprogramming of cancer and immune cells.
Education/Academic qualification
Molecular Virology, Postdoctoral Fellowship, Stanford University
Cancer Immunotherapy, Postdoctoral Fellowship, Surgery Branch, National Cancer Institute, Bethesda, MD
Molecular Genetics, PhD, University of Georgia
Research Area Keywords
- Cancer
- Immunobiology & Inflammation
Free-text keywords
- Cancer immunology
- Innate immune signaling
- Epigenetics of cancer and stem cells
- Cancer immunotherapy
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Network
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Novel Strategies for Intervention of Inflammatory Diseases and Cancer
7/1/04 → 6/30/23
Project: Federal Funding Agencies
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Novel Strategies for Intervention of Inflammatory Diseases and Cancer - Research Supplement to R01-CA101795
7/1/04 → 6/30/23
Project: Federal Funding Agencies
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Identification of novel immune targets and neoantigens for development of immunotherapy for breast cancer
Wang, R., Chang, J. C. & Liu, X.
12/1/16 → 11/30/19
Project: State
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NY-ESO-1-specific TCR-engineered T cell immunotherapy for triple negative breast cancer
9/30/16 → 10/28/19
Project: Federal Funding Agencies
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Center for Immunotherapeutic Transport Oncophysics
Herzog, T., Kojic, M., Liu, X., Schrefler, B. A. & Wang, R.
8/29/16 → 7/31/22
Project: Federal Funding Agencies
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Function and regulation of cGAS-STING signaling in infectious diseases
Du, Y., Hu, Z., Luo, Y., Wang, H. Y., Yu, X. & Wang, R. F., Feb 6 2023, In: Frontiers in immunology. 14, 1130423.Research output: Contribution to journal › Review article › peer-review
Open Access -
Activation of cGAS-STING by Lethal Malaria N67C Dictates Immunity and Mortality through Induction of CD11b+Ly6Chi Proinflammatory Monocytes
Du, Y., Luo, Y., Hu, Z., Lu, J., Liu, X., Xing, C., Wu, J., Duan, T., Chu, J., Wang, H. Y., Su, X. Z., Yu, X. & Wang, R. F., Aug 5 2022, In: Advanced Science. 9, 22, 2103701.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
A Phase I Study of Autologous Dendritic Cell Vaccine Pulsed with Allogeneic Stem-like Cell Line Lysate in Patients with Newly Diagnosed or Recurrent Glioblastoma
Hu, J. L., Omofoye, O. A., Rudnick, J. D., Kim, S., Tighiouart, M., Phuphanich, S., Wang, H., Mazer, M., Ganaway, T., Chu, R. M., Patil, C. G., Black, K. L., Shiao, S. L., Wang, R. & Yu, J. S., Feb 15 2022, In: Clinical Cancer Research. 28, 4, p. 689-696 8 p.Research output: Contribution to journal › Article › peer-review
Open Access13 Scopus citations -
Development of a TCR-like antibody and chimeric antigen receptor against NY-ESO-1/HLA-A2 for cancer immunotherapy
Liu, X., Xu, Y., Xiong, W., Yin, B., Huang, Y., Chu, J., Xing, C., Qian, C., Du, Y., Duan, T., Wang, H. Y., Zhang, N., Yu, J. S., An, Z. & Wang, R., Mar 1 2022, In: Journal for immunotherapy of cancer. 10, 3Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
Interaction between microbiota and immunity and its implication in colorectal cancer
Xing, C., Du, Y., Duan, T., Nim, K., Chu, J., Wang, H. Y. & Wang, R. F., Jul 29 2022, In: Frontiers in immunology. 13, 963819.Research output: Contribution to journal › Review article › peer-review
Open Access1 Scopus citations