Rongfu Wang, PhD

  • Phone713.441.7359
  • 10459 Citations
  • 55 h-Index
1991 …2020

Research output per year

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Personal profile

Personal profile

Dr. Wang received his Ph.D. from the University of Georgia in 1992. After receiving his doctoral degree in Molecular Genetics, Dr. Wang expanded his field of expertise by training with Dr. James Mullins in the Department of Microbiology and Immunology at Stanford University School of Medicine. In 1994, Dr. Wang joined the Surgery Branch in the Center for Cancer Research at the National Cancer Institute (NCI) in Bethesda, Maryland where he worked with Branch Chief, Dr. Steve Rosenberg, who is a pioneer of cancer immunotherapy. In 1996, Dr. Wang was promoted to Senior Principal Investigator. During his tenure at the NCI, Dr. Wang made insightful discoveries on how immune cells recognize solid tumors through specific cancer antigens and published a landmark paper in Science on the development of a novel genetic approach to identify cancer antigens recognized by CD4+ T cells. In 2000, Dr. Wang was appointed Associate Professor at Baylor College of Medicine in the Center for Cell and Gene Therapy and the Department of Pathology and Immunology. He was promoted to full Professor in 2004. His lab studies novel mechanisms in tumor immunity and tolerance, innate immune regulation, regulatory T cell biology, inflammation, and epigenetics.

Throughout his career Dr. Wang has published over hundred papers in the top class of journals, including Science, Cell, Nature Biotechnology, Nature Immunology, Cell Metabolism and Immunity, and has over 20 patents. His work has been supported by many grants from NIH, DoD, American Cancer Society, Cancer Research Institute and CPRIT.

Research interests

Research interests in Dr. Wang's laboratory include

  • cancer immunotherapy,
  • immune regulation in infectious and tumor immunity;
  • innate immune signaling and inflammation in diseases, 3) epigenetic reprogramming of cancer and immune cells. 

Education/Academic qualification

Molecular Virology, Postdoctoral Fellowship, Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA

Cancer Immunotherapy, Postdoctoral Fellowship, Surgery Branch, National Cancer Institute, Bethesda, MD

Molecular Genetics, PhD, University of Georgia

Free-text keywords

  • Cancer immunology
  • Innate immune signaling
  • Epigenetics of cancer and stem cells
  • Cancer immunotherapy

Research Area Keywords

  • Cancer
  • Immunobiology & Inflammation

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Projects

Research Output

Beclin 2 negatively regulates innate immune signaling and tumor development

Zhu, M., Deng, G., Tan, P., Xing, C., Guan, C., Jiang, C., Zhang, Y., Ning, B., Li, C., Yin, B., Chen, K., Zhao, Y., Wang, H. Y., Levine, B., Nie, G. & Wang, R. F., Oct 1 2020, In : Journal of Clinical Investigation. 130, 10, p. 5349-5369 21 p.

Research output: Contribution to journalArticle

  • Cell-Penetrating Nanoparticles Activate the Inflammasome to Enhance Antibody Production by Targeting Microtubule-Associated Protein 1-Light Chain 3 for Degradation

    Zhu, M., Du, L., Zhao, R., Wang, H. Y., Zhao, Y., Nie, G. & Wang, R. F., Mar 24 2020, In : ACS Nano. 14, 3, p. 3703-3717 15 p.

    Research output: Contribution to journalArticle

  • 1 Scopus citations

    Evaluation of Single-Cell Cytokine Secretion and Cell-Cell Interactions with a Hierarchical Loading Microwell Chip

    Zhou, Y., Shao, N., Bessa de Castro, R., Zhang, P., Ma, Y., Liu, X., Huang, F., Wang, R. F. & Qin, L., Apr 28 2020, In : Cell Reports. 31, 4, 107574.

    Research output: Contribution to journalArticle

  • 1 Scopus citations

    RTP4 inhibits IFN-I response and enhances experimental cerebral malaria and neuropathology

    He, X., Ashbrook, A. W., Du, Y., Wu, J., Hoffmann, H. H., Zhang, C., Xia, L., Peng, Y. C., Tumas, K. C., Singh, B. K., Qi, C. F., Myers, T. G., Long, C. A., Liu, C., Wang, R., Rice, C. M. & Su, X. Z., Aug 11 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 32, p. 19465-19474 10 p.

    Research output: Contribution to journalArticle

  • The E3 ubiquitin ligase MARCH1 regulates antimalaria immunity through interferon signaling and T cell activation

    Wu, J., Xia, L., Yao, X., Yu, X., Tumas, K. C., Sun, W., Cheng, Y., He, X., Peng, Y. C., Singh, B. K., Zhang, C., Qi, C. F., Bolland, S., Best, S. M., Gowda, C., Huang, R., Myers, T. G., Long, C. A., Wang, R. & Su, X. Z., Jul 14 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 28, p. 16567-16578 12 p.

    Research output: Contribution to journalArticle